Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTYXQF)

• Drug Name: NVP-AUY922 Drug Info
• Synonyms: Luminespib; 747412-49-3; AUY922; VER-52296; AUY-922; UNII-C6V1DAR5EB; AUY922 (NVP-AUY922); Luminespib (NVP-AUY922); NVP-AUY 922; 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide; C6V1DAR5EB; Luminespib (AUY-922, NVP-AUY922); CHEBI:83656; 5-[2,4-DIHYDROXY-5-ISOPROPYLPHENYL]-N-ETHYL-4-[4-(4-MORPHOLINYLMETHYL)PHENYL]-3-ISOXAZOLECARBOXAMIDE; AK174786; 5-[2,4-Dihydroxy-5-(1-Methylethyl)phenyl]-N-Ethyl-4-[4-(Morpholin-4-Ylmethyl)phenyl]isoxazole-3-Carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Multiple myeloma	2A83	Phase 2	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 135539077
  ChEBI ID: CHEBI:83656
  CAS Number: CAS 747412-49-3
  TTD Drug ID: DMTYXQF
  VARIDT Drug ID: DR00742

Molecule-Related Drug Atlas

Drug(s) Targeting Heat shock protein 90 alpha (HSP90A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cromoglicate	DM74LZK	Asthma	CA23	Approved	[6]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[6]
BIIB-021	DMPAJ41	Breast cancer	2C60-2C65	Phase 2	[7]
KW-2478	DMJGL72	Solid tumour/cancer	2A00-2F9Z	Phase 2	[8]
VER 50589	DMFLZPC	Breast cancer	2C60-2C65	Phase 2	[3]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[9]
Efungumab	DMBHP56	Breast cancer	2C60-2C65	Phase 2	[10]
SNX-5422	DMIU0VP	Haematological malignancy	2B33.Y	Phase 1/2	[11]
PU3	DMJO0BP	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
Debio 0932	DMWP3G1	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]

Drug(s) Affected By Anterior gradient protein 2 homolog (AGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[18]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[22]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[23]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[24]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[25]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[28]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[31]

Drug(s) Affected By Fibroblast growth factor 1 (FGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[38]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[13]

Drug(s) Affected By ATP synthase subunit beta, mitochondrial (ATP5F1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[44]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[42]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[45]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[46]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[47]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[19]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[52]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[53]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[54]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[55]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[55]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[33]

Drug(s) Affected By Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[61]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[62]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[63]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[66]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[67]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[68]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[67]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[69]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[72]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[28]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]

Drug(s) Affected By Mast/stem cell growth factor receptor Kit (KIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[85]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[86]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[87]

Drug(s) Affected By S-formylglutathione hydrolase (ESD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[91]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[94]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[95]

Drug(s) Affected By Elongation factor 2 (EEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[94]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[100]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[100]

Drug(s) Affected By Pyruvate kinase PKM (PKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[107]

Drug(s) Affected By Serine/threonine-protein kinase B-raf (BRAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[108]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[111]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[112]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[113]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[114]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[115]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[118]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[123]

Drug(s) Affected By Intron Large complex component GCFC2 (GCFC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[124]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[125]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[126]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[76]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[127]

Drug(s) Affected By Proteasome subunit alpha type-1 (PSMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[129]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[130]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[127]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[132]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[133]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[137]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[138]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[19]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[148]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[149]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[150]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[151]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[154]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[47]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[155]

Drug(s) Affected By Radixin (RDX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Haloperidol	DM96SE0	Delirium		Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[156]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[157]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[160]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[161]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[164]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[165]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[166]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[167]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[170]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[133]

Drug(s) Affected By Serpin H1 (SERPINH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[173]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[156]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[158]

Drug(s) Affected By Small ubiquitin-related modifier 3 (SUMO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[174]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[124]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[127]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[178]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase A (PPIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]

Drug(s) Affected By Echinoderm microtubule-associated protein-like 5 (EML5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[13]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[4]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[182]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[183]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[184]

Drug(s) Affected By Interleukin enhancer-binding factor 3 (ILF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[158]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[125]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[185]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[188]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit I (EIF3I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[156]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[4]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[190]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[127]

Drug(s) Affected By 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[129]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[191]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[192]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[193]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[194]

Drug(s) Affected By Phenylalanine--tRNA ligase beta subunit (FARSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[129]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[156]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[195]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[14]

Drug(s) Affected By Protein PALS2 (PALS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[92]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[200]

Drug(s) Affected By Cingulin (CGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[203]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[87]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]

Drug(s) Affected By Poly polymerase 2 (PARP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[19]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[158]

Drug(s) Affected By Hypoxia up-regulated protein 1 (HYOU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[94]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[193]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[208]

Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[209]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[52]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Heat shock protein 90 alpha (HSP90A)	TT78R5H	HS90A_HUMAN	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)	OT7RJON4	HCD2_HUMAN	Gene/Protein Processing	[4]
Anterior gradient protein 2 homolog (AGR2)	OTRRZT7W	AGR2_HUMAN	Gene/Protein Processing	[4]
ATP synthase subunit beta, mitochondrial (ATP5F1B)	OTLFZUQK	ATPB_HUMAN	Gene/Protein Processing	[4]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[5]
Cingulin (CGN)	OTBCQ8AQ	CING_HUMAN	Gene/Protein Processing	[4]
Echinoderm microtubule-associated protein-like 5 (EML5)	OT0EFCPB	EMAL5_HUMAN	Gene/Protein Processing	[4]
Elongation factor 2 (EEF2)	OTZ7SZ39	EF2_HUMAN	Gene/Protein Processing	[4]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Gene/Protein Processing	[5]
Eukaryotic translation initiation factor 3 subunit I (EIF3I)	OTE07WND	EIF3I_HUMAN	Gene/Protein Processing	[4]
Fibroblast growth factor 1 (FGF1)	OT8I64X8	FGF1_HUMAN	Gene/Protein Processing	[4]

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