Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSVOCZ)

Drug Name

Pantoprazole Drug Info

Synonyms

Astropan; Pantoprazol; Pantoprazolum; Pantoprozole; Pantor; Pantozol; Protium; Protonix; Somac; Pantoprazole Na; Pantoprazole Sodium; Protonix IV; BY 1023; Astropan (TN); BY-1023; Controloc (TN); Inipomp (TN); Pantecta (TN); Pantoloc (TN); Pantopan (TN); Pantoprazol [INN-Spanish]; Pantoprazolum [INN-Latin]; Pantor (TN); Pantotab (TN); Pantozol (TN); Protium (TN); Protonix (TN); SK&F 96022; SK-96022; SKF-96022; Somac (TN); Ulcepraz (TN); Pantoprazole (USAN/INN); Pantoprazole [USAN:BAN:INN]; SK&F-96022; 5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridyl)methyl)sulfinyl)benzimidazole; 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole; 6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole

Indication

Disease Entry	ICD 11	Status	REF
Gastrinoma	2C10.1	Approved	[1]
Gastroesophageal reflux disease	DA22.Z	Approved	[2]
Peptic ulcer	DA61	Approved	[1]

Therapeutic Class

Antiulcer Agents

Cross-matching ID

PubChem CID: 4679
ChEBI ID: CHEBI:7915
CAS Number: CAS 102625-70-7
TTD Drug ID: DMSVOCZ
VARIDT Drug ID: DR00458
INTEDE Drug ID: DR1236
ACDINA Drug ID: D00508

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Gastric H(+)/K(+) ATPase (Proton pump)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[3]
Dexlansoprazole	DM1DBV5	Erosive esophagitis	DA25.0	Approved	[3]
Esomeprazole	DM7BN0X	Cystic fibrosis	CA25	Approved	[3]
Vonoprazan	DMO6315	Helicobacter infection	DA42-DA63	Approved	[11]
RQ-00000004	DM9T8OF	Gastroesophageal reflux disease	DA22.Z	Phase 3	[12]
YH-4808	DMCHFB0	Duodenal ulcer	DA63	Phase 2	[13]
S-tenatoprazole	DMJ1DIB	Peptic ulcer	DA61	Phase 2	[14]
AZD-0865	DMM0N1F	Gastrointestinal disease	DE2Z	Phase 2	[15]
LEMINOPRAZOLE	DMBKNJT	Ulcerative colitis	DD71	Discontinued in Preregistration	[16]
SKF-96067	DMXW1Y3	Peptic ulcer	DA61	Discontinued in Phase 3	[17]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[18]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[20]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[21]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[22]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[24]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[27]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[30]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[31]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[30]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[32]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[33]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[34]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[35]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[40]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[41]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[35]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[42]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[43]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[44]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[45]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[47]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[40]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[49]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[50]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[51]
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Drug(s) Metabolized By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[52]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[53]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[56]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[57]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[58]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[59]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[60]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[61]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[62]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[63]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[65]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[8]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[69]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[70]
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Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[74]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
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Drug(s) Affected By Hepcidin (HAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[9]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[84]
Papaverine	DMCA9QP	Brain ischaemia	8B1Z	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[86]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gastric H(+)/K(+) ATPase (Proton pump)	TTLOKXP	ATP4A_HUMAN; ATP4B_HUMAN	Modulator	[3]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[4]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)^{Main DME}	DE4LYSA	CP3A4_HUMAN	Substrate	[6]
Mephenytoin 4-hydroxylase (CYP2C19)^{Main DME}	DEGTFWK	CP2CJ_HUMAN	Substrate	[7]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[8]
Sulfotransferase 1A1 (SULT1A1)	DEYWLRK	ST1A1_HUMAN	Substrate	[6]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Hepcidin (HAMP)	OT607RBL	HEPC_HUMAN	Gene/Protein Processing	[9]
Phospholipid-transporting ATPase ABCA1 (ABCA1)	OT94G6BQ	ABCA1_HUMAN	Gene/Protein Processing	[10]

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References

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