Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJCQKA)

Drug Name
Sphingosine-1-phosphate Drug Info
Synonyms
Sphingosine 1-phosphate; sphingosine-1-phosphate; 26993-30-6; D-erythro-Sphingosine-1-phosphate; C18-Sphingosine 1-phosphate; Sphing-4-enine 1-phosphate; S1P; CHEBI:37550; D-erythro-sphingosine 1-phosphate; UNII-YVE187NJ1U; Sphingosine 1-phosphic acid; (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate; Sphing-4-enine-1-phosphate; YVE187NJ1U; CHEMBL225155; DUYSYHSSBDVJSM-KRWOKUGFSA-N; 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E)-; (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-(Dihydroge
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Phase 1 [1]
Cross-matching ID
PubChem CID
5283560
ChEBI ID
CHEMBL225155
CAS Number
CAS 26993-30-6
TTD Drug ID
DMJCQKA
VARIDT Drug ID
DR00118
INTEDE Drug ID
DR1811

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Sphingosine-1-phosphate receptor 1 (S1PR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Siponimod DM2R86O Multiple sclerosis 8A40 Approved [14]
Fingolimod DM5JVAN Multiple sclerosis 8A40 Approved [15]
Ozanimod DMT6AM2 Multiple sclerosis 8A40 Approved [16]
Etrasimod DMT0A3Y Ulcerative colitis DD71 Approved [17]
Ponesimod DMEAOYJ Multiple sclerosis 8A40 Approved [18]
MT-1303 DMSE9TH Crohn disease DD70 Phase 2 [19]
ONO-4641 DMLUM3Y Rheumatoid arthritis FA20 Phase 2 [20]
KRP-203 DMOW9X2 Cutaneous lupus erythematosus EB5Z Phase 2 [20]
VTX-002 DMZ8Z5A Ulcerative colitis DD71 Phase 2 [21]
CBP-307 DM3TH6Y Ulcerative colitis DD71 Phase 2 [22]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [23]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Folic Acid DMEMBJC Colorectal carcinoma Approved [26]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [28]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [29]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [30]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Folic Acid DMEMBJC Colorectal carcinoma Approved [32]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [33]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [34]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [35]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [36]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [35]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [37]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [38]
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Drug(s) Affected By Sphingosine-1-phosphate transporter SPNS2 (SPNS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [45]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [46]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [47]
Milchsaure DM462BT Pruritus EC90 Investigative [48]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [49]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [50]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [51]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [52]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [53]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [54]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [55]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [59]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [50]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [60]
Paclitaxel DMLB81S Breast carcinoma Approved [61]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [62]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [49]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [52]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [53]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [65]
Selenium DM25CGV N. A. N. A. Approved [66]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [67]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [68]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [71]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [73]
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Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [74]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [78]
Estrone DM5T6US Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [81]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [82]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [83]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [84]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [85]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [86]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [87]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [90]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [88]
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Drug(s) Affected By CCN family member 2 (CCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [95]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [96]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [97]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [98]
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Drug(s) Affected By Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [101]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [102]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [103]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [102]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [104]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [63]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [105]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [10]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [10]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [107]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [108]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [10]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [10]
Ethacrynic acid DM60QMR Edema MG29 Approved [10]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [10]
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Drug(s) Affected By Laminin subunit beta-3 (LAMB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Selenium DM25CGV N. A. N. A. Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Testosterone DM7HUNW Hot flushes GA30 Approved [110]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [111]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [112]
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Drug(s) Affected By Laminin subunit gamma-2 (LAMC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [114]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [115]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [116]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [115]
Panobinostat DM58WKG Chronic graft versus host disease Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [112]
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Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [66]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [119]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [121]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [122]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [123]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [124]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [125]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [66]
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Drug(s) Affected By Laminin subunit alpha-3 (LAMA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [126]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [126]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [127]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [128]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [119]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [128]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [128]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sphingosine-1-phosphate receptor 1 (S1PR1) TT9JZCK S1PR1_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Protein spinster homolog 2 (SLC63A2) DT3Q1UO SPNS2_HUMAN Substrate [3]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [4]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Sphingosine kinase 1 (SPHK1) DELSNWC SPHK1_HUMAN Substrate [6]
Phospholipid phosphatase 1 (PLPP1) DE6WXTH PLPP1_HUMAN Substrate [7]
Sphingosine kinase 2 (SPHK2) DES1RUQ SPHK2_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4) OTPA0QHW PLCB4_HUMAN Gene/Protein Processing [8]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Gene/Protein Processing [9]
Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) OTOODWTU GNAQ_HUMAN Gene/Protein Processing [8]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Gene/Protein Processing [10]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [11]
Laminin subunit alpha-3 (LAMA3) OTFME7HT LAMA3_HUMAN Gene/Protein Processing [12]
Laminin subunit beta-3 (LAMB3) OTFPU6W8 LAMB3_HUMAN Gene/Protein Processing [12]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Gene/Protein Processing [12]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [13]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [13]

References

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2 Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2520-4.
3 The ABCs of membrane transporters in health and disease (SLC series): Introduction. Molecular Aspects of Medicine, 2013, 34(2-3):95-107. (GeneName=SLC63A2)
4 Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. J Biol Chem. 2010 Apr 2;285(14):10477-86.
5 Lipid dependence of ABC transporter localization and function. Chem Phys Lipids. 2009 Oct;161(2):57-64.
6 Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. J Biol Chem. 2003 Nov 28;278(48):47408-15.
7 Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice. PLoS One. 2018 Jun 11;13(6):e0198063.
8 A natural piper-amide-like compound NED-135 exhibits a potent inhibitory effect on the invasive breast cancer cells. Chem Biol Interact. 2015 Jul 25;237:58-65. doi: 10.1016/j.cbi.2015.05.006. Epub 2015 May 14.
9 Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP. FASEB J. 2015 Jun;29(6):2423-30. doi: 10.1096/fj.14-267856. Epub 2015 Feb 17.
10 A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
11 Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells. J Biol Chem. 2002 Aug 16;277(33):30227-35. doi: 10.1074/jbc.M111078200. Epub 2002 May 30.
12 Increase of laminin 5 synthesis in human keratinocytes by acute wound fluid, inflammatory cytokines and growth factors, and lysophospholipids. Br J Dermatol. 2004 Nov;151(5):961-70. doi: 10.1111/j.1365-2133.2004.06175.x.
13 Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin. Thromb Haemost. 2008 Jul;100(1):119-26.
14 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
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17 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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20 Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702.
21 Clinical pipeline report, company report or official report of Ventyx Biosciences
22 Clinical pipeline report, company report or official report of Connect Biopharma
23 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
24 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
25 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
26 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
27 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
28 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
29 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
30 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
31 Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
32 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
33 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
34 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
35 Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
36 The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
37 Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
38 Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
39 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
40 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
41 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
42 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
43 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
44 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
45 Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-beta-dependent mechanisms. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66.
46 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
47 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
48 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
49 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
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