Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML5VQ0)

Drug Name
Fenoprofen Drug Info
Synonyms
Fenoprofene; Fenoprofeno; Fenoprofenum; Feprona; Nalfon; Nalgesic; Feneprofen calcium salt dihydrate; Fenoprofen calcium; Fenoprofen calcium hydrate; Lilly 53838; Fenoprofen Dihydrate, Calcium Salt; Fenoprofene [INN-French]; Fenoprofeno [INN-Spanish]; Fenoprofenum [INN-Latin]; Fenopron (TN); Fenoprofen (USAN/INN); Fenoprofen [USAN:BAN:INN]; Alpha-(m-phenoxyphenyl)propionic acid; Alpha-Methyl-3-phenoxybenzeneacetic acid; (+-)-2-(3-Phenoxyphenyl)propionic acid; (+-)-m-Phenoxyhydratropic acid; 2-(3-Phenoxyphenyl)propanoic acid; 2-(3-Phenoxyphenyl)propionic acid; 2-(m-phenoxyphenyl)propionic acid; 2-[3-(phenyloxy)phenyl]propanoic acid
Indication
Disease Entry ICD 11 Status REF
Osteoarthritis FA00-FA05 Approved [1]
Pain MG30-MG3Z Approved [1]
Rheumatoid arthritis FA20 Approved [2]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
PubChem CID
3342
ChEBI ID
CHEBI:5004
CAS Number
CAS 29679-58-1
TTD Drug ID
DML5VQ0
ACDINA Drug ID
D00270

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin G/H synthase (COX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [9]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [10]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [11]
Dexibuprofen DMFYBD0 Ankylosing spondylitis FA92.0 Approved [12]
Ketorolac DMI4EL5 Postoperative inflammation 1A00-CA43.1 Approved [13]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [14]
Oxaprozin DM9UB0P Osteoarthritis FA00-FA05 Approved [3]
Aceclofenac DMZDF0B Inflammation 1A00-CA43.1 Approved [15]
Lornoxicam DMYZFXN Migraine 8A80 Approved [16]
Morniflumate DM9UTDE Otitis media AA80-AB0Z Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 16 (NGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [18]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Panobinostat DM58WKG Chronic graft versus host disease Approved [22]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [23]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [23]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [24]
Oxaprozin DM9UB0P Osteoarthritis FA00-FA05 Approved [3]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin reductase 1 (PTGR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [30]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [33]
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Drug(s) Affected By HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [34]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [6]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [6]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [35]
Allopurinol DMLPAOB Gout FA25 Approved [36]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [37]
Selenium DM25CGV N. A. N. A. Approved [38]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [40]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [41]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [42]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [4]
Diazepam DM08E9O Alcohol withdrawal Approved [43]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [44]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [45]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [46]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [38]
Fluoxetine DM3PD2C Bipolar depression Approved [6]
Cinoxacin DM4EWNS Urinary tract infection GC08 Approved [6]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [30]
Testosterone DM7HUNW Hot flushes GA30 Approved [50]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [6]
Testosterone enanthate DMB6871 N. A. N. A. Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [6]
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Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [5]
Quercetin DM3NC4M Obesity 5B81 Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [5]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [53]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [54]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [55]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [56]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase (COX) TTK0943 PGH1_HUMAN; PGH2_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [4]
Dehydrogenase/reductase SDR family member 11 (DHRS11) OTU3J0ZL DHR11_HUMAN Gene/Protein Processing [5]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1) OT7OG7Y2 DPA1_HUMAN Gene/Protein Processing [6]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Gene/Protein Processing [6]
Prostaglandin reductase 1 (PTGR1) OTMAR351 PTGR1_HUMAN Gene/Protein Processing [7]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Gene/Protein Processing [3]
UDP-glucuronosyltransferase 1A10 OTOTZVEY UD110_HUMAN Biotransformations [8]
UDP-glucuronosyltransferase 1A3 OTUEOER3 UD13_HUMAN Biotransformations [8]
UDP-glucuronosyltransferase 1A7 OTY4JJ32 UD17_HUMAN Biotransformations [8]
UDP-glucuronosyltransferase 1A8 OTTMABBG UD18_HUMAN Biotransformations [8]

References

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26 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
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31 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
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