Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKINJO)

• Drug Name: Gentamicin Drug Info
• Synonyms: Alcomicin; Apogen; Bristagen; Cidomycin; GENTAMYCIN; Garamycin; Garasol; Gentacidin; Gentacycol; Gentafair; Gentak; Gentamar; Gentamicina; Gentamicine; Gentamicins; Gentamicinum; Gentamycinum; Gentavet; Gentocin; Jenamicin; Refobacin; Uromycine; Garamycin Otic Solution; Genoptic Liquifilm; Gentamcin Sulfate; Gentamicin sulphate sterile; Refobacin TM; Gentamicin C1; G-Mycin; G-Myticin; Garamycin (TN); Gentamicin (BAN); Gentamicin (TN); Gentamicina [INN-Spanish]; Gentamicine [INN-French]; Gentamicinum [INN-Latin];Gentamycin-creme; Gentamycin-creme [German]; Ocu-Mycin; Spectro-Genta; U-Gencin; Genoptic S.O.P.; O-2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-alpha-D-ribo-heptopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-2-deoxy-D-streptamine; (1R,2S,3S,4R,6S)-4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyloxy]-2-hydroxycyclohexyl 2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-beta-L-lyxo-heptopyranoside; (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl (6x)-2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-alpha-D-erythro-heptopyranoside; (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol; 2-[4,6-diamino-3-[3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol; 4,6-diamino-3-{[3-deoxy-4-c-methyl-3-(methylamino)pentopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)heptopyranoside

Indication

Disease Entry	ICD 11	Status	REF
Bacteremia	1A73	Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Blepharoconjunctivitis		Approved	[1]
Cholangitis		Approved	[1]
Dacryocystitis		Approved	[1]
Demodex blepharitis	1G07	Approved	[1]
Folliculitis		Approved	[1]
Neonatal sepsis		Approved	[1]
Paronychia	1F23.13	Approved	[1]
Peritonitis		Approved	[1]
Pseudomonas aeruginosa infectious disease		Approved	[1]

• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 3467
  CAS Number: CAS 1403-66-3
  TTD Drug ID: DMKINJO
  VARIDT Drug ID: DR01198
  INTEDE Drug ID: DR2174
  ACDINA Drug ID: D01123

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial 30S ribosomal RNA (Bact 30S rRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrofurazone	DMSM2KE	Skin burns	ME65.0	Approved	[14]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[15]
TP-434	DM5A31S	Intra-abdominal infection	1A40	Approved	[16]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[3]
Omadacycline	DMR2J95	Acute bacterial skin infection	1C41	Approved	[17]
Sarecycline	DMLZNIQ	Acne vulgaris	ED80	Approved	[18]
ME1100	DM39PSZ	Bacterial pneumonia	CA40.0	Phase 1	[19]
TP-6076	DM5RIT8	Enterobacteriaceae infection	MG50.C	Phase 1	[20]
TP-271	DM3PJSE	Pneumonia	CA40	Phase 1	[21]
TP 6076	DMD0NA1	Multidrug resistant infection	MG51	Phase 1	[20]

Drug(s) Metabolized By Aminoglycoside O-phosphotransferase (aphA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[5]
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[5]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[5]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[5]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[5]
Streptomycin	DME1LQN	Bacterial infection	1A00-1C4Z	Approved	[5]

Drug(s) Metabolized By Aminoglycoside phosphotransferase (aph-Ib)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[4]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[4]
Sisomicin	DM92P0F	N. A.	N. A.	Approved	[22]
Dibekacin	DMTX0PZ	N. A.	N. A.	Phase 4	[22]

Drug(s) Metabolized By Kanamycin/gentamycin-resistance enzyme (aacA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[4]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[4]

Drug(s) Metabolized By Endoglucanase Y (EGY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[7]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[7]
Streptomycin	DME1LQN	Bacterial infection	1A00-1C4Z	Approved	[7]
Bacitracin	DM5OHYE	Blepharoconjunctivitis		Approved	[7]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[7]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[7]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[7]
Streptomycin	DME1LQN	Bacterial infection	1A00-1C4Z	Approved	[7]

Drug(s) Affected By Alpha-L-iduronidase (IDUA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[23]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[28]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[23]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[29]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[29]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[29]

Drug(s) Affected By Tripeptidyl-peptidase 1 (TPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Selenium	DM25CGV	N. A.	N. A.	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]

Drug(s) Affected By Exocyst complex component 3 (EXOC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[38]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[41]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[42]

Drug(s) Affected By Slit homolog 1 protein (SLIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[46]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[47]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[45]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[45]

Drug(s) Affected By Coagulation factor VIII (F8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[48]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Betaine	DMGRZW2	Cystitis	GC00	Approved	[50]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[51]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[42]

Drug(s) Affected By Coagulation factor IX (F9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Betaine	DMGRZW2	Cystitis	GC00	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[55]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[56]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[57]

Drug(s) Affected By Cystatin-C (CST3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]

Drug(s) Affected By Pro-epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[71]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[72]
Fructose	DM43AN2	Vomiting	MD90	Approved	[8]
Ketoprofen	DMRKXPT	Bursitis		Approved	[8]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[74]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[75]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[76]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[82]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[83]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[84]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[85]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[87]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[89]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[89]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[8]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[91]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[94]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[95]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[96]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[97]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[99]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[100]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[96]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[106]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[107]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Selenium	DM25CGV	N. A.	N. A.	Approved	[23]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[111]

Drug(s) Affected By Dystrophin (DMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[42]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[116]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[117]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[116]

Drug(s) Affected By Xaa-Pro dipeptidase (PEPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]

Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivacaftor	DMZC1HS	Cystic fibrosis	CA25	Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Miglustat	DM5J64S	Niemann-Pick disease type C		Approved	[125]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[126]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[123]
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[127]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[128]

Drug(s) Affected By Aminopeptidase N (ANPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Selenium	DM25CGV	N. A.	N. A.	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[132]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]

Drug(s) Affected By Methylmalonyl-CoA mutase, mitochondrial (MMUT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]
Selenium	DM25CGV	N. A.	N. A.	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[107]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[144]

Drug(s) Affected By Endothelin receptor type B (EDNRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[149]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[150]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[151]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[152]

Drug(s) Affected By Insulin-like growth factor-binding protein 5 (IGFBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[156]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain F (HLA-F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[157]
Selenium	DM25CGV	N. A.	N. A.	Approved	[23]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[58]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[149]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[157]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[161]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[83]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[162]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[163]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[164]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[165]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[166]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[167]

Drug(s) Affected By Leukemia inhibitory factor receptor (LIFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[169]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[170]

Drug(s) Affected By ATP-sensitive inward rectifier potassium channel 1 (KCNJ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[172]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[173]
G418	DMKTJBU	Discovery agent	N.A.	Investigative	[11]

Drug(s) Affected By Cytosolic purine 5'-nucleotidase (NT5C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Bortezomib	DMNO38U	Leukemia		Approved	[175]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[38]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[176]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[177]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[179]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[182]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[183]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[184]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[185]

Drug(s) Affected By Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[187]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[188]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Beta-2-microglobulin (B2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[190]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[193]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[194]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[196]

Drug(s) Affected By Neutrophil gelatinase-associated lipocalin (LCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[197]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[197]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[51]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[182]
Selenium	DM25CGV	N. A.	N. A.	Approved	[23]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[202]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[203]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[204]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[111]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[211]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[212]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[213]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]

Drug(s) Affected By Polycystin-2 (PKD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[215]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[217]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[52]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[218]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[218]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[28]

Drug(s) Affected By Runt-related transcription factor 3 (RUNX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[219]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[220]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[38]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[221]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[223]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[225]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[212]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[229]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[230]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[128]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[231]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[232]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[231]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[233]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[235]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[236]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[182]
Selenium	DM25CGV	N. A.	N. A.	Approved	[23]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[184]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]

Drug(s) Affected By Partitioning defective 3 homolog (PARD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]

Drug(s) Affected By GATOR1 complex protein NPRL2 (NPRL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[52]

Drug(s) Affected By Hepatitis A virus cellular receptor 1 (HAVCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[238]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[239]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[240]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[121]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[242]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[217]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[28]

Drug(s) Affected By Rho guanine nucleotide exchange factor 26 (ARHGEF26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[112]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[243]

Drug(s) Affected By G-protein coupled receptor 20 (GPR20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[244]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[187]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[245]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[246]

Drug(s) Affected By Polyadenylate-binding protein-interacting protein 1 (PAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[247]

Drug(s) Affected By Large subunit GTPase 1 homolog (LSG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[187]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]

Drug(s) Affected By Glyoxalase domain-containing protein 4 (GLOD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[249]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[250]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[52]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[37]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[251]

Drug(s) Affected By DNA-directed DNA/RNA polymerase mu (POLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Bortezomib	DMNO38U	Leukemia		Approved	[175]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[40]
MK-886	DMT0O7H	Asthma	CA23	Discontinued in Phase 2	[253]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[40]

Drug(s) Affected By Ubiquitin-like-conjugating enzyme ATG3 (ATG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[254]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[44]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[255]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[257]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]

Drug(s) Affected By Phospholipase A2 (PLA2G1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[8]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[8]
Dibekacin	DMTX0PZ	N. A.	N. A.	Phase 4	[8]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[258]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[112]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[259]
EGTA	DMW9MRO	Discovery agent	N.A.	Investigative	[260]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[215]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[261]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Methamphetamine	DMPM4SK	Anxiety		Approved	[262]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[263]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[264]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[265]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[244]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[47]

Drug(s) Affected By Solute carrier family 22 member 2 (SLC22A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[266]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[267]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[268]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[269]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[268]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[270]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[271]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[273]

Drug(s) Affected By Lysosomal Pro-X carboxypeptidase (PRCP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[215]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[52]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[274]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[28]

Drug(s) Affected By Dipeptidyl aminopeptidase-like protein 6 (DPP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[112]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[245]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial 30S ribosomal RNA (Bact 30S rRNA)	TTOVFH2	NOUNIPROTAC	Modulator	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Aminoglycoside phosphotransferase (aph-Ib)	DE5WGIM	A0A075C7U3_CAMJU	Substrate	[4]
Aminoglycoside O-phosphotransferase (aphA6)	DEWPAJD	KKA6_ACIBA	Substrate	[5]
Kanamycin/gentamycin-resistance enzyme (aacA)	DECXWN8	J3S7E2_CAMCO	Substrate	[4]
Aminoglycoside 6'-N-acetyltransferase (aacA)	DE48UAX	C5MQW3_KLEPO	Substrate	[6]
Endoglucanase Y (EGY)	DE2M583	A0A256VAC0_LACRE	Substrate	[7]
Endoglucanase Y (EGY)	DE2AZTG	A0A256VAC0_LACRE	Substrate	[7]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Drug Response	[8]
Alpha-L-iduronidase (IDUA)	OTTQQ7FN	IDUA_HUMAN	Gene/Protein Processing	[9]
Aminopeptidase N (ANPEP)	OTP3WYFD	AMPN_HUMAN	Protein Interaction/Cellular Processes	[10]
ATP-sensitive inward rectifier potassium channel 1 (KCNJ1)	OTIXCRI6	KCNJ1_HUMAN	Gene/Protein Processing	[11]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[12]
Beta-2-microglobulin (B2M)	OTDWN6NX	B2MG_HUMAN	Gene/Protein Processing	[13]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[12]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[12]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Gene/Protein Processing	[12]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[12]

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