Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCUT21)

• Drug Name: Ursodeoxycholic acid Drug Info
• Synonyms: Actigall; Antigall; Arsacol; Delursan; Destolit; Deursil; Litursol; Lyeton; Peptarom; Solutrat; UDCA; UDCS; UrSO; Urosiol; Ursacol; Ursobilin; Ursochol; Ursodamor; Ursodeoxycholate; Ursodiol; Ursofalk; Ursolvan; Ursosan; Acide ursodesoxycholique; Acido ursodeossicolico; Acido ursodeossicolico [Italian]; Acido ursodeoxicolico; Acidum ursodeoxycholicum; Deoxyursocholic Acid; Sodium Ursodeoxycholate; Ursacholic Acid; Urso DS; Urso Forte; Ursodeoxy cholic acid; Ursodesoxycholicacid; Ursodexycholic Acid; Ursodiol [USAN]; IU5; U0030; Urso 250; Acide ursodesoxycholique [INN-French]; Acido ursodeoxicolico [INN-Spanish]; Acidum ursodeoxycholicum [INN-Latin]; Actigall (TN); Cholit-ursan; Deursil (TN); Dom-ursodiol c; ISO-URSODEOXYCHOLIC ACID; PHL-ursodiol c; PMS-ursodiol c; U-9000; Urso (TN); Urso Forte (TN); Ursodiol (USP); Ursosan (TN); Ursodeoxycholic acid (JP15/INN); Ursodeoxycholic acid, UDCA, Ursosan, Ursofalk, Urso Forte, Udiliv, Ursodiol; Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-beta)-(9CI); (3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid; (3alpha,5beta,7beta,8xi)-3,7-dihydroxycholan-24-oic acid; (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; 17-beta-(1-Methyl-3-carboxypropyl)etiocholane-3-alpha,7-beta-diol; 3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid; 3,7-Dihydroxycholan-24-oic acid; 3-alpha,7-beta-Dihydroxy-5-beta-cholanoic acid; 3-alpha,7-beta-Dihydroxycholanic acid; 3-alpha,7-beta-Dioxycholanic acid; 3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid; 3alpha,7beta-Dihydroxy-5beta-cholanic acid; 5beta-Cholan-24-oic acid-3alpha,7beta-diol; 5beta-Cholanic Acid-3alpha,7beta-diol; 7-beta-Hydroxylithocholic acid; 7beta-Hydroxylithocholic acid

Indication

Disease Entry	ICD 11	Status	REF
Cholelithiasis	DC11	Approved	[1]
Primary biliary cholangitis	DB96.1	Approved	[2]
Primary biliary cirrhosis	DB96.1	Approved	[3]
Colon cancer	2B90.Z	Investigative	[4]

• Therapeutic Class: Cholagogues and Choleretics
• Cross-matching ID:
  PubChem CID: 31401
  ChEBI ID: CHEBI:9907
  CAS Number: CAS 128-13-2
  TTD Drug ID: DMCUT21
  VARIDT Drug ID: DR00615
  INTEDE Drug ID: DR2172
  ACDINA Drug ID: D00713

Molecule-Related Drug Atlas

Drug(s) Targeting Solute carrier family 23 member 2 (SLC23A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[12]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[79]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[85]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[86]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]

Drug(s) Targeting Biliverdin reductase A (BLVRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[13]

Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[15]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[16]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[17]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[16]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[18]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[19]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[20]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[21]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[18]

Drug(s) Metabolized By Beta-hydroxysteroid dehydrogenase (hdhB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dehydrocholic acid	DMFK8Y9	Constipation	DD91.1	Approved	[7]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[22]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[23]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[24]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[27]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[6]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[28]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[29]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[32]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[33]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[34]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[34]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[32]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[32]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[39]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[32]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[43]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[44]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[32]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[32]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[47]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[45]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[32]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[48]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[50]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[51]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[52]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[53]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[54]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[55]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[56]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[54]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[57]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[60]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[62]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[63]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[64]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[65]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[66]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[66]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[67]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[69]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[66]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[66]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[66]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[70]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[71]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[72]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[76]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[73]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[77]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[73]

Drug(s) Affected By Solute carrier family 23 member 1 (SLC23A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[92]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Taurocholic Acid	DM2LZ8F	Type-2 diabetes	5A11	Phase 1/2	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[95]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[76]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[96]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[98]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[96]
Fructose	DM43AN2	Vomiting	MD90	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[96]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[101]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[102]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[101]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[107]

Drug(s) Affected By Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[112]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[117]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[72]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[118]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[121]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[122]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[123]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[127]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[132]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[133]

Drug(s) Affected By Splicing factor 3B subunit 1 (SF3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[135]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[139]

Drug(s) Affected By Rho-related BTB domain-containing protein 3 (RHOBTB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[140]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[142]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[144]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[145]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[145]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[24]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[144]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[145]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[146]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[144]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[147]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[144]

Drug(s) Affected By Fibroblast growth factor 19 (FGF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[148]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[151]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[152]

Drug(s) Affected By HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[154]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[155]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[156]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[157]
Bortezomib	DMNO38U	Leukemia		Approved	[85]

Drug(s) Affected By Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[160]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[161]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[162]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[165]

Drug(s) Affected By Fibrinogen gamma chain (FGG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[169]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]

Drug(s) Affected By Myelin basic protein (MBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[171]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[173]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[174]
Bortezomib	DMNO38U	Leukemia		Approved	[85]

Drug(s) Affected By C4b-binding protein alpha chain (C4BPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[92]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[175]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[176]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[178]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[179]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[180]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[182]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[186]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[187]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[188]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[190]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[191]

Drug(s) Affected By ADP/ATP translocase 2 (SLC25A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[192]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[193]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[194]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[139]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[196]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[201]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[202]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[203]

Drug(s) Affected By Large ribosomal subunit protein P2 (RPLP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[205]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[207]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[208]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[176]

Drug(s) Affected By Protein kinase C beta type (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[212]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[213]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[214]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[215]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[218]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[219]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[220]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[222]

Drug(s) Affected By Involucrin (IVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[223]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[223]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[110]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[227]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[124]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[226]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[98]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[232]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[231]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[233]

Drug(s) Affected By 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[234]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[234]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[235]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[236]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[238]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[239]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[240]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[239]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[241]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[244]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[247]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[194]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[248]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[249]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[250]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[251]

Drug(s) Affected By Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[234]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[234]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[252]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[252]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[253]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[256]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[257]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[258]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[259]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[261]

Drug(s) Affected By Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[262]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[86]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[264]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[265]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[266]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[268]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[269]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[270]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[98]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[182]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[275]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[276]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[277]

Drug(s) Affected By Large ribosomal subunit protein eL33 (RPL35A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[156]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[207]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[278]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[279]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[110]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[280]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[281]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[282]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[283]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[284]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[285]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[286]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]

Drug(s) Affected By Alpha-1-acid glycoprotein 2 (ORM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[288]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[288]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[288]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[289]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[289]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]

Drug(s) Affected By Endothelin-2 (EDN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[290]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[291]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[169]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[292]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[92]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]

Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[72]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[293]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[294]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[295]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[285]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[296]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[293]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[297]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[251]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[299]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[300]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[302]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[303]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[304]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[305]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[306]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[250]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[307]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[308]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[309]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[310]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[311]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[312]

Drug(s) Affected By Large ribosomal subunit protein uL16 (RPL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[313]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[314]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[138]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[315]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[135]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[316]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[317]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[305]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[319]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[320]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[321]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[304]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[194]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[250]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[307]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[222]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[323]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[324]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[325]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[326]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[328]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[329]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[330]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[251]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[331]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[332]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[333]
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[334]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[302]

Drug(s) Affected By Intercellular adhesion molecule 3 (ICAM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[335]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[336]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[337]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[156]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[338]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[341]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[342]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[344]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[345]

Drug(s) Affected By Glycine--tRNA ligase (GARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[346]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[347]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[348]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[349]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[349]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[349]

Drug(s) Affected By Eukaryotic translation initiation factor 1 (EIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[350]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[351]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[349]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[349]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[349]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[352]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[353]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[76]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[354]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[358]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[140]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[359]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[360]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[361]

Drug(s) Affected By Glutathione synthetase (GSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[362]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[154]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[264]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[364]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[365]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[264]

Drug(s) Affected By T-complex protein 1 subunit epsilon (CCT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[366]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[367]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[368]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[156]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[369]
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[334]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[254]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[370]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[371]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[372]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[373]

Drug(s) Affected By T-complex protein 1 subunit gamma (CCT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[374]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[313]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[139]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[176]

Drug(s) Affected By Gastrotropin (FABP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[375]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[113]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[376]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[377]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[206]

Drug(s) Affected By Small ribosomal subunit protein mS29 (DAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[378]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[379]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[380]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[156]
Bortezomib	DMNO38U	Leukemia		Approved	[381]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[382]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[193]

Drug(s) Affected By Exportin-2 (CSE1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[347]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[289]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[383]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[379]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[252]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[252]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[207]

Drug(s) Affected By Nucleosome assembly protein 1-like 1 (NAP1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[384]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[385]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[383]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[386]

Drug(s) Affected By Large ribosomal subunit protein eL27 (RPL27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[135]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[278]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[387]

Drug(s) Affected By Transforming protein RhoA (RHOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[231]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[391]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[392]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[393]

Drug(s) Affected By Small ribosomal subunit protein uS15 (RPS13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[313]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[206]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[394]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[317]
all-trans-4-oxo-retinoic acid	DMM2R1N	Discovery agent	N.A.	Investigative	[231]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[280]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[395]

Drug(s) Affected By Small ribosomal subunit protein eS28 (RPS28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[313]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[396]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[207]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[397]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[394]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[398]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[394]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[399]

Drug(s) Affected By Large ribosomal subunit protein eL32 (RPL32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[400]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[206]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[278]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[387]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[401]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[402]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[403]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[280]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 1 (RAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[404]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[328]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[405]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[407]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[408]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[409]

Drug(s) Affected By Large ribosomal subunit protein eL6 (RPL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[410]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[411]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[410]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[412]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[413]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[413]

Drug(s) Affected By Single-stranded DNA-binding protein, mitochondrial (SSBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[192]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[414]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[415]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]

Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[359]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[416]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[417]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[418]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[419]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[244]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[420]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[248]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[124]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[421]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[422]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[240]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[250]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[124]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[423]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[424]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[262]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[425]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[426]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[133]

Drug(s) Affected By ATP-dependent RNA helicase A (DHX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[410]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[427]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[169]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[120]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[428]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[386]

Drug(s) Affected By Fibrinogen-like protein 1 (FGL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[289]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[289]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[429]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[364]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[430]

Drug(s) Affected By Serine/threonine-protein kinase 3 (STK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[431]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[316]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[432]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[432]

Drug(s) Affected By DnaJ homolog subfamily C member 3 (DNAJC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[140]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[359]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[433]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[43]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[434]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[435]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[436]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[437]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[438]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[439]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[238]
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[440]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[441]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[442]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[281]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[443]
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[444]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[445]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[446]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[447]

Drug(s) Affected By Protein Smaug homolog 2 (SAMD4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[432]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[432]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[432]

Drug(s) Affected By Chondroitin sulfate proteoglycan 4 (CSPG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[156]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[252]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[252]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[92]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[448]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[449]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Ribosomal protein eS27-like (RPS27L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[43]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[349]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[367]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[349]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[349]

Drug(s) Affected By Endoplasmic reticulum metallopeptidase 1 (ERMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[450]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[367]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[252]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[252]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[451]

Drug(s) Affected By E3 ubiquitin-protein ligase RBBP6 (RBBP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[350]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[379]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[452]

Drug(s) Affected By Out at first protein homolog (OAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[315]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[453]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[90]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[278]

Drug(s) Affected By Organic solute transporter subunit alpha (SLC51A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[80]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[204]

Drug(s) Affected By Organic solute transporter subunit beta (SLC51B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[454]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[80]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[455]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[456]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]

Drug(s) Affected By Shieldin complex subunit 2 (SHLD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[453]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[457]

Drug(s) Affected By G-protein coupled bile acid receptor 1 (GPBAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[148]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[174]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[148]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[458]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[176]
tauroursodeoxycholic acid	DMFKRQE	Discovery agent	N.A.	Investigative	[459]

Drug(s) Affected By E3 ubiquitin-protein ligase rififylin (RFFL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[204]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[349]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[349]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[349]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[349]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[460]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[461]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[462]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[463]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[464]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[465]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[148]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[466]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]

Drug(s) Affected By AP-2 complex subunit mu (AP2M1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Haloperidol	DM96SE0	Delirium		Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[467]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[176]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[278]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[432]

Drug(s) Affected By Ribosomal protein eL39-like 2 (RPL39L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[156]
Indomethacin	DMSC4A7	Bursitis		Approved	[468]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[206]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[176]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[278]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[317]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[469]

Drug(s) Affected By Rho GTPase-activating protein 7 (DLC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[335]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[470]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[471]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[472]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[285]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[471]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[148]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[473]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]

Drug(s) Affected By Protein sprouty homolog 4 (SPRY4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[290]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[154]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[111]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[474]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[75]

Drug(s) Affected By Endosialin (CD248)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[475]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[176]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[278]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[476]

Drug(s) Affected By Soluble lamin-associated protein of 75 kDa (FAM169A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[433]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[431]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[397]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[315]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[176]

Drug(s) Affected By Sulfotransferase 2A1 (SULT2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[384]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[231]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[285]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[477]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[478]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[479]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[28]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[480]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[148]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[80]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[481]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Biliverdin reductase A (BLVRA)	TTJBPN3	BIEA_HUMAN	Activator	[5]
Solute carrier family 23 member 2 (SLC23A2)	TTOP832	S23A2_HUMAN	Activator	[5]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[6]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-hydroxysteroid dehydrogenase (hdhB) Main DME	DEOMLHG	A4ECA9_9ACTN	Substrate	[7]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP)	OTB8HCED	CN37_HUMAN	Gene/Protein Processing	[8]
ADP/ATP translocase 2 (SLC25A5)	OT1XIBMN	ADT2_HUMAN	Gene/Protein Processing	[8]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[9]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[9]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[9]
Alpha-1-acid glycoprotein 2 (ORM2)	OTRJGZP8	A1AG2_HUMAN	Gene/Protein Processing	[8]
AP-2 complex subunit mu (AP2M1)	OTQCOSFN	AP2M1_HUMAN	Gene/Protein Processing	[8]
Apolipoprotein A-I (APOA1)	OT5THARI	APOA1_HUMAN	Gene/Protein Processing	[10]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[11]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[11]

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