Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJCQKA)

• Drug Name: Sphingosine-1-phosphate Drug Info
• Synonyms: Sphingosine 1-phosphate; sphingosine-1-phosphate; 26993-30-6; D-erythro-Sphingosine-1-phosphate; C18-Sphingosine 1-phosphate; Sphing-4-enine 1-phosphate; S1P; CHEBI:37550; D-erythro-sphingosine 1-phosphate; UNII-YVE187NJ1U; Sphingosine 1-phosphic acid; (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate; Sphing-4-enine-1-phosphate; YVE187NJ1U; CHEMBL225155; DUYSYHSSBDVJSM-KRWOKUGFSA-N; 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E)-; (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-(Dihydroge

Indication

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 5283560
  ChEBI ID: CHEBI:37550
  CAS Number: CAS 26993-30-6
  TTD Drug ID: DMJCQKA
  VARIDT Drug ID: DR00118
  INTEDE Drug ID: DR1811

Molecule-Related Drug Atlas

Drug(s) Targeting Sphingosine-1-phosphate receptor 1 (S1PR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Siponimod	DM2R86O	Multiple sclerosis	8A40	Approved	[16]
Fingolimod	DM5JVAN	Multiple sclerosis	8A40	Approved	[17]
Ozanimod	DMT6AM2	Multiple sclerosis	8A40	Approved	[18]
Etrasimod	DMT0A3Y	Ulcerative colitis	DD71	Approved	[19]
Ponesimod	DMEAOYJ	Multiple sclerosis	8A40	Approved	[20]
MT-1303	DMSE9TH	Crohn disease	DD70	Phase 2	[21]
ONO-4641	DMLUM3Y	Rheumatoid arthritis	FA20	Phase 2	[22]
KRP-203	DMOW9X2	Cutaneous lupus erythematosus	EB5Z	Phase 2	[22]
VTX-002	DMZ8Z5A	Ulcerative colitis	DD71	Phase 2	[23]
CBP-307	DM3TH6Y	Ulcerative colitis	DD71	Phase 2	[24]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[28]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[29]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[30]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[31]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[34]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[37]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[39]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[40]

Drug(s) Affected By Sphingosine kinase 1 (SPHK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Bortezomib	DMNO38U	Leukemia		Approved	[48]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[50]

Drug(s) Affected By Sphingosine-1-phosphate transporter SPNS2 (SPNS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[58]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[59]

Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[60]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[64]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[65]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[66]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[66]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[67]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[68]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[74]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[75]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[76]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[78]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[80]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[82]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[83]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[86]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[78]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[87]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[88]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[90]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[80]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[92]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[93]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[94]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[96]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[97]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[98]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]

Drug(s) Affected By Sphingosine 1-phosphate receptor 2 (S1PR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[106]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[107]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[108]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[109]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[110]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Selenium	DM25CGV	N. A.	N. A.	Approved	[114]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[115]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[116]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[117]
Fructose	DM43AN2	Vomiting	MD90	Approved	[90]
Ketoprofen	DMRKXPT	Bursitis		Approved	[90]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[118]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[119]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[120]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[123]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[124]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[126]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[129]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[130]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Selenium	DM25CGV	N. A.	N. A.	Approved	[114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[138]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[139]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[141]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[142]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[147]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[148]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[151]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[154]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[155]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[100]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[129]
Selenium	DM25CGV	N. A.	N. A.	Approved	[157]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[158]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[159]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[165]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[166]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[167]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[168]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[126]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[170]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[171]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[100]

Drug(s) Affected By Hepatocyte growth factor (HGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[176]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[177]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[178]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[180]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Selenium	DM25CGV	N. A.	N. A.	Approved	[114]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[182]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[185]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[186]

Drug(s) Affected By C-X-C chemokine receptor type 1 (CXCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[188]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[190]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[191]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[192]
PBI-05204	DM05WIU	Pancreatic cancer	2C10	Phase 2	[193]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[71]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[194]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[195]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[123]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[197]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[90]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[201]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[202]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[203]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[204]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]

Drug(s) Affected By Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[208]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[208]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[211]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[14]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[14]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[213]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[214]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[14]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[215]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[216]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[217]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[218]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[219]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[221]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[222]

Drug(s) Affected By Laminin subunit beta-3 (LAMB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[223]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[224]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[226]

Drug(s) Affected By Laminin subunit gamma-2 (LAMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[227]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[223]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[229]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[226]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[233]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[236]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[237]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[238]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[71]

Drug(s) Affected By Laminin subunit alpha-3 (LAMA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[239]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[232]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[239]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[239]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[239]

Drug(s) Affected By Sphingosine 1-phosphate receptor 3 (S1PR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[240]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[242]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[243]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[244]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[233]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sphingosine-1-phosphate receptor 1 (S1PR1)	TT9JZCK	S1PR1_HUMAN	Inhibitor	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Protein spinster homolog 2 (SLC63A2)	DT3Q1UO	SPNS2_HUMAN	Substrate	[3]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[4]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Sphingosine kinase 1 (SPHK1)	DELSNWC	SPHK1_HUMAN	Substrate	[6]
Phospholipid phosphatase 1 (PLPP1)	DE6WXTH	PLPP1_HUMAN	Substrate	[7]
Sphingosine kinase 2 (SPHK2)	DES1RUQ	SPHK2_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4)	OTPA0QHW	PLCB4_HUMAN	Gene/Protein Processing	[8]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[9]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[10]
C-X-C chemokine receptor type 1 (CXCR1)	OT5512B2	CXCR1_HUMAN	Gene/Protein Processing	[11]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Gene/Protein Processing	[12]
Cyclic AMP-responsive element-binding protein 1 (CREB1)	OT1MDLA1	CREB1_HUMAN	Post-Translational Modifications	[13]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Post-Translational Modifications	[9]
Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ)	OTOODWTU	GNAQ_HUMAN	Gene/Protein Processing	[8]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Gene/Protein Processing	[14]
Hepatocyte growth factor (HGF)	OTGHUA23	HGF_HUMAN	Gene/Protein Processing	[15]

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