Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZA017)

• Drug Name: Tetracycline Drug Info
• Synonyms: Amycin; Biocycline; Bristaciclin; Bristaciclina; Bristacycline; Ciclibion; Copharlan; Cyclomycin; Cytome; Dumocyclin; Enterocycline; Medocycline; Resteclin; Robitet; Sanclomycine; Tetrachel; Veracin; Bristaciclin alpha; Cefracycline suspension; Component of Tetrastatin; Sumycin syrup; Tetracycline Free Base; Tetracycline I; Tetracycline II; Tetracycline Monohydrochloride; Achromycin (naphthacene derivative); Achromycin, naphthacene derivative; Centet (base); Lemtrex (base); Liquamycin (Veterinary); Liquamycin, veterinary; Panmycin (TN); Piracaps (base); Polycycline (VAN); Polycycline (antibiotic); Polycycline, antibiotic; SK-Tetracycline; Sumycin (TN); T-125; Tetra-Co; Tetraciclina [INN-Spanish]; Tetracycline & VRC3375; Tetracycline (internal use); Tetracyclinum [INN-Latin]; Tetracyn (TN); Vetquamycin-324 (free base); Tetracycline (JAN/USP/INN); Tetracycline [USAN:INN:BAN:JAN]; Methyl-1,11-dioxo-2-naphthacenecarboxamide; 6-Methyl-1,11-dioxy-2-naphthacenecarboxamide

Indication

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Approved	[1]
Actinomycosis		Approved	[1]
Acute gonococcal cervicitis		Approved	[1]
Acute gonococcal epididymo-orchitis		Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Bronchitis	CA20	Approved	[1]
Brucellosis		Approved	[1]
Lymphogranuloma venereum		Approved	[1]
Ornithosis		Approved	[1]
Pneumonia	CA40	Approved	[1]
Q fever		Approved	[1]
Relapsing fever		Approved	[1]
Rickettsialpox		Approved	[1]
Rocky mountain spotted fever		Approved	[1]
Syphilis		Approved	[1]
Trachoma		Approved	[1]
Typhus		Approved	[1]
Urinary tract infection	GC08	Approved	[1]
Yaws		Approved	[1]
Pelvic inflammatory disease	GA05	Investigative	[1]
Sinusitis	CA0A.Z	Investigative	[1]

• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 54675776
  ChEBI ID: CHEMBL27902
  CAS Number: CAS 60-54-8
  TTD Drug ID: DMZA017
  VARIDT Drug ID: DR00127
  ACDINA Drug ID: D00668

Molecule-Related Drug Atlas

Drug(s) Targeting Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[12]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[13]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[14]
Clomocycline	DM0ZRMQ	Bacterial infection	1A00-1C4Z	Approved	[15]
Spectinomycin	DM0MQ35	Acute gonococcal cervicitis		Approved	[16]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[17]
Lymecycline	DMOMLHJ	Bacterial infection	1A00-1C4Z	Approved	[18]
Rolitetracycline	DMBR5Q7	Acne vulgaris	ED80	Approved	[19]
Meclocycline	DMSFQ8I	Bacterial infection	1A00-1C4Z	Approved	[20]
Minocycline	DMVN5OH	Acne vulgaris	ED80	Approved	[21]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[22]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[24]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[6]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[25]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[6]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[27]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[30]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[33]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[35]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[36]

Drug(s) Transported By Organic anion transporter 2 (SLC22A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[38]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[39]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[40]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[43]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[44]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[45]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[41]

Drug(s) Transported By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[46]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[39]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[40]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[47]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[48]
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[49]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[50]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[51]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[52]
Cilostazol	DMZMSCT	Intermittent claudication	BD40.00	Approved	[53]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[66]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[47]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[44]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[44]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[67]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[67]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]

Drug(s) Transported By Organic anion transporter 4 (SLC22A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[39]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[55]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[40]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[56]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[57]
Estrone sulfate	DMVBIZL	Atrophic vaginitis	GA30.2	Approved	[58]
Levocetirizine	DMQYLGP	Allergic rhinitis	CA08.0	Approved	[59]
PGF2alpha	DM4XAU7	Solid tumour/cancer	2A00-2F9Z	Clinical trial	[39]
uric acid	DMA1MKT	Discovery agent	N.A.	Investigative	[60]

Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[61]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[63]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[38]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[38]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[38]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[38]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[38]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[44]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[61]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[70]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[77]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[78]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[79]

Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[81]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[7]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[82]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[81]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[7]

Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[82]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[81]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[81]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[86]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[87]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[81]

Drug(s) Affected By Inhibin beta E chain (INHBE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[81]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[82]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[81]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[88]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[7]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[81]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[89]

Drug(s) Affected By AP-1 complex subunit sigma-1A (AP1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[93]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[82]

Drug(s) Affected By Fibronectin type III domain-containing protein 4 (FNDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[81]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[81]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[81]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[7]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[81]
Haloperidol	DM96SE0	Delirium		Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[81]

Drug(s) Affected By Protein DEPP1 (DEPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[81]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[7]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[81]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[7]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[7]

Drug(s) Affected By Alternative prion protein (PRNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[102]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[103]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[103]

Drug(s) Affected By Claudin-11 (CLDN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[105]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[106]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[108]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[109]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[109]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[109]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[112]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[115]

Drug(s) Affected By Neutrophil collagenase (MMP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Prinomastat	DM9HOKG	Lung cancer	2C25.0	Approved	[11]
Edetic acid	DM10D85	Hypercalcaemia	5B91.0	Investigative	[117]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Integrin alpha-3 (ITGA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[123]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[125]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[127]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[128]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[129]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[130]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[131]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[134]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[125]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[135]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[136]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[110]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[127]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[128]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[138]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[139]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[138]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[140]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[141]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[139]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[144]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]

Drug(s) Affected By Gap junction alpha-8 protein (GJA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[147]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[148]

Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[149]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[149]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[150]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[152]

Drug(s) Affected By Claudin-15 (CLDN15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[154]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[157]

Drug(s) Affected By Claudin-8 (CLDN8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[159]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[163]

Drug(s) Affected By Claudin-2 (CLDN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[166]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[167]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[170]

Drug(s) Affected By Claudin-10 (CLDN10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[173]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[174]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[174]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[175]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[176]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[176]

Drug(s) Affected By Peroxisomal bifunctional enzyme (EHHADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[178]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[179]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[150]

Drug(s) Affected By Neurogenic locus notch homolog protein 4 (NOTCH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[147]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[180]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[181]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[157]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[182]
Manganese	DMKT129	N. A.	N. A.	Investigative	[183]

Drug(s) Affected By Gap junction delta-2 protein (GJD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[184]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[185]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[148]

Drug(s) Affected By Neurogenic locus notch homolog protein 3 (NOTCH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[186]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[187]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[188]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[167]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[189]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[190]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[148]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[191]

Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[61]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[61]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[61]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[192]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[61]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[193]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[61]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[196]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[93]

Drug(s) Affected By Organic anion transporter 7 (SLC22A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[61]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[63]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[201]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[61]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[88]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)	TTQ8KVI	F4NA87_STAAU	Binder	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporter 2 (SLC22A7)	DT0OC1Q	S22A7_HUMAN	Substrate	[4]
Organic anion transporter 4 (SLC22A11)	DT06JWZ	S22AB_HUMAN	Substrate	[4]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[5]
Organic anion transporter 3 (SLC22A8)	DTVP67E	S22A8_HUMAN	Substrate	[4]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alpha-1-antichymotrypsin (SERPINA3)	OT9BP2S0	AACT_HUMAN	Gene/Protein Processing	[7]
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Protein Interaction/Cellular Processes	[8]
AP-1 complex subunit sigma-1A (AP1S1)	OTQ2H8DN	AP1S1_HUMAN	Gene/Protein Processing	[7]
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Regulation of Drug Effects	[9]
Claudin-10 (CLDN10)	OT2CVAKY	CLD10_HUMAN	Gene/Protein Processing	[10]
Claudin-11 (CLDN11)	OTNN6UTL	CLD11_HUMAN	Gene/Protein Processing	[10]
Claudin-15 (CLDN15)	OT9K0KI7	CLD15_HUMAN	Gene/Protein Processing	[10]
Claudin-2 (CLDN2)	OTRF3D6Y	CLD2_HUMAN	Gene/Protein Processing	[10]
Claudin-8 (CLDN8)	OT7IIWXG	CLD8_HUMAN	Gene/Protein Processing	[10]
Collagenase 3 (MMP13)	OTY8BZIE	MMP13_HUMAN	Gene/Protein Processing	[11]

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