General Information of Disease (ID: DISCXYIZ)

Disease Name Lymphoma, non-Hodgkin, familial
Synonyms non-Hodgkin lymphoma; lymphoma, non-Hodgkin, familial; lymphoma, non-Hodgkin, somatic; lymphoma, non-Hodgkin; lymphoma, follicular, somatic
Disease Hierarchy
DISS2Y8A: Non-hodgkin lymphoma
DISCXYIZ: Lymphoma, non-Hodgkin, familial
Disease Identifiers
MONDO ID
MONDO_0011508
MESH ID
D008228
UMLS CUI
C4721532
OMIM ID
605027
MedGen ID
1648388

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 56 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
BTK TTGM6VW Limited Biomarker [1]
CCND3 TT1JXNR Limited Genetic Variation [2]
CD22 TTM6QSK Limited Biomarker [3]
CD37 TTFCW29 Limited Biomarker [4]
CYP2C9 TTR40YJ Limited Genetic Variation [5]
EZH2 TT9MZCQ Limited Biomarker [6]
FGFR4 TT1KX2S Limited Genetic Variation [7]
PAX5 TTA4REJ Limited Biomarker [8]
SERPINA6 TTJL8VG Limited Altered Expression [9]
CXCR5 TTIW59R Disputed Genetic Variation [10]
CYP2E1 TTWVHQ5 Disputed Genetic Variation [5]
TYMS TTP1UKZ Disputed Genetic Variation [11]
BRAF TT0EOB8 moderate Biomarker [12]
ALK TTPMQSO Strong Biomarker [13]
ATRAID TTFLIKM Strong Biomarker [14]
B2M TTY7FKA Strong Altered Expression [15]
CASP10 TTX5HEK Strong Genetic Variation [16]
CBS TTVZJ7G Strong Biomarker [17]
CD19 TTW640A Strong Biomarker [18]
CD28 TTQ13FT Strong Biomarker [19]
CD47 TT28S46 Strong Biomarker [20]
CD52 TTQT5S9 Strong Biomarker [21]
CD79B TTBN5I7 Strong Altered Expression [22]
CRY2 TTAO58M Strong Genetic Variation [23]
CSF2 TTNYZG2 Strong Therapeutic [24]
CSF3 TT5TQ2W Strong Biomarker [25]
CSF3R TTC70AJ Strong Biomarker [26]
DYRK2 TT84OS6 Strong Biomarker [27]
FCGR1A TTZK4I3 Strong Altered Expression [28]
FCGR3A TTIFOC0 Strong Genetic Variation [29]
GBA TT1B5PU Strong Biomarker [30]
GPR34 TTVXSTQ Strong Altered Expression [31]
HLA-DRB1 TTUXSTW Strong Biomarker [32]
IFNA2 TTSIUJ9 Strong Therapeutic [33]
KMT5A TTGC95K Strong Genetic Variation [34]
LTK TT1JZG6 Strong Genetic Variation [35]
MAP2K1 TTIDAPM Strong Biomarker [36]
NPM1 TTHBS98 Strong Biomarker [37]
NPR2 TTNB7IF Strong Biomarker [30]
NRAS TTW2R9X Strong Genetic Variation [38]
PTPN13 TT405FP Strong Biomarker [39]
RHOA TTP2U16 Strong Genetic Variation [38]
RNF34 TTEWDK1 Strong Biomarker [40]
RORB TTGB2LZ Strong Genetic Variation [41]
SERPING1 TTVQ6R9 Strong Biomarker [42]
TCL1A TTUKRDV Strong Biomarker [43]
TFRC TT8MG4S Strong Biomarker [44]
TIGIT TTWNL74 Strong Biomarker [45]
TNFRSF13C TT7NJSE Strong Biomarker [46]
TNFRSF8 TT2GM5R Strong Biomarker [13]
TSPAN7 TTMT6VE Strong Altered Expression [47]
VIPR1 TTCL30I Strong Genetic Variation [48]
BCL2 TTFOUV4 Definitive Genetic Variation [1]
CHEK2 TT9ABMF Definitive Biomarker [49]
LTA TTP73TM Definitive Genetic Variation [50]
NR1I3 TTRANFM Definitive Biomarker [51]
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⏷ Show the Full List of 56 DTT(s)
This Disease Is Related to 5 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
CES2 DETHCPD Strong Biomarker [52]
EPHX1 DELB4KP Strong Biomarker [53]
FPGS DECWT2V Strong Biomarker [17]
NAT1 DE7OAB3 Strong Genetic Variation [54]
NAT2 DER7TA0 Definitive Genetic Variation [54]
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This Disease Is Related to 74 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ASPG OT5E2EKR Limited Biomarker [55]
BACH2 OT17GS18 Limited Genetic Variation [56]
CALM2 OTNYA92F Limited Biomarker [57]
CAMKMT OTLJBRUW Limited Biomarker [57]
CLEC4D OTT7X1UC Limited Biomarker [58]
FH OTEQWU6Q Limited Biomarker [58]
KRIT1 OT58AP1I Limited Biomarker [57]
MOS OTNMQPFJ Limited Biomarker [59]
MRPL28 OT4LUTZU Limited Biomarker [60]
NXT1 OT0VO6AY Limited Biomarker [60]
PRF1 OTFVXD7H Limited Unknown [61]
RIT1 OTVNOGOH Limited Biomarker [52]
TRAF1 OTTLM5RU Limited Genetic Variation [62]
SMC4 OTEJE6AG Disputed Biomarker [63]
HOXC5 OTPQTLKZ moderate Altered Expression [64]
HOXC6 OTBCRAZV moderate Altered Expression [64]
KRT81 OTMKIK2S moderate Genetic Variation [65]
TMEM260 OTICII2L moderate Genetic Variation [66]
ACSBG1 OTM040MW Strong Biomarker [67]
ADAM12 OTZKOTDB Strong Altered Expression [57]
BHMT OTYB6PXZ Strong Biomarker [17]
C6orf47 OTMKBNDD Strong Genetic Variation [68]
CARD11 OTRCTLYC Strong Genetic Variation [69]
CAV3 OTWSFDB4 Strong Altered Expression [70]
CCAR1 OTUXLQZZ Strong Biomarker [40]
CDC6 OTX93FE7 Strong Genetic Variation [71]
CFC1 OT5DHGI8 Strong Biomarker [72]
DERL2 OTI3TUUZ Strong Biomarker [73]
DHX33 OTREUESJ Strong Altered Expression [74]
EEF1E1 OTRA6XOB Strong Biomarker [14]
EIF4A2 OT08H03R Strong Biomarker [75]
ERCC2 OT1C8HQ4 Strong Genetic Variation [76]
GCHFR OTEOT8GI Strong Biomarker [77]
GPANK1 OT1TN2KT Strong Genetic Variation [68]
GSTM3 OTLA2WJT Strong Genetic Variation [5]
HSPA1L OTC2V1K6 Strong Genetic Variation [78]
HSPH1 OTVRR73T Strong Biomarker [79]
IL10RA OTOX3D1D Strong Genetic Variation [80]
ISL1 OTVNVKAX Strong Altered Expression [81]
LAMTOR1 OTIBJBW9 Strong Biomarker [14]
LGALS7 OTMSVI7R Strong Biomarker [82]
LIMD1 OTN1CG6R Strong Biomarker [83]
MAFK OTZJUE4P Strong Biomarker [14]
MEF2B OT880SE6 Strong Genetic Variation [84]
MRE11 OTGU8TZM Strong Genetic Variation [85]
NBN OT73B5MD Strong Genetic Variation [86]
NCF4 OTX007YL Strong Genetic Variation [87]
NCOR2 OTY917X0 Strong Biomarker [88]
NLRP2 OTJA81JU Strong Genetic Variation [86]
NPAS2 OTMRT2TS Strong Biomarker [89]
ORC4 OT3ACTST Strong Genetic Variation [90]
PLEKHG2 OTMGR6I6 Strong Biomarker [55]
PLEKHO1 OTMVUQ9W Strong Altered Expression [91]
PRRC2A OTBX6FM5 Strong Genetic Variation [92]
RAD50 OTYMU9G1 Strong Genetic Variation [85]
RAPH1 OTMQXW7S Strong Biomarker [67]
RNASE3 OTVE2XD1 Strong Genetic Variation [93]
RTEL1 OTI3PJCT Strong Biomarker [94]
SEMG1 OT6Z4BPQ Strong Biomarker [95]
SMARCAL1 OTTKXLUZ Strong Biomarker [96]
STIL OT9799VN Strong Biomarker [97]
TCL1B OT4CSO39 Strong Biomarker [43]
TIA1 OTGPN3P8 Strong Biomarker [98]
TJP1 OTBDCUPK Strong Biomarker [99]
TNFAIP8 OT1G9297 Strong Genetic Variation [100]
TNIP1 OTRAOTEW Strong Altered Expression [101]
TP73 OT0LUO47 Strong Biomarker [102]
TPPP2 OTI3WA6X Strong Biomarker [14]
ARR3 OTRZ00CH Definitive Biomarker [51]
BCL10 OT47MCLI Definitive Genetic Variation [103]
CXADR OT9ZP02A Definitive Biomarker [51]
SHMT1 OTIINA3J Definitive Genetic Variation [104]
SPG7 OT8OY9ST Definitive Biomarker [51]
TRIM13 OTQIUACB Definitive Biomarker [51]
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⏷ Show the Full List of 74 DOT(s)

References

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23 Clock-cancer connection in non-Hodgkin's lymphoma: a genetic association study and pathway analysis of the circadian gene cryptochrome 2.Cancer Res. 2009 Apr 15;69(8):3605-13. doi: 10.1158/0008-5472.CAN-08-4572. Epub 2009 Mar 24.
24 DICE (dexamethasone, ifosfamide, cisplatin, etoposide) infusional chemotherapy for refractory or relapsed non-Hodgkin's lymphoma (NHL).Eur J Haematol Suppl. 2001 Jul;64:41-5.
25 Febrile neutropenia hospitalization due to pegfilgrastim on-body injector failure compared to single-injection pegfilgrastim and daily injections with reference and biosimilar filgrastim: US cost simulation for lung cancer and non-Hodgkin lymphoma.J Med Econ. 2020 Jan;23(1):28-36. doi: 10.1080/13696998.2019.1658591. Epub 2019 Sep 3.
26 G-CSF administration favours SDF-1 release and activation of neutrophils and monocytes in recipients of autologous peripheral blood progenitor cells.Cytokine. 2019 Apr;116:38-47. doi: 10.1016/j.cyto.2018.12.011. Epub 2019 Jan 24.
27 Silencing of DYRK2 increases cell proliferation but reverses CAM-DR in Non-Hodgkin's Lymphoma.Int J Biol Macromol. 2015 Nov;81:809-17. doi: 10.1016/j.ijbiomac.2015.08.067. Epub 2015 Sep 2.
28 CD64 surface expression on neutrophils and monocytes is significantly up-regulated after stimulation with granulocyte colony-stimulating factor during CHOP chemotherapy for patients with non-Hodgkin's lymphoma.Int J Hematol. 2004 Jan;79(1):55-62. doi: 10.1007/BF02983535.
29 The FCGR3A polymorphism predicts the response to rituximab-based therapy in patients with non-Hodgkin lymphoma: a meta-analysis.Ann Hematol. 2016 Sep;95(9):1483-90. doi: 10.1007/s00277-016-2723-x. Epub 2016 Jul 19.
30 Primary central nervous system diffuse large B-cell lymphoma shows an activated B-cell-like phenotype with co-expression of C-MYC, BCL-2, and BCL-6.Pathol Res Pract. 2017 Jun;213(6):659-665. doi: 10.1016/j.prp.2017.02.012. Epub 2017 Feb 24.
31 t(X;14)(p11;q32) in MALT lymphoma involving GPR34 reveals a role for GPR34 in tumor cell growth.Blood. 2012 Nov 8;120(19):3949-57. doi: 10.1182/blood-2011-11-389908. Epub 2012 Sep 10.
32 Variation in effects of non-Hodgkin lymphoma risk factors according to the human leukocyte antigen (HLA)-DRB1*01:01 allele and ancestral haplotype 8.1.PLoS One. 2011;6(11):e26949. doi: 10.1371/journal.pone.0026949. Epub 2011 Nov 9.
33 Intensive conventional-dose chemotherapy for stage IV low-grade lymphoma: high remission rates and reversion to negative of peripheral blood bcl-2 rearrangement.Ann Oncol. 1994;5 Suppl 2:73-7. doi: 10.1093/annonc/5.suppl_2.s73.
34 Prognostic value of microRNA 502 binding site SNP in the 3'-untranslated region of the SET8 gene in patients with non-Hodgkin's lymphoma.Tumori. 2014 Sep-Oct;100(5):553-8. doi: 10.1700/1660.18180.
35 ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK).Oncogene. 1997 May 8;14(18):2175-88. doi: 10.1038/sj.onc.1201062.
36 Pan-class I PI3-kinase inhibitor BKM120 induces MEK1/2-dependent mitotic catastrophe in non-Hodgkin lymphoma leading to apoptosis or polyploidy determined by Bax/Bak and p53.Cell Death Dis. 2018 Mar 7;9(3):384. doi: 10.1038/s41419-018-0413-4.
37 The expression of CD30 in anaplastic large cell lymphoma is regulated by nucleophosmin-anaplastic lymphoma kinase-mediated JunB level in a cell type-specific manner.Cancer Res. 2006 Sep 15;66(18):9002-8. doi: 10.1158/0008-5472.CAN-05-4101.
38 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.Nat Biotechnol. 2016 Feb;34(2):155-63. doi: 10.1038/nbt.3391. Epub 2015 Nov 30.
39 5-Azacitidine induces demethylation of PTPL1 and inhibits growth in non-Hodgkin lymphoma.Int J Mol Med. 2015 Sep;36(3):698-704. doi: 10.3892/ijmm.2015.2269. Epub 2015 Jul 1.
40 Cell cycle and apoptosis regulatory protein (CARP)-1 is a novel, adriamycin-inducible, diffuse large B-cell lymphoma (DLBL) growth suppressor.Cancer Chemother Pharmacol. 2011 Jun;67(6):1401-13. doi: 10.1007/s00280-010-1442-6. Epub 2010 Aug 31.
41 Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.Oncotarget. 2017 Apr 4;8(14):23978-23995. doi: 10.18632/oncotarget.15074.
42 Angioedema due to acquired C1-inhibitor deficiency: spectrum and treatment with C1-inhibitor concentrate.Orphanet J Rare Dis. 2019 Mar 13;14(1):65. doi: 10.1186/s13023-019-1043-3.
43 EBNA2 interferes with the germinal center phenotype by downregulating BCL6 and TCL1 in non-Hodgkin's lymphoma cells.J Virol. 2007 Mar;81(5):2274-82. doi: 10.1128/JVI.01822-06. Epub 2006 Dec 6.
44 The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer.Clin Immunol. 2006 Nov;121(2):144-58. doi: 10.1016/j.clim.2006.06.010. Epub 2006 Aug 10.
45 TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma.Cancer Immunol Res. 2019 Mar;7(3):355-362. doi: 10.1158/2326-6066.CIR-18-0351. Epub 2019 Jan 18.
46 A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling.J Exp Med. 2010 Nov 22;207(12):2569-79. doi: 10.1084/jem.20100857. Epub 2010 Nov 1.
47 The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. Leukemia. 2014 Jul;28(7):1501-10.
48 Rare HVR1-HCV genotype 1b variants in patients with B non Hodgkin's lymphoma. Comparison with viral sequences detected in cases of lymphoproliferative disorders and B cell compartmentalisation.New Microbiol. 2007 Jul;30(3):265-70.
49 Association of Germline CHEK2 Gene Variants with Risk and Prognosis of Non-Hodgkin Lymphoma.PLoS One. 2015 Oct 27;10(10):e0140819. doi: 10.1371/journal.pone.0140819. eCollection 2015.
50 The +252A/G polymorphism in the Lymphotoxin- gene and the risk of non-Hodgkin lymphoma: a meta-analysis.Eur Rev Med Pharmacol Sci. 2014;18(4):544-52.
51 Preclinical Evaluation of Allogeneic CAR T Cells Targeting BCMA for the Treatment of Multiple Myeloma.Mol Ther. 2019 Jun 5;27(6):1126-1138. doi: 10.1016/j.ymthe.2019.04.001. Epub 2019 Apr 8.
52 Yttrium-90 ibritumomab tiuxetan (Zevalin) followed by BEAM (Z-BEAM) conditioning regimen and autologous stem cell transplantation (ASCT) in relapsed or refractory high-risk B-cell non-Hodgkin lymphoma (NHL): a single institution Italian experience.Ann Hematol. 2018 Sep;97(9):1619-1626. doi: 10.1007/s00277-018-3328-3. Epub 2018 Apr 16.
53 Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas.Hum Mol Genet. 2001 Jun 1;10(12):1265-73. doi: 10.1093/hmg/10.12.1265.
54 Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium.Cancer Causes Control. 2013 Jan;24(1):125-34. doi: 10.1007/s10552-012-0098-4. Epub 2012 Nov 18.
55 Prolonged versus standard native E. coli asparaginase therapy in childhood acute lymphoblastic leukemia and non-Hodgkin lymphoma: final results of the EORTC-CLG randomized phase III trial 58951.Haematologica. 2017 Oct;102(10):1727-1738. doi: 10.3324/haematol.2017.165845. Epub 2017 Jul 27.
56 High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma.Leuk Res. 2009 May;33(5):731-4. doi: 10.1016/j.leukres.2008.09.007. Epub 2008 Oct 16.
57 Upregulation of ADAM12 contributes to accelerated cell proliferation and cell adhesion-mediated drug resistance (CAM-DR) in Non-Hodgkin's Lymphoma.Hematology. 2017 Oct;22(9):527-535. doi: 10.1080/10245332.2017.1312205. Epub 2017 Apr 10.
58 Mantle cell lymphoma - does primary intensive immunochemotherapy improve overall survival for younger patients?.Leuk Lymphoma. 2009 Aug;50(8):1249-56. doi: 10.1080/10428190903040030.
59 Expression of common fragile sites in untreated non-Hodgkin's lymphoma with aphidicolin and folate deficiency.Cancer Lett. 1994 Oct 28;86(1):111-7. doi: 10.1016/0304-3835(94)90187-2.
60 Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and sezary syndrome.J Invest Dermatol. 2002 Mar;118(3):493-9. doi: 10.1046/j.0022-202x.2001.01682.x.
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62 TRAF1 Signaling in Human Health and Disease.Front Immunol. 2018 Dec 18;9:2969. doi: 10.3389/fimmu.2018.02969. eCollection 2018.
63 Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma.Cancer Sci. 2007 Jul;98(7):1041-7. doi: 10.1111/j.1349-7006.2007.00500.x. Epub 2007 May 4.
64 HOXC4, HOXC5, and HOXC6 expression in non-Hodgkin's lymphoma: preferential expression of the HOXC5 gene in primary cutaneous anaplastic T-cell and oro-gastrointestinal tract mucosa-associated B-cell lymphomas.Blood. 1997 Nov 15;90(10):4116-25.
65 A miR-SNP of the KRT81 gene is associated with the prognosis of non-Hodgkin's lymphoma.Gene. 2014 Apr 15;539(2):198-202. doi: 10.1016/j.gene.2014.02.010. Epub 2014 Feb 12.
66 A polymorphism at the microRNA binding site in the 3' untranslated region of C14orf101 is associated with non-Hodgkin lymphoma overall survival.Cancer Genet. 2014 Apr;207(4):141-6. doi: 10.1016/j.cancergen.2014.03.007. Epub 2014 Mar 22.
67 BCL-6 gene mutations in posttransplantation lymphoproliferative disorders predict response to therapy and clinical outcome.Blood. 1998 Oct 1;92(7):2294-302.
68 Interactions within the MHC contribute to the genetic architecture of celiac disease.PLoS One. 2017 Mar 10;12(3):e0172826. doi: 10.1371/journal.pone.0172826. eCollection 2017.
69 Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease.Front Immunol. 2018 Sep 19;9:2105. doi: 10.3389/fimmu.2018.02105. eCollection 2018.
70 Deletion of 6q16-q21 in human lymphoid malignancies: a mapping and deletion analysis.Cancer Res. 2000 Jun 1;60(11):2775-9.
71 Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma.Mutat Res. 2009 Mar 9;662(1-2):10-5. doi: 10.1016/j.mrfmmm.2008.11.014. Epub 2008 Dec 3.
72 Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus.Nature. 1984 Jan 26-Feb 1;307(5949):334-40. doi: 10.1038/307334a0.
73 Characterization of two novel cell lines, DERL-2 (CD56+/CD3+/Tcry5+) and DERL-7 (CD56+/CD3-/TCRgammadelta-), derived from a single patient with CD56+ non-Hodgkin's lymphoma.Leukemia. 2001 Oct;15(10):1641-9. doi: 10.1038/sj.leu.2402239.
74 Role of DHX33 in c-Myc-induced cancers.Carcinogenesis. 2017 Jun 1;38(6):649-660. doi: 10.1093/carcin/bgx041.
75 Translation initiation complex eIF4F is a therapeutic target for dual mTOR kinase inhibitors in non-Hodgkin lymphoma.Oncotarget. 2015 Apr 20;6(11):9488-501. doi: 10.18632/oncotarget.3378.
76 Association between the ERCC2 Asp312Asn polymorphism and risk of cancer.Oncotarget. 2017 Jul 18;8(29):48488-48506. doi: 10.18632/oncotarget.17290.
77 Th1/Th2 cytokine expression and its relationship with tumor growth in B cell non-Hodgkin's lymphoma (NHL).Leuk Lymphoma. 2002 Jun;43(6):1313-21. doi: 10.1080/10428190290026385.
78 Polymorphism in the tumor necrosis factor-alpha promotor region and in the heat shock protein 70 genes associated with malignant tumors.Cancer. 1997 Oct 15;80(8):1489-96. doi: 10.1002/(sici)1097-0142(19971015)80:8<1489::aid-cncr17>3.0.co;2-1.
79 Serological identification of HSP105 as a novel non-Hodgkin lymphoma therapeutic target.Blood. 2011 Oct 20;118(16):4421-30. doi: 10.1182/blood-2011-06-364570. Epub 2011 Aug 22.
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