Details of the Drug Reposition

General Information of This Drug (ID: DM7ICNU)

• Drug Name: Doxycycline (DM7ICNU)
• Synonyms: Atridox; Azudoxat; DOXY; Deoxymykoin; Dossiciclina; Doxiciclina; Doxitard; Doxivetin; Doxycen; Doxychel; Doxycin; Doxycyclin; Doxycyclinum; Doxysol; Doxytec; Doxytetracycline; Hydramycin; Investin; Jenacyclin; Liviatin; Monodox; Oracea; Ronaxan; Spanor; Supracyclin; Vibramycin; Vibramycine; Vibravenos; DOXCYCLINE ANHYDROUS; DOXYCYCLINE CALCIUM; DOXYCYCLINE MONOHYDRATE; Dossiciclina [DCIT]; Doxiciclina [Italian]; Doxycycline anhydrous; Doxycycline hyclate; Vibramycin Novum; Alpha-Doxycycline; Alti-Doxycycline; Apo-Doxy; BMY-28689; BU-3839T; Doxiciclina [INN-Spanish]; Doxy-Caps; Doxy-Puren; Doxy-Tabs; Doxychel (TN); Doxycycline (INN); Doxycycline (TN); Doxycycline (anhydrous); Doxycycline (internal use); Doxycycline-Chinoin; Doxycyclinum [INN-Latin]; Novo-Doxylin; Nu-Doxycycline; Periostat (TN); Vibra-tabs; Alpha-6-Deoxyoxytetracycline; DMSC (*Fosfatex); Doxycycline (200mg/day) or Placebo; Monodox (*monohydrate); Vibramycin (*monohydrate); Vivox (*Hyclate); GS-3065 (*monohydrate); Alpha-6-Deoxy-5-hydroxytetracycline; (2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS); 5-Hydroxy-alpha-6-deoxytetracycline; 6-Deoxyoxytetracycline; 6-Deoxytetracycline; 6-alpha-Deoxy-5-oxytetracycline; 6alpha-Deoxy-5-oxytetracycline
• Therapeutic Class: Antiinflammatory Agents
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

34 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Yaws	DISLTH3X	N.A.	Approved	[1]
Typhus	DISJ5JX1	N.A.	Approved	[1]
Trachoma	DIS2WZUR	N.A.	Approved	[1]
Syphilis	DISJ73BS	N.A.	Approved	[1]
Rocky mountain spotted fever	DISFN72S	N.A.	Approved	[1]
Rickettsiosis	DIS4GUSE	N.A.	Approved	[1]
Rickettsialpox	DISEMENW	N.A.	Approved	[1]
Relapsing fever	DISEA4L7	N.A.	Approved	[1]
Q fever	DISK1S90	N.A.	Approved	[1]
Ornithosis	DIS4YMZ8	N.A.	Approved	[1]
Mycoplasma pneumoniae pneumonia	DIS1AW2Z	N.A.	Approved	[1]
Lymphogranuloma venereum	DIS0MMFT	N.A.	Approved	[1]
Listeriosis	DISKMQBM	N.A.	Approved	[1]
Inhalational anthrax	DISII8HD	N.A.	Approved	[1]
Gastrointestinal anthrax	DIS7DTI1	N.A.	Approved	[1]
Epidemic louse-borne typhus	DISHV9EH	N.A.	Approved	[1]
Endemic typhus	DIS1D29X	N.A.	Approved	[1]
Cutaneous anthrax	DISA6ECE	N.A.	Approved	[1]
Colorectal carcinoma	DIS5PYL0	N.A.	Approved	[1]
Chlamydiaceae infections	DIS208D8	N.A.	Approved	[1]
Chancroid	DISMVLOF	N.A.	Approved	[1]
Brucellosis	DISEAYGH	N.A.	Approved	[1]
Brill-Zinsser disease	DISG4YLE	N.A.	Approved	[1]
Boutonneuse fever	DISGAGZ3	N.A.	Approved	[1]
Bartonellosis	DISMKP1N	N.A.	Approved	[1]
Acute gonococcal epididymo-orchitis	DISBF6L8	N.A.	Approved	[1]
Acute gonococcal cervicitis	DIS4LKDT	N.A.	Approved	[1]
Actinomycosis	DIS7YFRP	N.A.	Approved	[1]
Tularemia	DISF94A2	1B94	Approved	[1]
Anthrax	DISFPT78	1B97	Approved	[1]
Bronchitis	DISBM6EQ	CA20	Approved	[1]
Chronic periodontitis	DISJKAFL	DA0C.Y	Approved	[2]
Advanced gum disease	DISU68RU	DA0D	Approved	[2]
Acne vulgaris	DISKW8PI	ED80	Approved	[1]

1 Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Diabetic foot ulcer	DISXVPHM	BD54	Phase 2	[3]

1 Withdrawn Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Acute gonococcal endometritis	DISZ8BW7	N.A.	Withdrawn	[4]

2 Discontinued in Phase 3 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Scrub typhus	DISRXONX	N.A.	Discontinued in Phase 3	[5]
Pharyngitis	DISSN548	CA02.Z	Discontinued in Phase 3	[6]

3 Discontinued in Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Granuloma inguinale	DISRKXBH	N.A.	Discontinued in Phase 2	[7]
Gonorrhea	DISQ5AO6	1A7Z	Discontinued in Phase 2	[8]
Bacterial pneumonia	DISPW7PH	CA40.0	Discontinued in Phase 2	[9]

2 Investigative Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Vibrio cholerae infection	DISW7E3U	1A00	Investigative	[1]
Sinusitis	DISX5NCF	CA0A.Z	Investigative	[1]

References

• [1] Doxycycline FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6464).
• [3] ClinicalTrials.gov (NCT00764361) Safety Study of Topical Doxycycline Gel for Adult Diabetic Lower Extremity Ulcers. U.S. National Institutes of Health.
• [4] Combination Chemotherapy in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer
• [5] Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition.
• [6] Local Anesthetic Treatments for Overactive Bladder
• [7] A Study to Determine Whether Therapy With Daclizumab Will Benefit Patients With Bone Marrow Failure
• [8] Radiolabeled Monoclonal Antibody Plus Rituximab With and Without Filgrastim and Interleukin-11 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
• [9] Romidepsin in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors