Details of the Drug Combination

General Information of Drug Combination (ID: DC0MIZ8)

• Drug Combination Name: Etoposide + DTI-015
• Indication: Lymphoma; Status: Phase 2 [1]
• Component Drugs:
  Etoposide (DMNH3PG): Small molecular drug
  DTI-015 (DMXZRW0): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Etoposide

Disease Entry	ICD 11	Status	REF
Acute myelogenous leukaemia	2A41	Approved	[2]
Adult acute monocytic leukemia	N.A.	Approved	[2]
Adult kidney Wilms tumor	N.A.	Approved	[2]
Beckwith-Wiedemann syndrome	N.A.	Approved	[2]
Childhood kidney Wilms tumor	N.A.	Approved	[2]
Hamartoma	N.A.	Approved	[2]
Kidney neoplasm	N.A.	Approved	[2]
Lung cancer	2C25.0	Approved	[2]
Non-small-cell lung cancer	2C25.Y	Approved	[2]
Plasma cell myeloma	2A83.1	Approved	[2]
Small-cell lung cancer	2C25.Y	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Approved	[3]
Testicular cancer	2C80	Approved	[4]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[5]
Neuroblastoma	2D11.2	Investigative	[2]

Etoposide Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Modulator	[32]

Etoposide Interacts with 8 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[33]
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[34]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[35]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[36]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[37]
Multidrug resistance-associated protein 3 (ABCC3)	DTQ3ZHF	MRP3_HUMAN	Substrate	[38]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[39]
Organic anion transporting polypeptide 2B1 (SLCO2B1)	DTPFTEQ	SO2B1_HUMAN	Substrate	[37]

Etoposide Interacts with 9 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[40]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[40]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[11]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[41]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Metabolism	[42]
Glutathione S-transferase pi (GSTP1)	DEK6079	GSTP1_HUMAN	Metabolism	[43]
Prostaglandin G/H synthase 1 (COX-1)	DE073H6	PGH1_HUMAN	Metabolism	[44]
Glutathione S-transferase theta-1 (GSTT1)	DE3PKUG	GSTT1_HUMAN	Metabolism	[43]
Prostaglandin G/H synthase 2 (COX-2)	DE492CE	PGH2_HUMAN	Metabolism	[44]

Etoposide Interacts with 347 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[45]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Decreases Response To Substance	[46]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Phosphorylation	[47]
Tumor protein p73 (TP73)	OT0LUO47	P73_HUMAN	Increases Expression	[12]
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)	OTTK98BH	CP27B_HUMAN	Increases Expression	[12]
Dihydropyrimidinase-related protein 4 (DPYSL4)	OT3SBS2S	DPYL4_HUMAN	Increases Expression	[13]
Copper chaperone for superoxide dismutase (CCS)	OTXHT3QO	CCS_HUMAN	Increases Expression	[13]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[13]
Ubiquitin-like protein ISG15 (ISG15)	OT53QQ7N	ISG15_HUMAN	Increases Expression	[13]
Integrin alpha-IIb (ITGA2B)	OT4Y17PY	ITA2B_HUMAN	Increases Expression	[13]
Ras-related protein R-Ras (RRAS)	OTBBF28C	RRAS_HUMAN	Increases Expression	[13]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[13]
Stomatin (STOM)	OTC8R6EH	STOM_HUMAN	Increases Expression	[13]
Cellular retinoic acid-binding protein 2 (CRABP2)	OTY01V9G	RABP2_HUMAN	Increases Expression	[13]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Increases Expression	[13]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Increases Expression	[13]
Galectin-7 (LGALS7)	OTMSVI7R	LEG7_HUMAN	Increases Expression	[13]
Rho GDP-dissociation inhibitor 2 (ARHGDIB)	OT9PD6CS	GDIR2_HUMAN	Increases Expression	[13]
Epithelial membrane protein 1 (EMP1)	OTSZHUHQ	EMP1_HUMAN	Increases Expression	[13]
Epithelial membrane protein 3 (EMP3)	OTODMJ1D	EMP3_HUMAN	Increases Expression	[13]
Protein ripply3 (RIPPLY3)	OT1HK35I	DSCR6_HUMAN	Increases Expression	[13]
Kinesin-like protein KIF1A (KIF1A)	OT3JVEGV	KIF1A_HUMAN	Increases Expression	[13]
Filamin-C (FLNC)	OT3F8J6Y	FLNC_HUMAN	Increases Expression	[13]
Immediate early response gene 5 protein (IER5)	OTJPTXMD	IER5_HUMAN	Increases Expression	[13]
Keratin, type II cytoskeletal 80 (KRT80)	OTAU54U3	K2C80_HUMAN	Increases Expression	[13]
All-trans-retinol 13,14-reductase (RETSAT)	OTC3AOPX	RETST_HUMAN	Increases Expression	[13]
Mitochondria-eating protein (SPATA18)	OTOEHTHU	MIEAP_HUMAN	Increases Expression	[13]
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)	OTB82PFO	TNR14_HUMAN	Increases Expression	[13]
Major histocompatibility complex class I-related gene protein (MR1)	OTZU3XX7	HMR1_HUMAN	Increases Expression	[13]
Roundabout homolog 3 (ROBO3)	OTPVG40S	ROBO3_HUMAN	Increases Expression	[13]
Neuronal PAS domain-containing protein 1 (NPAS1)	OTZKO6ZN	NPAS1_HUMAN	Increases Expression	[13]
Ankyrin repeat domain-containing protein 10 (ANKRD10)	OTIZ2VK8	ANR10_HUMAN	Decreases Expression	[13]
Serine/threonine-protein kinase PLK2 (PLK2)	OTKMJXJ8	PLK2_HUMAN	Increases Expression	[13]
Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6)	OTVUZCLG	GTR6_HUMAN	Increases Expression	[13]
Glutaminase liver isoform, mitochondrial (GLS2)	OT08MSHL	GLSL_HUMAN	Increases Expression	[13]
Endothelial protein C receptor (PROCR)	OTRHED17	EPCR_HUMAN	Increases Expression	[13]
Fatty acid desaturase 3 (FADS3)	OT9RVXGE	FADS3_HUMAN	Increases Expression	[13]
NADH-ubiquinone oxidoreductase chain 4 (ND4)	OT4RQVAA	NU4M_HUMAN	Increases Expression	[48]
Transcription factor A, mitochondrial (TFAM)	OTXXV5V7	TFAM_HUMAN	Increases Expression	[48]
TP53-binding protein 1 (TP53BP1)	OTL8879S	TP53B_HUMAN	Increases Expression	[48]
Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B)	OTN6FKCB	PRGC2_HUMAN	Increases Expression	[48]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)	OTHCDQ22	PRGC1_HUMAN	Increases Expression	[48]
Calsequestrin-2 (CASQ2)	OT09MNQ8	CASQ2_HUMAN	Decreases Expression	[14]
Telethonin (TCAP)	OTQQMJ94	TELT_HUMAN	Decreases Expression	[14]
LIM domain-binding protein 3 (LDB3)	OTGQL1AM	LDB3_HUMAN	Decreases Expression	[14]
Creatine kinase M-type (CKM)	OTME0KO7	KCRM_HUMAN	Decreases Expression	[14]
Myosin light chain 3 (MYL3)	OTKD3RSX	MYL3_HUMAN	Decreases Expression	[14]
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MYL2)	OT78PC0C	MLRV_HUMAN	Decreases Expression	[14]
Ankyrin-1 (ANK1)	OTU79URK	ANK1_HUMAN	Increases Expression	[14]
Desmin (DES)	OTI09KBW	DESM_HUMAN	Decreases Expression	[14]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[14]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Increases Expression	[14]
Thrombospondin-4 (THBS4)	OTA1T9KK	TSP4_HUMAN	Increases Expression	[14]
Gap junction alpha-5 protein (GJA5)	OTRMZVO6	CXA5_HUMAN	Decreases Expression	[14]
Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2)	OTCF8OWW	AT1A2_HUMAN	Decreases Expression	[14]
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)	OTDAC6Z0	PRKX_HUMAN	Increases Expression	[14]
Myomesin-2 (MYOM2)	OTD2UOXW	MYOM2_HUMAN	Decreases Expression	[14]
Actin, alpha skeletal muscle (ACTA1)	OTOVGLPG	ACTS_HUMAN	Decreases Expression	[14]
Iroquois-class homeodomain protein IRX-4 (IRX4)	OT0TV6WK	IRX4_HUMAN	Decreases Expression	[14]
Arginase-2, mitochondrial (ARG2)	OTCPI0E8	ARGI2_HUMAN	Decreases Expression	[14]
Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2)	OTQR5SXD	CX6A2_HUMAN	Decreases Expression	[14]
Pro-neuregulin-1, membrane-bound isoform (NRG1)	OTZO6F1X	NRG1_HUMAN	Increases Expression	[14]
Dual specificity protein phosphatase 4 (DUSP4)	OT6WAO12	DUS4_HUMAN	Increases Expression	[14]
Krueppel-like factor 5 (KLF5)	OT1ABI9N	KLF5_HUMAN	Increases Expression	[14]
Four and a half LIM domains protein 2 (FHL2)	OT0OAYWT	FHL2_HUMAN	Decreases Expression	[14]
kinase isozyme 1, mitochondrial (PDK1)	OTMABK9Z	PDK1_HUMAN	Decreases Expression	[14]
kinase isozyme 4, mitochondrial (PDK4)	OTCMHMBZ	PDK4_HUMAN	Increases Expression	[14]
PDZ and LIM domain protein 3 (PDLIM3)	OTVXQC81	PDLI3_HUMAN	Increases Expression	[14]
Nebulin-related-anchoring protein (NRAP)	OTO6H3YF	NRAP_HUMAN	Decreases Expression	[14]
Sodium channel subunit beta-4 (SCN4B)	OT3JSUWO	SCN4B_HUMAN	Increases Expression	[14]
Actin-binding Rho-activating protein (ABRA)	OTBQ2C1J	ABRA_HUMAN	Increases Expression	[14]
Transient receptor potential cation channel subfamily V member 1 (TRPV1)	OTHHDR03	TRPV1_HUMAN	Increases Expression	[14]
Ryanodine receptor 2 (RYR2)	OT0PF19E	RYR2_HUMAN	Decreases Expression	[14]
Small conductance calcium-activated potassium channel protein 2 (KCNN2)	OTQVTMK5	KCNN2_HUMAN	Decreases Expression	[14]
Regulator of cell cycle RGCC (RGCC)	OTYJMLWM	RGCC_HUMAN	Increases Expression	[14]
Myotilin (MYOT)	OTCEW5XW	MYOTI_HUMAN	Increases Expression	[14]
Protein ATP1B4 (ATP1B4)	OT2YC9GZ	AT1B4_HUMAN	Increases Expression	[14]
Succinate dehydrogenase assembly factor 1, mitochondrial (SDHAF1)	OTDG5VW7	SDHF1_HUMAN	Decreases Expression	[16]
Agrin (AGRN)	OTWJENAZ	AGRIN_HUMAN	Increases Expression	[15]
E3 ubiquitin-protein ligase TRIM38 (TRIM38)	OT6SP1M9	TRI38_HUMAN	Decreases Expression	[16]
Etoposide-induced protein 2.4 homolog (EI24)	OTD4NOYS	EI24_HUMAN	Increases Expression	[15]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[49]
Tax1-binding protein 3 (TAX1BP3)	OTQ6IB4T	TX1B3_HUMAN	Increases Expression	[15]
Proepiregulin (EREG)	OTRM4NQY	EREG_HUMAN	Increases Expression	[50]
Transcription factor EC (TFEC)	OTUST8MR	TFEC_HUMAN	Decreases Expression	[16]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)	OTLF4ZB1	IKKA_HUMAN	Decreases Expression	[51]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Increases Expression	[52]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Increases Expression	[53]
E3 ubiquitin-protein ligase RNF113A (RNF113A)	OTR6N7HU	R113A_HUMAN	Decreases Expression	[16]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)	OT0KMIYQ	RIPK2_HUMAN	Increases Expression	[52]
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Increases Phosphorylation	[54]
Cytoplasmic protein NCK2 (NCK2)	OTUYPF55	NCK2_HUMAN	Decreases Expression	[15]
Protein regulator of cytokinesis 1 (PRC1)	OTHD0XS0	PRC1_HUMAN	Decreases Expression	[15]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)	OT80DZMT	BUB1_HUMAN	Decreases Expression	[55]
HMG box-containing protein 1 (HBP1)	OTDPGGDV	HBP1_HUMAN	Decreases Expression	[16]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)	OT8KME51	BUB1B_HUMAN	Decreases Expression	[55]
Cell division control protein 45 homolog (CDC45)	OT6NNLOD	CDC45_HUMAN	Decreases Expression	[55]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Activity	[56]
Kinesin-like protein KIF20A (KIF20A)	OTXOQHE0	KI20A_HUMAN	Decreases Expression	[16]
Myelin protein zero-like protein 1 (MPZL1)	OTJSUUHR	MPZL1_HUMAN	Decreases Expression	[16]
Serine/threonine-protein kinase Chk2 (CHEK2)	OT8ZPCNS	CHK2_HUMAN	Increases Phosphorylation	[57]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[58]
Ferritin light chain (FTL)	OTYQA8A6	FRIL_HUMAN	Increases Expression	[59]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Decreases Expression	[60]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Increases Expression	[61]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Decreases Expression	[50]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Decreases Phosphorylation	[62]
Annexin A4 (ANXA4)	OTUCRYXL	ANXA4_HUMAN	Increases Expression	[15]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[63]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[64]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Increases Expression	[64]
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)	OTPWI88U	CEAM1_HUMAN	Increases Expression	[15]
HLA class I histocompatibility antigen, alpha chain E (HLA-E)	OTX1CTFB	HLAE_HUMAN	Affects Expression	[65]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[66]
Receptor tyrosine-protein kinase erbB-3 (ERBB3)	OTRSST0A	ERBB3_HUMAN	Decreases Expression	[50]
rRNA 2'-O-methyltransferase fibrillarin (FBL)	OTRODIE5	FBRL_HUMAN	Affects Localization	[67]
NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR)	OTPDCK1F	ADRO_HUMAN	Increases Expression	[15]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)	OTIN6G20	CPT2_HUMAN	Decreases Expression	[16]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[47]
M-phase inducer phosphatase 1 (CDC25A)	OTSLKKCO	MPIP1_HUMAN	Decreases Expression	[16]
M-phase inducer phosphatase 3 (CDC25C)	OTPQI71S	MPIP3_HUMAN	Decreases Expression	[55]
Replication factor C subunit 1 (RFC1)	OT3L5PK3	RFC1_HUMAN	Decreases Expression	[16]
Tumor necrosis factor receptor superfamily member 3 (LTBR)	OT2HVZGV	TNR3_HUMAN	Increases Expression	[52]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Decreases Expression	[68]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[55]
Transcription factor ETV6 (ETV6)	OTCZMG61	ETV6_HUMAN	Increases Mutagenesis	[69]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9)	OTV9L89D	TNFL9_HUMAN	Increases Expression	[15]
RNA-binding protein 34 (RBM34)	OTX3LUGI	RBM34_HUMAN	Decreases Expression	[16]
DNA repair protein RAD52 homolog (RAD52)	OT0OTDHI	RAD52_HUMAN	Increases Expression	[70]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Increases Expression	[54]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)	OTI2OREX	MP2K3_HUMAN	Increases Expression	[15]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Activity	[71]
Iron-responsive element-binding protein 2 (IREB2)	OT747D24	IREB2_HUMAN	Decreases Expression	[59]
Nuclear receptor-interacting protein 1 (NRIP1)	OTIZOJQV	NRIP1_HUMAN	Decreases Expression	[72]
Centromere protein F (CENPF)	OT7AG0SW	CENPF_HUMAN	Decreases Expression	[55]
CCAAT/enhancer-binding protein alpha (CEBPA)	OTOM9OE4	CEBPA_HUMAN	Decreases Expression	[73]
DNA replication licensing factor MCM2 (MCM2)	OTGGORIQ	MCM2_HUMAN	Decreases Expression	[55]
LIM/homeobox protein Lhx2 (LHX2)	OTK61NP8	LHX2_HUMAN	Decreases Expression	[16]
Serine/threonine-protein kinase Nek2 (NEK2)	OT1H27HO	NEK2_HUMAN	Decreases Expression	[55]
DNA mismatch repair protein Msh6 (MSH6)	OT46FP09	MSH6_HUMAN	Decreases Expression	[16]
Death-associated protein kinase 1 (DAPK1)	OTNCNUCO	DAPK1_HUMAN	Increases Expression	[51]
Mitogen-activated protein kinase 12 (MAPK12)	OTTCKE27	MK12_HUMAN	Increases Activity	[74]
RecQ-like DNA helicase BLM (BLM)	OTEJOAJX	BLM_HUMAN	Decreases Expression	[16]
Ataxin-1 (ATXN1)	OTQF0HNR	ATX1_HUMAN	Decreases Expression	[16]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Increases Expression	[52]
Triosephosphate isomerase (TPI1)	OT14KP4B	TPIS_HUMAN	Increases Phosphorylation	[75]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Increases Phosphorylation	[76]
Protein BTG2 (BTG2)	OTZF6K1H	BTG2_HUMAN	Increases Expression	[16]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Affects Localization	[61]
Myelin transcription factor 1 (MYT1)	OTC3660I	MYT1_HUMAN	Decreases Expression	[55]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Increases Expression	[59]
Histone-lysine N-methyltransferase 2A (KMT2A)	OT9GLJI6	KMT2A_HUMAN	Increases Cleavage	[77]
CCAAT/enhancer-binding protein zeta (CEBPZ)	OT11BATG	CEBPZ_HUMAN	Decreases Expression	[15]
Chromatin assembly factor 1 subunit A (CHAF1A)	OTXSSY4H	CAF1A_HUMAN	Decreases Expression	[16]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Increases Phosphorylation	[78]
DNA topoisomerase 3-alpha (TOP3A)	OT3CKUI9	TOP3A_HUMAN	Decreases Expression	[16]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Decreases Expression	[55]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Increases Expression	[79]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Increases Expression	[80]
Protein BTG3 (BTG3)	OT9ANHVT	BTG3_HUMAN	Decreases Expression	[16]
Histone RNA hairpin-binding protein (SLBP)	OTVYYQRT	SLBP_HUMAN	Decreases Expression	[16]
Hypermethylated in cancer 1 protein (HIC1)	OTI9TWY4	HIC1_HUMAN	Increases Expression	[81]
Receptor tyrosine-protein kinase erbB-4 (ERBB4)	OT9L6C41	ERBB4_HUMAN	Decreases Expression	[50]
Neutral amino acid transporter B(0) (SLC1A5)	OTE2H26Q	AAAT_HUMAN	Decreases Expression	[16]
Mothers against decapentaplegic homolog 2 (SMAD2)	OTC6VB4K	SMAD2_HUMAN	Increases Phosphorylation	[82]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Increases Expression	[83]
Cyclin-dependent kinase inhibitor 3 (CDKN3)	OTBE3H07	CDKN3_HUMAN	Decreases Expression	[55]
Quinone oxidoreductase PIG3 (TP53I3)	OTSCM68G	QORX_HUMAN	Increases Expression	[15]
Ribosomal protein eS27-like (RPS27L)	OTZWHU0N	RS27L_HUMAN	Increases Expression	[84]
Protein MCM10 homolog (MCM10)	OTV0O3JN	MCM10_HUMAN	Decreases Expression	[16]
EPM2A-interacting protein 1 (EPM2AIP1)	OT21ALNF	EPMIP_HUMAN	Increases Expression	[15]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)	OTE8GBUR	RIR2B_HUMAN	Increases Expression	[85]
Partner and localizer of BRCA2 (PALB2)	OT6DNDBG	PALB2_HUMAN	Decreases Expression	[16]
Jouberin (AHI1)	OT8K2YWY	AHI1_HUMAN	Increases Expression	[86]
Leucine-rich repeat-containing protein 47 (LRRC47)	OTSE8NAO	LRC47_HUMAN	Decreases Expression	[16]
RelA-associated inhibitor (PPP1R13L)	OTNCPLWE	IASPP_HUMAN	Increases Expression	[87]
DNA repair and recombination protein RAD54-like (RAD54L)	OTEGMAKG	RAD54_HUMAN	Increases Expression	[17]
Cytochrome c oxidase assembly factor 7 (COA7)	OTRQJYL6	COA7_HUMAN	Decreases Expression	[16]
Mitochondrial potassium channel (CCDC51)	OTOJNHNA	MITOK_HUMAN	Decreases Expression	[16]
Integrator complex subunit 15 (INTS15)	OT3O4INM	INT15_HUMAN	Decreases Expression	[16]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Increases Expression	[80]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Decreases Expression	[16]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)	OTQR6ENW	M3K5_HUMAN	Decreases Expression	[15]
Cell division control protein 6 homolog (CDC6)	OTX93FE7	CDC6_HUMAN	Decreases Expression	[55]
SOSS complex subunit B1 (NABP2)	OTQU8081	SOSB1_HUMAN	Increases Acetylation	[88]
Protein pelota homolog (PELO)	OTF3WLIM	PELO_HUMAN	Decreases Expression	[16]
TIMELESS-interacting protein (TIPIN)	OT9PZHXV	TIPIN_HUMAN	Decreases Expression	[16]
Cell cycle regulator of non-homologous end joining (CYREN)	OT5ZL00R	CYREN_HUMAN	Affects Localization	[89]
Caspase recruitment domain-containing protein 10 (CARD10)	OT2RPM4I	CAR10_HUMAN	Increases Expression	[52]
Sulfiredoxin-1 (SRXN1)	OTYDBO4L	SRXN1_HUMAN	Increases Expression	[90]
tRNA pseudouridine(38/39) synthase (PUS3)	OT6WG6M2	PUS3_HUMAN	Decreases Expression	[16]
Serine/threonine-protein kinase PLK3 (PLK3)	OT19CT2Z	PLK3_HUMAN	Increases Expression	[15]
Transmembrane protein 185B (TMEM185B)	OTGNYS0J	T185B_HUMAN	Decreases Expression	[16]
Interferon-stimulated 20 kDa exonuclease-like 2 (ISG20L2)	OT3Q11WQ	I20L2_HUMAN	Decreases Expression	[16]
GrpE protein homolog 1, mitochondrial (GRPEL1)	OT8O00YJ	GRPE1_HUMAN	Decreases Expression	[16]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)	OT5V52LN	TNR12_HUMAN	Increases Expression	[52]
Programmed cell death 1 ligand 1 (CD274)	OTJ0VFDL	PD1L1_HUMAN	Increases Expression	[91]
rRNA methyltransferase 2, mitochondrial (MRM2)	OTRYA1HU	MRM2_HUMAN	Decreases Expression	[16]
DNA helicase MCM8 (MCM8)	OTC93H3S	MCM8_HUMAN	Decreases Expression	[55]
Frizzled-1 (FZD1)	OTZATHVS	FZD1_HUMAN	Decreases Expression	[16]
Calcium-binding protein 39 (CAB39)	OT2CL9ST	CAB39_HUMAN	Decreases Expression	[15]
5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)	OT1OG4QZ	AAKB1_HUMAN	Increases Expression	[16]
Sestrin-1 (SESN1)	OTSFDZWL	SESN1_HUMAN	Increases Expression	[16]
Molybdenum cofactor sulfurase (MOCOS)	OT0TL3Q5	MOCOS_HUMAN	Affects Response To Substance	[21]
Tripartite motif-containing protein 2 (TRIM2)	OT0V1YVC	TRIM2_HUMAN	Affects Response To Substance	[21]
V-type proton ATPase 116 kDa subunit a 4 (ATP6V0A4)	OT149Z7Q	VPP4_HUMAN	Affects Response To Substance	[21]
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Affects Response To Substance	[21]
Calcipressin-1 (RCAN1)	OT1MVXC7	RCAN1_HUMAN	Affects Response To Substance	[21]
Melanoma antigen recognized by T-cells 1 (MLANA)	OT1N2S2K	MAR1_HUMAN	Affects Response To Substance	[21]
Serine palmitoyltransferase small subunit A (SPTSSA)	OT2PNKOP	SPTSA_HUMAN	Affects Response To Substance	[21]
Large neutral amino acids transporter small subunit 1 (SLC7A5)	OT2WPVXD	LAT1_HUMAN	Affects Response To Substance	[21]
Chitinase-3-like protein 1 (CHI3L1)	OT2Z7VJH	CH3L1_HUMAN	Decreases Response To Substance	[92]
Syncytin-2 (ERVFRD-1)	OT3064D7	SYCY2_HUMAN	Affects Response To Substance	[21]
DNA-directed RNA polymerase I subunit RPA12 (POLR1H)	OT30S3SB	RPA12_HUMAN	Decreases Response To Substance	[93]
Protein FAM171A1 (FAM171A1)	OT33BHEP	F1711_HUMAN	Affects Response To Substance	[21]
Fatty acid CoA ligase Acsl3 (ACSL3)	OT3MWER1	ACSL3_HUMAN	Affects Response To Substance	[21]
Nuclear protein 1 (NUPR1)	OT4FU8C0	NUPR1_HUMAN	Affects Response To Substance	[21]
DNA repair nuclease/redox regulator APEX1 (APEX1)	OT53OI14	APEX1_HUMAN	Decreases Response To Substance	[94]
Lymphokine-activated killer T-cell-originated protein kinase (PBK)	OT5Z27TW	TOPK_HUMAN	Affects Response To Substance	[21]
Protein E7 (E7)	OT6BIMFN	VE7_HPV16	Increases ADR	[95]
G-protein-signaling modulator 2 (GPSM2)	OT6RPMRM	GPSM2_HUMAN	Affects Response To Substance	[21]
CD40 ligand (CD40LG)	OT75Z6A6	CD40L_HUMAN	Decreases Response To Substance	[96]
Monocarboxylate transporter 7 (SLC16A6)	OT7BIIZX	MOT7_HUMAN	Affects Response To Substance	[21]
Homeobox protein engrailed-2 (EN2)	OT7EZCM2	HME2_HUMAN	Affects Response To Substance	[21]
Ras-related protein Rab-17 (RAB17)	OT7NBUGQ	RAB17_HUMAN	Affects Response To Substance	[21]
Myelin proteolipid protein (PLP1)	OT8CM9CX	MYPR_HUMAN	Affects Response To Substance	[21]
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1B)	OT8JQ1F7	PI51B_HUMAN	Affects Response To Substance	[21]
Neuronal membrane glycoprotein M6-b (GPM6B)	OT8Q1582	GPM6B_HUMAN	Affects Response To Substance	[21]
Melanoma-associated antigen 12 (MAGEA12)	OT8ULELL	MAGAC_HUMAN	Affects Response To Substance	[21]
Solute carrier family 22 member 18 (SLC22A18)	OT9C3KR4	S22AI_HUMAN	Affects Response To Substance	[21]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2)	OT9PBQVT	SIA7B_HUMAN	Affects Response To Substance	[21]
Splicing factor 45 (RBM17)	OT9ROJCL	SPF45_HUMAN	Decreases Response To Substance	[97]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Affects Response To Substance	[98]
Retinoblastoma tumor suppressor (RB1)	OT9VMY7B	Q5J3Q9_FUNHE	Increases ADR	[95]
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM)	OTA4P0FC	ACADM_HUMAN	Affects Response To Substance	[21]
POM121 and ZP3 fusion protein (POMZP3)	OTAH2JOK	POZP3_HUMAN	Affects Response To Substance	[21]
Transmembrane protein 47 (TMEM47)	OTAJ4CPX	TMM47_HUMAN	Affects Response To Substance	[21]
Glutathione S-transferase theta-2 (GSTT2)	OTANW3TJ	GST2_HUMAN	Affects Response To Substance	[21]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)	OTAYZZE6	AL3A1_HUMAN	Affects Response To Substance	[99]
5-hydroxytryptamine receptor 4 (HTR4)	OTBIB44K	5HT4R_HUMAN	Affects Response To Substance	[21]
Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1)	OTBML9D9	CGAT1_HUMAN	Affects Response To Substance	[21]
Microtubule-associated tumor suppressor 1 (MTUS1)	OTBPALMU	MTUS1_HUMAN	Affects Response To Substance	[21]
Melanocyte protein PMEL (PMEL)	OTCDDHHM	PMEL_HUMAN	Affects Response To Substance	[21]
BMP and activin membrane-bound inhibitor homolog (BAMBI)	OTCEJ8W5	BAMBI_HUMAN	Affects Response To Substance	[21]
Alkaline phosphatase, germ cell type (ALPG)	OTCIM29R	PPBN_HUMAN	Affects Response To Substance	[21]
Creatine kinase U-type, mitochondrial (CKMT1A)	OTCINHH5	KCRU_HUMAN	Affects Response To Substance	[21]
Ras-interacting protein 1 (RASIP1)	OTCRY2AN	RAIN_HUMAN	Affects Response To Substance	[21]
Collagen alpha-3(IX) chain (COL9A3)	OTCUJOEK	CO9A3_HUMAN	Affects Response To Substance	[21]
A-kinase anchor protein 12 (AKAP12)	OTCVRDDX	AKA12_HUMAN	Affects Response To Substance	[21]
Interferon-stimulated gene 20 kDa protein (ISG20)	OTCWRJJW	ISG20_HUMAN	Affects Response To Substance	[21]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Response To Substance	[100]
P protein (OCA2)	OTDWIGBF	P_HUMAN	Affects Response To Substance	[21]
Cystatin-SN (CST1)	OTE4I83Q	CYTN_HUMAN	Affects Response To Substance	[21]
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Decreases Response To Substance	[101]
Fructose-bisphosphate aldolase C (ALDOC)	OTEC13I5	ALDOC_HUMAN	Affects Response To Substance	[21]
Interferon-induced transmembrane protein 1 (IFITM1)	OTECO1G8	IFM1_HUMAN	Affects Response To Substance	[21]
Epidermal growth factor-like protein 8 (EGFL8)	OTECTJ7K	EGFL8_HUMAN	Affects Response To Substance	[21]
dTDP-D-glucose 4,6-dehydratase (TGDS)	OTEOFLOS	TGDS_HUMAN	Affects Response To Substance	[21]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Increases ADR	[95]
Ras association domain-containing protein 1 (RASSF1)	OTEZIPB7	RASF1_HUMAN	Increases Response To Substance	[102]
Transcription factor SOX-10 (SOX10)	OTF25ULQ	SOX10_HUMAN	Affects Response To Substance	[21]
Eukaryotic translation initiation factor 3 subunit A (EIF3A)	OTFABY9G	EIF3A_HUMAN	Increases Response To Substance	[103]
Kelch-like ECH-associated protein 1 (KEAP1)	OTFHOD0C	KEAP1_HUMAN	Increases Response To Substance	[104]
Protein AF1q (MLLT11)	OTG5RVHC	AF1Q_HUMAN	Affects Response To Substance	[21]
Tudor domain-containing protein 3 (TDRD3)	OTG83E2C	TDRD3_HUMAN	Affects Response To Substance	[21]
Voltage-gated potassium channel subunit beta-2 (KCNAB2)	OTH115IE	KCAB2_HUMAN	Affects Response To Substance	[21]
Dual specificity protein phosphatase 2 (DUSP2)	OTH54FMR	DUS2_HUMAN	Affects Response To Substance	[21]
Melanoma-associated antigen C1 (MAGEC1)	OTHMFHH8	MAGC1_HUMAN	Affects Response To Substance	[21]
Tribbles homolog 2 (TRIB2)	OTHSX3MX	TRIB2_HUMAN	Affects Response To Substance	[21]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Affects Response To Substance	[21]
BAG family molecular chaperone regulator 2 (BAG2)	OTI6LD27	BAG2_HUMAN	Affects Response To Substance	[21]
Nucleosome assembly protein 1-like 1 (NAP1L1)	OTI7WBZV	NP1L1_HUMAN	Affects Response To Substance	[21]
Prosaposin receptor GPR37 (GPR37)	OTIMDDI3	GPR37_HUMAN	Affects Response To Substance	[21]
Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)	OTIOLNHE	LICH_HUMAN	Affects Response To Substance	[21]
Baculoviral IAP repeat-containing protein 7 (BIRC7)	OTITCGHB	BIRC7_HUMAN	Decreases Response To Substance	[105]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Increases Response To Substance	[106]
cAMP-responsive element modulator (CREM)	OTJIJ5AL	CREM_HUMAN	Affects Response To Substance	[21]
Alpha-(1,6)-fucosyltransferase (FUT8)	OTJJCVG1	FUT8_HUMAN	Affects Response To Substance	[21]
Trefoil factor 3 (TFF3)	OTJJDRTU	TFF3_HUMAN	Affects Response To Substance	[21]
Transcription factor-like 5 protein (TCFL5)	OTJL4348	TCFL5_HUMAN	Affects Response To Substance	[21]
Uncharacterized protein C4orf19 (C4ORF19)	OTJMU7N6	CD019_HUMAN	Affects Response To Substance	[21]
Sorbin and SH3 domain-containing protein 2 (SORBS2)	OTJSX44Y	SRBS2_HUMAN	Affects Response To Substance	[21]
Myc box-dependent-interacting protein 1 (BIN1)	OTK8O0X8	BIN1_HUMAN	Increases Response To Substance	[107]
Transmembrane channel-like protein 6 (TMC6)	OTKH50J4	TMC6_HUMAN	Affects Response To Substance	[21]
B-cell receptor-associated protein 31 (BCAP31)	OTKSACR4	BAP31_HUMAN	Increases ADR	[95]
Myelin P2 protein (PMP2)	OTKYV2NE	MYP2_HUMAN	Affects Response To Substance	[21]
Histone-binding protein RBBP7 (RBBP7)	OTLB56HX	RBBP7_HUMAN	Increases ADR	[95]
Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)	OTLNA39Z	NMT2_HUMAN	Affects Response To Substance	[21]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Affects Response To Substance	[21]
Lymphocyte antigen 6E (LY6E)	OTMG16BZ	LY6E_HUMAN	Affects Response To Substance	[21]
Bridging integrator 3 (BIN3)	OTMIWWDW	BIN3_HUMAN	Affects Response To Substance	[21]
Bcl-2-like protein 2 (BCL2L2)	OTMKVO0J	B2CL2_HUMAN	Decreases Response To Substance	[108]
Histone-lysine N-methyltransferase 2B (KMT2B)	OTMMAZQX	KMT2B_HUMAN	Increases ADR	[95]
Copper-transporting ATPase 1 (ATP7A)	OTMR3GXP	ATP7A_HUMAN	Decreases Response To Substance	[109]
Transcription factor AP-2-alpha (TFAP2A)	OTMYT3NK	AP2A_HUMAN	Increases Response To Substance	[110]
Four and a half LIM domains protein 1 (FHL1)	OTN535SU	FHL1_HUMAN	Affects Response To Substance	[21]
Epithelial splicing regulatory protein 1 (ESRP1)	OTNCS4SL	ESRP1_HUMAN	Affects Response To Substance	[21]
Beta-secretase 2 (BACE2)	OTO5YQVK	BACE2_HUMAN	Affects Response To Substance	[21]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Affects Response To Substance	[21]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Increases Response To Substance	[54]
Ras-related protein Rab-20 (RAB20)	OTP9OOVS	RAB20_HUMAN	Affects Response To Substance	[21]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)	OTPL0AI1	ABC3C_HUMAN	Affects Response To Substance	[21]
Epithelial membrane protein 2 (EMP2)	OTPS2H0L	EMP2_HUMAN	Affects Response To Substance	[21]
Ropporin-1A (ROPN1)	OTPXKZTX	ROP1A_HUMAN	Affects Response To Substance	[21]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)	OTPYQX3K	C1QBP_HUMAN	Decreases Response To Substance	[111]
Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A)	OTQDYH8E	ASM3A_HUMAN	Affects Response To Substance	[21]
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28)	OTRBREQ9	ANR28_HUMAN	Affects Response To Substance	[21]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Response To Substance	[112]
Disabled homolog 2 (DAB2)	OTRMQTMZ	DAB2_HUMAN	Affects Response To Substance	[21]
Large ribosomal subunit protein eL6 (RPL6)	OTRU71O4	RL6_HUMAN	Decreases Response To Substance	[113]
Band 4.1-like protein 3 (EPB41L3)	OTS6CHG2	E41L3_HUMAN	Affects Response To Substance	[21]
Heat shock-related 70 kDa protein 2 (HSPA2)	OTSDET7B	HSP72_HUMAN	Affects Response To Substance	[21]
MyoD family inhibitor domain-containing protein (MDFIC)	OTSRYBWZ	MDFIC_HUMAN	Affects Response To Substance	[21]
Terminal nucleotidyltransferase 5A (TENT5A)	OTSYF511	TET5A_HUMAN	Affects Response To Substance	[21]
Collagen alpha-1(XV) chain (COL15A1)	OTTFKK18	COFA1_HUMAN	Affects Response To Substance	[21]
Bcl-2-interacting killer (BIK)	OTTH1T3D	BIK_HUMAN	Increases Response To Substance	[114]
Serine/threonine-protein kinase Chk1 (CHEK1)	OTTTI622	CHK1_HUMAN	Affects Response To Substance	[115]
Max-interacting protein 1 (MXI1)	OTUQ9E0D	MXI1_HUMAN	Affects Response To Substance	[21]
Calcium-dependent secretion activator 2 (CADPS2)	OTV1FW0M	CAPS2_HUMAN	Affects Response To Substance	[21]
Forkhead box protein F2 (FOXF2)	OTV20NGX	FOXF2_HUMAN	Affects Response To Substance	[21]
Metastasis-associated in colon cancer protein 1 (MACC1)	OTV3DLX0	MACC1_HUMAN	Increases ADR	[116]
Matrilin-2 (MATN2)	OTVDR68G	MATN2_HUMAN	Affects Response To Substance	[21]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1)	OTVIHD77	MACF1_HUMAN	Affects Response To Substance	[21]
Poly polymerase tankyrase-1 (TNKS)	OTVOUTPX	TNKS1_HUMAN	Affects Response To Substance	[21]
Ensconsin (MAP7)	OTVSSJ33	MAP7_HUMAN	Affects Response To Substance	[21]
Sorbin and SH3 domain-containing protein 1 (SORBS1)	OTWH8762	SRBS1_HUMAN	Affects Response To Substance	[21]
Anamorsin (CIAPIN1)	OTWS90F9	CPIN1_HUMAN	Decreases Response To Substance	[117]
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1)	OTX8L3M5	SAHH2_HUMAN	Affects Response To Substance	[21]
Long-chain fatty acid transport protein 3 (SLC27A3)	OTXB60L7	S27A3_HUMAN	Affects Response To Substance	[21]
Coiled-coil domain-containing protein 6 (CCDC6)	OTXRQDYG	CCDC6_HUMAN	Decreases Response To Substance	[118]
Arginine vasopressin-induced protein 1 (AVPI1)	OTXSBR60	AVPI1_HUMAN	Affects Response To Substance	[21]
Carbamoyl-phosphate synthase , mitochondrial (CPS1)	OTXV8NSR	CPSM_HUMAN	Affects Response To Substance	[21]
Peripheral myelin protein 22 (PMP22)	OTXWYWCZ	PMP22_HUMAN	Affects Response To Substance	[21]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B)	OTY94WRA	HM20B_HUMAN	Affects Response To Substance	[21]
Protein Niban 1 (NIBAN1)	OTYOLI12	NIBA1_HUMAN	Affects Response To Substance	[21]
LIM and calponin homology domains-containing protein 1 (LIMCH1)	OTYPC4XA	LIMC1_HUMAN	Affects Response To Substance	[21]
L-dopachrome tautomerase (DCT)	OTYVNTBG	TYRP2_HUMAN	Affects Response To Substance	[21]
PRA1 family protein 3 (ARL6IP5)	OTYZ6BEQ	PRAF3_HUMAN	Increases Response To Substance	[119]
DNA (DNMT3B)	OTZ0JCNP	DNM3B_HUMAN	Decreases Response To Substance	[120]
Calcitonin (CALCA)	OTZ11LHB	CALC_HUMAN	Decreases Response To Substance	[121]
Hephaestin (HEPH)	OTZ2F15Z	HEPH_HUMAN	Affects Response To Substance	[21]
Tissue factor pathway inhibitor 2 (TFPI2)	OTZCRWOR	TFPI2_HUMAN	Affects Response To Substance	[21]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Affects Response To Substance	[21]
Suppressor of tumorigenicity 7 protein (ST7)	OTZG8RC6	ST7_HUMAN	Affects Response To Substance	[21]
UPF0489 protein C5orf22 (C5ORF22)	OTZN0DCX	CE022_HUMAN	Affects Response To Substance	[21]
Alkaline phosphatase, placental type (ALPP)	OTZU4G9W	PPB1_HUMAN	Affects Response To Substance	[21]
Drebrin (DBN1)	OTZVKG8A	DREB_HUMAN	Affects Response To Substance	[21]

Indication(s) of DTI-015

Disease Entry	ICD 11	Status	REF
Brain cancer	2A00	Approved	[6]
Glioblastoma of brain	2A00.00	Approved	[7]
Liver cancer	2C12	Approved	[8]
Malignant glioma	2A00.0	Approved	[9]
Plasma cell myeloma	2A83.1	Approved	[10]
Classic Hodgkin lymphoma	N.A.	Investigative	[10]

DTI-015 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Binder	[8]

DTI-015 Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[125]
Glutathione S-transferase alpha-1 (GSTA1)	DE4ZHS1	GSTA1_HUMAN	Metabolism	[126]

DTI-015 Interacts with 293 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Decreases Response To Substance	[123]
Probable G-protein coupled receptor 25 (GPR25)	OTXTNEW3	GPR25_HUMAN	Decreases Expression	[122]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Decreases Expression	[122]
Ladinin-1 (LAD1)	OT6YGTVX	LAD1_HUMAN	Decreases Expression	[122]
Immunoglobulin superfamily containing leucine-rich repeat protein (ISLR)	OTOLYLGI	ISLR_HUMAN	Decreases Expression	[122]
Homeobox protein CDX-4 (CDX4)	OTD1SQKM	CDX4_HUMAN	Decreases Expression	[122]
Segment polarity protein dishevelled homolog DVL-1 (DVL1)	OTD67RF1	DVL1_HUMAN	Decreases Expression	[122]
Tetraspanin-4 (TSPAN4)	OTKFK57F	TSN4_HUMAN	Decreases Expression	[122]
Actin-related protein 2/3 complex subunit 2 (ARPC2)	OTSOKOMY	ARPC2_HUMAN	Decreases Expression	[122]
Short stature homeobox protein (SHOX)	OTE0YZJO	SHOX_HUMAN	Decreases Expression	[122]
Polyunsaturated fatty acid lipoxygenase ALOX15B (ALOX15B)	OTWQQ08W	LX15B_HUMAN	Decreases Expression	[122]
Prosaposin receptor GPR37 (GPR37)	OTIMDDI3	GPR37_HUMAN	Decreases Expression	[122]
Protein phosphatase 1G (PPM1G)	OTLZL9CG	PPM1G_HUMAN	Decreases Expression	[122]
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1)	OTCDAVBQ	SHIP2_HUMAN	Decreases Expression	[122]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Decreases Expression	[122]
Beta-1,4-galactosyltransferase 5 (B4GALT5)	OTHMZY12	B4GT5_HUMAN	Decreases Expression	[122]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1)	OTJ5TNHB	NDUC1_HUMAN	Decreases Expression	[122]
Transcription factor 21 (TCF21)	OT393IMA	TCF21_HUMAN	Decreases Expression	[122]
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (DHX16)	OTW8KZAU	DHX16_HUMAN	Decreases Expression	[122]
LIM homeobox transcription factor 1-beta (LMX1B)	OTM8145D	LMX1B_HUMAN	Decreases Expression	[122]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2)	OTG7NW98	F262_HUMAN	Decreases Expression	[122]
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)	OT4CA13K	ATS4_HUMAN	Decreases Expression	[122]
Probable G-protein coupled receptor 32 (GPR32)	OTTWHSP9	GPR32_HUMAN	Decreases Expression	[122]
Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4)	OTJFA4AV	LRCH4_HUMAN	Decreases Expression	[122]
Extracellular matrix protein 2 (ECM2)	OTNGYVMR	ECM2_HUMAN	Increases Expression	[122]
Aquaporin-8 (AQP8)	OT99JKME	AQP8_HUMAN	Decreases Expression	[122]
BAI1-associated protein 3 (BAIAP3)	OTS1H0J0	BAIP3_HUMAN	Decreases Expression	[122]
Sorbin and SH3 domain-containing protein 2 (SORBS2)	OTJSX44Y	SRBS2_HUMAN	Decreases Expression	[122]
Homeobox protein Nkx-2.2 (NKX2-2)	OTDCOYNG	NKX22_HUMAN	Decreases Expression	[122]
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL)	OTPUGCZO	ASML_HUMAN	Decreases Expression	[122]
Adenomatous polyposis coli protein 2 (APC2)	OTRH91CX	APCL_HUMAN	Decreases Expression	[122]
B-cell lymphoma/leukemia 10 (BCL10)	OT47MCLI	BCL10_HUMAN	Increases Expression	[122]
Ferritin light chain (FTL)	OTYQA8A6	FRIL_HUMAN	Decreases Expression	[122]
Ferritin heavy chain (FTH1)	OT6IFS0O	FRIH_HUMAN	Decreases Expression	[122]
Muellerian-inhibiting factor (AMH)	OT5FH4BD	MIS_HUMAN	Decreases Expression	[122]
Protamine-2 (PRM2)	OTSAXTSQ	PRM2_HUMAN	Decreases Expression	[122]
Non-histone chromosomal protein HMG-17 (HMGN2)	OTN20MEF	HMGN2_HUMAN	Decreases Expression	[122]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Decreases Expression	[122]
Creatine kinase M-type (CKM)	OTME0KO7	KCRM_HUMAN	Decreases Expression	[122]
Acetylcholine receptor subunit gamma (CHRNG)	OTXC2UR7	ACHG_HUMAN	Decreases Expression	[122]
Profilin-1 (PFN1)	OTHTGA1H	PROF1_HUMAN	Decreases Expression	[122]
ATP-dependent 6-phosphofructokinase, muscle type (PFKM)	OT1QY9JM	PFKAM_HUMAN	Decreases Expression	[122]
U2 small nuclear ribonucleoprotein B'' (SNRPB2)	OT6XISJD	RU2B_HUMAN	Increases Expression	[122]
Glycodelin (PAEP)	OTQA0NV4	PAEP_HUMAN	Decreases Expression	[122]
B-cell antigen receptor complex-associated protein alpha chain (CD79A)	OTOJC8DV	CD79A_HUMAN	Decreases Expression	[122]
Alpha-actinin-1 (ACTN1)	OTUCLNXH	ACTN1_HUMAN	Decreases Expression	[122]
Platelet glycoprotein Ib beta chain (GP1BB)	OTD7XNLL	GP1BB_HUMAN	Decreases Expression	[122]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Increases Expression	[122]
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3)	OTM8EG6H	AT1A3_HUMAN	Decreases Expression	[122]
Glial fibrillary acidic protein (GFAP)	OTQ01ZAS	GFAP_HUMAN	Decreases Expression	[122]
Myoblast determination protein 1 (MYOD1)	OTV2S79X	MYOD1_HUMAN	Decreases Expression	[122]
Myogenin (MYOG)	OTPLJKFA	MYOG_HUMAN	Decreases Expression	[122]
Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1)	OT7US3NO	SIAT1_HUMAN	Increases Expression	[122]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Decreases Expression	[122]
Pituitary adenylate cyclase-activating polypeptide (ADCYAP1)	OT0LQH93	PACA_HUMAN	Decreases Expression	[122]
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E)	OTH5IL2A	RPAB1_HUMAN	Decreases Expression	[122]
Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1)	OTSXJGQF	ITIH1_HUMAN	Decreases Expression	[122]
Protachykinin-1 (TAC1)	OTM842YW	TKN1_HUMAN	Decreases Expression	[122]
Collagen alpha-1(IX) chain (COL9A1)	OTWBR27Y	CO9A1_HUMAN	Decreases Expression	[122]
Midkine (MDK)	OTF24HKC	MK_HUMAN	Decreases Expression	[122]
Macrophage scavenger receptor types I and II (MSR1)	OTHANJ7A	MSRE_HUMAN	Decreases Expression	[122]
Calretinin (CALB2)	OTSNMCG9	CALB2_HUMAN	Decreases Expression	[122]
Splicing factor, proline- and glutamine-rich (SFPQ)	OTLCIAPJ	SFPQ_HUMAN	Decreases Expression	[122]
Carbonic anhydrase 6 (CA6)	OTIX56CJ	CAH6_HUMAN	Decreases Expression	[122]
Integrin alpha-3 (ITGA3)	OTBCH21D	ITA3_HUMAN	Decreases Expression	[122]
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)	OTSLZBVY	PTN3_HUMAN	Decreases Expression	[122]
Elongation factor 1-gamma (EEF1G)	OTW7DH2F	EF1G_HUMAN	Increases Expression	[122]
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C)	OTKPL09B	VATL_HUMAN	Decreases Expression	[122]
Cystatin-D (CST5)	OTHJXNJG	CYTD_HUMAN	Decreases Expression	[122]
Cellular retinoic acid-binding protein 1 (CRABP1)	OTISDG5X	RABP1_HUMAN	Decreases Expression	[122]
ATP synthase subunit delta, mitochondrial (ATP5F1D)	OTXTAG2V	ATPD_HUMAN	Decreases Expression	[122]
Rab GDP dissociation inhibitor alpha (GDI1)	OTYM3928	GDIA_HUMAN	Increases Expression	[122]
T-lymphocyte activation antigen CD80 (CD80)	OTJBLUQE	CD80_HUMAN	Increases Expression	[122]
Ribonuclease 4 (RNASE4)	OTA5SZLC	RNAS4_HUMAN	Increases Expression	[122]
Macrosialin (CD68)	OTOYEY3J	CD68_HUMAN	Decreases Expression	[122]
Serine hydroxymethyltransferase, mitochondrial (SHMT2)	OT5NCAZN	GLYM_HUMAN	Decreases Expression	[122]
General transcription factor IIF subunit 1 (GTF2F1)	OTVXS75P	T2FA_HUMAN	Decreases Expression	[122]
Small proline-rich protein 2B (SPRR2B)	OTQ9WPKY	SPR2B_HUMAN	Decreases Expression	[122]
Alpha-1B adrenergic receptor (ADRA1B)	OTSAYAFD	ADA1B_HUMAN	Decreases Expression	[122]
Fibrillin-1 (FBN1)	OTYCJT63	FBN1_HUMAN	Decreases Expression	[122]
Monocarboxylate transporter 8 (SLC16A2)	OTLRA7C0	MOT8_HUMAN	Increases Expression	[122]
Signal recognition particle 14 kDa protein (SRP14)	OTAVZ94Y	SRP14_HUMAN	Decreases Expression	[122]
Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3)	OTZG1W8W	CEAM3_HUMAN	Decreases Expression	[122]
Pre-B-cell leukemia transcription factor 2 (PBX2)	OTEBYCAW	PBX2_HUMAN	Decreases Expression	[122]
Radiation-inducible immediate-early gene IEX-1 (IER3)	OTZJI5FZ	IEX1_HUMAN	Decreases Expression	[122]
Solute carrier organic anion transporter family member 1A2 (SLCO1A2)	OTO70C5O	SO1A2_HUMAN	Decreases Expression	[122]
RPE-retinal G protein-coupled receptor (RGR)	OTKCF5AZ	RGR_HUMAN	Decreases Expression	[122]
Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2)	OT9TZ2E0	GBRA2_HUMAN	Decreases Expression	[122]
Olfactory marker protein (OMP)	OT7JH0DY	OMP_HUMAN	Decreases Expression	[122]
Neuropeptides B/W receptor type 2 (NPBWR2)	OTABA9JW	NPBW2_HUMAN	Decreases Expression	[122]
CD151 antigen (CD151)	OTF3UZS7	CD151_HUMAN	Decreases Expression	[122]
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA)	OTCV2Q89	FNTA_HUMAN	Decreases Expression	[122]
Choline-phosphate cytidylyltransferase A (PCYT1A)	OTMH0YLN	PCY1A_HUMAN	Decreases Expression	[122]
Rab GDP dissociation inhibitor beta (GDI2)	OTGLY3I7	GDIB_HUMAN	Increases Expression	[122]
Potassium-transporting ATPase subunit beta (ATP4B)	OTIP2EYJ	ATP4B_HUMAN	Decreases Expression	[122]
Tyrosine-protein kinase Blk (BLK)	OT1EB8MT	BLK_HUMAN	Decreases Expression	[122]
Insulin-like 3 (INSL3)	OT7KUNTE	INSL3_HUMAN	Decreases Expression	[122]
Host cell factor 1 (HCFC1)	OT0UCK62	HCFC1_HUMAN	Decreases Expression	[122]
Clathrin heavy chain 2 (CLTCL1)	OT6W5BNR	CLH2_HUMAN	Increases Expression	[122]
Mitogen-activated protein kinase 10 (MAPK10)	OTC46VX1	MK10_HUMAN	Decreases Expression	[122]
UV excision repair protein RAD23 homolog A (RAD23A)	OTBPAWHX	RD23A_HUMAN	Decreases Expression	[122]
Eukaryotic translation initiation factor 6 (EIF6)	OTEXMUED	IF6_HUMAN	Decreases Expression	[122]
Syntaxin-1B (STX1B)	OTSW59X0	STX1B_HUMAN	Decreases Expression	[122]
Pterin-4-alpha-carbinolamine dehydratase (PCBD1)	OTDSRUD5	PHS_HUMAN	Decreases Expression	[122]
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)	OT6285L4	FKB1A_HUMAN	Decreases Expression	[122]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Decreases Expression	[122]
Actin, alpha cardiac muscle 1 (ACTC1)	OTJU04B1	ACTC_HUMAN	Decreases Expression	[122]
Contactin-associated protein 1 (CNTNAP1)	OT5Y03EU	CNTP1_HUMAN	Increases Expression	[122]
Homeobox protein Hox-A4 (HOXA4)	OTNVTQDT	HXA4_HUMAN	Decreases Expression	[122]
S-adenosylmethionine synthase isoform type-1 (MAT1A)	OTK72E4F	METK1_HUMAN	Decreases Expression	[122]
Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2)	OTQR5SXD	CX6A2_HUMAN	Decreases Expression	[122]
Mucin-2 (MUC2)	OT3X4QVX	MUC2_HUMAN	Decreases Expression	[122]
Transducin-like enhancer protein 3 (TLE3)	OTR9PH95	TLE3_HUMAN	Decreases Expression	[122]
Sex-determining region Y protein (SRY)	OT516T6D	SRY_HUMAN	Decreases Expression	[122]
Neuronal acetylcholine receptor subunit beta-3 (CHRNB3)	OTE5XENW	ACHB3_HUMAN	Decreases Expression	[122]
Paired box protein Pax-8 (PAX8)	OTRPD9MI	PAX8_HUMAN	Decreases Expression	[122]
Golgin subfamily A member 2 (GOLGA2)	OT5S9KYM	GOGA2_HUMAN	Decreases Expression	[122]
Lysyl oxidase homolog 1 (LOXL1)	OTA0NEJU	LOXL1_HUMAN	Decreases Expression	[122]
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (MGAT3)	OTXI5X4T	MGAT3_HUMAN	Decreases Expression	[122]
Kinesin heavy chain isoform 5A (KIF5A)	OT3ETTI6	KIF5A_HUMAN	Decreases Expression	[122]
Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)	OTM7V78U	M4K2_HUMAN	Decreases Expression	[122]
Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2)	OTLUTKJQ	IRAG2_HUMAN	Decreases Expression	[122]
TNF receptor-associated factor 1 (TRAF1)	OTTLM5RU	TRAF1_HUMAN	Decreases Expression	[122]
Myosin-binding protein H (MYBPH)	OTQJBPUR	MYBPH_HUMAN	Decreases Expression	[122]
Golgin subfamily A member 4 (GOLGA4)	OTCMEHNJ	GOGA4_HUMAN	Increases Expression	[122]
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15)	OTZ7VLTP	ADA15_HUMAN	Decreases Expression	[122]
Laminin subunit beta-3 (LAMB3)	OTFPU6W8	LAMB3_HUMAN	Decreases Expression	[122]
Translation initiation factor eIF2B subunit alpha (EIF2B1)	OT4NCVY1	EI2BA_HUMAN	Increases Expression	[122]
Guanidinoacetate N-methyltransferase (GAMT)	OTVC87ES	GAMT_HUMAN	Decreases Expression	[122]
Growth factor receptor-bound protein 7 (GRB7)	OTF8Y9XY	GRB7_HUMAN	Decreases Expression	[122]
Procollagen C-endopeptidase enhancer 1 (PCOLCE)	OTJXOAN4	PCOC1_HUMAN	Decreases Expression	[122]
Reticulocalbin-1 (RCN1)	OT3JBGAG	RCN1_HUMAN	Decreases Expression	[122]
Keratin, type I cuticular Ha1 (KRT31)	OTB6RCAH	K1H1_HUMAN	Decreases Expression	[122]
Cytohesin-1 (CYTH1)	OTYH9NRJ	CYH1_HUMAN	Increases Expression	[122]
Mediator of RNA polymerase II transcription subunit 1 (MED1)	OTOO24C4	MED1_HUMAN	Decreases Expression	[122]
Striated muscle preferentially expressed protein kinase (SPEG)	OTQXWJR4	SPEG_HUMAN	Decreases Expression	[122]
Syntaxin-binding protein 2 (STXBP2)	OTX8GUC4	STXB2_HUMAN	Decreases Expression	[122]
Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6)	OTX4UC3O	GBRA6_HUMAN	Decreases Expression	[122]
snRNA-activating protein complex subunit 1 (SNAPC1)	OTAPN1NI	SNPC1_HUMAN	Increases Expression	[122]
Alpha-sarcoglycan (SGCA)	OTCLJVZV	SGCA_HUMAN	Decreases Expression	[122]
Hydroxyacylglutathione hydrolase, mitochondrial (HAGH)	OTYMDAYV	GLO2_HUMAN	Decreases Expression	[122]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)	OTJDOL20	HCDH_HUMAN	Decreases Expression	[122]
Artemin (ARTN)	OTWIWGL6	ARTN_HUMAN	Decreases Expression	[122]
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1)	OTXIGC6I	LAIR1_HUMAN	Increases Expression	[122]
Psychosine receptor (GPR65)	OTCF5O4G	PSYR_HUMAN	Increases Expression	[122]
Ataxin-2-like protein (ATXN2L)	OTP5M3R9	ATX2L_HUMAN	Decreases Expression	[122]
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1)	OTGND2YZ	SIA8A_HUMAN	Increases Expression	[122]
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)	OTXGJ8N1	P55G_HUMAN	Increases Expression	[122]
Signal transducing adapter molecule 1 (STAM)	OT6X5RR1	STAM1_HUMAN	Decreases Expression	[122]
Deoxyribonuclease-1-like 2 (DNASE1L2)	OT56VFRL	DNSL2_HUMAN	Decreases Expression	[122]
Forkhead box protein J1 (FOXJ1)	OT7LLBZ7	FOXJ1_HUMAN	Decreases Expression	[122]
snRNA-activating protein complex subunit 3 (SNAPC3)	OTSGZZCJ	SNPC3_HUMAN	Increases Expression	[122]
Transcription factor IIIB 90 kDa subunit (BRF1)	OTQC6DMG	TF3B_HUMAN	Decreases Expression	[122]
Protein bicaudal D homolog 1 (BICD1)	OT78IYPF	BICD1_HUMAN	Decreases Expression	[122]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1)	OTHFFT6G	SMRD1_HUMAN	Increases Expression	[122]
GTP-binding protein Rit2 (RIT2)	OTSNYG0D	RIT2_HUMAN	Decreases Expression	[122]
Cell cycle checkpoint control protein RAD9A (RAD9A)	OTJ3AJQU	RAD9A_HUMAN	Decreases Expression	[122]
Septin-5 (SEPTIN5)	OT6JTJBO	SEPT5_HUMAN	Decreases Expression	[122]
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3)	OTEY876E	ZNT3_HUMAN	Decreases Expression	[122]
Neuronal PAS domain-containing protein 1 (NPAS1)	OTZKO6ZN	NPAS1_HUMAN	Decreases Expression	[122]
Neurturin (NRTN)	OT4PAKUY	NRTN_HUMAN	Decreases Expression	[122]
Chorion-specific transcription factor GCMa (GCM1)	OT5CPAUT	GCM1_HUMAN	Increases Expression	[122]
Alpha-catulin (CTNNAL1)	OTESJ6JD	CTNL1_HUMAN	Increases Expression	[122]
Intercellular adhesion molecule 5 (ICAM5)	OTDGGAFH	ICAM5_HUMAN	Decreases Expression	[122]
Protocadherin gamma-C3 (PCDHGC3)	OTDXTUMI	PCDGK_HUMAN	Decreases Expression	[122]
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2)	OT1KKMYZ	BAIP2_HUMAN	Decreases Expression	[122]
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1)	OTJCX8K9	MD1L1_HUMAN	Decreases Expression	[122]
NF-kappa-B essential modulator (IKBKG)	OTNWJWSD	NEMO_HUMAN	Decreases Expression	[122]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Decreases Activity	[127]
Protein regulator of cytokinesis 1 (PRC1)	OTHD0XS0	PRC1_HUMAN	Decreases Expression	[15]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[128]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[129]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[130]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Increases Expression	[131]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[132]
Fanconi anemia group D2 protein (FANCD2)	OTVEB5LF	FACD2_HUMAN	Increases Ubiquitination	[133]
Three-prime repair exonuclease 1 (TREX1)	OTQG7K12	TREX1_HUMAN	Increases Expression	[134]
Eukaryotic initiation factor 4A-II (EIF4A2)	OT08H03R	IF4A2_HUMAN	Affects Response To Substance	[123]
Sodium channel protein type 8 subunit alpha (SCN8A)	OT0JGIZN	SCN8A_HUMAN	Affects Response To Substance	[123]
Transmembrane protein 158 (TMEM158)	OT0KUBBI	TM158_HUMAN	Affects Response To Substance	[123]
Four and a half LIM domains protein 2 (FHL2)	OT0OAYWT	FHL2_HUMAN	Affects Response To Substance	[123]
Glutaminyl-peptide cyclotransferase (QPCT)	OT0TSHP4	QPCT_HUMAN	Affects Response To Substance	[123]
Rho-related BTB domain-containing protein 3 (RHOBTB3)	OT1BFKPH	RHBT3_HUMAN	Affects Response To Substance	[123]
Retinaldehyde dehydrogenase 3 (ALDH1A3)	OT1C9NKQ	AL1A3_HUMAN	Affects Response To Substance	[123]
Nuclear factor 1 X-type (NFIX)	OT1DPZAE	NFIX_HUMAN	Affects Response To Substance	[123]
ATP-binding cassette sub-family G member 5 (ABCG5)	OT1OMY93	ABCG5_HUMAN	Affects Response To Substance	[123]
Protein Lines homolog 1 (LINS1)	OT1USO08	LINES_HUMAN	Affects Response To Substance	[123]
Protein ERGIC-53-like (LMAN1L)	OT2CSBR3	LMA1L_HUMAN	Affects Response To Substance	[123]
Spermatogenesis-associated protein 12 (SPATA12)	OT2EPI7P	SPT12_HUMAN	Affects Response To Substance	[123]
Importin-4 (IPO4)	OT2N5020	IPO4_HUMAN	Affects Response To Substance	[123]
Msx2-interacting protein (SPEN)	OT37A2MD	MINT_HUMAN	Affects Response To Substance	[123]
Probable RNA-binding protein 19 (RBM19)	OT3Q6UIM	RBM19_HUMAN	Affects Response To Substance	[123]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Affects Response To Substance	[123]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2)	OT4DJFFU	DNA2_HUMAN	Affects Response To Substance	[123]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Affects Response To Substance	[123]
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Affects Response To Substance	[123]
DNA repair nuclease/redox regulator APEX1 (APEX1)	OT53OI14	APEX1_HUMAN	Increases Response To Substance	[135]
Leukocyte elastase inhibitor (SERPINB1)	OT5RDUFO	ILEU_HUMAN	Affects Response To Substance	[123]
Cytoplasmic phosphatidylinositol transfer protein 1 (PITPNC1)	OT64TTGC	PITC1_HUMAN	Affects Response To Substance	[123]
CCN family member 4 (CCN4)	OT69BER9	CCN4_HUMAN	Affects Response To Substance	[123]
ETS translocation variant 1 (ETV1)	OT6PMJIK	ETV1_HUMAN	Affects Response To Substance	[123]
Transcription factor Dp-1 (TFDP1)	OT6RZ7VT	TFDP1_HUMAN	Affects Response To Substance	[123]
Melanophilin (MLPH)	OT7ADCXL	MELPH_HUMAN	Affects Response To Substance	[123]
Golgin subfamily A member 8B (GOLGA8B)	OT807QHZ	GOG8B_HUMAN	Affects Response To Substance	[123]
Paired mesoderm homeobox protein 2 (PRRX2)	OT8UR4AU	PRRX2_HUMAN	Affects Response To Substance	[123]
Serine/threonine-protein kinase LMTK2 (LMTK2)	OT93MVIC	LMTK2_HUMAN	Affects Response To Substance	[123]
Doublesex- and mab-3-related transcription factor C2 (DMRTC2)	OT959L3E	DMRTD_HUMAN	Affects Response To Substance	[123]
Metallothionein-1X (MT1X)	OT9AKFVS	MT1X_HUMAN	Affects Response To Substance	[123]
Secretory carrier-associated membrane protein 5 (SCAMP5)	OT9MXA2J	SCAM5_HUMAN	Affects Response To Substance	[123]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Affects Response To Substance	[123]
N-acetylneuraminate lyase (NPL)	OTA7P0TO	NPL_HUMAN	Affects Response To Substance	[123]
DNA-3-methyladenine glycosylase (MPG)	OTAHW80B	3MG_HUMAN	Decreases Response To Substance	[136]
Transcriptional and immune response regulator (TCIM)	OTARUXQF	TCIM_HUMAN	Increases Response To Substance	[123]
Cyclin-dependent kinase inhibitor 1C (CDKN1C)	OTASTJ3Q	CDN1C_HUMAN	Affects Response To Substance	[123]
Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1)	OTBML9D9	CGAT1_HUMAN	Affects Response To Substance	[123]
Bone morphogenetic protein 5 (BMP5)	OTC0Y6E0	BMP5_HUMAN	Affects Response To Substance	[123]
Organic cation/carnitine transporter 2 (SLC22A5)	OTC36TYB	S22A5_HUMAN	Affects Response To Substance	[123]
Synaptopodin-2 (SYNPO2)	OTC3U0YH	SYNP2_HUMAN	Affects Response To Substance	[123]
3-mercaptopyruvate sulfurtransferase (MPST)	OTCDPH5D	THTM_HUMAN	Affects Response To Substance	[123]
Protein naked cuticle homolog 2 (NKD2)	OTCYT3I6	NKD2_HUMAN	Affects Response To Substance	[123]
Cadherin-13 (CDH13)	OTD2CYM5	CAD13_HUMAN	Affects Response To Substance	[123]
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA)	OTD5QPCI	NT2NA_HUMAN	Affects Response To Substance	[123]
DNA polymerase subunit gamma-2 (POLG2)	OTDBMZJB	DPOG2_HUMAN	Affects Response To Substance	[123]
Maturin (MTURN)	OTEBJNVG	MTURN_HUMAN	Affects Response To Substance	[123]
Cysteine and glycine-rich protein 3 (CSRP3)	OTECBJMV	CSRP3_HUMAN	Affects Response To Substance	[123]
Testis development-related protein (TDRP)	OTEFLMGF	TDRP_HUMAN	Affects Response To Substance	[123]
Glycine receptor subunit beta (GLRB)	OTF37UG4	GLRB_HUMAN	Affects Response To Substance	[123]
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1)	OTFCO8QX	SIA4A_HUMAN	Affects Response To Substance	[123]
Pleckstrin homology-like domain family A member 1 (PHLDA1)	OTFTWMIQ	PHLA1_HUMAN	Affects Response To Substance	[123]
Glutathione S-transferase Mu 2 (GSTM2)	OTG4WT05	GSTM2_HUMAN	Decreases Nitrosation	[137]
Polyhomeotic-like protein 2 (PHC2)	OTG7ZO80	PHC2_HUMAN	Affects Response To Substance	[123]
COUP transcription factor 1 (NR2F1)	OTGWZWYL	COT1_HUMAN	Affects Response To Substance	[123]
Voltage-gated potassium channel subunit beta-2 (KCNAB2)	OTH115IE	KCAB2_HUMAN	Affects Response To Substance	[123]
Ankyrin repeat domain-containing protein 1 (ANKRD1)	OTHJ7JV9	ANKR1_HUMAN	Affects Response To Substance	[123]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Affects Response To Substance	[123]
Phosphopentomutase (PGM2)	OTIR1VDW	PGM2_HUMAN	Affects Response To Substance	[123]
Differentially expressed in FDCP 6 homolog (DEF6)	OTIRBYVK	DEFI6_HUMAN	Affects Response To Substance	[123]
Protocadherin beta-2 (PCDHB2)	OTJ9UCIH	PCDB2_HUMAN	Affects Response To Substance	[123]
Alpha-(1,6)-fucosyltransferase (FUT8)	OTJJCVG1	FUT8_HUMAN	Affects Response To Substance	[123]
Nuclear factor of activated T-cells 5 (NFAT5)	OTKIE59S	NFAT5_HUMAN	Affects Response To Substance	[123]
Adenomatous polyposis coli protein (APC)	OTKV0TIK	APC_HUMAN	Affects Response To Substance	[123]
Transmembrane protein 19 (TMEM19)	OTKWMDYH	TMM19_HUMAN	Affects Response To Substance	[123]
Pleckstrin homology domain-containing family G member 5 (PLEKHG5)	OTL0S21W	PKHG5_HUMAN	Affects Response To Substance	[123]
Glutathione S-transferase Mu 3 (GSTM3)	OTLA2WJT	GSTM3_HUMAN	Decreases Nitrosation	[137]
Splicing factor 1 (SF1)	OTLEDM2S	SF01_HUMAN	Affects Response To Substance	[123]
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)	OTLUM9L7	PK3C3_HUMAN	Affects Response To Substance	[123]
Probable ATP-dependent RNA helicase DHX37 (DHX37)	OTM1A5KP	DHX37_HUMAN	Affects Response To Substance	[123]
T-box transcription factor TBX3 (TBX3)	OTM64N7K	TBX3_HUMAN	Affects Response To Substance	[123]
Neuronal PAS domain-containing protein 2 (NPAS2)	OTMRT2TS	NPAS2_HUMAN	Affects Response To Substance	[123]
Exostosin-like 1 (EXTL1)	OTMSNY9N	EXTL1_HUMAN	Affects Response To Substance	[123]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Increases Response To Substance	[138]
Popeye domain-containing protein 3 (POPDC3)	OTN4FJ5J	POPD3_HUMAN	Affects Response To Substance	[123]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)	OTOMP6TH	PK3CD_HUMAN	Affects Response To Substance	[123]
Anterior gradient protein 3 (AGR3)	OTONJPDP	AGR3_HUMAN	Affects Response To Substance	[123]
Histone-lysine N-methyltransferase MECOM (MECOM)	OTP983W8	MECOM_HUMAN	Affects Response To Substance	[123]
Ras-related protein Rab-27B (RAB27B)	OTPF9D0K	RB27B_HUMAN	Affects Response To Substance	[123]
Plakophilin-3 (PKP3)	OTPL1HRB	PKP3_HUMAN	Affects Response To Substance	[123]
SPARC (SPARC)	OTPN90H0	SPRC_HUMAN	Affects Response To Substance	[123]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Affects Response To Substance	[123]
Prolyl 3-hydroxylase 3 (P3H3)	OTRC8QCM	P3H3_HUMAN	Affects Response To Substance	[123]
Chromodomain-helicase-DNA-binding protein 2 (CHD2)	OTRKL6YC	CHD2_HUMAN	Affects Response To Substance	[123]
Cell adhesion molecule 1 (CADM1)	OTRWG9QS	CADM1_HUMAN	Affects Response To Substance	[123]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Affects Response To Substance	[123]
Tumor protein D53 (TPD52L1)	OTSA6U0I	TPD53_HUMAN	Affects Response To Substance	[123]
Neuroblastoma suppressor of tumorigenicity 1 (NBL1)	OTT37U4O	NBL1_HUMAN	Affects Response To Substance	[123]
Fanconi anemia group C protein (FANCC)	OTTIDM3P	FANCC_HUMAN	Affects Response To Substance	[123]
Keratin, type II cytoskeletal 8 (KRT8)	OTTM4X11	K2C8_HUMAN	Affects Response To Substance	[123]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)	OTTVT4MB	TNR19_HUMAN	Affects Response To Substance	[123]
RAB6A-GEF complex partner protein 2 (RGP1)	OTTZ63A6	RGP1_HUMAN	Affects Response To Substance	[123]
Protein Mdm4 (MDM4)	OTU10BSF	MDM4_HUMAN	Decreases Response To Substance	[139]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)	OTU1KZPV	AAPK2_HUMAN	Affects Response To Substance	[123]
Transcription factor AP-2 gamma (TFAP2C)	OTUDIW05	AP2C_HUMAN	Affects Response To Substance	[123]
F-box only protein 32 (FBXO32)	OTUE978R	FBX32_HUMAN	Affects Response To Substance	[123]
Syntaxin-binding protein 6 (STXBP6)	OTUEKTIP	STXB6_HUMAN	Affects Response To Substance	[123]
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Affects Response To Substance	[123]
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1)	OTUTPVA9	PREX1_HUMAN	Affects Response To Substance	[123]
Forkhead box protein F2 (FOXF2)	OTV20NGX	FOXF2_HUMAN	Affects Response To Substance	[123]
Transcription factor SOX-9 (SOX9)	OTVDJFGN	SOX9_HUMAN	Affects Response To Substance	[123]
Arrestin domain-containing protein 2 (ARRDC2)	OTVEOXAG	ARRD2_HUMAN	Affects Response To Substance	[123]
Ninein (NIN)	OTVH3M4Z	NIN_HUMAN	Affects Response To Substance	[123]
Polypeptide N-acetylgalactosaminyltransferase 15 (GALNT15)	OTVK9EHD	GLT15_HUMAN	Affects Response To Substance	[123]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Increases Response To Substance	[123]
Ankyrin-2 (ANK2)	OTWB4R1Y	ANK2_HUMAN	Affects Response To Substance	[123]
Mannan-binding lectin serine protease 1 (MASP1)	OTWWCNZP	MASP1_HUMAN	Affects Response To Substance	[123]
Nuclear factor 1 B-type (NFIB)	OTX94PD0	NFIB_HUMAN	Affects Response To Substance	[123]
E3 ubiquitin-protein ligase TRIM50 (TRIM50)	OTXA2IXF	TRI50_HUMAN	Affects Response To Substance	[123]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)	OTXOQDSG	IFIT1_HUMAN	Affects Response To Substance	[123]
Engulfment and cell motility protein 1 (ELMO1)	OTY2ORXK	ELMO1_HUMAN	Affects Response To Substance	[123]
Regulator of cell cycle RGCC (RGCC)	OTYJMLWM	RGCC_HUMAN	Affects Response To Substance	[123]
GTPase-activating Rap/Ran-GAP domain-like protein 3 (GARNL3)	OTYK950M	GARL3_HUMAN	Affects Response To Substance	[123]
Tissue factor pathway inhibitor 2 (TFPI2)	OTZCRWOR	TFPI2_HUMAN	Affects Response To Substance	[123]
AP-1 complex subunit sigma-2 (AP1S2)	OTZHJFYI	AP1S2_HUMAN	Affects Response To Substance	[123]
Metallothionein-1F (MT1F)	OTZVUYG1	MT1F_HUMAN	Affects Response To Substance	[123]

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