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Arsenic trioxide FDA Label
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Megestrol acetate drives endometrial carcinoma cell senescence via interacting with progesterone receptor B/FOXO1 axis. Exp Biol Med (Maywood). 2021 Nov;246(21):2307-2316.
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Progesterone FDA Label
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Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes.Nat Genet. 2012 Dec;44(12):1310-5. doi: 10.1038/ng.2455. Epub 2012 Oct 28.
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Expression of a retinol dehydrogenase (hRoDH-4), a member of the retinol/steroid dehydrogenase family implicated in retinoic acid biosynthesis, in normal and neoplastic endometria.Am J Obstet Gynecol. 2002 Apr;186(4):675-83. doi: 10.1067/mob.2002.122127.
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High AGR2 protein is a feature of low grade endometrial cancer cells.Oncotarget. 2018 Jul 31;9(59):31459-31472. doi: 10.18632/oncotarget.25838. eCollection 2018 Jul 31.
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Silencing of angiotensin receptor 1 interferes with angiotensin II oncogenic activity in endometrial cancer.J Cell Biochem. 2018 Nov;119(11):9110-9121. doi: 10.1002/jcb.27174. Epub 2018 Aug 13.
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Genetic alterations in endometrial cancer by targeted next-generation sequencing.Exp Mol Pathol. 2016 Feb;100(1):8-12. doi: 10.1016/j.yexmp.2015.11.026. Epub 2015 Nov 25.
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Transcriptome analysis reveals that Mllerian inhibiting substance regulates signaling pathways that contribute to endometrial carcinogenesis.Int J Oncol. 2015 May;46(5):2039-46. doi: 10.3892/ijo.2015.2920. Epub 2015 Mar 6.
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Delayed endometrial decidualisation in polycystic ovary syndrome; the role of AR-MAGEA11.J Mol Med (Berl). 2019 Sep;97(9):1315-1327. doi: 10.1007/s00109-019-01809-6. Epub 2019 Jun 29.
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ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma.Oncotarget. 2015 Sep 29;6(29):28440-52. doi: 10.18632/oncotarget.4955.
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Biglycan enhances the ability of migration and invasion in endometrial cancer.Arch Gynecol Obstet. 2016 Feb;293(2):429-38. doi: 10.1007/s00404-015-3844-5. Epub 2015 Aug 15.
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Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.Nat Med. 2017 Sep;23(9):1046-1054. doi: 10.1038/nm.4372. Epub 2017 Aug 14.
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The G protein-coupled receptor GPR30 mediates the nontranscriptional effect of estrogen on the activation of PI3K/Akt pathway in endometrial cancer cells.Int J Gynecol Cancer. 2013 Jan;23(1):52-9. doi: 10.1097/IGC.0b013e31827912b8.
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Significance of calreticulin as a prognostic factor in endometrial cancer.Oncol Lett. 2018 Jun;15(6):8999-9008. doi: 10.3892/ol.2018.8495. Epub 2018 Apr 13.
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Detection of CCNE1/URI (19q12) amplification by in situ hybridisation is common in high grade and type II endometrial cancer.Oncotarget. 2017 Feb 28;8(9):14794-14805. doi: 10.18632/oncotarget.11605.
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Met Signaling Cascade Is Amplified by the Recruitment of Phosphorylated Met to Lipid Rafts via CD24 and Leads to Drug Resistance in Endometrial Cancer Cell Lines.Mol Cancer Ther. 2015 Oct;14(10):2353-63. doi: 10.1158/1535-7163.MCT-15-0187. Epub 2015 Jul 30.
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Alteration of G2 cell cycle regulators occurs during carcinogenesis of the endometrium.Oncology. 2003;65(2):159-66. doi: 10.1159/000072342.
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Paired box 2 promotes progression of endometrial cancer via regulating cell cycle pathway.J Cancer. 2018 Sep 25;9(20):3743-3754. doi: 10.7150/jca.22418. eCollection 2018.
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Stimulation of CEACAM1 expression by 12-O-tetradecanoylphorbol-13-acetate (TPA) and calcium ionophore A23187 in endometrial carcinoma cells.Carcinogenesis. 2006 Mar;27(3):483-90. doi: 10.1093/carcin/bgi275. Epub 2005 Dec 6.
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hLH/hCG-receptor expression correlates with in vitro invasiveness in human primary endometrial cancer.Gynecol Oncol. 2008 Dec;111(3):496-501. doi: 10.1016/j.ygyno.2008.08.018. Epub 2008 Oct 1.
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GNA14 silencing suppresses the proliferation of endometrial carcinoma cells through inducing apoptosis and G(2)/M cell cycle arrest.Biosci Rep. 2018 Sep 7;38(5):BSR20180574. doi: 10.1042/BSR20180574. Print 2018 Oct 31.
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Targeted Proteomics Identifies Proteomic Signatures in Liquid Biopsies of the Endometrium to Diagnose Endometrial Cancer and Assist in the Prediction of the Optimal Surgical Treatment.Clin Cancer Res. 2017 Nov 1;23(21):6458-6467. doi: 10.1158/1078-0432.CCR-17-0474. Epub 2017 Aug 8.
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Colonystimulating factor 1 receptor inhibition blocks macrophage infiltration and endometrial cancer cell proliferation.Mol Med Rep. 2019 Apr;19(4):3139-3147. doi: 10.3892/mmr.2019.9963. Epub 2019 Feb 18.
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Non-endometrioid and high-grade endometrioid endometrial cancers show DNA fragmentation factor 40 (DFF40) and B-cell lymphoma 2 protein (BCL2) underexpression, which predicts disease-free and overall survival, but not DNA fragmentation factor 45 (DFF45) underexpression.BMC Cancer. 2018 Apr 13;18(1):418. doi: 10.1186/s12885-018-4333-6.
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Preoperative quantitative dynamic contrast-enhanced MRI and diffusion-weighted imaging predict aggressive disease in endometrial cancer.Acta Radiol. 2018 Aug;59(8):1010-1017. doi: 10.1177/0284185117740932. Epub 2017 Nov 14.
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Metastasis-associated protein 1, modulated by miR-30c, promotes endometrial cancer progression through AKT/mTOR/4E-BP1 pathway.Gynecol Oncol. 2019 Jul;154(1):207-217. doi: 10.1016/j.ygyno.2019.04.005. Epub 2019 Apr 9.
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Expression Profile of Endoglin in Different Grades of Endometrial Cancer.Curr Pharm Biotechnol. 2018;19(12):990-995. doi: 10.2174/1389201020666181127152605.
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The effect of estrogen on the proliferation of endometrial cancer cells is mediated by ERR through AKT and ERK1/2.Eur J Cancer Prev. 2014 Sep;23(5):418-24. doi: 10.1097/CEJ.0000000000000052.
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Upregulation of miR-183-5p is responsible for the promotion of apoptosis and inhibition of the epithelial-mesenchymal transition, proliferation, invasion and migration of human endometrial cancer cells by downregulating Ezrin.Int J Mol Med. 2018 Nov;42(5):2469-2480. doi: 10.3892/ijmm.2018.3853. Epub 2018 Sep 4.
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Fatty acid synthase is a potential therapeutic target in estrogen receptor-/progesterone receptor-positive endometrioid endometrial cancer.Oncology. 2013;84(3):166-73. doi: 10.1159/000342967. Epub 2013 Jan 9.
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Expression Profile of VEGF-C, VEGF-D, and VEGFR-3 in Different Grades of Endometrial Cancer.Curr Pharm Biotechnol. 2019;20(12):1004-1010. doi: 10.2174/1389201020666190718164431.
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Roles of SIRT1/FoxO1/SREBP-1 in the development of progestin resistance in endometrial cancer.Arch Gynecol Obstet. 2018 Nov;298(5):961-969. doi: 10.1007/s00404-018-4893-3. Epub 2018 Sep 11.
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(99m)Tc-LHRH in tumor receptor imaging.Oncol Lett. 2017 Jul;14(1):569-578. doi: 10.3892/ol.2017.6246. Epub 2017 May 24.
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Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1.Cell Commun Signal. 2019 Mar 5;17(1):22. doi: 10.1186/s12964-019-0336-4.
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Hepatoma-Derived Growth Factor and DDX5 Promote Carcinogenesis and Progression of Endometrial Cancer by Activating -Catenin.Front Oncol. 2019 Apr 11;9:211. doi: 10.3389/fonc.2019.00211. eCollection 2019.
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Transcriptional profiling endometrial carcinomas microdissected from DES-treated mice identifies changes in gene expression associated with estrogenic tumor promotion.Int J Cancer. 2006 Oct 15;119(8):1843-9. doi: 10.1002/ijc.22063.
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Expression and functional significance of HtrA1 loss in endometrial cancer.Clin Cancer Res. 2011 Feb 1;17(3):427-36. doi: 10.1158/1078-0432.CCR-09-3069. Epub 2010 Nov 23.
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IGFBP-rP1 acts as a potential tumor suppressor via the suppression of ERK signaling pathway in endometrial cancer cells.Mol Med Rep. 2017 Aug;16(2):1445-1450. doi: 10.3892/mmr.2017.6713. Epub 2017 Jun 7.
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Amplification of c-erbB2 oncogene: a major prognostic indicator in uterine serous papillary carcinoma.Cancer. 2005 Oct 1;104(7):1391-7. doi: 10.1002/cncr.21308.
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Blockage of intermediate-conductance-Ca(2+) -activated K(+) channels inhibits progression of human endometrial cancer.Oncogene. 2007 Aug 2;26(35):5107-14. doi: 10.1038/sj.onc.1210308. Epub 2007 Feb 19.
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KDM4B and KDM4A promote endometrial cancer progression by regulating androgen receptor, c-myc, and p27kip1.Oncotarget. 2015 Oct 13;6(31):31702-20. doi: 10.18632/oncotarget.5165.
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TGF- activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth.Cell Cycle. 2016;15(7):931-47. doi: 10.1080/15384101.2016.1150393.
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Altered expression of lysophosphatidic acid receptors, in association with the synthesis of estrogens and androgens in type 1 endometrial cancer biology.Gynecol Endocrinol. 2018 May;34(5):422-427. doi: 10.1080/09513590.2017.1409707. Epub 2017 Nov 28.
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Impact of MDM2, TP53 and P14ARF Polymorphisms on Endometrial Cancer Risk and Onset.In Vivo. 2019 May-Jun;33(3):917-924. doi: 10.21873/invivo.11559.
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Overexpression of the matrix metalloproteinase 11 gene is a potential biomarker for type 1 endometrial cancer.Oncol Lett. 2018 Jul;16(1):1073-1078. doi: 10.3892/ol.2018.8714. Epub 2018 May 16.
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Matrix metalloproteinase-7 (MMP-7) polymorphism is a risk factor for endometrial cancer susceptibility.Clin Chem Lab Med. 2010 Mar;48(3):337-44. doi: 10.1515/CCLM.2010.082.
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MTDH is an oncogene in multiple myeloma, which is suppressed by Bortezomib treatment.Oncotarget. 2016 Jan 26;7(4):4559-69. doi: 10.18632/oncotarget.6610.
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Comparison of serum human epididymis protein 4 and CA125 on endometrial cancer detection: A meta-analysis.Clin Chim Acta. 2019 Jan;488:215-220. doi: 10.1016/j.cca.2018.11.011. Epub 2018 Nov 7.
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Significant association of genetic polymorphism of human nonmetastatic clone 23 type 1 gene with an increased risk of endometrial cancer.Gynecol Oncol. 2010 Oct;119(1):70-5. doi: 10.1016/j.ygyno.2010.06.013.
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Immunohistochemical Detection of Hematopoietic Cell-specific Protein-Tyrosine Phosphatase (Tyrosine Phosphatase SHP-1) in a Series of Endometrioid and Serous Endometrial Carcinoma.Appl Immunohistochem Mol Morphol. 2018 Aug;26(7):468-477. doi: 10.1097/PAI.0000000000000456.
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Association analysis between 8-oxoguanine DNA glycosylase genetic variants and endometrial cancer susceptibility in Chinese Han population.J Pharm Pharmacol. 2015 Apr;67(4):559-64. doi: 10.1111/jphp.12348. Epub 2014 Dec 10.
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Cross-talk between p21-activated kinase 4 and ER signaling triggers endometrial cancer cell proliferation.Oncotarget. 2017 Jul 12;8(40):68083-68094. doi: 10.18632/oncotarget.19188. eCollection 2017 Sep 15.
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Prognostic implication of programmed cell death 1 protein and its ligand expressions in endometrial cancer.Gynecol Oncol. 2018 May;149(2):381-387. doi: 10.1016/j.ygyno.2018.02.013. Epub 2018 Mar 21.
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Macrophage ER promoted invasion of endometrial cancer cell by mTOR/KIF5B-mediated epithelial to mesenchymal transition.Immunol Cell Biol. 2019 Jul;97(6):563-576. doi: 10.1111/imcb.12245. Epub 2019 Mar 14.
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Down-regulation of focal adhesion signaling in response to cyclophilin A knockdown in human endometrial cancer cells, implicated by cDNA microarray analysis.Gynecol Oncol. 2013 Oct;131(1):191-7. doi: 10.1016/j.ygyno.2013.07.095. Epub 2013 Jul 27.
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Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models.Tumour Biol. 2016 Sep;37(9):11835-11842. doi: 10.1007/s13277-016-5036-8. Epub 2016 Apr 5.
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Targeting cancer stem cell signature gene SMOC-2 Overcomes chemoresistance and inhibits cell proliferation of endometrial carcinoma.EBioMedicine. 2019 Feb;40:276-289. doi: 10.1016/j.ebiom.2018.12.044. Epub 2018 Dec 26.
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Bu Shen Yang Xue Prescription Has Treating Effect on Endometrial Cancer through FSH/PI3K/AKT/Gankyrin/HIF-/cyclinD 1 Pathway in Ishikawa Cells.Evid Based Complement Alternat Med. 2018 Oct 9;2018:8412984. doi: 10.1155/2018/8412984. eCollection 2018.
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Prostaglandin E2 triggers cytochrome P450 17 hydroxylase overexpression via signal transducer and activator of transcription 3 phosphorylation and promotes invasion in endometrial cancer.Oncol Lett. 2018 Oct;16(4):4577-4585. doi: 10.3892/ol.2018.9165. Epub 2018 Jul 18.
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Association of polymorphisms in the 5' untranslated region of RAD51 gene with risk of endometrial cancer in the Polish population.Arch Gynecol Obstet. 2014 Nov;290(5):985-91. doi: 10.1007/s00404-014-3305-6. Epub 2014 Jun 15.
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Loss of RUNX3 is significantly associated with advanced tumor grade and stage in endometrial cancers.Mol Med Rep. 2018 Jun;17(6):8173-8179. doi: 10.3892/mmr.2018.8915. Epub 2018 Apr 23.
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Relaxin 2/RXFP1 Signaling Induces Cell Invasion via the -Catenin Pathway in Endometrial Cancer.Int J Mol Sci. 2018 Aug 18;19(8):2438. doi: 10.3390/ijms19082438.
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Effects of sex steroid hormones on corticosteroid-binding globulin gene expression in human endometrial cancer cell line Ishikawa.Ann Clin Biochem. 1998 Sep;35 ( Pt 5):637-42. doi: 10.1177/000456329803500507.
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Effects of RNAi-induced Skp2 inhibition on cell cycle, apoptosis and proliferation of endometrial carcinoma cells.Exp Ther Med. 2019 May;17(5):3441-3450. doi: 10.3892/etm.2019.7392. Epub 2019 Mar 13.
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Expression of organic cation transporter SLC22A16 in human endometria.Int J Gynecol Pathol. 2007 Jan;26(1):53-60. doi: 10.1097/01.pgp.0000225845.67245.b3.
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Alternative splicing of synuclein gamma in endometrial cancer: identification of a novel isoform.Oncotarget. 2015 Sep 8;6(26):22553-63. doi: 10.18632/oncotarget.4155.
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Stanniocalcin 2 expression is regulated by hormone signalling and negatively affects breast cancer cell viability in vitro.J Endocrinol. 2008 Jun;197(3):517-29. doi: 10.1677/JOE-08-0043.
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Nucleotide excision repair genotype and the incidence of endometrial cancer: effect of other risk factors on the association.Gynecol Oncol. 2006 Dec;103(3):891-6. doi: 10.1016/j.ygyno.2006.05.020. Epub 2006 Jun 23.
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ALCAM shedding at the invasive front of the tumor is a marker of myometrial infiltration and promotes invasion in endometrioid endometrial cancer.Oncotarget. 2018 Mar 30;9(24):16648-16664. doi: 10.18632/oncotarget.24625. eCollection 2018 Mar 30.
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Identification of prognosis markers for endometrial cancer by integrated analysis of DNA methylation and RNA-Seq data.Sci Rep. 2019 Jul 9;9(1):9924. doi: 10.1038/s41598-019-46195-8.
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Downregulation of Proline Hydroxylase 2 and Upregulation of Hypoxia-Inducible Factor 1 are Associated with Endometrial Cancer Aggressiveness.Cancer Manag Res. 2019 Nov 22;11:9907-9912. doi: 10.2147/CMAR.S223421. eCollection 2019.
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Final analysis of a phase I/IIa trial of the folate-binding protein-derived E39 peptide vaccine to prevent recurrence in ovarian and endometrial cancer patients.Cancer Med. 2019 Aug;8(10):4678-4687. doi: 10.1002/cam4.2378. Epub 2019 Jul 5.
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Regulation of matriptase and HAI-1 system, a novel therapeutic target in human endometrial cancer cells.Oncotarget. 2018 Jan 3;9(16):12682-12694. doi: 10.18632/oncotarget.23913. eCollection 2018 Feb 27.
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NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling.Gynecol Oncol. 2015 Oct;139(1):127-33. doi: 10.1016/j.ygyno.2015.07.098. Epub 2015 Jul 17.
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LINC01016 promotes the malignant phenotype of endometrial cancer cells by regulating the miR-302a-3p/miR-3130-3p/NFYA/SATB1 axis.Cell Death Dis. 2018 Feb 21;9(3):303. doi: 10.1038/s41419-018-0291-9.
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Expression of keratinocyte growth factor and its receptor in human endometrial cancer in cooperation with steroid hormones.Int J Oncol. 2008 Mar;32(3):565-74.
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Use of Porphysomes to detect primary tumour, lymph node metastases, intra-abdominal metastases and as a tool for image-guided lymphadenectomy: proof of concept in endometrial cancer.Theranostics. 2019 Apr 13;9(9):2727-2738. doi: 10.7150/thno.31225. eCollection 2019.
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Folate receptor- targeted near-infrared fluorescence imaging in high-risk endometrial cancer patients: a tissue microarray and clinical feasibility study.Oncotarget. 2017 Dec 11;9(1):791-801. doi: 10.18632/oncotarget.23155. eCollection 2018 Jan 2.
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Leptin receptor expression during the progression of endometrial carcinoma is correlated with estrogen and progesterone receptors.Arch Med Sci. 2017 Feb 1;13(1):228-235. doi: 10.5114/aoms.2017.64721. Epub 2016 Dec 19.
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Combined silencing of VEGF-A and angiopoietin-2, a more effective way to inhibit the Ishikawa endometrial cancer cell line.Onco Targets Ther. 2019 Feb 14;12:1215-1223. doi: 10.2147/OTT.S194064. eCollection 2019.
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Silencing Bmi1 expression suppresses cancer stemness and enhances chemosensitivity in endometrial cancer cells.Biomed Pharmacother. 2018 Dec;108:584-589. doi: 10.1016/j.biopha.2018.09.041. Epub 2018 Sep 20.
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Durable response in a woman with recurrent low-grade endometrioid endometrial cancer and a germline BRCA2 mutation treated with a PARP inhibitor.Gynecol Oncol. 2018 Aug;150(2):219-226. doi: 10.1016/j.ygyno.2018.05.028. Epub 2018 Jun 22.
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