General Information of Drug (ID: DMM1IAU)

Drug Name
PHENYLTHIOUREA Drug Info
Synonyms
Phenylthiourea; N-Phenylthiourea; 1-Phenylthiourea; 103-85-5; 1-PHENYL-2-THIOUREA; Phenylthiocarbamide; Thiourea, phenyl-; Phenyl-2-thiourea; Urea, 1-phenyl-2-thio-; phenyl-thiourea; Thiourea, N-phenyl-; Fenylthiomocovina; USAF EK-1569; RCRA waste number P093; NCI-C02017; CCRIS 514; Fenylthiomocovina [Czech]; NSC 5779; N-Phenyl-Thiourea; N-phenylisothiourea; alpha-Phenylthiourea; U 6324; UNII-6F82C6Q54C; HSDB 4105; .alpha.-Phenylthiourea; EINECS 203-151-2; RCRA waste no. P093; AI3-07549; CHEMBL263376; CHEBI:46261
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
676454
ChEBI ID
CHEBI:46261
CAS Number
CAS 103-85-5
TTD Drug ID
DMM1IAU

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Drug(s) Targeting Tyrosinase (TYR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [7]
Monobenzone DMVJS2K Vitiligo ED63.0 Approved [7]
Multi-epitope peptide melanoma vaccine DMZPEHY Melanoma 2C30 Phase 3 [8]
Melanoma vaccine DMQEC6Z Melanoma 2C30 Phase 3 [9]
Polynoma-1 DM3QDA6 Melanoma 2C30 Phase 2 [10]
MKC-1106-MT DMXKOW6 Melanoma 2C30 Phase 2 [11]
Multi-epitope tyrosinase/gp100 vaccine DMN68ZL Melanoma 2C30 Phase 2 [12]
PMID29130358-Compound-Figure11(3) DMSME2B N. A. N. A. Patented [13]
Benzothiazole analog 1 DMHXFCQ Albinism EC23.2 Patented [14]
Monoamine derivative 2 DMAZ6DI Albinism EC23.2 Patented [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [6]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [6]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [15]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [16]
Drug(s) Affected By Carbonic anhydrase 1 (CA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [17]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [18]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [19]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [20]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [21]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [18]
Indomethacin DMSC4A7 Bursitis Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Phenylephrine DMZHUO5 Allergic rhinitis CA08.0 Approved [24]
GUAIACOL DMN4E7T N. A. N. A. Phase 3 [20]
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Drug(s) Affected By Carbonic anhydrase 2 (CA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [22]
Epinephrine DM3KJBC Acute asthma CA23 Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [28]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [29]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [30]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [31]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [34]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [36]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [41]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [42]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [45]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [48]
Meloxicam DM2AR7L Arthritis FA20 Approved [49]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [50]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [51]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [53]
Selenium DM25CGV N. A. N. A. Approved [54]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [55]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [56]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [64]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [65]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [66]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [67]
Testosterone DM7HUNW Hot flushes GA30 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [71]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [72]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [73]
Almogran DM7I64Z Migraine 8A80 Approved [74]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [75]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [76]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [77]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [78]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tyrosinase (TYR) TTULVH8 TYRO_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Carbonic anhydrase 1 (CA1) OTNFBVVQ CAH1_HUMAN Gene/Protein Processing [2]
Carbonic anhydrase 2 (CA2) OTJRMUAG CAH2_HUMAN Gene/Protein Processing [2]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [3]
Flavin-containing monooxygenase 3 (FMO3) OT1G2EV3 FMO3_HUMAN Drug Response [4]
Peroxisome proliferator-activated receptor alpha (PPARA) OTK095PP PPARA_HUMAN Gene/Protein Processing [3]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Gene/Protein Processing [5]
Taste receptor type 2 member 38 (TAS2R38) OTX5MM36 T2R38_HUMAN Gene/Protein Processing [6]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Gene/Protein Processing [3]

References

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31 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
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42 Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology. 2003 Sep;144(9):3852-9. doi: 10.1210/en.2003-0098.
43 Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
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