Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2CZFA)

Drug Name
Etretinate Drug Info
Synonyms
etretinate; 54350-48-0; Tegison; Ethyl etrinoate; Retinoid; Etretinatum; Etretinato; Ro 10-9359; Etretinatum [INN-Latin]; Etretinato [INN-Spanish]; UNII-65M2UDR9AG; CCRIS 3615; HSDB 7185; EINECS 259-119-3; NSC 297936; 65M2UDR9AG; Ro-10-9359; Tigason; CHEBI:4913; C23H30O3; Ethyl all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate; Ethyl (all-E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate; 3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonanetetraenoic acid ethy
Indication
Disease Entry ICD 11 Status REF
Keratosis ED56 Approved [1]
Cross-matching ID
PubChem CID
5282375
ChEBI ID
CHEMBL464
CAS Number
CAS 54350-48-0
TTD Drug ID
DM2CZFA
INTEDE Drug ID
DR0672

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By Tumor protein p73 (TP73)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [6]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [9]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [10]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [11]
Menthol DMG2KW7 Back pain ME84.Z Approved [12]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [13]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [5]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [14]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [15]
Gefitinib DM15F0X Colon adenocarcinoma Approved [16]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [17]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [18]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [19]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [20]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [22]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
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Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [28]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [29]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [30]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [31]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
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Drug(s) Affected By Interstitial collagenase (MMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [44]
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Drug(s) Affected By Fructose-bisphosphate aldolase A (ALDOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [49]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [50]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [30]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [51]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [51]
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Drug(s) Affected By ATP synthase subunit beta, mitochondrial (ATP5F1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [57]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Ethanol DMDRQZU Chronic pain MG30 Approved [58]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [55]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [55]
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Drug(s) Affected By Alpha-enolase (ENO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [28]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [61]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [62]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [31]
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Drug(s) Affected By Protein disulfide-isomerase (P4HB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [63]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [64]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [48]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [28]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
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Drug(s) Affected By Profilin-1 (PFN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Selenium DM25CGV N. A. N. A. Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [50]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [69]
Haloperidol DM96SE0 Delirium Approved [70]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [32]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Benzatropine DMF7EXL Parkinsonian disorder Approved [70]
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Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Selenium DM25CGV N. A. N. A. Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [73]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [28]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
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Drug(s) Affected By Tropomyosin alpha-1 chain (TPM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Testosterone DM7HUNW Hot flushes GA30 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [80]
Bortezomib DMNO38U Leukemia Approved [81]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [82]
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Drug(s) Affected By POTE ankyrin domain family member I (POTEI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [83]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [84]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [84]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [85]
Milchsaure DM462BT Pruritus EC90 Investigative [86]
Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [89]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [90]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [28]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [91]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [89]
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Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [92]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [93]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [94]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [95]
Leflunomide DMR8ONJ Arthritis FA20 Approved [96]
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Drug(s) Affected By Elastin (ELN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [99]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [100]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [101]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [102]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [103]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [104]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [105]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [106]
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Drug(s) Affected By Replication protein A 32 kDa subunit (RPA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [107]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [108]
Testosterone DM7HUNW Hot flushes GA30 Approved [109]
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [110]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [109]
Leflunomide DMR8ONJ Arthritis FA20 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [111]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Selenium DM25CGV N. A. N. A. Approved [45]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [114]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [116]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [117]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [119]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [107]
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Drug(s) Affected By Proteasome subunit beta type-1 (PSMB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [10]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [121]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [103]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [122]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [123]
Paclitaxel DMLB81S Breast carcinoma Approved [123]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [124]
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Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [126]
Testosterone DM7HUNW Hot flushes GA30 Approved [109]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [128]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Ethanol DMDRQZU Chronic pain MG30 Approved [129]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [130]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [131]
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Drug(s) Affected By Cofilin-1 (CFL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [93]
Haloperidol DM96SE0 Delirium Approved [70]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [128]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [132]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [133]
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Drug(s) Affected By Elongation factor 1-gamma (EEF1G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [49]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Menthol DMG2KW7 Back pain ME84.Z Approved [12]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [133]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [134]
Arsenic DMTL2Y1 N. A. N. A. Approved [135]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [136]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [103]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [137]
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Drug(s) Affected By Protein disulfide-isomerase A3 (PDIA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [128]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Benzatropine DMF7EXL Parkinsonian disorder Approved [70]
Clozapine DMFC71L Schizophrenia 6A20 Approved [70]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [138]
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Drug(s) Affected By Leukocyte elastase inhibitor (SERPINB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [139]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [140]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [142]
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Drug(s) Affected By Peroxiredoxin-2 (PRDX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Quercetin DM3NC4M Obesity 5B81 Approved [145]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [107]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [90]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [146]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [128]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
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Drug(s) Affected By Fibrillin-1 (FBN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Panobinostat DM58WKG Chronic graft versus host disease Approved [142]
Leflunomide DMR8ONJ Arthritis FA20 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [81]
Paclitaxel DMLB81S Breast carcinoma Approved [149]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [103]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [142]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [150]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [151]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [152]
Gefitinib DM15F0X Colon adenocarcinoma Approved [16]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [153]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Prednisone DM2HG4X Acute asthma CA23 Approved [155]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [156]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [157]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [139]
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Drug(s) Affected By Macrophage-capping protein (CAPG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [29]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [128]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [158]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [133]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [159]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [160]
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Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [161]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ethanol DMDRQZU Chronic pain MG30 Approved [164]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [165]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [166]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [167]
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Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein M (HNRNPM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Arsenic DMTL2Y1 N. A. N. A. Approved [135]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [168]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [169]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [45]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [170]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [171]
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Drug(s) Affected By Rho GDP-dissociation inhibitor 1 (ARHGDIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [172]
Selenium DM25CGV N. A. N. A. Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Estrone DM5T6US Acne vulgaris ED80 Approved [173]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [174]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Ampicillin DMHWE7P Acute epiglottitis Approved [26]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [132]
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Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor D (CDKN2D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [172]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [175]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [176]
Testosterone DM7HUNW Hot flushes GA30 Approved [109]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [177]
Menthol DMG2KW7 Back pain ME84.Z Approved [12]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [178]
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Drug(s) Affected By Triosephosphate isomerase (TPI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [179]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
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Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [172]
Selenium DM25CGV N. A. N. A. Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [180]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Leflunomide DMR8ONJ Arthritis FA20 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [128]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase A (PPIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [181]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [128]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
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Drug(s) Affected By Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [182]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Benzatropine DMF7EXL Parkinsonian disorder Approved [70]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [183]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [184]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [185]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [186]
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Drug(s) Affected By Elongation factor 1-alpha 1 (EEF1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [49]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [140]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [88]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [31]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Menthol DMG2KW7 Back pain ME84.Z Approved [12]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [111]
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Drug(s) Affected By Forkhead box protein K2 (FOXK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [128]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [158]
Menthol DMG2KW7 Back pain ME84.Z Approved [12]
Arsenic DMTL2Y1 N. A. N. A. Approved [135]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [187]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [184]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [103]
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Drug(s) Affected By Peroxiredoxin-1 (PRDX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [188]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [48]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [189]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [88]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine-protein kinase ATM (ATM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [190]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [191]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [192]
Quercetin DM3NC4M Obesity 5B81 Approved [193]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [194]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [28]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [195]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [9]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [196]
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Drug(s) Affected By Beta-actin-like protein 2 (ACTBL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Benzatropine DMF7EXL Parkinsonian disorder Approved [70]
Clozapine DMFC71L Schizophrenia 6A20 Approved [70]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [131]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [83]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [197]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [84]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [198]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [199]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [171]
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Drug(s) Affected By POTE ankyrin domain family member E (POTEE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Testosterone DM7HUNW Hot flushes GA30 Approved [109]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [109]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [128]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [187]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [201]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [103]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [84]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [84]
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Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estrone DM5T6US Acne vulgaris ED80 Approved [202]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [202]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [204]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [44]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [205]
Testosterone DM7HUNW Hot flushes GA30 Approved [109]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [206]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Retinoic acid 4-hydroxylase 26B1 (CYP26B1) Main DME DEZT8FM CP26B_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
14-3-3 protein epsilon OT3WQXNA 1433E_HUMAN Gene/Protein Processing [3]
14-3-3 protein theta OTWG7F3H 1433T_HUMAN Gene/Protein Processing [3]
14-3-3 protein zeta/delta OT2TKG9P 1433Z_HUMAN Gene/Protein Processing [3]
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) OT3K7HY5 DHB2_HUMAN Regulation of Drug Effects [4]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Gene/Protein Processing [3]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Gene/Protein Processing [3]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Gene/Protein Processing [3]
ATP synthase subunit beta, mitochondrial (ATP5F1B) OTLFZUQK ATPB_HUMAN Gene/Protein Processing [3]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [5]
Beta-actin-like protein 2 (ACTBL2) OTD6B81U ACTBL_HUMAN Gene/Protein Processing [3]

References

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2 Lipopolysaccharide opposes the induction of CYP26A1 and CYP26B1 gene expression by retinoic acid in the rat liver in vivo. Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1029-36.
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4 Transgenic male mice expressing human hydroxysteroid dehydrogenase 2 indicate a role for the enzyme independent of its action on sex steroids. Endocrinology. 2007 Aug;148(8):3827-36. doi: 10.1210/en.2007-0365. Epub 2007 May 17.
5 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
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8 Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
9 Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
10 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
11 Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
12 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
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14 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
15 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
16 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
17 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
18 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
19 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
20 Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
21 Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
22 Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
23 Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
24 CyclinB2 and BIRC5 genes as surrogate biomarkers for neurite outgrowth in SH-SY5Y subclonal cells. Neuropharmacology. 2006 Jun;50(8):1041-7. doi: 10.1016/j.neuropharm.2006.02.004. Epub 2006 Mar 30.
25 PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells. Biosci Biotechnol Biochem. 2008 Jul;72(7):1799-808. doi: 10.1271/bbb.80079. Epub 2008 Jul 7.
26 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
27 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
28 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
29 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
30 Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
31 Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
32 Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
33 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
34 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
35 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
36 Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
37 Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy. Arthritis Rheum. 2002 Nov;46(11):3034-40. doi: 10.1002/art.10617.
38 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
39 Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1043-9. doi: 10.1161/ATVBAHA.107.139881. Epub 2007 Feb 15.
40 Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase. Arch Biochem Biophys. 2001 Jul 1;391(1):72-8. doi: 10.1006/abbi.2001.2402.
41 Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
42 Interaction between the aryl hydrocarbon receptor and retinoic acid pathways increases matrix metalloproteinase-1 expression in keratinocytes. J Biol Chem. 2004 Jun 11;279(24):25284-93. doi: 10.1074/jbc.M402168200. Epub 2004 Apr 9.
43 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
44 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
45 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
46 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
47 Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):197-210. doi: 10.1016/j.taap.2006.12.030. Epub 2007 Jan 9.
48 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
49 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
50 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
51 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
52 Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Mol Endocrinol. 2010 May;24(5):969-80. doi: 10.1210/me.2009-0148. Epub 2010 Mar 8.
53 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
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