Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMTAJC)

Drug Name
Potassium Chloride Drug Info
Synonyms
Acronitol; Celeka; Chloropotassuril; Chlorvescent; Durekal; Durules; Enpott; Enseal; Infalyte; KCL; KSR; Kadalex; Kalcorid; Kaleorid; Kaleorod; Kaliduron; Kaliglutol; Kalilente; Kalinorm; Kaliolite; Kalipor; Kalipoz; Kalitabs; Kaliumchlorid; Kaochlor; Kaskay; Kato; Kayback; Kayciel; Kaysiel; Keylyte; Kloren; Klorvess; Klotrix; Kolyum; Miopotasio; Neobakasal; Pfiklor; Potasion; Potasol; Potavescent; Rekawan; Selora; Steropotassium; Sylvite; [KCl]; Chlorid draselny; Chlorid draselny [Czech]; Chloride of potash; Conductance standard solution; Dipotassium dichloride; Emplets potassium chloride; K Tab; KCL Retard; KM potassium chloride; Kalinorm Depottab; Kalitrans Retard; Kalium Duriles; Kalium Durules; Kalium Retard; Kalium SR; Kaon Cl; Kaon Ultra; Kay Ciel; Kelp salt; Leo K; Monopotassium chloride; Muriate of potash; Natural sylvite; Plus Kalium Retard; Potassium Chloride BP; Potassium Chloride in Plastic Container; Potassium Cl; Potassium chloride [JAN]; Potassium chloride solution; Potassium chloride standard; Potassium monochloride; Potassium muriate; Rekawan Retard; Repone K; Sal digestnum sylvii; Super K; Tripotassium trichloride; Trona muriate of potash; Trona potassium chloride; Ultra K Chlor; IN2900; Potassium Chloride 10meq in Plastic Container; Potassium chloride 20meq inplastic container; Potassium chloride 30meq in plastic container; Potassium chloride 40meq in plastic container; Addi-K; Apo-K; Cena-K; Chloride, Potassium; Chloropotassuril diffu-K; Diffu-K; Duffi-K; Durules-K; K+10; K+8; K-10; K-Care; K-Contin; K-Dur; K-Grad; K-Lease; K-Lor; K-Lyte Cl; K-Norm; K-SR; K-Sol; K-Tab; K. tab; KCL (TN); KCl-retard Zyma; Kalinor-Retard P; Kalium S.R; Kalium-Durettes; Kalium-R; Kalium-duriles; Kaon Cl-10; Kaon-Cl; Kaon-Cl 10; Kaon-Cl TABS; Kaon-ci; Kay-Ciel; Kay-EM; Klor-Con; Klor-Con M10; Klor-Con M15; Klor-Con M20; Klor-Lyte; Klotrix (TN); Lento-K; Lento-Kalium; Leo-K; Micro-K; Micro-K 10; Micro-K Extentcaps; Micro-K LS; Micro-Kalium Retard; Nu-K; POTASSIUM CHLORIDE, ACS; Peter-kal; Potassium atomic spectroscopy standard concentrate 1.00 g K; Potassium chloride (K3Cl3); Potassium chloride (KCl); Potassium standard concentrate 10.00 g K; Potassium thallium chloride (KTlCl); Repone-K; Rum-K; Sando-K; Slow-K; Slow-K tablets; Span-K; Super K (salt); Ten-K; Clor-K-Zaf; Hydrochloric acid potassium salt (1:1); ISA (ionic strength adjustment solution: 1 M KCl); K-Lyte/Cl; K-Predne-Dome; K-dur (TN); K-lyte/C1; Kalium S.R.; Kaon-Cl (TN); Kay-Cee-L; Klor-con (TN); Potassium chloride (JP15/USP); Ultra-K-Chlor; Conductivity Standard Solution, 1413-S/cm; Conductivity Standard Solution, 500-S/cm; POTASSIUM CHLORIDE, U.S.P.; 11118_FLUKA
Indication
Disease Entry ICD 11 Status REF
Hypokalemia 5C77 Approved [1]
Therapeutic Class
Dietary supplement
Cross-matching ID
PubChem CID
4873
ChEBI ID
CHEBI:32588
CAS Number
CAS 7447-40-7
TTD Drug ID
DMMTAJC
VARIDT Drug ID
DR00184
ACDINA Drug ID
D00543

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Solute carrier family 12 member 1 (SLC12A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [14]
Furosemide DMMQ8ZG Congestive heart failure BD10 Approved [15]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [16]
Ethacrynic acid DM60QMR Edema MG29 Approved [17]
Torasemide DMXKJ6C Congestive heart failure BD10 Approved [18]
Bendroflumethiazide DM7EVLC High blood pressure BA00 Approved [19]
Trichlormethiazide DMHAQCO Hypertension BA00-BA04 Approved [20]
Hydroflumethiazide DMVPUQI Congestive heart failure BD10 Approved [19]
Methyclothiazide DMN7SDE Edema MG29 Approved [19]
Chlorthalidone DM4DMBT Edema MG29 Approved [21]
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Drug(s) Transported By Organic cation/carnitine transporter 2 (SLC22A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [22]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [23]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [24]
Levacecarnine hci DMJBOCR Cognitive impairment 6D71 Approved [25]
Amphetamine DMSZQAK Attention deficit hyperactivity disorder 6A05.Z Approved [26]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [27]
Ipratropium DMFQ320 Obstructive lung disease CA22.Z Approved [27]
Mepyramine DMB4SFH Allergic rhinitis CA08.0 Approved [28]
Acetylcarnitine DM4UE3K Chronic fatigue syndrome 8E49 Phase 4 [29]
acetyl-L-carnitine DM74HGJ Discovery agent N.A. Investigative [23]
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Drug(s) Transported By Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 (SLC12A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sodium chloride DMM3950 Skin burns ME65.0 Approved [30]
Drug(s) Transported By Basolateral Na-K-Cl symporter (SLC12A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sodium chloride DMM3950 Skin burns ME65.0 Approved [6]
Drug(s) Affected By Kallikrein-8 (KLK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [31]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Arsenic DMTL2Y1 N. A. N. A. Approved [34]
Magnesium DMU4ORS Ischemic stroke 8B11.5Z Approved [10]
Magnesium Sulfate DMVEK07 Acute pain MG31 Approved [10]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [35]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [37]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [31]
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Drug(s) Affected By Progesterone receptor (PGR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [38]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Estrone DM5T6US Acne vulgaris ED80 Approved [41]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [42]
Testosterone DM7HUNW Hot flushes GA30 Approved [43]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [44]
Goserelin DMAT8CG Breast cancer 2C60-2C65 Approved [45]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
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Drug(s) Affected By Cytochrome P450 11B1, mitochondrial (CYP11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [47]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Ethanol DMDRQZU Chronic pain MG30 Approved [50]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [51]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [52]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [53]
Anacetrapib DMP2BFG Arteriosclerosis BD40 Phase 3 [53]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [54]
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Drug(s) Affected By Cytochrome P450 11B2, mitochondrial (CYP11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [55]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [48]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [57]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [58]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [56]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [59]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [60]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
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Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [66]
Testosterone DM7HUNW Hot flushes GA30 Approved [67]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [67]
Leflunomide DMR8ONJ Arthritis FA20 Approved [68]
Febuxostat DMDEXQ0 Hyperuricaemia 5C55.Y Approved [69]
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Drug(s) Affected By Protein FosB (FOSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [73]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [74]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [66]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [12]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [76]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [77]
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Drug(s) Affected By Lipoprotein lipase (LPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [52]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [78]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [82]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [83]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [84]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [85]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [84]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Solute carrier family 12 member 1 (SLC12A1) TTS087L S12A1_HUMAN Modulator [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Electroneutral potassium-chloride cotransporter 3 (SLC12A6) DTMA4FJ S12A6_HUMAN Substrate [3]
Electroneutral potassium-chloride cotransporter 2 (SLC12A5) DTD62VB S12A5_HUMAN Substrate [4]
Electroneutral potassium-chloride cotransporter 1 (SLC12A4) DTY25IU S12A4_HUMAN Substrate [5]
Basolateral Na-K-Cl symporter (SLC12A2) DTHKL3Q S12A2_HUMAN Substrate [6]
Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 (SLC12A1) DTO1UQY S12A1_HUMAN Substrate [7]
Organic cation/carnitine transporter 2 (SLC22A5) DT3HUVD S22A5_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 11B1, mitochondrial (CYP11B1) OTKKL894 C11B1_HUMAN Gene/Protein Processing [9]
Cytochrome P450 11B2, mitochondrial (CYP11B2) OTIOLWYN C11B2_HUMAN Gene/Protein Processing [9]
Kallikrein-8 (KLK8) OTGVGHXY KLK8_HUMAN Gene/Protein Processing [10]
Lipoprotein lipase (LPL) OTTW0267 LIPL_HUMAN Drug Response [11]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) OTGP6GA4 NR4A1_HUMAN Gene/Protein Processing [12]
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Gene/Protein Processing [13]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Gene/Protein Processing [12]

References

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62 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
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64 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
65 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
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67 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
68 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
69 Febuxostat Increases Ventricular Arrhythmogenesis Through Calcium Handling Dysregulation in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Toxicol Sci. 2022 Sep 24;189(2):216-224. doi: 10.1093/toxsci/kfac073.
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