Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOVH1M)

Drug Name
Oxytetracycline Drug Info
Synonyms
Adamycin; Biostat; Dabicycline; Dalimycin; Fanterrin; Geomycin; Geotilin; Hydroxytetracycline; Imperacin; Lenocycline; Macocyn; OTC; Oksisyklin; Ossitetraciclina; Oxacycline; Oxitetraciclina; Oxitetracyclin; Oxitetracycline; Oxitetracyclinum; Oxymycin; Oxymykoin; Oxypam; Oxyterracin; Oxyterracine; Oxyterracyne; Oxytetracid; Oxytetracyclin; Oxytetracyclinum; Proteroxyna; Riomitsin; Ryomycin; Solkaciclina; Tarocyn; Tarosin; Teravit; Terrafungine; Terramitsin; Terramycin; Tetran; Unimycin; Ursocyclin; Ursocycline; Vendarcin; Biostat PA; Ossitetraciclina [DCIT]; Oxytetracycline HCl; Oxytetracycline [INN]; Oxytetracycline amphoteric; Oxytetracycline anhydrous; Oxytetracycline calcium; Terramycin im; Antibiotic TM 25; LA 200; Liquamycin LA 200; Mycoshield TMQTHC 20; Pennox 200; TM 5; Terramycin Q50; Geomycin (Streptomyces vimosus); OTC (antibiotic); Oxitetraciclina [INN-Spanish]; Oxytetracycline (anhydrous); Oxytetracycline (internal use); Oxytetracyclinum [INN-Latin]; Terramycin, Liquamycin, Oxytetracycline; (2E,4S,4aR,5S,5aR,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione; (2E,4S,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione; (2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione; (2Z,4S,4aR,5S,5aR,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione; (4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; 5-Hydroxytetracycline
Indication
Disease Entry ICD 11 Status REF
Actinomycosis Approved [1]
Acute gonococcal cervicitis Approved [1]
Acute gonococcal epididymo-orchitis Approved [1]
Bacterial infection 1A00-1C4Z Approved [2]
Bronchitis CA20 Approved [1]
Brucellosis Approved [1]
Lymphogranuloma venereum Approved [1]
Ornithosis Approved [1]
Pneumonia CA40 Approved [1]
Q fever Approved [1]
Relapsing fever Approved [1]
Rickettsialpox Approved [1]
Rocky mountain spotted fever Approved [1]
Syphilis Approved [1]
Trachoma Approved [1]
Typhus Approved [1]
Urinary tract infection GC08 Approved [1]
Yaws Approved [1]
Sinusitis CA0A.Z Investigative [1]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
54675779
ChEBI ID
CHEBI:27701
CAS Number
CAS 2058-46-0
TTD Drug ID
DMOVH1M
VARIDT Drug ID
DR00635

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tetracycline DMZA017 Acne vulgaris ED80 Approved [7]
Framycetin DMF8DNE Acute liver failure DB91 Approved [8]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [9]
Amikacin DM5PDRB Bacteremia 1A73 Approved [10]
Clomocycline DM0ZRMQ Bacterial infection 1A00-1C4Z Approved [11]
Spectinomycin DM0MQ35 Acute gonococcal cervicitis Approved [12]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [13]
Lymecycline DMOMLHJ Bacterial infection 1A00-1C4Z Approved [14]
Rolitetracycline DMBR5Q7 Acne vulgaris ED80 Approved [15]
Meclocycline DMSFQ8I Bacterial infection 1A00-1C4Z Approved [3]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [16]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [17]
Haloperidol DM96SE0 Delirium Approved [18]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [19]
Selenium DM25CGV N. A. N. A. Approved [20]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [21]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [26]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [27]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [28]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Testosterone enanthate DMB6871 N. A. N. A. Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [4]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [33]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [34]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [35]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [36]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [38]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [39]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [16]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [42]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [41]
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Drug(s) Affected By C-C motif chemokine 3 (CCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [44]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [48]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [4]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [4]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [43]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 4 (CCL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [44]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [48]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [50]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [4]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [54]
Gefitinib DM15F0X Colon adenocarcinoma Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [57]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [58]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 5 (CCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [67]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [48]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Type I iodothyronine deiodinase (DIO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [72]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [73]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [72]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [34]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [74]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) TTQ8KVI F4NA87_STAAU Binder [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [4]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Gene/Protein Processing [4]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Gene/Protein Processing [4]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Gene/Protein Processing [4]
Catalase (CAT) OTHEBX9R CATA_HUMAN Gene/Protein Processing [5]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Gene/Protein Processing [4]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [4]
Type I iodothyronine deiodinase (DIO1) OTFYLYJ0 IOD1_HUMAN Gene/Protein Processing [6]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Gene/Protein Processing [4]

References

1 Oxytetracycline FDA Label
2 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 060634.
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57 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
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70 Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
71 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
72 Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases. Toxicol Sci. 2019 Apr 1;168(2):430-442. doi: 10.1093/toxsci/kfy302.
73 Effects of all-trans and 9-cis retinoic acid on differentiating human neural stem cells in vitro. Toxicology. 2023 Mar 15;487:153461. doi: 10.1016/j.tox.2023.153461. Epub 2023 Feb 16.
74 Regulation of type 1 iodothyronine deiodinase in health and disease. Thyroid. 2005 Aug;15(8):835-40. doi: 10.1089/thy.2005.15.835.