Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPH7EO)

Drug Name
Apomorphine SL Drug Info
Synonyms
Apomorphine HCl; Apomorphine chloride; (R)-(-)-Apomorphine hydrochloride; Apomorphinium chloride; Apomorphin hydrochlorid; 314-19-2; pomorphini hydrochloridum; Apomorphinum hydrochloricum; N-Methylnorapomorphine hydrochloride; UNII-9K13MD7A0D; (-)-Apomorphinium hydrochloride; Apomorphine hydrochloride anhydrous; EINECS 206-243-0; NSC 11442; 9K13MD7A0D; 6a-beta-Aporphine-10,11-diol, hydrochloride; 6abeta-Noraporphine-10,11-diol, 6-methyl-, hyd
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9410
CAS Number
CAS 314-19-2
TTD Drug ID
DMPH7EO

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Neuron-specific vesicular protein calcyon (CALY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CY-208243 DMP8TKA Pain MG30-MG3Z Discontinued in Phase 2 [6]
Drug(s) Affected By Vasopressin-neurophysin 2-copeptin (AVP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [7]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [8]
Oxprenolol DM51OQW Anxiety Approved [9]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [10]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [11]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [12]
Luvox DMJKROX Anxiety disorder 6B00-6B0Z Approved [13]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [14]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [8]
Chlorpropamide DMPHZQE Non-insulin dependent diabetes 5A11 Approved [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prolactin (PRL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [16]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [17]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [18]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [21]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [22]
Aripiprazole DM3NUMH Bipolar I disorder Approved [23]
Fluoxetine DM3PD2C Bipolar depression Approved [24]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Somatotropin (GH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [26]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [27]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [28]
Cyproheptadine DM92AH3 Allergic rhinitis CA08.0 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [11]
Sodium oxybate DMBOV5P Narcolepsy 7A20 Approved [30]
Ethanol DMDRQZU Chronic pain MG30 Approved [26]
Connexyn DMF29Q5 Attention deficit hyperactivity disorder 6A05.Z Approved [31]
Gamma Hydroxybutyric Acid DMGBKVD Narcolepsy 7A20 Approved [32]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Furin (FURIN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [34]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [35]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [11]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [40]
Paclitaxel DMLB81S Breast carcinoma Approved [41]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [42]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bone morphogenetic protein receptor type-1A (BMPR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [46]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [47]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [48]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [2]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [49]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepcidin (HAMP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [53]
Leflunomide DMR8ONJ Arthritis FA20 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [2]
Papaverine DMCA9QP Brain ischaemia 8B1Z Approved [2]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [11]
Ethanol DMDRQZU Chronic pain MG30 Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [3]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [57]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [58]
Estrone DM5T6US Acne vulgaris ED80 Approved [59]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [60]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [61]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [62]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [63]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [64]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Neuron-specific vesicular protein calcyon (CALY) TT0R12H CALY_HUMAN Activator [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bone morphogenetic protein receptor type-1A (BMPR1A) OTQOA4ZH BMR1A_HUMAN Gene/Protein Processing [2]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [3]
Furin (FURIN) OTM2665Z FURIN_HUMAN Gene/Protein Processing [2]
Hepcidin (HAMP) OT607RBL HEPC_HUMAN Gene/Protein Processing [2]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Gene/Protein Processing [4]
Somatotropin (GH1) OT92RTRD SOMA_HUMAN Gene/Protein Processing [4]
Vasopressin-neurophysin 2-copeptin (AVP) OTAVZ76K NEU2_HUMAN Gene/Protein Processing [5]

References

1 Dopamine and sexual function. Int J Impot Res. 2001 Aug;13 Suppl 3:S18-28.
2 A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. Exp Hematol. 2015 May;43(5):404-413.e5. doi: 10.1016/j.exphem.2015.01.005. Epub 2015 Jan 26.
3 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
4 A study of dopaminergic sensitivity in Parkinson's disease: comparison in "de novo" and levodopa-treated patients. Clin Neuropharmacol. 1996 Oct;19(5):420-7. doi: 10.1097/00002826-199619050-00005.
5 Betamethasone does not prevent nausea and vomiting induced by the dopamine-agonist apomorphine. Can J Anaesth. 2006 Apr;53(4):370-4. doi: 10.1007/BF03022501.
6 Dopamine D1 receptor agonists induce penile erections in rats. Eur J Pharmacol. 2003 Jan 26;460(1):71-4.
7 [Increased secretion of vasopressin and edema formation in high dosage methotrexate therapy]. Z Gesamte Inn Med. 1988 Aug 1;43(15):411-4.
8 Blood pressure and vasopressin in progressive autonomic failure. Response to postural stimulation, L-dopa and naloxone. Brain. 1983 Jun;106 (Pt 2):503-11. doi: 10.1093/brain/106.2.503.
9 Increased plasma vasopressin and serum uric acid in the low renin type of essential hypertension. Acta Med Scand. 1984;215(2):165-72. doi: 10.1111/j.0954-6820.1984.tb04988.x.
10 Antipsychotic drugs and plasma vasopressin in normals and acute schizophrenic patients. Biol Psychiatry. 1987 Apr;22(4):453-62. doi: 10.1016/0006-3223(87)90167-3.
11 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
12 Lower plasma noradrenaline and blood viscosity on carvedilol vs atenolol in men with recent myocardial infarction. Blood Press. 2002;11(6):377-84. doi: 10.1080/080370502321095357.
13 [Three cases of severe hyponatremia under taking selective serotonin reuptake inhibitor (SSRI)]. Nihon Jinzo Gakkai Shi. 2000 Oct;42(8):644-8.
14 Osmoregulation of vasopressin and thirst: comparison of 20% mannitol with 5% saline as osmotic stimulants in healthy man. Clin Endocrinol (Oxf). 1994 Aug;41(2):207-12. doi: 10.1111/j.1365-2265.1994.tb02531.x.
15 Inappropriate secretion of antidiuretic hormone induced by chlorpropamide. Am J Med Sci. 1972 Mar;263(3):137-41. doi: 10.1097/00000441-197203000-00002.
16 Verapamil-induced hyperprolactinemia complicated by a pituitary incidentaloma. Ann Pharmacother. 1995 Oct;29(10):999-1001. doi: 10.1177/106002809502901009.
17 [Impotence and gynecomastia secondary to hyperprolactinemia induced by ranitidine]. Therapie. 1994 Jul-Aug;49(4):361-2.
18 Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release. Mol Cell Endocrinol. 2005 Jul 15;239(1-2):27-36. doi: 10.1016/j.mce.2005.04.008.
19 Cholinergic modulation of the cerebral metabolic response to citalopram in Alzheimer's disease. Brain. 2009 Feb;132(Pt 2):392-401. doi: 10.1093/brain/awn326. Epub 2009 Jan 19.
20 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
21 The effect of thioridazine on prolactinoma growth in a schizophrenic man: case report. Gen Hosp Psychiatry. 1985 Oct;7(4):364-6. doi: 10.1016/0163-8343(85)90053-2.
22 Influence of naloxone on muscle sympathetic nerve activity, systemic and calf haemodynamics and ambulatory blood pressure after exercise in mild essential hypertension. J Hypertens. 1995 Apr;13(4):447-61.
23 The efficacy, safety, and tolerability of aripiprazole for the treatment of schizoaffective disorder: results from a pooled analysis of a sub-population of subjects from two randomized, double-blind, placebo-controlled, pivotal trials. J Affect Disord. 2009 May;115(1-2):18-26. doi: 10.1016/j.jad.2008.12.017. Epub 2009 Feb 23.
24 Serum prolactin levels among outpatients with major depressive disorder during the acute phase of treatment with fluoxetine. J Clin Psychiatry. 2006 Jun;67(6):952-7. doi: 10.4088/jcp.v67n0612.
25 Massive breast enlargement in a patient receiving D-penicillamine for systemic sclerosis. J Rheumatol. 1985 Oct;12(5):990-1.
26 Metal-catalyzed oxidation of human growth hormone: modulation by solvent-induced changes of protein conformation. J Pharm Sci. 2001 Jan;90(1):58-69. doi: 10.1002/1520-6017(200101)90:1<58::aid-jps7>3.0.co;2-w.
27 Assessment of MK-912, an alpha 2-adrenoceptor antagonist, with use of intravenous clonidine. Clin Pharmacol Ther. 1989 Jul;46(1):103-9. doi: 10.1038/clpt.1989.113.
28 Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells. J Biol Chem. 2003 Feb 21;278(8):6075-84. doi: 10.1074/jbc.M204702200. Epub 2002 Dec 5.
29 [Toxicity of cyproheptadine. Side effects and accidental overdosage (author's transl)]. Monatsschr Kinderheilkd (1902). 1978 Mar;126(3):123-6.
30 Failure of gammahydroxy butyric acid to stimulate growth hormone secretion in cocaine addicts. Neuropeptides. 1997 Oct;31(5):459-62. doi: 10.1016/s0143-4179(97)90040-8.
31 Effect of centrally acting alpha-adrenergic agonists on sympathetic nervous system function in humans. Hypertension. 1984 Sep-Oct;6(5 Pt 2):II57-62. doi: 10.1161/01.hyp.6.5_pt_2.ii57.
32 Thyrotropin-releasing hormone-induced GH release after cocaine withdrawal in cocaine addicts. Neuropeptides. 1999 Dec;33(6):522-5. doi: 10.1054/npep.1999.0773.
33 Effects of cortisol and cocaine on plasma prolactin and growth hormone levels in cocaine-dependent volunteers. Addict Behav. 2005 May;30(4):859-64. doi: 10.1016/j.addbeh.2004.08.019.
34 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
35 10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin. Osteoarthritis Cartilage. 2010 Mar;18(3):455-63. doi: 10.1016/j.joca.2009.10.014. Epub 2009 Nov 4.
36 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
37 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
38 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
39 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
40 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
41 cDNA microarray analysis of isogenic paclitaxel- and doxorubicin-resistant breast tumor cell lines reveals distinct drug-specific genetic signatures of resistance. Breast Cancer Res Treat. 2006 Mar;96(1):17-39. doi: 10.1007/s10549-005-9026-6. Epub 2005 Dec 2.
42 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
43 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
44 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
45 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
46 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
47 Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/-Catenin Pathway Stimulation by Regulating GSK3b Activity. Int J Mol Sci. 2021 May 25;22(11):5571. doi: 10.3390/ijms22115571.
48 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
49 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
50 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
51 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
52 Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
53 Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway. Toxicol Lett. 2020 Jan;318:86-91. doi: 10.1016/j.toxlet.2019.10.016. Epub 2019 Oct 24.
54 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
55 Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem. 2006 Aug 11;281(32):22974-82. doi: 10.1074/jbc.M602098200. Epub 2006 May 31.
56 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
57 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
58 Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
59 In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids. 2005 Mar;70(3):161-72. doi: 10.1016/j.steroids.2004.11.004.
60 Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94.
61 Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7.
62 Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicol In Vitro. 2020 Feb;62:104669. doi: 10.1016/j.tiv.2019.104669. Epub 2019 Oct 16.
63 Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
64 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.