Details of Disease

General Information of Disease (ID: DISW7E3U)

• Disease Name: Vibrio cholerae infection
• Synonyms: Vibrio cholerae infection; Vibrio cholerae caused disease or disorder; cholera due to Vibrio cholerae; Vibrio cholerae disease or disorder; Vibrio cholerae; cholera - Vibrio cholerae; Vibrio cholerae infectious disease
• Disease Class: 1A00: Cholera
• Definition: Cholera is an infectious disease, caused by intestinal infection with Vibrio cholerae, characterized by massive watery diarrhea and severe dehydration that can lead to shock and death if left untreated.
• Disease Hierarchy:
  DISFAMTH: Vibrio infectious disease
  DIS8ZVFW: Primary bacterial infectious disease
  DISE1NRW: Intestinal infectious disease
  DISEM33Q: Infectious disease
  DISW7E3U: Vibrio cholerae infection
• ICD Code:
  ICD-11: ICD-11: 1A00
  ICD-10: ICD-10: A00, A00.9
• Disease Identifiers:
  MONDO ID: MONDO_0015766
  MESH ID: D002771
  UMLS CUI: C0008354
  MedGen ID: 40263
  Orphanet ID: 173
  SNOMED CT ID: 63650001

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 7 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cholera vaccine	DMG5JDP	Approved	NA	[1]
Cynarin	DMUY2OR	Approved	Small molecular drug	[1]
Doxycycline	DM7ICNU	Approved	Small molecular drug	[2]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[3]
Minocycline	DMVN5OH	Approved	Small molecular drug	[4]
ORC-Vax	DMHJW8B	Approved	NA	[1]
Orochol	DM5NMPN	Approved	NA	[1]

This Disease is Treated as An Indication in 4 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Vaxchora	DM5106Q	Phase 3	NA	[5]
CholeraGarde cholera vaccine live attenuated	DMSI1YS	Phase 2	NA	[6]
Live attenuated cholera vaccine	DMZP9UD	Phase 2	NA	[7]
ETEC vaccine	DMSCD8Y	Phase 1	NA	[8]

This Disease is Treated as An Indication in 2 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AKT-10082	DMAV6YK	Investigative	NA	[9]
Cholera EPVaccine	DMUPLZQ	Investigative	NA	[9]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 19 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CRLF2	TTRMZ0N	Limited	Altered Expression	[10]
NAGLU	TTDM6HZ	Limited	Genetic Variation	[11]
SLC5A1	TT2UE56	Limited	Biomarker	[12]
SLC9A3	TTFZVPO	Limited	Biomarker	[13]
TYRP1	TTFRV98	Limited	Altered Expression	[14]
ACKR1	TTKY2NS	Strong	Genetic Variation	[15]
CACNA1E	TTYRP0M	Strong	Biomarker	[16]
CHRM1	TTZ9SOR	Strong	Biomarker	[17]
CYP11A1	TTSYVO6	Strong	Altered Expression	[18]
CYP26A1	TTD7Q0R	Strong	Altered Expression	[19]
DLG4	TT9PB26	Strong	Genetic Variation	[20]
GPR39	TTTPCNU	Strong	Biomarker	[21]
HSD17B1	TTIWB6L	Strong	Altered Expression	[22]
NTF4	TTIM2WO	Strong	Biomarker	[23]
PRSS1	TT2WR1T	Strong	Altered Expression	[14]
PRSS8	TTT4N0Q	Strong	Biomarker	[24]
SLC39A6	TTZN1CF	Strong	Altered Expression	[25]
TPH2	TT3KLDP	Strong	Biomarker	[26]
TRPC1	TTA76X0	Strong	Biomarker	[27]

This Disease Is Related to 3 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYP27A1	DEBS639	Limited	Genetic Variation	[28]
SPR	DEJVDAT	Strong	Biomarker	[29]
WARS1	DEPVE0M	Strong	Altered Expression	[30]

This Disease Is Related to 43 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ATP8B1	OTALGS63	Limited	Biomarker	[31]
NBAS	OTW9IBRI	Limited	Genetic Variation	[11]
SCN7A	OTK05PXY	Limited	Genetic Variation	[11]
TAPBP	OTL81AVZ	Limited	Altered Expression	[32]
ADCY6	OTFOY4WW	Strong	Biomarker	[33]
ADPRH	OTLJ5511	Strong	Biomarker	[34]
AKAP13	OTOZAR14	Strong	Biomarker	[35]
ARFIP1	OTXHWO6M	Strong	Altered Expression	[36]
ART5	OTEZUT8V	Strong	Genetic Variation	[37]
BPIFB1	OTOZYJMO	Strong	Genetic Variation	[38]
CAV3	OTWSFDB4	Strong	Biomarker	[39]
CAVIN1	OTFO915U	Strong	Biomarker	[40]
CKB	OTUCKOTT	Strong	Altered Expression	[41]
CLEC11A	OT9KBH7C	Strong	Biomarker	[35]
CMIP	OTZN8Z4A	Strong	Biomarker	[42]
CNOT1	OTTEU05F	Strong	Biomarker	[43]
EFEMP2	OT0I2B4J	Strong	Biomarker	[44]
EVPL	OTZIAFEK	Strong	Biomarker	[45]
FASTK	OTTHFZMP	Strong	Biomarker	[46]
FDX1	OT7I3DN0	Strong	Altered Expression	[47]
GGTLC1	OTWJKUHQ	Strong	Biomarker	[48]
HIVEP1	OT7CAG4A	Strong	Biomarker	[44]
IFT172	OT12DW08	Strong	Biomarker	[49]
LCN1	OT8BWXTV	Strong	Altered Expression	[50]
LDLRAP1	OT6QTX7R	Strong	Biomarker	[34]
MAP1LC3A	OTPMGIU4	Strong	Biomarker	[51]
NRSN1	OT1KKXC8	Strong	Biomarker	[52]
NSFL1C	OTIKQF3U	Strong	Biomarker	[35]
PHF12	OTECRO7N	Strong	Biomarker	[53]
PLEK	OTB73XXA	Strong	Biomarker	[35]
POU4F1	OTMHYGWQ	Strong	Altered Expression	[54]
PPIL1	OTS5S837	Strong	Biomarker	[55]
PRG2	OT0BCPQG	Strong	Biomarker	[44]
PTF1A	OT7SWA57	Strong	Biomarker	[56]
RANBP2	OTFG5CVF	Strong	Altered Expression	[14]
SEPTIN3	OTOZ6PIM	Strong	Genetic Variation	[57]
SLC6A16	OT1MJ5BD	Strong	Biomarker	[23]
SNRNP35	OTHHFU00	Strong	Biomarker	[17]
SPINK1	OTSUVAL2	Strong	Biomarker	[58]
SUMF2	OT37I8JL	Strong	Genetic Variation	[59]
TMED2	OTBLO7RW	Strong	Biomarker	[52]
TNMD	OTHLVA9G	Strong	Genetic Variation	[60]
TPPP	OTCFMSUF	Strong	Biomarker	[52]

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