Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWFHMZ)

• Drug Name: Aminoglutethimide Drug Info
• Synonyms: Aminoglutethimidum; Aminoglutetimida; Cytadren; Elipten; Orimeten; Ciba Vision Brand of Aminoglutethimide; Novartis Brand of Aminoglutethimide; A 9657; Ba 16038; AG-1; Aminoglutethimide (AG); Aminoglutethimide [INN:BAN]; Aminoglutethimidum [INN-Latin]; Aminoglutetimida [INN-Spanish]; Ba-16038; C 16038-BA; Cytadren (TN); Dl-Aminoglutethimide; P-Aminoglutethimide; Aminoglutethimide (USP/INN); Glutethimide, para-amino; Alpha-(p-Aminophenyl)-alpha-ethylglutarimide; (+-)-3-(p-Aminophenyl)-3-ethyl-2,6-piperidinedione; (+/-)-p-AMINOGLUTETHIMIDE; (inverted question mark)-p-Aminoglutethimide; 2-(p-Aminophenyl)-2-ethylglutarimide; 3-(4-Aminophenyl)-3-ethyl-2,6-piperidindion; 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione; 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione; 3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione; 3-Ethyl-3-(p-aminophenyl)-2,6-dioxopiperidine

Indication

Disease Entry	ICD 11	Status	REF
Cushing disease	5A70	Approved	[1]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 2145
  ChEBI ID: CHEBI:2654
  CAS Number: CAS 125-84-8
  TTD Drug ID: DMWFHMZ
  INTEDE Drug ID: DR2260
  ACDINA Drug ID: D00834

Molecule-Related Drug Atlas

Drug(s) Targeting Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Anastrozole	DMNP60F	Breast cancer	2C60-2C65	Approved	[8]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[9]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[9]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[10]
Testolactone	DMVY4GN	Breast cancer	2C60-2C65	Approved	[11]
LIAROZOLE	DM4OYXE	Dermatological disease	DA24.Y	Phase 2/3	[12]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[13]
BGS-649	DMO4MNQ	Endometriosis	GA10	Phase 2	[14]
NARINGENIN	DMHAZLM	N. A.	N. A.	Phase 1	[12]
FORMESTANE	DMWIDJK	Breast cancer	2C60-2C65	Withdrawn from market	[15]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[24]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[26]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[27]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[29]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[26]

Drug(s) Targeting Cholesterol desmolase (CYP11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MK-5684	DMU93NS	Prostate cancer	2C82.0	Phase 1/2	[16]
3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione	DM20DXS	Discovery agent	N.A.	Investigative	[17]
3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione	DMD5YKO	Discovery agent	N.A.	Investigative	[17]

Drug(s) Affected By Adenylate kinase isoenzyme 1 (AK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[5]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[5]
Anastrozole	DMNP60F	Breast cancer	2C60-2C65	Approved	[5]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[21]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]

Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[32]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[36]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[37]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[37]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[38]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[45]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[46]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[47]

Drug(s) Affected By Peroxisomal multifunctional enzyme type 2 (HSD17B4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[48]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Haloperidol	DM96SE0	Delirium		Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[53]

Drug(s) Affected By Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial (GATD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[54]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[55]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[56]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[58]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[59]

Drug(s) Affected By Histone H2B type 1-K (H2BC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[63]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[45]

Drug(s) Affected By Protein CutA (CUTA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[70]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[59]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[72]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[73]

Drug(s) Affected By Nucleoplasmin-3 (NPM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[76]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[77]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[78]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[79]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[83]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]

Drug(s) Affected By Lupus La protein (SSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[74]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[74]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[89]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[66]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[90]

Drug(s) Affected By Gelsolin (GSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[97]
Selenium	DM25CGV	N. A.	N. A.	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[104]

Drug(s) Affected By Histone H2A.Z (H2AZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[107]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[56]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[110]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[109]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[113]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]

Drug(s) Affected By Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[84]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[121]

Drug(s) Affected By Translationally-controlled tumor protein (TPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[126]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[122]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[128]

Drug(s) Affected By N-acetylglucosamine-6-sulfatase (GNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[52]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[131]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[72]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[132]

Drug(s) Affected By Histone H1.2 (H1-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[55]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]

Drug(s) Affected By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[135]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[135]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[135]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[136]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]

Drug(s) Affected By Low molecular weight phosphotyrosine protein phosphatase (ACP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[139]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[140]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[141]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[18]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[142]

Drug(s) Affected By DNA replication licensing factor MCM3 (MCM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]

Drug(s) Affected By High mobility group protein B2 (HMGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[150]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]

Drug(s) Affected By Proteasome subunit beta type-4 (PSMB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[87]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[127]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[153]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[18]

Drug(s) Affected By Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[56]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[77]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[159]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[87]

Drug(s) Affected By T-complex protein 1 subunit zeta (CCT6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[21]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[161]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[164]

Drug(s) Affected By Phosphatidylinositol transfer protein beta isoform (PITPNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[21]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[166]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]

Drug(s) Affected By T-complex protein 1 subunit delta (CCT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[142]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[167]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[74]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[73]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[168]

Drug(s) Affected By B-cell receptor-associated protein 31 (BCAP31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[169]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[5]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[70]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[18]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[170]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[141]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]

Drug(s) Affected By Histone H3.1 (H3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[176]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]

Drug(s) Affected By Brain acid soluble protein 1 (BASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[178]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]

Drug(s) Affected By Lamin-B2 (LMNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[179]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[180]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[142]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[181]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[182]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[72]

Drug(s) Affected By Histone H3.2 (H3C13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[184]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[183]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Nuclear pore membrane glycoprotein 210 (NUP210)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[162]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[166]

Drug(s) Affected By Unconventional myosin-XVIIIa (MYO18A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[187]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[188]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[128]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[189]

Drug(s) Affected By Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[87]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[77]

Drug(s) Affected By Histone H2A type 1-H (H2AC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[190]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[162]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[191]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[184]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[192]

Drug(s) Affected By 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[194]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[195]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[196]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[197]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[198]

Drug(s) Affected By T-complex protein 1 subunit eta (CCT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[21]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[21]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[79]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[74]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[89]

Drug(s) Affected By RNA transcription, translation and transport factor protein (RTRAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[59]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[200]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[201]

Drug(s) Affected By Hypoxia up-regulated protein 1 (HYOU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[56]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[204]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[205]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[206]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[206]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[207]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[208]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[209]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[206]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[206]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[206]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[210]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[211]

Drug(s) Affected By Follitropin subunit beta (FSHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[212]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[213]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[214]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[215]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[216]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[217]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[218]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[219]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[220]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]

Drug(s) Affected By Lutropin subunit beta (LHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[221]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[223]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[224]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[212]
Alprazolam	DMC7XDN	Anxiety		Approved	[225]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Norethindrone acetate	DMDGCQP	N. A.	N. A.	Approved	[222]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[224]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[216]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[227]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[228]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[229]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[230]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[231]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[232]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[233]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aromatase (CYP19A1)	TTSZLWK	CP19A_HUMAN	Inhibitor	[2]
Cholesterol desmolase (CYP11A1)	TTSYVO6	CP11A_HUMAN	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein theta	OTWG7F3H	1433T_HUMAN	Gene/Protein Processing	[4]
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)	OT7RJON4	HCD2_HUMAN	Gene/Protein Processing	[4]
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B)	OT3SQMLU	AN32B_HUMAN	Gene/Protein Processing	[4]
Adenylate kinase isoenzyme 1 (AK1)	OT614AR3	KAD1_HUMAN	Drug Response	[5]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[6]
B-cell receptor-associated protein 31 (BCAP31)	OTKSACR4	BAP31_HUMAN	Gene/Protein Processing	[4]
Brain acid soluble protein 1 (BASP1)	OTF4VS5G	BASP1_HUMAN	Gene/Protein Processing	[4]
Catechol O-methyltransferase (COMT)	OTPWKTQG	COMT_HUMAN	Gene/Protein Processing	[4]
DNA replication licensing factor MCM3 (MCM3)	OTOOHQPM	MCM3_HUMAN	Gene/Protein Processing	[4]
Follitropin subunit beta (FSHB)	OTGLS283	FSHB_HUMAN	Gene/Protein Processing	[7]

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