Details of Disease

General Information of Disease (ID: DISFF2NI)

• Disease Name: Arrhythmia
• Synonyms: arrhythmia
• Disease Class: BC9Z: Cardiac arrhythmia
• Definition: Any variation from the normal rate or rhythm (which may include the origin of the impulse and/or its subsequent propagation) in the heart.
• Disease Hierarchy:
  DISVO1I5: Cardiac disease
  DISFF2NI: Arrhythmia
• ICD Code:
  ICD-11: ICD-11: BC9Z
  ICD-9: ICD-9: 427
  Expand ICD-11: 'BC9Z
  Expand ICD-10: 'I47.0; 'I49; 'I49.4; 'I49.8; 'I49.9; 'R00.0; 'R00.1
  Expand ICD-9: 427
• Disease Identifiers:
  MONDO ID: MONDO_0007263
  MESH ID: D001145
  UMLS CUI: C0003811
  MedGen ID: 2039
  HPO ID: HP:0011675
  SNOMED CT ID: 698247007

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 7 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Acetaminophen	DMUIE76	Approved	Small molecular drug	[1]
Deslanoside	DMB3ZSK	Approved	Small molecular drug	[2]
Digitoxin	DMWVIGP	Approved	Small molecular drug	[3]
Digoxin	DMQCTIH	Approved	Small molecular drug	[4]
Moricizine	DMOMBJW	Approved	Small molecular drug	[5]
Oxymetazoline	DM8ZXT6	Approved	Small molecular drug	[6]
Phenylephrine	DMZHUO5	Approved	Small molecular drug	[7]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
BMS-394136	DMGDJQR	Phase 1	NA	[8]

This Disease is Treated as An Indication in 2 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SB-209670	DMJYW80	Discontinued in Phase 2	Small molecular drug	[9]
SB-237376	DMBCANZ	Terminated	Small molecular drug	[10]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 76 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ABCC9	TTEF5MJ	Limited	Biomarker	[11]
ADRB1	TTR6W5O	Limited	Biomarker	[12]
ATP2A2	TTE6THL	Limited	Genetic Variation	[13]
CACNA1H	TTZPWGN	Limited	Biomarker	[14]
CACNA2D1	TTFK1JQ	Limited	Biomarker	[15]
CLN3	TTORF9W	Limited	Biomarker	[16]
DMPK	TTZQTY2	Limited	Genetic Variation	[17]
DYSF	TTA7MXQ	Limited	Genetic Variation	[18]
EPHX2	TT7WVHI	Limited	Biomarker	[19]
ESRRG	TT9ZRHB	Limited	Biomarker	[20]
GP6	TTTJUVZ	Limited	Altered Expression	[21]
HCN4	TTQP04A	Limited	Genetic Variation	[22]
KCNC4	TTODZF1	Limited	Genetic Variation	[23]
KCND3	TTPLQO0	Limited	Biomarker	[24]
MAPKAP1	TTWDKCL	Limited	Biomarker	[25]
MC5R	TT6QAJ3	Limited	Biomarker	[26]
PDF	TT9SL3Q	Limited	Altered Expression	[27]
PPARGC1B	TTKSQ3W	Limited	Biomarker	[28]
PREP	TTNGKET	Limited	Genetic Variation	[29]
RAPGEF3	TTOE7I0	Limited	Biomarker	[30]
RAPGEF4	TTOS63B	Limited	Biomarker	[31]
SCN10A	TT90XZ8	Limited	Genetic Variation	[32]
SIRPA	TTBRJS9	Limited	Biomarker	[33]
SQLE	TTE14XG	Limited	Biomarker	[34]
TEC	TT1ZV49	Limited	Biomarker	[35]
TNNT2	TTWAS18	Limited	Biomarker	[36]
TRPA1	TTELV3W	Limited	Biomarker	[37]
TRPC3	TTNVC34	Limited	Biomarker	[38]
UGCG	TTPHEX3	Limited	Biomarker	[39]
ADM	TTV14YH	Strong	Biomarker	[40]
AGT	TT5C0UB	Strong	Biomarker	[41]
APLN	TT87D3J	Strong	Altered Expression	[42]
AVP	TTJ8EWH	Strong	Biomarker	[43]
BMP2	TTP3IGX	Strong	Biomarker	[44]
CACNA1C	TTZIFHC	Strong	Genetic Variation	[45]
CACNA2D2	TTU8P3M	Strong	Biomarker	[46]
CD36	TTPJMCU	Strong	ModifyingMutation	[47]
DMD	TTWLFXU	Strong	Biomarker	[48]
DPP10	TTOVUPC	Strong	Altered Expression	[49]
EPHA3	TTHS2LR	Strong	Biomarker	[50]
ESR2	TTOM3J0	Strong	Biomarker	[51]
GJA5	TTFQKZ7	Strong	Altered Expression	[52]
GJC1	TTEP7OC	Strong	Biomarker	[53]
HRC	TTR4FKD	Strong	Genetic Variation	[54]
HTR4	TT07C3Y	Strong	Biomarker	[55]
IDS	TTNY2AP	Strong	Biomarker	[56]
KCNH2	TTQ6VDM	Strong	Genetic Variation	[57]
KCNJ2	TTH7UO3	Strong	Genetic Variation	[58]
KCNJ5	TTEO25X	Strong	Genetic Variation	[59]
KCNK3	TTGR91N	Strong	Biomarker	[60]
KNG1	TTDJ4MY	Strong	Therapeutic	[61]
LAMP2	TTULDG7	Strong	Genetic Variation	[62]
LNPEP	TTY2KP7	Strong	Genetic Variation	[63]
NR3C2	TT26PHO	Strong	Biomarker	[64]
OPRD1	TT27RFC	Strong	Biomarker	[65]
OPRK1	TTQW87Y	Strong	Therapeutic	[66]
OPRL1	TTNT7K8	Strong	Therapeutic	[66]
P2RX1	TTJW7B3	Strong	Altered Expression	[67]
PLN	TTMCVJF	Strong	Genetic Variation	[68]
REN	TTB2MXP	Strong	Biomarker	[69]
RGS6	TTJ96M8	Strong	Genetic Variation	[70]
SCN1A	TTANOZH	Strong	Altered Expression	[71]
SCN4A	TT84DRB	Strong	Genetic Variation	[72]
SGO1	TTBPKGD	Strong	Biomarker	[73]
SIGMAR1	TT5TPI6	Strong	Biomarker	[74]
SLC22A2	TT0XOJN	Strong	Biomarker	[75]
SLC8A1	TTCF82X	Strong	Altered Expression	[76]
SPTBN1	TTS9BDA	Strong	Genetic Variation	[77]
TACR3	TTBPGLU	Strong	Biomarker	[78]
TNNI3	TTNLDK6	Strong	Biomarker	[79]
TRH	TT2Z39D	Strong	Biomarker	[80]
TTR	TTPOYU7	Strong	Genetic Variation	[81]
GLA	TTIS03D	Definitive	Genetic Variation	[82]
MECP2	TTTAU9R	Definitive	Altered Expression	[83]
RYR1	TTU5CIX	Definitive	Genetic Variation	[84]
TRPM4	TTJ2HKA	Definitive	Genetic Variation	[85]

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC22A5	DT3HUVD	Limited	Biomarker	[86]
KCNK2	DTENHUP	Strong	Genetic Variation	[87]

This Disease Is Related to 5 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CES2	DETHCPD	Limited	Genetic Variation	[88]
PGM1	DEA3VM1	Limited	Biomarker	[89]
CHDH	DEAHED0	Strong	Genetic Variation	[90]
SCLY	DEH4TD6	Strong	Altered Expression	[91]
SULT2A1	DE0P6LK	Strong	Biomarker	[92]

This Disease Is Related to 133 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACTN2	OT9FOLD7	Limited	Genetic Variation	[93]
ADCY10	OTYSTB0R	Limited	Altered Expression	[94]
AIP	OTDJ3OSV	Limited	Biomarker	[95]
ALG10	OTM1ATVR	Limited	Altered Expression	[96]
ALG10B	OTAHWAKE	Limited	Altered Expression	[96]
BET1	OTGX2557	Limited	Biomarker	[97]
BVES	OT4GT1WC	Limited	Altered Expression	[98]
CAAP1	OTD2DN1Z	Limited	Biomarker	[99]
CASQ2	OT09MNQ8	Limited	Altered Expression	[100]
CAVIN4	OTB1DM2C	Limited	Biomarker	[101]
CDAN1	OTCVZRG6	Limited	Biomarker	[102]
CTNNA3	OT9Z0P1E	Limited	Altered Expression	[103]
CUZD1	OTDQJVZ8	Limited	Biomarker	[34]
DPP6	OTWW3H0K	Limited	Biomarker	[104]
DSC2	OTODVH8K	Limited	Genetic Variation	[105]
EBPL	OT59J1GY	Limited	Genetic Variation	[106]
EHD4	OT7G5JTT	Limited	Biomarker	[107]
ESAM	OTF518AI	Limited	Biomarker	[108]
FAM20C	OTW5YZ7X	Limited	Biomarker	[109]
FANCC	OTTIDM3P	Limited	Biomarker	[110]
GATA5	OTO81B63	Limited	Genetic Variation	[111]
GNG11	OTHIXBGW	Limited	Genetic Variation	[70]
HAND1	OTN4IPVV	Limited	Biomarker	[112]
HCLS1	OTX7WGYN	Limited	Biomarker	[113]
HOPX	OTBSR6C9	Limited	Altered Expression	[22]
KCNA4	OTTIGYN7	Limited	Biomarker	[60]
KCND2	OTIFUVV7	Limited	Genetic Variation	[114]
KCNE4	OTNYW0OL	Limited	Biomarker	[115]
KCNIP2	OTY4BLOJ	Limited	Biomarker	[116]
KCNIP4	OTB1BS0X	Limited	Biomarker	[117]
LRRC10	OT9V0ZBY	Limited	Biomarker	[118]
MEF2A	OTV2SF6E	Limited	Altered Expression	[119]
MMD	OTB5I4OC	Limited	Genetic Variation	[18]
MOCOS	OT0TL3Q5	Limited	Genetic Variation	[120]
MYH6	OT3YNCH1	Limited	Biomarker	[121]
MYZAP	OTAZCNBT	Limited	Genetic Variation	[122]
NCS1	OT6JHAWM	Limited	Biomarker	[104]
OBSCN	OTT14OVX	Limited	Genetic Variation	[123]
PACC1	OTKBS8CC	Limited	Genetic Variation	[124]
PAEP	OTQA0NV4	Limited	Genetic Variation	[29]
PDPR	OTYAERF2	Limited	Biomarker	[125]
PKP2	OTJOVF68	Limited	Genetic Variation	[126]
POPDC2	OTDAZSY5	Limited	Genetic Variation	[98]
PPP1R1A	OTGTAGCV	Limited	Genetic Variation	[127]
PRKAG2	OTHTAM54	Limited	Genetic Variation	[128]
PTPN22	OTDCNTC3	Limited	Genetic Variation	[29]
QRSL1	OTJDU2UG	Limited	Altered Expression	[22]
RBM20	OTOQZNKS	Limited	Genetic Variation	[129]
RBM25	OTVOUOAG	Limited	Biomarker	[130]
SCG2	OTXWUQQL	Limited	Biomarker	[131]
SELENON	OTSGKO5M	Limited	Genetic Variation	[132]
SHOC2	OTUNQ2CT	Limited	Altered Expression	[133]
SHOX2	OTLCZZJW	Limited	Genetic Variation	[134]
SMCP	OTXKY794	Limited	Genetic Variation	[120]
SNRNP70	OTP52YZ3	Limited	Biomarker	[135]
SNTA1	OTUICTGZ	Limited	Genetic Variation	[136]
SPRED2	OTUX685J	Limited	Biomarker	[137]
SRL	OT7IEBWZ	Limited	Biomarker	[60]
STIL	OT9799VN	Limited	Biomarker	[138]
TBX2	OTTOT7A9	Limited	Altered Expression	[22]
TBX20	OTMPU2XQ	Limited	Genetic Variation	[139]
TBX5	OT70PISV	Limited	Genetic Variation	[22]
TEAD4	OTJS0T2B	Limited	Biomarker	[140]
MYOZ2	OTMEIQJA	Disputed	Genetic Variation	[141]
COL4A5	OTHG60RE	moderate	Genetic Variation	[142]
KCNJ8	OTZ8G8FE	moderate	Biomarker	[143]
ACE	OTDF1964	Strong	Biomarker	[144]
ADCY6	OTFOY4WW	Strong	Biomarker	[145]
ANK2	OTWB4R1Y	Strong	Biomarker	[146]
ASAP2	OTGEXULW	Strong	Biomarker	[147]
BIN1	OTK8O0X8	Strong	Biomarker	[148]
CALM2	OTNYA92F	Strong	Biomarker	[149]
CAMK2D	OTJ5XLVU	Strong	Biomarker	[150]
CAMKMT	OTLJBRUW	Strong	Genetic Variation	[151]
CAP1	OTYM8A2N	Strong	Genetic Variation	[63]
CAV3	OTWSFDB4	Strong	Biomarker	[152]
CAVIN1	OTFO915U	Strong	Biomarker	[153]
CNNM2	OTZHO8WU	Strong	Biomarker	[154]
CPT1A	OTI862QH	Strong	Altered Expression	[155]
CPT2	OTIN6G20	Strong	Altered Expression	[155]
CREG1	OTRHJ8HK	Strong	Biomarker	[156]
DSG2	OTJPB2TO	Strong	Biomarker	[124]
DSP	OTB2MOP8	Strong	Genetic Variation	[157]
EDA	OTAKS5WS	Strong	Altered Expression	[158]
EMD	OTR8ZANE	Strong	Biomarker	[159]
ETV1	OT6PMJIK	Strong	Altered Expression	[160]
FKBP1B	OT8CMPB2	Strong	Biomarker	[161]
FLNC	OT3F8J6Y	Strong	Genetic Variation	[162]
FSD1	OT8P6PT3	Strong	Altered Expression	[163]
FSD1L	OTBQ48RF	Strong	Altered Expression	[163]
GDF11	OTOSNMND	Strong	Biomarker	[164]
GNAI2	OTTLGRGH	Strong	Therapeutic	[165]
GPD1L	OTVLWW9T	Strong	Altered Expression	[166]
GYG1	OT9PU6I2	Strong	Biomarker	[167]
HACD1	OTEC7EP7	Strong	Genetic Variation	[63]
HARS1	OTHOEOTS	Strong	Altered Expression	[168]
HGS	OTCYYCAC	Strong	Altered Expression	[168]
HSPB7	OTLATAOV	Strong	Genetic Variation	[169]
ITPKB	OTSVVPAV	Strong	Biomarker	[170]
KCNE1	OTZNQUW9	Strong	Genetic Variation	[171]
KCNE2	OTUO214Y	Strong	Biomarker	[172]
KCNE3	OTKWKR91	Strong	Genetic Variation	[173]
KCNK17	OTG2NEZM	Strong	Biomarker	[174]
KLHL24	OTWZSX5C	Strong	Altered Expression	[175]
KRIT1	OT58AP1I	Strong	Genetic Variation	[151]
LMNA	OT3SG7ZR	Strong	Genetic Variation	[176]
MAP6	OTPUI00F	Strong	Genetic Variation	[177]
MRPS30	OTDXIAGG	Strong	Biomarker	[147]
MTPAP	OT6HQ02S	Strong	Biomarker	[147]
NKX2-5	OTS1SAWM	Strong	Genetic Variation	[178]
NOS1AP	OTDFOBRU	Strong	Genetic Variation	[179]
P2RX2	OT0LF34A	Strong	Altered Expression	[67]
P2RX6	OT1FNTXA	Strong	Altered Expression	[67]
PAPOLA	OTPHD65D	Strong	Biomarker	[147]
PDAP1	OTJSWMOD	Strong	Biomarker	[147]
PICALM	OTQVRPMQ	Strong	Biomarker	[149]
PITX2	OTWMXAOY	Strong	Altered Expression	[180]
POU2F3	OTIOOJWD	Strong	Genetic Variation	[181]
RANGRF	OTKQC813	Strong	Biomarker	[182]
SCN1B	OTGD78J3	Strong	Genetic Variation	[183]
SCN3B	OTNTQT9O	Strong	CausalMutation	[184]
SERPINB6	OT7G55IK	Strong	Genetic Variation	[63]
SNAP91	OTE3EXWZ	Strong	Biomarker	[149]
SORBS1	OTWH8762	Strong	Genetic Variation	[63]
SRSF5	OTC5WP98	Strong	Altered Expression	[168]
STX6	OTC5F5M6	Strong	Biomarker	[185]
TAL1	OTX4K6QZ	Strong	Altered Expression	[91]
TANGO2	OTT9UI89	Strong	Genetic Variation	[186]
TECRL	OTXLSNCP	Strong	Genetic Variation	[187]
TPM1	OTD73X6R	Strong	Genetic Variation	[188]
TRDN	OTXVE9SF	Strong	Genetic Variation	[189]
TBX3	OTM64N7K	Definitive	Altered Expression	[22]
TTN	OT0LZ058	Definitive	Biomarker	[129]

References

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