General Information of Disease (ID: DISER9XT)

Disease Name Renal carcinoma
Synonyms renal cancer; kidney (renal) cancer; kidney cancer; kidney (including renal cell) cancer; carcinoma of kidney; kidney carcinoma; renal carcinoma
Definition
A carcinoma arising from the epithelium of the renal parenchyma or the renal pelvis. The majority are renal cell carcinomas. Kidney carcinomas usually affect middle aged and elderly adults. Hematuria, abdominal pain, and a palpable mass are common symptoms.
Disease Hierarchy
DISH9F1N: Carcinoma
DISBIPKM: Kidney cancer
DISER9XT: Renal carcinoma
Disease Identifiers
MONDO ID
MONDO_0005206
UMLS CUI
C1378703
MedGen ID
235133

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 56 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ATP1A1 TTWK8D0 Limited Biomarker [1]
CFLAR TTJZQYH Limited Altered Expression [2]
COPS5 TTSTNJR Limited Biomarker [3]
CTSG TTQAJF1 Limited Biomarker [4]
DKK3 TTY2ZV6 Limited Biomarker [5]
EPAS1 TTWPA54 Limited Altered Expression [6]
HLA-G TTLKFB3 Limited Altered Expression [7]
KDM3A TTKXS4A Limited Altered Expression [8]
KDM6B TTDIJUQ Limited Biomarker [9]
KIF20B TTQECT2 Limited Biomarker [10]
MCAM TTHRE05 Limited Biomarker [11]
RALBP1 TTVSRUA Limited Biomarker [12]
ACO2 TTMTF2P moderate Genetic Variation [13]
CRY2 TTAO58M moderate Altered Expression [14]
F12 TTRJSMV moderate Altered Expression [15]
KIF11 TTBGTCW moderate Biomarker [16]
MMP16 TTNP4CU moderate Biomarker [17]
STXBP4 TTKS60G moderate Biomarker [18]
ACVR2B TTLFRKS Strong Biomarker [19]
APOH TT2OUI9 Strong Biomarker [20]
ATP4A TTF1QVM Strong Genetic Variation [21]
CASP5 TTWR48J Strong Genetic Variation [22]
CD274 TT8ZLTI Strong Altered Expression [23]
CDH6 TT9QHUK Strong Altered Expression [24]
CRHBP TT3PKZE Strong Altered Expression [25]
CRTC1 TT4GO0F Strong Biomarker [26]
CYP11B1 TTIQUX7 Strong Altered Expression [27]
CYP11B2 TT9MNE2 Strong Altered Expression [27]
DIO1 TTU3X26 Strong Altered Expression [28]
DKK2 TTST5KX Strong Biomarker [29]
EGLN2 TTMHFRY Strong Biomarker [30]
FKBP1A TTMW94E Strong Biomarker [31]
FOSL1 TTY8LZG Strong Biomarker [32]
FOSL2 TT689IR Strong Biomarker [32]
GRHL2 TTUGH4C Strong Biomarker [33]
HRC TTR4FKD Strong Genetic Variation [34]
JUN TTS7IR5 Strong Biomarker [32]
KDM5C TT94UCF Strong Posttranslational Modification [35]
MC2R TTPWFDX Strong Altered Expression [36]
NDUFA13 TTRU1NG Strong Altered Expression [37]
PAK4 TT7Y3BZ Strong Biomarker [38]
PBRM1 TTH8ZRL Strong Biomarker [39]
PGRMC1 TTY3LAZ Strong Biomarker [40]
PINX1 TT4FJ3A Strong Biomarker [41]
PLA2R1 TTHKW7D Strong Biomarker [42]
RPS6KA6 TT3KYWB Strong Altered Expression [43]
SDHD TTVH9W8 Strong Genetic Variation [44]
SLC11A2 TT2IS7P Strong Altered Expression [45]
SLC16A3 TTG6VD5 Strong Biomarker [46]
SORD TTLSRBZ Strong Biomarker [47]
SYVN1 TT8XKYM Strong Biomarker [48]
THRB TTGER3L Strong Altered Expression [49]
TMEM97 TT9NXW4 Strong Altered Expression [50]
TRPC4 TTX0H5W Strong Biomarker [51]
CA9 TT2LVK8 Definitive Biomarker [52]
NF2 TTZIK7P Definitive Genetic Variation [53]
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⏷ Show the Full List of 56 DTT(s)
This Disease Is Related to 2 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ATP12A DT5NLZA Strong Genetic Variation [21]
SLC25A5 DTL1TRY Strong Biomarker [54]
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This Disease Is Related to 4 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ME1 DE97WM8 moderate Biomarker [55]
PRODH DEVJIHS moderate Biomarker [56]
THOP1 DE95LJC moderate Biomarker [57]
UGT2B7 DEB3CV1 Strong Altered Expression [58]
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This Disease Is Related to 149 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CALM2 OTNYA92F Limited Biomarker [59]
CAMKMT OTLJBRUW Limited Biomarker [59]
CIAPIN1 OTWS90F9 Limited Biomarker [60]
COPS8 OTNAD2S4 Limited Biomarker [61]
KRIT1 OT58AP1I Limited Biomarker [59]
MAPK13 OT0W9GE7 Limited Altered Expression [62]
NPRL2 OTOB10MO Limited Biomarker [63]
PSMA5 OT38E6Y1 Limited Altered Expression [64]
SDHB OTRE1M1T Limited Biomarker [47]
SMARCA1 OT0Y6PTU Limited Biomarker [65]
TCF21 OT393IMA Limited Altered Expression [66]
TMEM106A OTHTBYDN Limited Biomarker [67]
ATG16L2 OTJYU0W8 Disputed Biomarker [68]
GABARAPL1 OT4U7SBG Disputed Altered Expression [68]
AP5M1 OTDLWEBL moderate Altered Expression [13]
CBFA2T2 OTNOIB23 moderate Altered Expression [69]
CDK5RAP3 OTC0Q2QS moderate Biomarker [70]
CHRDL1 OTGMWVVA moderate Biomarker [71]
DBP OTE0W7LN moderate Genetic Variation [72]
ELOC OT0XHHWP moderate Genetic Variation [73]
FAM83H OTN0SF11 moderate Biomarker [74]
FNDC5 OT5CSK9X moderate Biomarker [75]
FNIP2 OT7EX8JJ moderate Biomarker [76]
FRK OTEKV1SC moderate Biomarker [77]
GABPB1 OTEXDEJN moderate Altered Expression [78]
HAVCR1 OT184CRZ moderate Biomarker [79]
KLF6 OTQY9S7F moderate Biomarker [80]
KLHDC8B OTKP6LCR moderate Biomarker [71]
MAP1LC3C OTM4ECDK moderate Altered Expression [68]
MKS1 OT83W5PB moderate Biomarker [55]
MTA2 OTCCYIQJ moderate Biomarker [81]
NPAS2 OTMRT2TS moderate Biomarker [14]
NR1D2 OT9CVF41 moderate Biomarker [14]
NSD2 OTQ6SW4R moderate Altered Expression [82]
PANX2 OTAQ2S8R moderate Biomarker [74]
PIK3R2 OTZSUQK5 moderate Altered Expression [69]
PLAC8 OT3SYRUJ moderate Biomarker [83]
PLIN3 OT9ZA7MR moderate Biomarker [84]
PPP1R12C OT9Q86JO moderate Altered Expression [69]
PPP1R13B OTC88VQO moderate Altered Expression [69]
RGN OTD04KB1 moderate Altered Expression [85]
SART1 OTHMOGO1 moderate Altered Expression [15]
SGK2 OTCTVSHF moderate Biomarker [86]
SPOP OTP0107S moderate Genetic Variation [87]
SRSF2 OTVDHO6U moderate Biomarker [88]
STARD13 OTB4U1HY moderate Biomarker [89]
TBCK OTP38GVK moderate Biomarker [90]
TFEB OTJUJJQY moderate Biomarker [91]
TSC2 OT47LWI9 moderate Biomarker [92]
AKT1S1 OT4JHN4Y Strong Altered Expression [93]
ALDH9A1 OTNWHUJ1 Strong Genetic Variation [94]
AMER1 OT8EFJPM Strong Genetic Variation [95]
APH1A OT97F1TU Strong Genetic Variation [96]
BBS2 OTPF9JIB Strong Biomarker [97]
BCL2L12 OTS6IFZY Strong Biomarker [98]
BTG2 OTZF6K1H Strong Altered Expression [99]
C1orf52 OT8RQW3W Strong Biomarker [100]
C4orf46 OTXL7SLI Strong Biomarker [101]
CACYBP OTJMZD2T Strong Biomarker [102]
CAV2 OT1FGRQX Strong Biomarker [103]
CCNG2 OTII38K2 Strong Biomarker [104]
CDCP1 OTD7RRWK Strong Biomarker [105]
CDR2 OTD3ZJST Strong Biomarker [30]
CHL1 OT6E6E8P Strong Biomarker [106]
CHMP2B OTZA7RJB Strong Altered Expression [45]
CLTC OTBFASMA Strong Genetic Variation [107]
COL4A3 OT6SB8X5 Strong Altered Expression [108]
COPS3 OTZWPJ24 Strong Biomarker [109]
CREB3L4 OTSGQGT2 Strong Altered Expression [110]
CUL1 OTXPE1UZ Strong Altered Expression [111]
DDT OTF5HTYL Strong Biomarker [112]
DERL2 OTI3TUUZ Strong Biomarker [113]
DERL3 OTRZRT6Q Strong Biomarker [48]
DHRS2 OTFHWIY8 Strong Biomarker [114]
DLEC1 OTMKKBUW Strong Biomarker [115]
DMRT1 OT5PU9U1 Strong Altered Expression [45]
ELF5 OTLRU8YF Strong Altered Expression [116]
EPB41L5 OTPPQPLU Strong Biomarker [117]
ESM1 OT331Y8V Strong Altered Expression [118]
FEZ1 OTWCXPRE Strong Biomarker [119]
FLCN OTVM78XM Strong Autosomal dominant [120]
FNIP1 OTB1CC41 Strong Biomarker [121]
FOXP4 OTHCGIEZ Strong Altered Expression [122]
FRZB OTTO3DPY Strong Biomarker [123]
GDF9 OTNTVKVU Strong Altered Expression [124]
GIPC1 OTXLVCPJ Strong Biomarker [125]
HEPACAM OT1MJ51D Strong Altered Expression [126]
HOXB1 OTGC0EKI Strong Genetic Variation [127]
HOXB2 OTTD6HMV Strong Genetic Variation [127]
HOXB3 OT9UC5PE Strong Genetic Variation [127]
HOXB4 OTH1HRW5 Strong Genetic Variation [127]
HOXB5 OTU74TB8 Strong Genetic Variation [127]
HOXB6 OT3TFQ0U Strong Genetic Variation [127]
HOXB7 OTC7WYU8 Strong Genetic Variation [127]
HOXB8 OTKHOD17 Strong Genetic Variation [127]
HOXB9 OTMVHQOU Strong Genetic Variation [127]
IFNA17 OTHXRYG3 Strong Genetic Variation [128]
JADE1 OTBPJIRI Strong Altered Expression [129]
JAM3 OTX0F9QL Strong Biomarker [130]
JUNB OTG2JXV5 Strong Biomarker [32]
JUND OTNKACJD Strong Biomarker [32]
KANK1 OT2E7A6W Strong Altered Expression [131]
KLF8 OTUC5CDB Strong Altered Expression [132]
KLHL1 OTAX6SAD Strong Altered Expression [133]
KLLN OTV3FPH0 Strong Posttranslational Modification [134]
LRRC4 OT7XJ70N Strong Biomarker [100]
LZTS1 OTXXL864 Strong Biomarker [119]
MAML1 OTQA4DDN Strong Biomarker [135]
MCPH1 OTYT3TT5 Strong Altered Expression [136]
MITF OT6XJCZH Strong Genetic Variation [137]
MYBBP1A OTIVEMIU Strong Biomarker [138]
MYCL OT1MFQ5U Strong Genetic Variation [139]
NMU OTW9X7BQ Strong Biomarker [140]
OSGIN1 OT9KIVZW Strong Biomarker [141]
P3H4 OTZPXYSH Strong Biomarker [142]
PCLAF OTMVIOUU Strong Altered Expression [143]
PHLDA1 OTFTWMIQ Strong Biomarker [144]
PLIN2 OTRXJ9UN Strong Biomarker [145]
PRCC OTJ0KRYX Strong Altered Expression [146]
PRKX OTDAC6Z0 Strong Altered Expression [43]
PYCR1 OTQHB52T Strong Biomarker [147]
QKI OTTAUGLB Strong Biomarker [148]
RAB27B OTPF9D0K Strong Altered Expression [149]
RADIL OTQTRGMB Strong Biomarker [150]
RAP1GAP OTC31ONQ Strong Altered Expression [151]
RCHY1 OTAE7504 Strong Altered Expression [152]
RHEB OTFLTSEC Strong Genetic Variation [153]
RIT2 OTSNYG0D Strong Biomarker [154]
RPS15A OT0BUA12 Strong Genetic Variation [155]
SARDH OTQ49Q27 Strong Biomarker [47]
SDHA OTOJ8QFF Strong Genetic Variation [156]
SDHC OTC8G2MX Strong Genetic Variation [157]
SDS OT5WTJ2M Strong Biomarker [47]
SF3B3 OTAC9LZT Strong Altered Expression [158]
SFPQ OTLCIAPJ Strong Genetic Variation [96]
SLC16A4 OT1YXBKC Strong Biomarker [46]
SLC49A4 OTXL3KAM Strong Biomarker [159]
SOSTDC1 OTAKDNSM Strong Altered Expression [160]
STAMBPL1 OTI4CYTF Strong Altered Expression [161]
SYCE1L OTXU44F3 Strong Altered Expression [133]
TCHP OTVDMHSY Strong Altered Expression [162]
TESC OTI8C76M Strong Biomarker [163]
TFE3 OTM99ZWH Strong Genetic Variation [164]
TMEM45A OT54KJG6 Strong Altered Expression [165]
TOP3B OTNFEUOO Strong Genetic Variation [166]
TRIP11 OT4FJEAR Strong Biomarker [167]
TTBK2 OT90YSM5 Strong Altered Expression [43]
RNF139 OT0PR1X5 Definitive Genetic Variation [168]
TMEM132D OTV6I4Z0 Definitive Biomarker [169]
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⏷ Show the Full List of 149 DOT(s)

References

1 Downregulation of ATP1A1 promotes cancer development in renal cell carcinoma.Clin Proteomics. 2017 May 4;14:15. doi: 10.1186/s12014-017-9150-4. eCollection 2017.
2 Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma.Int J Mol Sci. 2019 Jul 2;20(13):3253. doi: 10.3390/ijms20133253.
3 Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5.Oncogene. 2005 May 12;24(21):3503-11. doi: 10.1038/sj.onc.1208509.
4 Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin.Oncotarget. 2017 Nov 20;8(63):106672-106684. doi: 10.18632/oncotarget.22508. eCollection 2017 Dec 5.
5 Exogenous DKK-3/REIC inhibits Wnt/-catenin signaling and cell proliferation in human kidney cancer KPK1.Oncol Lett. 2017 Nov;14(5):5638-5642. doi: 10.3892/ol.2017.6833. Epub 2017 Aug 28.
6 Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma.J Biol Chem. 2019 Mar 8;294(10):3760-3771. doi: 10.1074/jbc.RA118.004902. Epub 2019 Jan 7.
7 Analysis of HLA antigen expression in benign and malignant melanocytic lesions reveals that upregulation of HLA-G expression correlates with malignant transformation, high inflammatory infiltration and HLA-A1 genotype.Int J Cancer. 2004 Jan 10;108(2):243-50. doi: 10.1002/ijc.11456.
8 Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells.Acta Biochim Biophys Sin (Shanghai). 2012 Apr;44(4):330-8. doi: 10.1093/abbs/gms004. Epub 2012 Feb 7.
9 Calcitriol induces cell senescence of kidney cancer through JMJD3 mediated histone demethylation.Oncotarget. 2017 Oct 26;8(59):100187-100195. doi: 10.18632/oncotarget.22124. eCollection 2017 Nov 21.
10 KIF20B promotes the progression of clear cell renal cell carcinoma by stimulating cell proliferation.J Cell Physiol. 2019 Sep;234(9):16517-16525. doi: 10.1002/jcp.28322. Epub 2019 Feb 25.
11 Identification and characterization of angiogenesis targets through proteomic profiling of endothelial cells in human cancer tissues.PLoS One. 2013 Nov 13;8(11):e78885. doi: 10.1371/journal.pone.0078885. eCollection 2013.
12 RIP1-dependent reactive oxygen species production executes artesunate-induced cell death in renal carcinoma Caki cells.Mol Cell Biochem. 2017 Nov;435(1-2):15-24. doi: 10.1007/s11010-017-3052-7. Epub 2017 May 2.
13 Landscape of cancer diagnostic biomarkers from specifically expressed genes.Brief Bioinform. 2020 Dec 1;21(6):2175-2184. doi: 10.1093/bib/bbz131.
14 Research on circadian clock genes in common abdominal malignant tumors.Chronobiol Int. 2019 Jul;36(7):906-918. doi: 10.1080/07420528.2018.1477792. Epub 2019 Apr 24.
15 Hypoxia-Associated Factor (HAF) Mediates Neurofibromin Ubiquitination and Degradation Leading to Ras-ERK Pathway Activation in Hypoxia.Mol Cancer Res. 2019 May;17(5):1220-1232. doi: 10.1158/1541-7786.MCR-18-1080. Epub 2019 Jan 31.
16 High kinesin family member 11 expression predicts poor prognosis in patients with clear cell renal cell carcinoma.J Clin Pathol. 2019 May;72(5):354-362. doi: 10.1136/jclinpath-2018-205390. Epub 2019 Feb 28.
17 HOXA11-AS promotes the growth and invasion of renal cancer by sponging miR-146b-5p to upregulate MMP16 expression.J Cell Physiol. 2018 Dec;233(12):9611-9619. doi: 10.1002/jcp.26864. Epub 2018 Jun 28.
18 Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor.EMBO J. 2020 Jan 2;39(1):e102406. doi: 10.15252/embj.2019102406. Epub 2019 Nov 29.
19 LncRNA MALAT1 modified progression of clear cell kidney carcinoma (KIRC) by regulation of miR-194-5p/ACVR2B signaling.Mol Carcinog. 2019 Feb;58(2):279-292. doi: 10.1002/mc.22926. Epub 2018 Oct 31.
20 Beta-2-glycoprotein-1 and alpha-1-antitrypsin as urinary markers of renal cancer in von Hippel-Lindau patients.Biomarkers. 2018 Mar;23(2):123-130. doi: 10.1080/1354750X.2016.1269132. Epub 2016 Dec 22.
21 Medication use and kidney cancer risk: Apopulation-based study.Eur J Cancer. 2017 Sep;83:203-210. doi: 10.1016/j.ejca.2017.07.001. Epub 2017 Jul 24.
22 An analysis of growth, differentiation and apoptosis genes with risk of renal cancer.PLoS One. 2009 Mar 24;4(3):e4895. doi: 10.1371/journal.pone.0004895.
23 Glutamine Deprivation Induces PD-L1 Expression via Activation of EGFR/ERK/c-Jun Signaling in Renal Cancer.Mol Cancer Res. 2020 Feb;18(2):324-339. doi: 10.1158/1541-7786.MCR-19-0517. Epub 2019 Oct 31.
24 Cadherin-6 gene expression in conventional renal cell carcinoma: a useful marker to detect circulating tumor cells.Anticancer Res. 2005 Jan-Feb;25(1A):377-81.
25 Reduced mRNA expression level of corticotropin-releasing hormone-binding protein is associated with aggressive human kidney cancer.BMC Cancer. 2013 Apr 22;13:199. doi: 10.1186/1471-2407-13-199.
26 microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion.PLoS One. 2012;7(6):e37366. doi: 10.1371/journal.pone.0037366. Epub 2012 Jun 4.
27 Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas. Eur J Endocrinol. 2002 Dec;147(6):795-802.
28 Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system.PLoS One. 2017 Dec 22;12(12):e0190179. doi: 10.1371/journal.pone.0190179. eCollection 2017.
29 Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways.Clin Cancer Res. 2009 Sep 15;15(18):5678-87. doi: 10.1158/1078-0432.CCR-09-0558.
30 Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response.Oncogene. 2009 Sep 17;28(37):3274-85. doi: 10.1038/onc.2009.186. Epub 2009 Jul 6.
31 FKBP-12 exhibits an inhibitory activity on calcium oxalate crystal growth in vitro.J Korean Med Sci. 2002 Feb;17(1):41-8. doi: 10.3346/jkms.2002.17.1.41.
32 Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model.Biochem Biophys Res Commun. 1997 Dec 8;241(1):24-30. doi: 10.1006/bbrc.1997.7731.
33 Integrative bioinformatics analysis reveals new prognostic biomarkers of clear cell renal cell carcinoma.Clin Chem. 2014 Oct;60(10):1314-26. doi: 10.1373/clinchem.2014.225854. Epub 2014 Aug 19.
34 Linking human genetics with molecular medicine: will hereditary renal cancer play a major role?.Cancer Biol Ther. 2004 May;3(5):441-6. doi: 10.4161/cbt.3.5.807. Epub 2004 May 18.
35 Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer.J Clin Invest. 2015 Dec;125(12):4625-37. doi: 10.1172/JCI81040. Epub 2015 Nov 9.
36 Expression of adrenocorticotropin receptor gene in adrenocortical adenomas from patients with Cushing syndrome: possible contribution for the autonomous production of cortisol.Ann Surg. 2001 Jul;234(1):85-91. doi: 10.1097/00000658-200107000-00013.
37 The effect of a gene associated with retinoid-interferon-induced mortality 19 (GRIM-19) on STAT3-induced gene expression in renal carcinoma.J Biochem. 2018 Oct 1;164(4):285-294. doi: 10.1093/jb/mvy052.
38 Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth.Mol Cancer Ther. 2016 Sep;15(9):2119-29. doi: 10.1158/1535-7163.MCT-16-0197. Epub 2016 Jul 7.
39 High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1.Mol Oncol. 2019 Apr;13(4):811-828. doi: 10.1002/1878-0261.12434. Epub 2019 Feb 2.
40 PGRMC1 Is a Novel Potential Tumor Biomarker of Human Renal Cell Carcinoma Based on Quantitative Proteomic and Integrative Biological Assessments. PLoS One. 2017 Jan 20;12(1):e0170453.
41 PinX1 represses renal cancer angiogenesis via the mir-125a-3p/VEGF signaling pathway.Angiogenesis. 2019 Nov;22(4):507-519. doi: 10.1007/s10456-019-09675-z. Epub 2019 Jun 28.
42 Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth.Oncotarget. 2014 Feb 28;5(4):1004-13. doi: 10.18632/oncotarget.1681.
43 PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines.Int J Cancer. 2012 Jul 15;131(2):E45-55. doi: 10.1002/ijc.26486. Epub 2012 Feb 28.
44 Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer.J Urol. 2012 Dec;188(6):2063-71. doi: 10.1016/j.juro.2012.08.030. Epub 2012 Oct 18.
45 Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancer.Clin Cancer Res. 2013 Jul 1;19(13):3345-52. doi: 10.1158/1078-0432.CCR-13-0304. Epub 2013 Apr 30.
46 Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells.Cancer Cell Int. 2019 Jun 28;19:170. doi: 10.1186/s12935-019-0889-8. eCollection 2019.
47 Urological cancer related to familial syndromes.Int Braz J Urol. 2017 Mar-Apr;43(2):192-201. doi: 10.1590/S1677-5538.IBJU.2016.0125.
48 Loss of der(3) in renal carcinoma cells of a patient with constitutional t(3;12).Hum Genet. 1988 Feb;78(2):148-50. doi: 10.1007/BF00278186.
49 Epigenetic regulation of thyroid hormone receptor beta in renal cancer.PLoS One. 2014 May 21;9(5):e97624. doi: 10.1371/journal.pone.0097624. eCollection 2014.
50 Expression analysis of MAC30 in human pancreatic cancer and tumors of the gastrointestinal tract.Histol Histopathol. 2004 Oct;19(4):1021-31. doi: 10.14670/HH-19.1021.
51 Data-driven Analysis of TRP Channels in Cancer: Linking Variation in Gene Expression to Clinical Significance.Cancer Genomics Proteomics. 2016 Jan-Feb;13(1):83-90.
52 Combining DNA Vaccine and AIM2 in H1 Nanoparticles Exert Anti-Renal Carcinoma Effects via Enhancing Tumor-Specific Multi-functional CD8(+) T-cell Responses.Mol Cancer Ther. 2019 Feb;18(2):323-334. doi: 10.1158/1535-7163.MCT-18-0832. Epub 2018 Nov 6.
53 YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells.Dev Cell. 2019 May 6;49(3):425-443.e9. doi: 10.1016/j.devcel.2019.04.014.
54 Coordinate expression of nuclear and mitochondrial genes involved in energy production in carcinoma and oncocytoma.Biochim Biophys Acta. 1996 Aug 23;1316(3):203-9. doi: 10.1016/0925-4439(96)00026-9.
55 Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates.J Am Chem Soc. 2018 Mar 14;140(10):3690-3711. doi: 10.1021/jacs.7b12692. Epub 2018 Jan 30.
56 miR-23b targets proline oxidase, a novel tumor suppressor protein in renal cancer. Oncogene. 2010 Sep 2;29(35):4914-24.
57 Efficient proximal gradient algorithm for inference of differential gene networks.BMC Bioinformatics. 2019 May 2;20(1):224. doi: 10.1186/s12859-019-2749-x.
58 Expression of UGT2B7 is driven by two mutually exclusive promoters and alternative splicing in human tissues: changes from prenatal life to adulthood and in kidney cancer.Pharmacogenet Genomics. 2013 Dec;23(12):684-96. doi: 10.1097/FPC.0000000000000008.
59 The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.Carcinogenesis. 2011 Nov;32(11):1713-23. doi: 10.1093/carcin/bgr195. Epub 2011 Aug 30.
60 Expression of CIAPIN1 in human colorectal cancer and its correlation with prognosis.BMC Cancer. 2010 Sep 3;10:477. doi: 10.1186/1471-2407-10-477.
61 Mutation screening of ACKR3 and COPS8 in kidney cancer cases from the CONFIRM study.Fam Cancer. 2017 Jul;16(3):411-416. doi: 10.1007/s10689-016-9961-x.
62 MAPK13 is preferentially expressed in gynecological cancer stem cells and has a role in the tumor-initiation.Biochem Biophys Res Commun. 2016 Apr 15;472(4):643-7. doi: 10.1016/j.bbrc.2016.03.004. Epub 2016 Mar 9.
63 Biological characteristics of renal cancer cells after CTP-mediated cancer suppressor gene NPRL2 protein treatment.Biol Chem. 2016 Nov 1;397(11):1163-1171. doi: 10.1515/hsz-2016-0143.
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