Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMUCG4)

• Drug Name: Eicosapentaenoic acid/docosa-hexaenoic acid Drug Info
• Synonyms: Docosahexaenoic acid; Doconexent; Cervonic acid; 6217-54-5; all-cis-DHA; Doconexentum; Doconexento; Doxonexent; (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid; AquaGrow Advantage; all-Z-Docosahexaenoic acid; Martek DHA HM; Ropufa 60; cis-4,7,10,13,16,19-Docosahexaenoic acid; Docosahexaenoate; UNII-ZAD9OKH9JC; (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid; Docosahexaenoic acid (all-Z); CCRIS 7670; all-cis-4,7,10,13,16,19-Docosahexaenoic acid; ZAD9OKH9JC; all-cis-docosa-4,7,10,13,16,19-hexaenoic acid; CHEMBL367149; Espanova (TN); DOCOSAHEXAENOIC ACID

Indication

Disease Entry	ICD 11	Status	REF
Hypertriglyceridemia	5C80.1	Approved	[1]
Alzheimer disease	8A20	Phase 3	[2]

• Cross-matching ID:
  PubChem CID: 445580
  ChEBI ID: CHEBI:28125
  CAS Number: CAS 6217-54-5
  TTD Drug ID: DMMUCG4
  VARIDT Drug ID: DR00274
  INTEDE Drug ID: DR0521

Molecule-Related Drug Atlas

Drug(s) Targeting Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[15]
Naproxen	DMZ5RGV	Bursitis		Approved	[16]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[17]
Bromfenac	DMKB79O	Pain	MG30-MG3Z	Approved	[18]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[19]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[20]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[19]
Suprofen	DMKXJZ7	Miosis	LA11.62	Approved	[21]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[22]
FENBUFEN	DMXGDFK	Arthritis	FA20	Approved	[23]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[41]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[41]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[41]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[41]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[41]
Ketobemidone	DMM3L6Z	Pain	MG30-MG3Z	Approved	[41]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[41]

Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[24]
Naproxen	DMZ5RGV	Bursitis		Approved	[16]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[25]
Indomethacin	DMSC4A7	Bursitis		Approved	[19]
Celecoxib	DM6LOQU	Dysmenorrhea	GA34.3	Approved	[26]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[27]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[28]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[29]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[19]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[30]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[42]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[41]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[43]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[6]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[6]
Omega-6-FA	DMBWY8V	N. A.	N. A.	Phase 3	[44]
Arachidonic Acid	DMUOQZD	Discovery agent	N.A.	Investigative	[45]
alpha-linolenic acid	DMY64HE	Discovery agent	N.A.	Investigative	[6]
Eicosadienoic acid	DMVJK9W	N. A.	N. A.	Investigative	[6]
Icosapentum	DMF1CM7	N. A.	N. A.	Investigative	[6]

Drug(s) Transported By Major facilitator superfamily domain-containing protein 2A (SLC59A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
lysophosphatidylcholine	DMOGFVH	Discovery agent	N.A.	Investigative	[31]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[32]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[35]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[37]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[38]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[48]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[49]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[50]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[51]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[48]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[49]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[48]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[52]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[53]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[56]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[58]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[60]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[62]

Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[67]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[76]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[80]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[80]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[80]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[50]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[81]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[82]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[83]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[84]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[85]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[86]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[87]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[88]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[49]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[48]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[89]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[90]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[91]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[92]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[93]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[49]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[94]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[50]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[48]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[82]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[48]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[93]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[86]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Haloperidol	DM96SE0	Delirium		Approved	[86]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[96]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[99]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[106]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[106]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[107]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[108]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[111]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[112]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[113]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[115]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[116]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[120]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[125]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[126]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[127]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[130]

Drug(s) Affected By Glutathione S-transferase Mu 2 (GSTM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[132]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[133]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[134]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[135]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[116]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[139]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[140]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[141]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[127]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[143]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[144]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[145]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[146]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[147]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[150]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[151]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[152]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[153]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[155]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[156]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[158]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[160]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[161]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[162]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[163]
Fructose	DM43AN2	Vomiting	MD90	Approved	[86]
Ketoprofen	DMRKXPT	Bursitis		Approved	[86]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[165]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[166]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[167]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[170]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[171]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[172]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[177]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[178]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[117]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[180]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[60]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[60]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[183]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[184]

Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[86]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[185]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[187]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[188]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[189]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[190]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[191]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[192]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[193]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[197]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[198]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[199]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[201]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[202]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[204]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[207]
Haloperidol	DM96SE0	Delirium		Approved	[208]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[211]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[212]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[213]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[212]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[214]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[217]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[218]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[219]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[220]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[86]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[221]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[222]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[165]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[223]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Selenium	DM25CGV	N. A.	N. A.	Approved	[225]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[226]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[227]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[228]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[229]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[96]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[211]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[231]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[233]
Fructose	DM43AN2	Vomiting	MD90	Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[235]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[237]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[238]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[165]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[239]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[241]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[242]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[245]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[237]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[246]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[247]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[248]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[86]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[165]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[239]

Drug(s) Affected By Retinoic acid receptor RXR-beta (RXRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[250]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[251]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[253]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[254]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[255]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[255]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[256]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[136]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[257]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[258]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[223]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[261]
Selenium	DM25CGV	N. A.	N. A.	Approved	[140]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[262]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[263]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[264]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[86]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[96]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[266]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[270]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[272]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[273]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[76]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[274]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[275]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[277]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[279]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[280]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[213]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[281]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[86]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[283]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[284]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[285]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]

Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[289]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[290]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[292]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[289]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[289]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[293]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[295]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[298]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[197]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[299]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[300]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[301]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[302]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[303]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[304]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[305]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[188]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[306]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[307]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[308]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[309]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[310]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[86]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[311]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[312]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[313]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[314]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[316]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[317]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[318]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[319]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[320]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[285]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[321]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[322]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[324]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[325]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[257]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[209]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[329]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[331]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[332]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[217]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[304]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[221]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[96]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[328]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[333]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[334]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[213]

Drug(s) Affected By Adiponectin (ADIPOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[289]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[289]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[335]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[336]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[289]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[337]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[289]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[293]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[340]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[341]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[342]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[343]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[340]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[341]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]

Drug(s) Affected By Bcl-2-like protein 12 (BCL2L12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[345]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[346]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[347]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[348]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[231]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[219]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[219]

Drug(s) Affected By Oxidative stress-induced growth inhibitor 1 (OSGIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[123]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[123]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[123]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[123]

Drug(s) Affected By Serum paraoxonase/arylesterase 2 (PON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[349]
Selenium	DM25CGV	N. A.	N. A.	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[350]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[347]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[132]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[351]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[352]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[353]

Drug(s) Affected By Serum paraoxonase/lactonase 3 (PON3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[354]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[347]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[208]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[356]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[353]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[354]
Phenylacetic acid	DMQ95GE	Hepatic encephalopathy	DB99.5	Approved	[357]
RTR-003632	DM45NHF	N. A.	N. A.	Phase 2	[358]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[360]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[361]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[362]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[364]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[365]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[366]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[161]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[359]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[367]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[368]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[86]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[369]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[370]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[353]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[371]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[347]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[86]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[93]

Drug(s) Affected By Fatty acid-binding protein, brain (FABP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[372]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[253]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[133]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[373]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[374]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[375]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[365]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[376]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[377]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[378]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[379]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[343]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[380]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[381]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[382]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[383]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[384]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[86]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[385]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[386]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[387]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[262]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[388]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[389]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[390]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[391]

Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[392]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[393]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[253]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[393]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[3]
Prostaglandin G/H synthase 2 (COX-2)	TTVKILB	PGH2_HUMAN	Inhibitor	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Major facilitator superfamily domain-containing protein 2A (SLC59A1)	DT5G94L	NLS1_HUMAN	Substrate	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[5]
Prostaglandin G/H synthase 2 (COX-2)	DE492CE	PGH2_HUMAN	Substrate	[6]
Prostaglandin G/H synthase 1 (COX-1)	DE073H6	PGH1_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Regulation of Drug Effects	[7]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Protein Interaction/Cellular Processes	[8]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Drug Response	[9]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[10]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[11]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Gene/Protein Processing	[12]
Bcl-2-like protein 12 (BCL2L12)	OTS6IFZY	B2L12_HUMAN	Gene/Protein Processing	[10]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Protein Interaction/Cellular Processes	[13]
C-reactive protein (CRP)	OT0RFT8F	CRP_HUMAN	Gene/Protein Processing	[14]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Gene/Protein Processing	[13]

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