Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMEQUR)

Drug Name
Ethidium Drug Info
Synonyms
Ethidium; homidium; Ethidium cation; Novidium; 3546-21-2; UNII-EN464416SI; 3,8-Diamino-5-ethyl-6-phenylphenanthridinium; Phenanthridinium, 3,8-diamino-5-ethyl-6-phenyl-; BRN 3627183; CHEBI:42478; EN464416SI; AB00053825_07; CHEMBL284328; NSC84423; NSC522843; 5-ethyl-6-phenyl-phenanthridin-5-ium-3,8-diamine; 5-ethyl-6-phenylphenanthridin-5-ium-3,8-diamine; C21H20N3; Spectrum_001500; AC1L1GCK; Spectrum2_001587; Spectrum5_001263; Spectrum4_000198; UPCMLD-DP076; NCIMech_000529; cid_3624; Piperine & Ethidium bromide; NCIOpen2_009324
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
3624
ChEBI ID
CHEBI:42478
CAS Number
CAS 3546-21-2
TTD Drug ID
DMMEQUR
VARIDT Drug ID
DR01442

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [9]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [10]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [2]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [11]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [12]
Carboplatin DMG281S Adenocarcinoma 2D40 Approved [13]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [14]
Procarbazine DMIK367 Hodgkin lymphoma 2B30 Approved [15]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [16]
Dacarbazine DMNPZL4 Adenocarcinoma 2D40 Approved [17]
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Drug(s) Affected By Cytochrome b (CYTB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [21]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [22]
Urethane DM7NSI0 N. A. N. A. Phase 4 [23]
Fialuridine DMCIGRB Hepatitis B virus infection 1E51.0 Phase 2 [24]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [25]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [26]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [27]
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Drug(s) Affected By Cytochrome c oxidase subunit 1 (COX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [6]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [28]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [29]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [30]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [21]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [33]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [34]
Nicotinamide DMUPE07 Acne vulgaris ED80 Approved [29]
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Drug(s) Affected By Cytochrome c oxidase subunit 2 (COX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [37]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [38]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [21]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [38]
Menthol DMG2KW7 Back pain ME84.Z Approved [40]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [41]
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Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 1 (ND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [5]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [42]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [22]
Capsaicin DMGMF6V Back pain ME84.Z Approved [43]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [44]
Haloperidol DM96SE0 Delirium Approved [44]
Thiothixene DMDINC4 Schizophrenia 6A20 Approved [44]
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Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 4 (ND4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [45]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [21]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [46]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [47]
Arsenic DMTL2Y1 N. A. N. A. Approved [48]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [22]
Urethane DM7NSI0 N. A. N. A. Phase 4 [23]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [51]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [52]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [53]
Paclitaxel DMLB81S Breast carcinoma Approved [54]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [57]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [58]
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Drug(s) Affected By CD59 glycoprotein (CD59)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [3]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Testosterone DM7HUNW Hot flushes GA30 Approved [63]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [21]
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Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [5]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [72]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [34]
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Drug(s) Affected By Nuclear respiratory factor 1 (NRF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [76]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [77]
Arsenic DMTL2Y1 N. A. N. A. Approved [48]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [78]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [79]
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Drug(s) Affected By Solute carrier family 22 member 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [80]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [81]
Trospium chloride DM32XZT Discovery agent N.A. Approved [82]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [83]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [84]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [87]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [85]
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Drug(s) Affected By Solute carrier family 22 member 2 (SLC22A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [81]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [88]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [88]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [89]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [84]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [89]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Trospium chloride DM32XZT Discovery agent N.A. Approved [82]
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
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Drug(s) Affected By P2X purinoceptor 7 (P2RX7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epinephrine DM3KJBC Acute asthma CA23 Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [78]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [92]
AZ11645373 DMDRXCP Discovery agent N.A. Investigative [93]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [94]
BzATP DM37GYA Discovery agent N.A. Investigative [95]
Milchsaure DM462BT Pruritus EC90 Investigative [96]
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Drug(s) Affected By Solute carrier family 22 member 3 (SLC22A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epinephrine DM3KJBC Acute asthma CA23 Approved [97]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [97]
Norepinephrine DMOUC09 Alopecia ED70 Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [99]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [100]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Intercalator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
CD59 glycoprotein (CD59) OTSUMQDH CD59_HUMAN Gene/Protein Processing [3]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [4]
Cytochrome b (CYTB) OTAHB98A CYB_HUMAN Gene/Protein Processing [5]
Cytochrome c oxidase subunit 1 (COX1) OTG3O9BN COX1_HUMAN Gene/Protein Processing [6]
Cytochrome c oxidase subunit 2 (COX2) OTTMVBJJ COX2_HUMAN Gene/Protein Processing [5]
NADH-ubiquinone oxidoreductase chain 1 (ND1) OTCLGIXV NU1M_HUMAN Gene/Protein Processing [5]
NADH-ubiquinone oxidoreductase chain 4 (ND4) OT4RQVAA NU4M_HUMAN Gene/Protein Processing [5]
Nuclear respiratory factor 1 (NRF1) OTOXWNV8 NRF1_HUMAN Gene/Protein Processing [5]
P2X purinoceptor 7 (P2RX7) OTNJ9XPL P2RX7_HUMAN Regulation of Drug Effects [7]
Solute carrier family 22 member 1 (SLC22A1) OT7817I4 S22A1_HUMAN Regulation of Drug Effects [8]

References

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20 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
21 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
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24 Mechanisms of Chronic Fialuridine Hepatotoxicity as Revealed in Primary Human Hepatocyte Spheroids. Toxicol Sci. 2019 Oct 1;171(2):385-395. doi: 10.1093/toxsci/kfz195.
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27 Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
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29 Examining the impact of skin lighteners in vitro. Oxid Med Cell Longev. 2013;2013:702120. doi: 10.1155/2013/702120. Epub 2013 Apr 28.
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38 A genome-wide analysis of targets of macrolide antibiotics in mammalian cells. J Biol Chem. 2020 Feb 14;295(7):2057-2067. doi: 10.1074/jbc.RA119.010770. Epub 2020 Jan 8.
39 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
40 Pod-based menthol and tobacco flavored e-cigarettes cause mitochondrial dysfunction in lung epithelial cells. Toxicol Lett. 2020 Oct 15;333:303-311. doi: 10.1016/j.toxlet.2020.08.003. Epub 2020 Aug 9.
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48 Aberrant cell proliferation by enhanced mitochondrial biogenesis via mtTFA in arsenical skin cancers. Am J Pathol. 2011 May;178(5):2066-76.
49 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
50 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
51 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
52 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
53 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
54 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
55 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
56 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
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