Details of Disease

General Information of Disease (ID: DIS1ZMM2)

Disease Name	Obsessive compulsive disorder
Synonyms	OCD; obsessive compulsive disorder; obsessive-compulsive disorder, susceptibility to; Anancastic neurosis; obsessive-compulsive disorder
Disease Class	6B20: Obsessive-compulsive disorder
Definition	A disorder characterized by the presence of persistent and recurrent irrational thoughts (obsessions), resulting in marked anxiety and repetitive excessive behaviors (compulsions) as a way to try to decrease that anxiety.
Disease Hierarchy	DISBI2BT: Anxiety disorder DISD715V: Hereditary neurological disease DIS1ZMM2: Obsessive compulsive disorder
ICD Code	ICD-11 ICD-11: 6B20 ICD-9 ICD-9: 300.3 Expand ICD-11 '6B20 Expand ICD-10 'F42; 'F42.0; 'F42.1; 'F42.2; 'F42.9 Expand ICD-9 300.3
Disease Identifiers	MONDO ID MONDO_0008114 MESH ID D009771 UMLS CUI C0028768 OMIM ID 164230 MedGen ID 14445 SNOMED CT ID 191736004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 6 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Clomipramine	DMINRKW	Approved	Small molecular drug	[1]
Cycloserine	DMT1I52	Approved	Small molecular drug	[2]
Fluoxetine	DM3PD2C	Approved	Small molecular drug	[3]
Fluvoxamine	DMQTJSX	Approved	Small molecular drug	[4]
Paroxetine	DM5PVQE	Approved	Small molecular drug	[5]
Sertraline	DM0FB1J	Approved	Small molecular drug	[6]
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⏷ Show the Full List of 6 Drug(s)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
NPL-2003	DM21JNW	Phase 2	NA	[7]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PNB-05	DMFKQH1	Investigative	NA	[8]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 28 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
DRD3	TT4C8EA	Limited	Biomarker	[9]
GRIK2	TT0K5RG	Limited	Genetic Variation	[10]
GRIN2B	TTN9D8E	Limited	Genetic Variation	[11]
HTR2C	TTWJBZ5	Limited	Biomarker	[12]
HTR3A	TTPC4TU	Limited	Genetic Variation	[13]
LRP2	TTPH1AJ	Limited	Biomarker	[14]
NTRK3	TTXABCW	Limited	Genetic Variation	[15]
OXTR	TTSCIUP	Limited	Biomarker	[16]
CCKBR	TTVFO0U	Strong	Biomarker	[17]
DLG4	TT9PB26	Strong	Altered Expression	[18]
ELK3	TT5OJMV	Strong	Biomarker	[19]
GAD2	TT7UY6K	Strong	Genetic Variation	[20]
GRIA3	TT82EZV	Strong	Genetic Variation	[21]
GRIK3	TTNP6O2	Strong	Genetic Variation	[22]
HCN4	TTQP04A	Strong	Genetic Variation	[23]
HTR1B	TTK8CXU	Strong	Biomarker	[24]
HTR1D	TT6MSOK	Strong	Biomarker	[25]
HTR2B	TT0K1SC	Strong	Genetic Variation	[26]
HTR3B	TTR6K75	Strong	Genetic Variation	[13]
HTT	TTIWZ0O	Strong	Biomarker	[27]
KDM4C	TTV8CRH	Strong	Genetic Variation	[28]
LCT	TTA0OSE	Strong	Genetic Variation	[29]
MAOA	TT3WG5C	Strong	Genetic Variation	[30]
MOG	TTQAFX5	Strong	Genetic Variation	[31]
NPSR1	TTV1C0Z	Strong	Genetic Variation	[32]
PGC	TT7K6AD	Strong	Biomarker	[33]
SCN3A	TTAXZ0K	Strong	Biomarker	[34]
TOR1A	TTF85KW	Strong	Biomarker	[35]
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⏷ Show the Full List of 28 DTT(s)

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC18A1	DTM953D	Strong	Genetic Variation	[12]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
SCLY	DEH4TD6	Strong	Biomarker	[36]
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This Disease Is Related to 51 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MCF2L	OTEURA8N	Limited	Biomarker	[14]
OLIG2	OTMCN6D3	Limited	Biomarker	[37]
SGCE	OT9F17JB	Limited	Genetic Variation	[38]
SLITRK1	OT1QQ7FR	Limited	Genetic Variation	[39]
AKAP13	OTOZAR14	Strong	Altered Expression	[40]
AQP6	OTXS6UYY	Strong	Biomarker	[41]
ARFGEF1	OTPAU0L4	Strong	Biomarker	[42]
ARFGEF2	OTM3CQZT	Strong	Biomarker	[42]
ARID2	OTIRJXWM	Strong	Biomarker	[43]
BMS1	OTEGQ8ZO	Strong	Biomarker	[44]
BTBD9	OTWQ6GA3	Strong	Genetic Variation	[45]
CCT6A	OTCYWL5F	Strong	Genetic Variation	[13]
CDH9	OTV9N5XK	Strong	Genetic Variation	[21]
DGKD	OTNI8HAH	Strong	Biomarker	[46]
DLGAP1	OTF2PUUI	Strong	Genetic Variation	[47]
DLGAP3	OT0GR2F6	Strong	Genetic Variation	[48]
DNASE1L3	OTEUIMC2	Strong	Altered Expression	[49]
DNM3	OTDMUGCR	Strong	Biomarker	[33]
EBPL	OT59J1GY	Strong	Biomarker	[19]
EFNA5	OTOH4DRR	Strong	Biomarker	[50]
GABBR1	OTU5A52J	Strong	Biomarker	[51]
GOLGA8A	OTSNE9EQ	Strong	Biomarker	[52]
HOXB8	OTKHOD17	Strong	Biomarker	[53]
HTR3C	OT65ZLIJ	Strong	Genetic Variation	[54]
HTR3D	OTP6L08T	Strong	Genetic Variation	[54]
HTR3E	OTIWF1R5	Strong	Genetic Variation	[54]
LMX1A	OTEEYD5L	Strong	Genetic Variation	[39]
LTBP3	OTME98V7	Strong	Biomarker	[55]
MEIS2	OTG4ADLM	Strong	Biomarker	[56]
NOS1AP	OTDFOBRU	Strong	Genetic Variation	[57]
NPS	OTEG25A2	Strong	Biomarker	[32]
OLIG1	OTIMFI31	Strong	Biomarker	[58]
OMD	OTFRELBB	Strong	Altered Expression	[59]
OR2AG1	OTEITRP4	Strong	Biomarker	[54]
PBX1	OTORABGO	Strong	Genetic Variation	[39]
PPP1R9B	OTDCTHTT	Strong	Biomarker	[60]
RYR3	OT4EHIP4	Strong	Genetic Variation	[61]
SETD1A	OTVVWRIC	Strong	Biomarker	[62]
SLITRK5	OTTSUSB8	Strong	Biomarker	[63]
SPRED2	OTUX685J	Strong	Biomarker	[64]
SRI	OT4R3EAC	Strong	Genetic Variation	[65]
SRM	OT4N5MDP	Strong	Biomarker	[66]
TAL1	OTX4K6QZ	Strong	Biomarker	[36]
TRRAP	OT68OI2Y	Strong	Genetic Variation	[67]
ADCK1	OTB7NSK3	Definitive	Genetic Variation	[68]
CARMIL1	OT1A5IX5	Definitive	Genetic Variation	[69]
GPR135	OTXOY5NW	Definitive	Genetic Variation	[68]
NECTIN1	OTTE5ZR6	Definitive	Genetic Variation	[70]
POU1F1	OTXT8A5C	Definitive	Genetic Variation	[70]
TAFA2	OTU6WP6J	Definitive	Genetic Variation	[69]
TPSG1	OTDESHKT	Definitive	Genetic Variation	[71]
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⏷ Show the Full List of 51 DOT(s)

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