Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEZO4M)

Drug Name

G6976 Drug Info

Synonyms

12H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile, 5,6,7,13-tetrahydro-13-methyl-5-oxo-; Go 6976; 136194-77-9; GO6976; Go-6976; Goe 6976; UNII-B9IQO7JZ16; 6976; Go 6976, Solution; B9IQO7JZ16; 5,6,7,13-Tetrahydro-13-Methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile; CHEMBL302449; CHEBI:51913; 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole; 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole; Go6976

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Cross-matching ID

PubChem CID: 3501
ChEBI ID: CHEBI:51913
CAS Number: CAS 136194-77-9
TTD Drug ID: DMEZO4M

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Investigative Drug(s)

Patented Agent(s)

Discontinued Drug(s)

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Protein kinase D (PRKD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
K252a	DMT68RG	Solid tumour/cancer	2A00-2F9Z	Investigative	[1]
CRT0066101	DMX09KI	Solid tumour/cancer	2A00-2F9Z	Investigative	[1]
BPKDi	DM5OHIY	Solid tumour/cancer	2A00-2F9Z	Investigative	[1]
CID755673	DMSHIQA	Solid tumour/cancer	2A00-2F9Z	Investigative	[1]
INDUS-815B	DMBOQ6M	Kidney disease	GC2Z	Investigative	[11]
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Drug(s) Targeting Protein kinase C zeta (PRKCZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methyl 2-amino-4-phenylthiophene-3-carboxylate	DM9BYJ0	N. A.	N. A.	Patented	[12]
Y-9680	DMHAVYS	N. A.	N. A.	Patented	[12]
US8889696, 39	DMKXRJ4	N. A.	N. A.	Patented	[13]
US8889672, 252-036-001	DM8B1Q4	N. A.	N. A.	Patented	[12]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[14]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[15]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[16]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[4]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[17]
[2,2':5',2'']Terthiophen-4-yl-methanol	DMRQC1F	Discovery agent	N.A.	Investigative	[18]
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Drug(s) Targeting Nuclear factor NF-kappa-B (NFKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[19]
Triptolide	DMCMDVR	Autoimmune diabetes	5A10	Phase 3	[20]
Laquinimod	DM3IWS8	Lupus	4A40	Phase 3	[21]
Edasalonexent	DMYVBF6	Duchenne dystrophy	8C70	Phase 3	[22]
MD1003	DMVZ57G	Multiple sclerosis	8A40	Phase 3	[22]
Vadimezan	DMK7CYX	Solid tumour/cancer	2A00-2F9Z	Phase 2	[23]
CAT 1004	DMQBP7R	Duchenne dystrophy	8C70	Phase 2	[24]
Parthenolide	DMCQBFT	N. A.	N. A.	Phase 2	[25]
Recoflavone	DMCSR8I	Inflammatory bowel disease	DD72	Phase 2	[26]
CZEN-002	DMUDMHA	Fungal infection	1F29-1F2F	Phase 2	[27]
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Drug(s) Targeting Protein kinase C (PRKC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Synthetic hypericin	DMXU4ON	Virus infection	1A24-1D9Z	Phase 3	[28]
APH-0812	DM756GE	Human immunodeficiency virus-1 infection	1C62	Phase 2	[29]
CYCLOPLATAM	DMXR8WN	Solid tumour/cancer	2A00-2F9Z	Phase 2	[30]
AEB07	DMJVN89	Transplant rejection	NE84	Phase 2	[31]
HO/03/03	DMA6HQJ	Diabetic foot ulcer	BD54	Phase 2	[32]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[33]
LXS196	DM65MEL	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[34]
SAFINGOL	DMBGUDR	Psoriasis vulgaris	EA90	Phase 1	[35]
GCC-1290K	DMJ7WRI	Parkinson disease	8A00.0	Phase 1	[36]
AEB701	DM8I4G0	Melanoma	2C30	Phase 1	[37]
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Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[47]
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Drug(s) Affected By 3-phosphoinositide-dependent protein kinase 1 (PDPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[53]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[52]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[56]
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Drug(s) Affected By Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[63]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[64]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[65]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[66]
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Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[67]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[70]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[71]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[72]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[73]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[66]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[75]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[79]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[74]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[80]
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Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[90]
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Drug(s) Affected By Neurotensin/neuromedin N (NTS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[96]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[97]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[98]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[92]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nuclear factor NF-kappa-B (NFKB)	TTSXVID	NFKB1_HUMAN; NFKB2_HUMAN; TF65_HUMAN; RELB_HUMAN; REL_HUMAN	Inhibitor	[2]
Protein kinase C (PRKC)	TTYVX59	NOUNIPROTAC	Inhibitor	[3]
Protein kinase C zeta (PRKCZ)	TTUWGRA	KPCZ_HUMAN	Inhibitor	[4]
Protein kinase D (PRKD1)	TTSLUMT	KPCD1_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)	OTNAZVKB	3BHS1_HUMAN	Gene/Protein Processing	[5]
3-phosphoinositide-dependent protein kinase 1 (PDPK1)	OTT09ZVP	PDPK1_HUMAN	Gene/Protein Processing	[6]
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)	OT2NV3AN	CP11A_HUMAN	Gene/Protein Processing	[5]
Neurotensin/neuromedin N (NTS)	OTPGDNQS	NEUT_HUMAN	Gene/Protein Processing	[7]
Protein kinase C alpha type (PRKCA)	OT5UWNRD	KPCA_HUMAN	Gene/Protein Processing	[8]
Serine/threonine-protein kinase Chk1 (CHEK1)	OTTTI622	CHK1_HUMAN	Gene/Protein Processing	[6]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Gene/Protein Processing	[9]
UL16-binding protein 1	OTUIBJD0	ULBP1_HUMAN	Gene/Protein Processing	[10]

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