Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHJLPS)

Drug Name
M-carboxycinnamic acid bishydroxamide Drug Info
Synonyms Cbha; Histone Deacetylase Inhibitor II; HDInhib_000062; M-Carboxycinnamic Acid bis-Hydroxamide; N-hydroxy-3-[(E)-3-(hydroxyamino)-3-oxoprop-1-enyl]benzamide
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Preclinical [1]
Cross-matching ID
PubChem CID
5353484
CAS Number
CAS 174664-65-4
TTD Drug ID
DMHJLPS

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histone deacetylase 1 (HDAC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [4]
Romidepsin DMT5GNL Cutaneous T-cell lymphoma 2B01 Approved [5]
Panobinostat DM58WKG Chronic graft versus host disease Approved [4]
HBI-8000 DMDWYUN Non-small-cell lung cancer 2C25.Y Registered [6]
ITF2357 DMFZBNE Duchenne dystrophy 8C70 Phase 3 [7]
NVP-LAQ824 DM8JWNA Mood disorder 6A60-6E23 Phase 3 [8]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [9]
Phenylbutyrate DMBHPDW Urea cycle disorder 5C50.A Phase 2 [10]
MGCD-0103 DM726HX Non-small-cell lung cancer 2C25.Y Phase 2 [4]
Resminostat DMNE1FR Hepatocellular carcinoma 2C12.02 Phase 2 [11]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [12]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [13]
Gefitinib DM15F0X Colon adenocarcinoma Approved [14]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [15]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [16]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [17]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [18]
Methotrexate DM2TEOL Anterior urethra cancer Approved [19]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [20]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [22]
Gefitinib DM15F0X Colon adenocarcinoma Approved [23]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [25]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [26]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [27]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [26]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [28]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [31]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [32]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [33]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [34]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [35]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [22]
Verapamil DMA7PEW Angina pectoris BA40 Approved [36]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [37]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [38]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [39]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [40]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [42]
Gefitinib DM15F0X Colon adenocarcinoma Approved [43]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [15]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Etretinate DM2CZFA Keratosis ED56 Approved [45]
Prednisone DM2HG4X Acute asthma CA23 Approved [46]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [27]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [47]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [48]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [49]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [50]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [51]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [52]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [53]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [54]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [55]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [56]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [57]
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Drug(s) Affected By Caspase-2 (CASP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [62]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [63]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [64]
Leflunomide DMR8ONJ Arthritis FA20 Approved [65]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [66]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [70]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [71]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [73]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [74]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [75]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [66]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [76]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [22]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [37]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [25]
Meloxicam DM2AR7L Arthritis FA20 Approved [79]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [80]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [81]
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Drug(s) Affected By BH3-interacting domain death agonist (BID)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [25]
Selenium DM25CGV N. A. N. A. Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [84]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [85]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [88]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [31]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [57]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [22]
Verapamil DMA7PEW Angina pectoris BA40 Approved [36]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [91]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [77]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [15]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [16]
Meloxicam DM2AR7L Arthritis FA20 Approved [92]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [27]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [25]
Selenium DM25CGV N. A. N. A. Approved [95]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [96]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [97]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [84]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [99]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [100]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [101]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [102]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Gefitinib DM15F0X Colon adenocarcinoma Approved [103]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [25]
Selenium DM25CGV N. A. N. A. Approved [95]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [105]
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Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [108]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [109]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [110]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [111]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [112]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [107]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [113]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [114]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histone deacetylase 1 (HDAC1) TT6R7JZ HDAC1_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Bcl-2-related protein A1 (BCL2A1) OTWRYSNA B2LA1_HUMAN Gene/Protein Processing [3]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Protein Interaction/Cellular Processes [3]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Protein Interaction/Cellular Processes [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [3]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Protein Interaction/Cellular Processes [3]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Protein Interaction/Cellular Processes [3]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [3]

References

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28 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
29 Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
30 Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
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41 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
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45 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
46 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
47 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
48 Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
49 [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
50 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
51 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
52 Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
53 Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
54 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
55 Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
56 mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
57 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
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