Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSF5DW)

Drug Name
Sanggenon C Drug Info
Synonyms
Sanggenon C; 80651-76-9; 2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-1,3,8,10a-tetrahydroxy-5a-(3-methylbut-2-enyl)-[1]benzofuro[3,2-b]chromen-11-one; AC1L9CVB; Sanggenone-C; C09834; CHEBI:9020; DTXSID20230468
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
442458
ChEBI ID
CHEBI:9020
CAS Number
CAS 80651-76-9
TTD Drug ID
DMSF5DW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting PTPN1 messenger RNA (PTPN1 mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [7]
TRYPAN BLUE DM4NTMO Ophthalmic surgery injury PK97 Approved [8]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [9]
ISIS 113715 DMUPD4G Type-2 diabetes 5A11 Phase 2 [10]
ISIS-PTP1Brx DMJGVXT Type-2 diabetes 5A11 Phase 2 [11]
ERTIPROTAFIB DMJXEV7 Type-2 diabetes 5A11 Terminated [12]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [13]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [13]
2-Methyl-2,4-Pentanediol DMD45CU Discovery agent N.A. Investigative [13]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [13]
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Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 1 (PTPN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [14]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [15]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [17]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [20]
Seocalcitol DMKL9QO Rickets 5B57 Phase 3 [21]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [22]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [23]
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Drug(s) Affected By Dynamin-1-like protein (DNM1L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [17]
Ethanol DMDRQZU Chronic pain MG30 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [31]
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Drug(s) Affected By Cocaine esterase (CES2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [32]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [33]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [34]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [37]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [38]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [39]
Testosterone enanthate DMB6871 N. A. N. A. Approved [40]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [41]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [42]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [43]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [44]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [45]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Verapamil DMA7PEW Angina pectoris BA40 Approved [48]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [49]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [50]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [51]
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Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Selenium DM25CGV N. A. N. A. Approved [54]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [55]
Methotrexate DM2TEOL Anterior urethra cancer Approved [56]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [57]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
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Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [63]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [64]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Fluoxetine DM3PD2C Bipolar depression Approved [66]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [69]
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Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [70]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Selenium DM25CGV N. A. N. A. Approved [54]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [64]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [73]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [75]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [76]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [50]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [80]
Gefitinib DM15F0X Colon adenocarcinoma Approved [81]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [84]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [76]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [85]
Paclitaxel DMLB81S Breast carcinoma Approved [86]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [87]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [75]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [50]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [78]
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Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [89]
Indomethacin DMSC4A7 Bursitis Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [56]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [94]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [95]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [96]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [97]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [99]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [100]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [101]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [102]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [103]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [104]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [105]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [107]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [108]
Gefitinib DM15F0X Colon adenocarcinoma Approved [109]
Prednisone DM2HG4X Acute asthma CA23 Approved [110]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [112]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [114]
Fluoxetine DM3PD2C Bipolar depression Approved [66]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [115]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [116]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [117]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [118]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [49]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [119]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [120]
Meloxicam DM2AR7L Arthritis FA20 Approved [121]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [122]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [123]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [42]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [107]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Verapamil DMA7PEW Angina pectoris BA40 Approved [48]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [124]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [119]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Meloxicam DM2AR7L Arthritis FA20 Approved [127]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [64]
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Drug(s) Affected By E3 ubiquitin-protein ligase MIB1 (MIB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [129]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [15]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [130]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [131]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [132]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [89]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [133]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PTPN1 messenger RNA (PTPN1 mRNA) TTELIN2 PTN1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [4]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [3]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Gene/Protein Processing [5]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Gene/Protein Processing [6]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Gene/Protein Processing [6]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [6]
Dynamin-1-like protein (DNM1L) OTXK1Q1G DNM1L_HUMAN Gene/Protein Processing [2]
E3 ubiquitin-protein ligase MIB1 (MIB1) OT5C404P MIB1_HUMAN Gene/Protein Processing [6]

References

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2 Sanggenon C Suppresses Tumorigenesis of Gastric Cancer by Blocking ERK-Drp1-Mediated Mitochondrial Fission. J Nat Prod. 2022 Oct 28;85(10):2351-2362. doi: 10.1021/acs.jnatprod.2c00524. Epub 2022 Oct 18.
3 Sanggenon?C induces apoptosis of colon cancer cells via inhibition of NO production, iNOS expression and ROS activation of the mitochondrial pathway. Oncol Rep. 2017 Oct;38(4):2123-2131. doi: 10.3892/or.2017.5912. Epub 2017 Aug 22.
4 [Sanggenon C induces apoptosis of prostate cancer PC3 cells by activating caspase 3 and caspase 9 pathways]. Nan Fang Yi Ke Da Xue Xue Bao. 2017 Sep 20;37(9):1206-1210. doi: 10.3969/j.issn.1673-4254.2017.09.11.
5 Identification and characterization of naturally occurring inhibitors against human carboxylesterase 2 in White Mulberry Root-bark. Fitoterapia. 2016 Dec;115:57-63. doi: 10.1016/j.fitote.2016.09.022. Epub 2016 Oct 1.
6 Sanggenon C inhibits cell proliferation and induces apoptosis by regulating the MIB1/DAPK1 axis in glioblastoma. MedComm (2020). 2023 Jun 19;4(4):e281. doi: 10.1002/mco2.281. eCollection 2023 Aug.
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16 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
17 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
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20 Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
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23 Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
24 Low doses of BPF-induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ER and calcineurin A-DRP1 signaling pathway. Cell Biol Toxicol. 2022 Jun;38(3):409-426. doi: 10.1007/s10565-021-09615-y. Epub 2021 May 22.
25 Tea polyphenols direct Bmal1-driven ameliorating of the redox imbalance and mitochondrial dysfunction in hepatocytes. Food Chem Toxicol. 2018 Dec;122:181-193.
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31 Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway. Toxicol In Vitro. 2018 Sep;51:1-10. doi: 10.1016/j.tiv.2018.05.001. Epub 2018 May 3.
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35 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
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39 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
40 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
41 Hepatoxicity mechanism of cantharidin-induced liver LO2 cells by LC-MS metabolomics combined traditional approaches. Toxicol Lett. 2020 Oct 15;333:49-61. doi: 10.1016/j.toxlet.2020.07.024. Epub 2020 Jul 26.
42 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
43 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
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45 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
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47 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
48 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
49 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
50 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
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