Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPGUCF)

• Drug Name: Dopamine Drug Info
• Synonyms: Dopamin; Dopamina; Dopaminum; Dophamine; Hydroxytyramin; Hydroxytyramine; Intropin; LDP; Oxytyramine; Revimine; ASL 279; IP 498; Dopamina [INN-Spanish]; Dopamine (INN); Dopamine [INN:BAN]; Dopaminum [INN-Latin]; L-DOPAMINE; M-Hydroxytyramine hydrochloride; Medopa (TN); Intropin [*hydrochloride*]; KW-3-060; Beta-(3,4-Dihydroxyphenyl)ethylamine hydrochloride; Dopamine (USAN)(*hydrochloride*); A-(3,4-Dihydroxyphenyl)-b-aminoethane; Alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane; Pyrocatechol, 4-(2-aminoethyl)-(8CI); Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride; (3H)-Dopamine; 1,2-Benzenediol, 4-(2-aminoethyl)-(9CI); 1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride; 1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium; 153C5321-5FEE-4B0B-8925-F388F0EEEBD1; 2-(3,4-dihydroxyphenyl)ethylamine; 2-benzenediol; 3,4-Dihydroxyphenethylamine hydrochloride; 3,4-Dihydroxyphenylethylamine; 3,4-dihydroxyphenethylamine; 3-Hydroxtyramine; 3-Hydroxytyramine; 3-Hydroxytyramine Hydrobromide; 3-Hydroxytyramine hydrochloride; 4-(2-Aminoethyl)-1; 4-(2-Aminoethyl)-1,2-benzenediol; 4-(2-Aminoethyl)-1,2-bezenediol; 4-(2-Aminoethyl)benzene-1,2-diol; 4-(2-Aminoethyl)catechol; 4-(2-Aminoethyl)pyrocatechol; 4-(2-Aminoethyl)pyrocatechol hydrochloride; 4-(2-aminoethyl)-pyrocatechol

Indication

Disease Entry	ICD 11	Status	REF
Acromegaly	5A60.0	Approved	[1]
Carcinoid syndrome	5B10	Approved	[1]
Parkinson disease	8A00.0	Approved	[2]
Parkinsonian disorder		Approved	[1]
Postencephalitic Parkinson disease		Approved	[1]
Hypotension	BA20-BA21	Phase 1	[2]

• Therapeutic Class: Cardiotonic Agents
• Cross-matching ID:
  PubChem CID: 681
  ChEBI ID: CHEBI:18243
  CAS Number: CAS 51-61-6
  TTD Drug ID: DMPGUCF
  VARIDT Drug ID: DR00283
  INTEDE Drug ID: DR0532
  ACDINA Drug ID: D00212

Molecule-Related Drug Atlas

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[20]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[21]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[22]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[23]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[24]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[25]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[26]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[27]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[28]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[29]

Drug(s) Transported By Organic cation transporter 2 (SLC22A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[31]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[32]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[33]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[34]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[35]
Metformin	DM89QE1	Colorectal carcinoma		Approved	[36]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[34]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[37]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[38]

Drug(s) Transported By Organic cation transporter 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[41]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[42]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[43]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[44]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[45]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[34]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[42]

Drug(s) Transported By Vesicular amine transporter 2 (SLC18A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[46]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[5]
Methamphetamine	DMPM4SK	Anxiety		Approved	[47]
SEROTONIN	DMOFCRY	Discovery agent	N.A.	Investigative	[5]

Drug(s) Transported By Vesicular amine transporter 1 (SLC18A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[48]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[5]
SEROTONIN	DMOFCRY	Discovery agent	N.A.	Investigative	[5]

Drug(s) Transported By Sodium-dependent dopamine transporter (SLC6A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[49]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[50]
Bretylium	DM1FX74	Long QT syndrome	BC65.0	Approved	[51]
Benztropine	DMGZOVN	Parkinson disease	8A00.0	Approved	[52]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[122]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[123]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[126]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[127]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[128]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[53]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[54]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[59]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[60]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[61]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[62]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[64]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[66]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[68]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[69]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[70]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[71]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[97]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[99]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[100]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[101]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[102]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[103]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[104]
Methadone	DMTW6IU	Advanced cancer	2A00-2F9Z	Approved	[105]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[73]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[76]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[78]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[79]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[82]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[73]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[76]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[85]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[87]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[88]

Drug(s) Metabolized By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[89]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[90]
METHYLENEDIOXYMETHAMPHETAMINE	DMYVU47	Discovery agent	N.A.	Investigative	[91]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[115]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[115]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[116]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[115]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]

Drug(s) Metabolized By Sulfotransferase 1B1 (SULT1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[92]
Rotigotine	DMP7X6Q	N. A.	N. A.	Approved	[93]
ABT-751	DMNG35S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[94]
Mononitrophenol	DM4QO9G	N. A.	N. A.	Investigative	[95]
Aminophenol	DMEMCQ9	N. A.	N. A.	Investigative	[95]

Drug(s) Affected By Amine oxidase B (MAOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
BENZYL BENZOATE	DMDPYI5	Infestations of lice and scabies	1G00.Z	Approved	[113]
Linezolid	DMGFPU2	Bacteremia	1A73	Approved	[114]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[108]

Drug(s) Affected By Synaptic vesicular amine transporter (SLC18A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[130]
Methamphetamine	DMPM4SK	Anxiety		Approved	[131]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[132]
Haloperidol	DM96SE0	Delirium		Approved	[132]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[132]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[134]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[136]

Drug(s) Affected By Glial fibrillary acidic protein (GFAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[139]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[141]
Haloperidol	DM96SE0	Delirium		Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[143]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[144]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[146]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[149]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[150]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[151]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[153]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[154]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[157]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[141]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[161]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[163]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[165]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[166]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[155]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[167]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[169]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[170]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[171]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[172]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[173]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[174]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[176]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[180]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[181]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[182]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[182]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[183]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[186]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[187]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[180]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[188]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[189]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[191]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]

Drug(s) Affected By Methionine synthase (MTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Nitrous oxide	DMTHWBI	Anxiety disorder	6B00-6B0Z	Approved	[199]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[201]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[202]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[203]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[204]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[102]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[102]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[205]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[206]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[207]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[208]

Drug(s) Affected By POTE ankyrin domain family member F (POTEF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[210]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[211]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[212]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[213]

Drug(s) Affected By Citrate synthase, mitochondrial (CS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[217]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[218]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[219]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[211]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[220]

Drug(s) Affected By ATP synthase subunit d, mitochondrial (ATP5PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[222]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[211]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[224]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[213]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[225]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[227]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[228]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[215]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[229]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[230]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]

Drug(s) Affected By Fructose-bisphosphate aldolase A (ALDOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[186]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[233]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[234]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[161]

Drug(s) Affected By Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[235]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[236]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[234]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[142]

Drug(s) Affected By ADP/ATP translocase 2 (SLC25A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[238]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[211]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[137]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[240]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[242]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[246]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[234]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[248]
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[236]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]

Drug(s) Affected By Small ribosomal subunit protein uS2 (RPSA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[253]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[254]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[255]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[218]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[256]

Drug(s) Affected By POTE ankyrin domain family member I (POTEI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[186]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[257]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[257]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[258]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[259]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[260]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[261]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[186]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[262]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[263]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[264]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[265]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[266]

Drug(s) Affected By ADP/ATP translocase 3 (SLC25A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[142]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[142]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[267]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[239]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[268]

Drug(s) Affected By Annexin A3 (ANXA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[270]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[271]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[269]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[133]

Drug(s) Affected By Pyruvate kinase PKM (PKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[270]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[229]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[237]

Drug(s) Affected By Endoplasmin (HSP90B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[248]
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[274]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[275]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[276]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[277]

Drug(s) Affected By Histone H1.5 (H1-5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[281]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[283]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[284]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[236]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[287]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[289]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[133]

Drug(s) Affected By Nucleolin (NCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[290]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[267]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[218]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[219]

Drug(s) Affected By Cofilin-1 (CFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[242]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Haloperidol	DM96SE0	Delirium		Approved	[142]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[237]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[293]

Drug(s) Affected By Myristoylated alanine-rich C-kinase substrate (MARCKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[294]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[294]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[295]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[196]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[277]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[297]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[298]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[299]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[300]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[127]

Drug(s) Affected By Protein disulfide-isomerase A3 (PDIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[142]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[142]

Drug(s) Affected By Serine hydroxymethyltransferase, mitochondrial (SHMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[217]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[218]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[303]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[304]

Drug(s) Affected By Prohibitin 1 (PHB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[305]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[306]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[234]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[305]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[307]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[143]

Drug(s) Affected By Stress-70 protein, mitochondrial (HSPA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[274]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[308]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[309]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[310]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[311]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By Small ribosomal subunit protein RACK1 (RACK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[312]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[250]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[313]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[313]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[142]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[142]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[314]

Drug(s) Affected By Elongation factor 1-alpha 1 (EEF1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[305]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[229]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[237]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[315]

Drug(s) Affected By Single-stranded DNA-binding protein, mitochondrial (SSBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[277]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[238]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[218]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[316]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]

Drug(s) Affected By Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[143]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[267]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[239]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[318]

Drug(s) Affected By Beta-actin-like protein 2 (ACTBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[142]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[142]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[319]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[320]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[257]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[321]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[322]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[323]

Drug(s) Affected By 5'-3' exonuclease PLD3 (PLD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[217]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[181]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[211]

Drug(s) Affected By Septin-9 (SEPTIN9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[326]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[327]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[223]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[328]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[329]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[330]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[331]

Drug(s) Affected By RuvB-like 1 (RUVBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[332]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]

Drug(s) Affected By E3 ubiquitin-protein ligase parkin (PRKN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Emtricitabine	DMBMUWZ	Hepatitis virus infection	1E50-1E51	Approved	[333]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[334]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[335]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[336]
Methamphetamine	DMPM4SK	Anxiety		Approved	[337]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[338]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[210]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[211]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[334]

Drug(s) Affected By Brain mitochondrial carrier protein 1 (SLC25A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[218]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[211]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[339]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[340]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[213]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]
Haloperidol	DM96SE0	Delirium		Approved	[137]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[342]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[344]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[345]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[346]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[347]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[348]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[349]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[350]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[351]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[352]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[353]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[146]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[354]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[355]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[356]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[357]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[358]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[359]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[146]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[360]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[361]
Fructose	DM43AN2	Vomiting	MD90	Approved	[362]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[363]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[364]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[365]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[366]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[367]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[368]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[369]
Fructose	DM43AN2	Vomiting	MD90	Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[370]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[371]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[285]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[372]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[373]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[374]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[278]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[375]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[376]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[163]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[377]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[378]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[377]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[379]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[380]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[382]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[383]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[384]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[385]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[278]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[386]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[387]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[389]

Drug(s) Affected By D(1A) dopamine receptor (DRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[137]
Haloperidol	DM96SE0	Delirium		Approved	[390]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[391]
Pergolide mesylate	DM5GKOV	N. A.	N. A.	Approved	[392]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[390]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[393]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Methamphetamine	DMPM4SK	Anxiety		Approved	[394]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[395]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[396]

Drug(s) Affected By Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Haloperidol	DM96SE0	Delirium		Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[142]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[211]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[244]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[398]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[399]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[400]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[401]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[402]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[403]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[404]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[406]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[407]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[408]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[312]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[400]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[401]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[409]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[410]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[412]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[413]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[414]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[415]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[416]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[417]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[149]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[418]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[419]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[420]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[421]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[422]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[423]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[424]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[426]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[427]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[427]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[235]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[428]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[429]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[382]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[423]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[278]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[386]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[342]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[430]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[431]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[432]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[378]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[433]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[435]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[435]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[436]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[437]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[438]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[439]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[405]

Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[299]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[440]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[441]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[92]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[441]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[442]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[444]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[445]
Fructose	DM43AN2	Vomiting	MD90	Approved	[137]
Ketoprofen	DMRKXPT	Bursitis		Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[446]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[447]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[448]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[449]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[450]

Drug(s) Affected By Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zonisamide	DM0DTF7	Alcohol dependence	6C40.2	Approved	[451]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[452]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[453]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[454]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[326]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[455]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[456]
Methamphetamine	DMPM4SK	Anxiety		Approved	[457]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[458]

Drug(s) Affected By Amine oxidase A (MAOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[287]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[295]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[459]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[460]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[461]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By Sulfotransferase 1A3 (SULT1A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[462]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[463]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[464]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[465]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[466]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[92]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[441]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[441]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[277]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[467]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[468]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[267]
Bortezomib	DMNO38U	Leukemia		Approved	[469]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[470]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[471]

Drug(s) Affected By Neuron-specific vesicular protein calcyon (CALY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[223]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[472]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[472]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[472]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[213]

Drug(s) Affected By Solute carrier family 22 member 3 (SLC22A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[473]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[473]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[473]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[474]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[475]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[476]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[455]

Drug(s) Affected By Secretin (SCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[477]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[460]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[181]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[303]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[478]
Pentagastrin	DMRCLZB	Diagnostic imaging	N.A.	Approved	[479]
CHLORIDE	DM1TJXA	Solid tumour/cancer	2A00-2F9Z	Phase 3	[480]
AMG 386	DMQJXL4	Breast cancer	2C60-2C65	Phase 3	[480]

Drug(s) Affected By Equilibrative nucleoside transporter 4 (SLC29A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[473]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[481]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[482]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[483]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[319]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[468]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[181]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[473]

Drug(s) Affected By GDP-mannose 4,6 dehydratase (GMDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[326]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[484]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[267]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[485]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[486]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[303]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Agonist	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Synaptic vesicle glycoprotein 2C (SLC22B3)	DT7A9GF	SV2C_HUMAN	Substrate	[4]
Vesicular amine transporter 2 (SLC18A2)	DTT7VPB	VMAT2_HUMAN	Substrate	[5]
Vesicular amine transporter 1 (SLC18A1)	DTM953D	VMAT1_HUMAN	Substrate	[5]
Sodium-dependent dopamine transporter (SLC6A3)	DT3BA8L	SC6A3_HUMAN	Substrate	[6]
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[7]
Organic cation transporter 2 (SLC22A2)	DT9IDPW	S22A2_HUMAN	Substrate	[8]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[9]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[9]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[9]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[10]
Catechol O-methyltransferase (COMT)	DEV3T4A	COMT_HUMAN	Substrate	[11]
Sulfotransferase 1B1 (SULT1B1)	DED5UR3	ST1B1_HUMAN	Substrate	[12]
Monoamine oxidase type B (MAO-B)	DET2NXO	AOFB_HUMAN	Substrate	[13]
Dopamine dehydroxylase (dadH)	DEL0D64	DADH_EGGLN	Substrate	[14]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5'-3' exonuclease PLD3 (PLD3)	OTL07SP2	PLD3_HUMAN	Gene/Protein Processing	[15]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Gene/Protein Processing	[15]
ADP/ATP translocase 2 (SLC25A5)	OT1XIBMN	ADT2_HUMAN	Gene/Protein Processing	[15]
ADP/ATP translocase 3 (SLC25A6)	OT9KAJP7	ADT3_HUMAN	Gene/Protein Processing	[15]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Drug Response	[16]
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Biotransformations	[17]
Amine oxidase B (MAOB)	OTTDFM1O	AOFB_HUMAN	Biotransformations	[17]
Annexin A3 (ANXA3)	OTDD8OI7	ANXA3_HUMAN	Gene/Protein Processing	[15]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[18]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[19]

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