Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSVOZT)

• Drug Name: Nifedipine Drug Info
• Synonyms: Adalat; Adalate; Adapine; Adapress; Afeditab; Alat; Aldipin; Alfadal; Alonix; Angipec; Anifed; Anpine; Aprical; Bonacid; Calcibloc; Calcigard; Calcilat; Camont; Cardifen; Cardilat; Cardionorm; Chronadalate; Citilat; Coracten; Coral; Cordafen; Cordaflex; Cordalat; Cordicant; Cordilan; Cordipin; Cordipine; Corinfar; Corotrend; Corynphar; Depin; Dignokonstant; Dilafed; Dipinkor; Duranifin; Ecodipi; Ecodipin; Emaberin; Fedcor; Fenamon; Fenigidin; Fenihidin; Fenihidine; Glopir; Hadipin; Hexadilat; Infedipin; Introcar; Kordafen; Korinfar; Macorel; Megalat; Myogard; Nedipin; Nicardia; Nifangin; Nifar; Nifdemin; Nifebene; Nifecard; Nifecor; Nifedepat; Nifediac; Nifedical; Nifedicor; Nifedin; Nifedine; Nifedipino; Nifedipinum; Nifedipres; Nifelan; Nifelat; Nifelate; Nificard; Nifidine; Nifipen; Niphedipine; Orix; Oxcord; Pidilat; Procardia; Sepamit; Tibricol; Vascard; Zenusin; AWD Pharma Brand of Nifedipine; Adalat CC; Adalat CR; Adalat Crono; Adalat FT; Adalat GITS; Adalat LA; Adalat LP; Adalat Oros; Adalat PA; Adalat Retard; Adalat XL; Adalate LP; Adcock Ingram Brand of Nifedipine; Adipine XL; Afeditab CR; Alonix S; Aprical long; Bayer Brand of Nifedipine; Chronadalate LP; Coracten XL; Ecodipin E; Fedcor Retard; Fenamon SR; Fortipine LA; KRKA Brand of Nifedipine; Nifedical XL; Nifedipine Bayer Brand; Nifedipine GTIS; Nifedipine KRKA Brand; Nifedipine Monohydrochloride; Nifedipine Orion Brand; Nifedipine Pfizer Brand; Nifedipine Retard; Nifedirex LP; Nifelat Q; Nifensar XL; Orion Brand of Nifedipine; Pfizer Brand of Nifedipine; Procardia XL; Slofedipine XL; Tensipine MR; Adalat 10; Adalat 20; Adalat 5; Adalat GITS 30; Bay1040; N 7634; N1fedilat; Adalat (TN); Afeditab CR (TN); Alpha-Nifedipine Retard;Apo-Nifed; Bay-1040; KB-1712P; Monohydrochloride, Nifedipine; Nifedical (TN); Nifedipine-GTIS; Nifedipino [INN-Spanish]; Nifedipinum [INN-Latin]; Procardia (TN); Bay-a-1040; Nifedipine (JP15/USP/INN); Nifedipine [USAN:BAN:INN:JAN]

Indication

Disease Entry	ICD 11	Status	REF
Angina pectoris	BA40	Approved	[1]
Premature labour	JB00	Approved	[2]

• Therapeutic Class: Analgesics
• Cross-matching ID:
  PubChem CID: 4485
  ChEBI ID: CHEBI:7565
  CAS Number: CAS 21829-25-4
  TTD Drug ID: DMSVOZT
  VARIDT Drug ID: DR00396
  INTEDE Drug ID: DR1152
  ACDINA Drug ID: D00467

Molecule-Related Drug Atlas

Drug(s) Targeting Voltage-gated L-type calcium channel (L-CaC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clevidipine butyrate	DMW4M97	Hypertension	BA00-BA04	Approved	[20]
Epalrestat	DM5OGK0	Diabetic neuropathy	8C0Z	Approved	[21]
Otilonium bromide	DM05968	Gastric motility disorder	DA21	Approved	[22]
Levamlodipine	DM92S6N	Hypertension	BA00-BA04	Phase 4	[23]
Cilnidipine	DM1975O	High blood pressure	BA00	Phase 3	[24]
Pinaverium bromide	DM7OSHC	Irritable bowel syndrome	DD91.0	Phase 3	[22]
MEM-1003	DMYZU6G	Bipolar disorder	6A60	Phase 2a	[25]
Gallopamil	DMXBR27	Asthma	CA23	Phase 2	[26]
BAY-Y-5959	DMLO18H	Cardiovascular disease	BA00-BE2Z	Phase 2	[27]
Furnidipine	DME94QF	Nerve injury	ND56.4	Discontinued in Phase 3	[28]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[29]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[4]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[31]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[4]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[32]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[4]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[34]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[35]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[36]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[41]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[42]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[36]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[43]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[81]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[82]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[84]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[85]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[86]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[87]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[44]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[45]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[48]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[49]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[41]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[50]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[51]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[52]
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[72]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[72]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[72]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[73]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[74]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[75]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[76]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[77]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[11]
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[78]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[53]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[54]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[56]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[57]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[58]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[59]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[60]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[62]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[66]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[68]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[69]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[64]

Drug(s) Metabolized By Cytochrome P450 102A1 (cyp102)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[10]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[70]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[71]
Dextromethorphan	DMUDJZM	Allergic rhinitis	CA08.0	Approved	[10]
Chlorzoxazone	DMCYVDT	Acute pain	MG31	Approved	[9]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[10]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[10]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[70]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[70]
GEA-6414	DM8J0MK	N. A.	N. A.	Phase 1/2	[70]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[88]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[89]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[90]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[91]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[92]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[93]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[94]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[95]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[96]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[94]

Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[97]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[98]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[97]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[98]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[99]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[97]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[97]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[97]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[100]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[101]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[102]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[17]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[17]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[103]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[102]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[17]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[104]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[102]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[105]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[102]

Drug(s) Affected By Cytochrome P450 2J2 (CYP2J2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[110]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[113]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[114]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[116]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[117]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[118]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[121]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[122]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[123]

Drug(s) Affected By Renin (REN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[124]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[125]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[126]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[127]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[128]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[129]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[130]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[131]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[132]
Chlorthalidone	DM4DMBT	Edema	MG29	Approved	[133]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[119]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[139]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[140]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]

Drug(s) Affected By Insulin-like growth factor II (IGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[151]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[152]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[154]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[155]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[156]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[158]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[160]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[161]

Drug(s) Affected By HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[162]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[163]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[163]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[165]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[166]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[169]

Drug(s) Affected By Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[173]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[174]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[175]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[178]

Drug(s) Affected By Apolipoprotein A-II (APOA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[180]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[176]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[182]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[183]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[187]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[186]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[191]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[194]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[197]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[201]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[203]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[204]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[205]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[207]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[208]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[209]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[19]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[210]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[211]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[213]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[215]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[216]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[217]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[218]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[221]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[222]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[223]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[224]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[226]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[227]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[228]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[232]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[233]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[234]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[236]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[237]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Selenium	DM25CGV	N. A.	N. A.	Approved	[238]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[239]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[241]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[242]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[243]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[244]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[245]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[11]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[247]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[248]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[250]

Drug(s) Affected By Hepatocyte growth factor (HGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[251]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[252]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[254]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[255]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[256]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[257]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[258]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[258]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[264]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[258]

Drug(s) Affected By Fibroblast growth factor 7 (FGF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[267]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[193]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[268]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[224]

Drug(s) Affected By Potassium voltage-gated channel subfamily A member 3 (KCNA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[269]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[270]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[267]
Econazole	DMFSWGH	Cutaneous candidiasis	1F23.14	Approved	[269]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[271]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[273]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[274]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[275]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[276]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[250]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[277]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[279]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[219]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[139]

Drug(s) Affected By Myosin-10 (MYH10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[280]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[282]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[283]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[267]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[284]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[182]

Drug(s) Affected By Myosin-11 (MYH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[285]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[287]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[288]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[152]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[289]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[290]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[290]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[271]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]

Drug(s) Affected By Tumor protein D52 (TPD52)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[291]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[258]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[258]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[267]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[284]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[294]

Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[295]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[295]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[297]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[298]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[299]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[300]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[295]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[295]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[301]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[303]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[303]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[304]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[305]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[303]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[303]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[306]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[237]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[307]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[308]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[309]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[311]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[312]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[313]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[314]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[315]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[316]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[317]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[236]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[258]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[318]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[258]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[319]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[320]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[321]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[258]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[322]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[16]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[323]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[325]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[16]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[323]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]

Drug(s) Affected By Myosin-7 (MYH7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[267]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[284]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[327]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[328]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[327]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[329]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[328]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[328]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[330]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[331]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[331]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[331]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[332]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[333]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[334]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[335]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[16]
Selenium	DM25CGV	N. A.	N. A.	Approved	[336]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[337]

Drug(s) Affected By S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[338]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[284]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[339]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[271]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[340]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[341]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[341]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[341]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated L-type calcium channel (L-CaC)	TTXHYV6	NOUNIPROTAC	Modulator	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[5]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[6]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[7]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[8]
Cytochrome P450 102A1 (cyp102)	DE4OGUF	CPXB_BACMB	Substrate	[9] , [10]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Drug Response	[11]
Apolipoprotein A-I (APOA1)	OT5THARI	APOA1_HUMAN	Gene/Protein Processing	[12]
Apolipoprotein A-II (APOA2)	OTQ3HGTC	APOA2_HUMAN	Gene/Protein Processing	[12]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[13]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Gene/Protein Processing	[14]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[15]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Gene/Protein Processing	[16]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[17]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[18]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[19]

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