Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIYFQ5)

Drug Name
SB216763 Drug Info
Synonyms
280744-09-4; SB 216763; 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione; SB216763; SB-216763; 3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione; 1H-Pyrrole-2,5-dione, 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-; CHEMBL102714; 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione; SR-01000076052; Tocris-1616; Lopac-S-3442; AC1L41YI; Lopac0_000934; SCHEMBL30251; MLS001074894; cid_176158; BDBM8296; GTPL8015; CTK8B4807; CHEBI:91421; AOB5004; SYN1075; EX-A291
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
176158
ChEBI ID
CHEBI:91421
CAS Number
CAS 280744-09-4
TTD Drug ID
DMIYFQ5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Glycogen synthase kinase-3 alpha (GSK-3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [11]
LY2090314 DMTBFE4 Acute myeloid leukaemia 2A60 Phase 2 [12]
Lithium DMZ3OU6 Bipolar disorder 6A60 Phase 2 [13]
KENPAULLONE DMAGVXW Discovery agent N.A. Patented [12]
CHIR-99021 DMB8MNU Allergic inflammation 4A80-4A85 Patented [12]
TDZD-8 DMG6Q45 Malignant glioma 2A00.0 Patented [12]
AR-A014418 DMUPN01 Ovarian cancer 2C73 Patented [12]
PMID27828716-Compound-21 DMO1NAR N. A. N. A. Patented [12]
Thiadiazolidindione derivative 2 DM5AUL0 N. A. N. A. Patented [12]
PMID27828716-Compound-18 DMNR6KL N. A. N. A. Patented [12]
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Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [20]
Leflunomide DMR8ONJ Arthritis FA20 Approved [21]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [22]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [23]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [25]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [26]
Gefitinib DM15F0X Colon adenocarcinoma Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Selenium DM25CGV N. A. N. A. Approved [29]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [30]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [31]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [34]
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [37]
Paclitaxel DMLB81S Breast carcinoma Approved [38]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [39]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [42]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [44]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [45]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [50]
Panobinostat DM58WKG Chronic graft versus host disease Approved [51]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [55]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Selenium DM25CGV N. A. N. A. Approved [59]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [30]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [60]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [67]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [70]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [71]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [72]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [73]
Gefitinib DM15F0X Colon adenocarcinoma Approved [74]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Etretinate DM2CZFA Keratosis ED56 Approved [76]
Prednisone DM2HG4X Acute asthma CA23 Approved [77]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [78]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [79]
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Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Gefitinib DM15F0X Colon adenocarcinoma Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Selenium DM25CGV N. A. N. A. Approved [59]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [83]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [88]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [91]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [92]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [94]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [95]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [96]
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Drug(s) Affected By Rapamycin-insensitive companion of mTOR (RICTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [103]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [97]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [104]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [105]
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Drug(s) Affected By Androgen receptor (AR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [106]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [106]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [106]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [107]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [108]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [109]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [110]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [111]
Selenium DM25CGV N. A. N. A. Approved [112]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [113]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glycogen synthase kinase-3 alpha (GSK-3A) TTRZQE3 GSK3A_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Drug Response [3]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [4]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [5]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Post-Translational Modifications [6]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [7]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [7]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [8]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Gene/Protein Processing [9]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [10]
Rapamycin-insensitive companion of mTOR (RICTOR) OTCC58QJ RICTR_HUMAN Gene/Protein Processing [10]

References

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21 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
22 Aldosterone induces epithelial-mesenchymal transition via ROS of mitochondrial origin. Am J Physiol Renal Physiol. 2007 Sep;293(3):F723-31. doi: 10.1152/ajprenal.00480.2006. Epub 2007 Jun 27.
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25 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
26 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
27 ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
28 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
29 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
30 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
31 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
32 Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
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36 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
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38 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
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40 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
41 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
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43 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
44 Nitric oxide causes anoikis through attenuation of E-cadherin and activation of caspase-3 in human gastric carcinoma AZ-521 cells infected with Mycoplasma hyorhinis. J Vet Med Sci. 2010 Jul;72(7):869-74.
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46 Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
47 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
48 Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Biochem Biophys Res Commun. 2009 Mar 13;380(3):614-9. doi: 10.1016/j.bbrc.2009.01.134. Epub 2009 Jan 27.
49 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
50 Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes. PLoS One. 2012;7(4):e36110.
51 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
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53 Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
54 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
55 Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
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57 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
58 Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
59 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
60 Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther. 2001 Sep;298(3):976-85.
61 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
62 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
63 Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
64 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
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