Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXJ7O8)

Drug Name
Vitamin C Drug Info
Synonyms
l-ascorbic acid; vitamin C; 50-81-7; L(+)-Ascorbic acid; Ascorbicap; Cevitamic acid; Ascoltin; Hybrin; Secorbate; Proscorbin; Lemascorb; Ascorteal; Ascorbajen; Vitascorbol; Vitamisin; Natrascorb; Citriscorb; Cescorbat; Ascorbutina; Testascorbic; Cevitamin; Cetemican; Allercorb; Vitacimin; Roscorbic; Laroscorbine; Viscorin; Redoxon; Cenetone; Cegiolan; Cebicure; Ascorvit; Viforcit; Concemin; Cevital; Cergona; Cemagyl; Cebione; Cantaxin; Ascorin; Vitacee; Vicelat; Cevimin; Cetamid; Cenolate; Celaskon; Vitacin; Adenex; Ascorb; Ascorbicab; Ascorbicin; Ascorbinsaeure; Cantan; Cebid; Cebion; Cecon; Ceglion; Celin; Cemill; Cereon; Cetebe; Cevalin; Cevatine; Cevex; Cevibid; Cevitan; Cevitex; Cewin; Ciamin; Cipca; Colascor; Cortalex; Duoscorb; Ferancee; Hicee; Magnorbin; Ribena; Scorbacid; Semidehydroascorbate; Sodascorbate; Stuartinic; Sunkist; Tolfrinic; Vitace; Xitix; Acid Ascorbic; Acide ascorbique; Acido ascorbico; Acidum ascorbicum; Acidum ascorbinicum; Antiscorbic vita min; Antiscorbic vitamin; Antiscorbutic factor; Antiscorbutic vitamin; Ascorbyl radical; Catavin C; Ce lent; Component of Cortalex; Component of Endoglobin Forte; Component of Ferancee; Davitamon C; Ferrous ascorbate; Kyselina askorbova; Kyselina askorbova [Czech]; Magnesium Ascorbicum; Monodehydroascorbic acid; Natrascorb injectable; Oral Vitamin C; Planavit C; Roscorbi c; Vicomin C; Acide ascorbique [INN-French]; Acido ascorbico [INN-Spanish]; Acidum ascorbicum [INN-Latin]; Arco-cee; Ascoltin (TN); Ascorbic Acid, Monosodium Salt; Ascorbicap (TN); C-Level; C-Long; C-Quin; C-Span; C-Vimin; Cee-Caps TD; Cee-Vite; Cee-caps td; Cetane-Caps TC; Cetane-Caps TD; Cevi-Bid; Component of E and C-Level; IDO-C; Iron(II) ascorbate; Iron-ascorbic acid complexes; L-Ascorbic acid; L-Lyxoascorbic acid; L-Xyloascorbic acid; L-ascorbic acid; Liqui-Cee; Meri-C; Sodium Ascorbate (Ascorbic Acid); Vitamin-C; Ascorbic acid [BAN:INN:JAN]; Ascorbic acid [INN:BAN:JAN]; CE-VI-Sol; Ce-Mi-Lin; Dora-C-500; L-3-Ketothreohexuronic acid lactone; L-3-ketothreohexuronic acid; L-Ascorbic acid, free radical form; Ascor-bid; Ascorbic acid (JP15/USP/INN); Ascor-BID; L-(+)-Ascorbic Acid; L-threo-Hex-2-enonic acid, gamma-lactone; L-threo-hex-1-eofuranos-3-ulose; L-threo-hex-2-enono-1,4-lactone; (2R)-2-[(1S)-1,2-Dihydroxyethyl]-4,5-dihydroxy-furan-3-one; (2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-one; (5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one; 2-(1,2-Dihydroxyethyl)-4,5-dihydroxyfuran-3-one; 3-Keto-L-gulofuranolactone; 3-Oxo-L-gulofuranolactone; 3-Oxo-L-gulofuranolactone (enol form); [14C]ascorbic acid
Indication
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [1]
Carcinoma 2A00-2F9Z Approved [2]
Coagulation defect 3B10.0 Approved [3]
Desmoplastic small round cell tumor Approved [4]
Plasma cell myeloma 2A83.1 Approved [5]
Refractory plasma cell neoplasm Approved [6]
Shock MG40 Approved [7]
Vitamin C deficiency 5B56 Approved [8]
Vitamin deficiency 5B55-5B71 Approved [9]
Urinary tract infection GC08 Phase 2 [8]
Therapeutic Class
Vitamins
Cross-matching ID
PubChem CID
54670067
ChEBI ID
CHEBI:29073
CAS Number
CAS 50-81-7
TTD Drug ID
DMXJ7O8
VARIDT Drug ID
DR00289
INTEDE Drug ID
DR0144

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Solute carrier family 23 member 2 (SLC23A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [28]
Drug(s) Targeting Solute carrier family 23 member 1 (SLC23A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
phloretin DMYA50U Discovery agent N.A. Investigative [29]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [54]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [56]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [45]
Taurocholic Acid DM2LZ8F Type-2 diabetes 5A11 Phase 1/2 [54]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [57]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [58]
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Drug(s) Targeting Collagen (CO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Collagenase DMFJ2OG Dermal ulcers 1A36 Approved [30]
MRG-201 DM9M5WV Keloid EE60 Phase 2 [31]
Clostridial collagenase DMWTBG8 Discovery agent N.A. Investigative [32]
Drug(s) Metabolized By Thiopurine methyltransferase (TPMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [34]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [35]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [36]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [37]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [38]
Epinephrine DM3KJBC Acute asthma CA23 Approved [39]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [40]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [41]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [42]
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Drug(s) Metabolized By Prolyl 4-hydroxylase alpha-2 (P4HA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
alpha-ketoglutaric acid DM5LFYN Discovery agent N.A. Investigative [16]
Drug(s) Metabolized By Prolyl 4-hydroxylase alpha-1 (P4HA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
alpha-ketoglutaric acid DM5LFYN Discovery agent N.A. Investigative [16]
Drug(s) Metabolized By HIF-prolyl hydroxylase 2 (EGLN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
alpha-ketoglutaric acid DM5LFYN Discovery agent N.A. Investigative [17]
Drug(s) Metabolized By Prolyl 4-hydroxylase alpha-3 (P4HA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
alpha-ketoglutaric acid DM5LFYN Discovery agent N.A. Investigative [18]
Drug(s) Affected By Prolyl 4-hydroxylase subunit alpha-2 (P4HA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Ethanol DMDRQZU Chronic pain MG30 Approved [48]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [49]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [51]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [52]
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Drug(s) Affected By Nitric oxide synthase 3 (NOS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [66]
Fructose DM43AN2 Vomiting MD90 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
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Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [71]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [72]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Panobinostat DM58WKG Chronic graft versus host disease Approved [75]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [76]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [77]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [69]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [78]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [79]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [80]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [81]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [82]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [83]
Ethacrynic acid DM60QMR Edema MG29 Approved [84]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [85]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [86]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [87]
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Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fomepizole DM6VOWQ Athylene glycol or methanol poisoning NE61 Approved [88]
Ademetionine DMYQDBO Hepatic fibrosis DB93.0 Approved [89]
Theophylline DMRJFN9 Bronchitis CA20 Approved [61]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [90]
Ethanol DMDRQZU Chronic pain MG30 Approved [91]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [56]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [92]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [61]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [93]
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Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tegafur DM31ZQM Solid tumour/cancer 2A00-2F9Z Approved [94]
Methoxsalen DME8FZ9 Cutaneous T-cell lymphoma 2B01 Approved [95]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [56]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [98]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [101]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [102]
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Drug(s) Affected By Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Testosterone DM7HUNW Hot flushes GA30 Approved [105]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [106]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [107]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [108]
Ethanol DMDRQZU Chronic pain MG30 Approved [109]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [110]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [111]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [112]
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Drug(s) Affected By Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [113]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [114]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [115]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [116]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [115]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [118]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [119]
Quercetin DM3NC4M Obesity 5B81 Approved [120]
Fluoxetine DM3PD2C Bipolar depression Approved [115]
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Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [121]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [122]
Testosterone DM7HUNW Hot flushes GA30 Approved [106]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [123]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [124]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [125]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [126]
Hexachlorophene DMLKSE0 Bacterial infection 1A00-1C4Z Approved [127]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [112]
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Drug(s) Affected By D-3-phosphoglycerate dehydrogenase (PHGDH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [128]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [122]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [131]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [131]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
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Drug(s) Affected By Asparagine--tRNA ligase, cytoplasmic (NARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [132]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [131]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [131]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [131]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [131]
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Drug(s) Affected By Dickkopf-related protein 1 (DKK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [135]
Quercetin DM3NC4M Obesity 5B81 Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [138]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [139]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Leflunomide DMR8ONJ Arthritis FA20 Approved [140]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
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Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [142]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [145]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [146]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [148]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
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Drug(s) Affected By Bifunctional glutamate/proline--tRNA ligase (EPRS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [131]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [131]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [131]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Testosterone enanthate DMB6871 N. A. N. A. Approved [149]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [131]
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Drug(s) Affected By Asparagine synthetase (ASNS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [150]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [151]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [132]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [151]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [152]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [153]
Fluoxetine DM3PD2C Bipolar depression Approved [151]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
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Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [154]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [155]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [156]
Etretinate DM2CZFA Keratosis ED56 Approved [157]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [158]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [159]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [160]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [161]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [162]
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Drug(s) Affected By Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [152]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [163]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [163]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Leflunomide DMR8ONJ Arthritis FA20 Approved [140]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [163]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [164]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
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Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [165]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [166]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [131]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [167]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [56]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [167]
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Drug(s) Affected By Threonine--tRNA ligase 1, cytoplasmic (TARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [168]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [132]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Panobinostat DM58WKG Chronic graft versus host disease Approved [75]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Leflunomide DMR8ONJ Arthritis FA20 Approved [140]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [131]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [131]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
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Drug(s) Affected By Serine hydroxymethyltransferase, mitochondrial (SHMT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [51]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [169]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [170]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [171]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystathionine beta-synthase (CBS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [173]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [174]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ethanol DMDRQZU Chronic pain MG30 Approved [48]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [175]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [49]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stress-70 protein, mitochondrial (HSPA9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [177]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [178]
Clozapine DMFC71L Schizophrenia 6A20 Approved [168]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [169]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycine--tRNA ligase (GARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [179]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [147]
Leflunomide DMR8ONJ Arthritis FA20 Approved [140]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [131]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [131]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Isoleucine--tRNA ligase, cytoplasmic (IARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [176]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [182]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [152]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [147]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [131]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [131]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [131]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alanine--tRNA ligase, cytoplasmic (AARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [183]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [131]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [131]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [184]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Clozapine DMFC71L Schizophrenia 6A20 Approved [168]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [131]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [185]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic initiation factor 4A-I (EIF4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [186]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [187]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [188]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [189]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Paclitaxel DMLB81S Breast carcinoma Approved [190]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [167]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [133]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein disulfide-isomerase A2 (PDIA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Arsenic DMTL2Y1 N. A. N. A. Approved [193]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [194]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [195]
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [196]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [197]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit A (EIF3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [198]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [200]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [201]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [167]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [202]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [171]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [150]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [203]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [204]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [205]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [206]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [207]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Racecadotril DMFOTZ7 Diarrhea ME05.1 Approved [208]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [152]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [175]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [209]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [183]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [174]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [184]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Clozapine DMFC71L Schizophrenia 6A20 Approved [168]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [210]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tribbles homolog 3 (TRIB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [150]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [175]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [211]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [163]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [212]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [213]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [163]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [174]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [206]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Structural maintenance of chromosomes protein 6 (SMC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [123]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [201]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Bortezomib DMNO38U Leukemia Approved [214]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [171]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [176]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [215]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [121]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit C (EIF3C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [131]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [131]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [216]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [131]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [167]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysyl oxidase homolog 2 (LOXL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [217]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [122]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Testosterone enanthate DMB6871 N. A. N. A. Approved [149]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Ethanol DMDRQZU Chronic pain MG30 Approved [218]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [219]
Indomethacin DMSC4A7 Bursitis Approved [220]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [221]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [222]
Methotrexate DM2TEOL Anterior urethra cancer Approved [223]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [225]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [83]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [226]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfotransferase 1A3 (SULT1A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [228]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ethanol DMDRQZU Chronic pain MG30 Approved [229]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [230]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [231]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [232]
Epinephrine DM3KJBC Acute asthma CA23 Approved [233]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [233]
Estrone DM5T6US Acne vulgaris ED80 Approved [234]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [56]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [235]
Minoxidil DMA2Z4F Alopecia ED70 Approved [233]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [232]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [233]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [236]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [237]
Methotrexate DM2TEOL Anterior urethra cancer Approved [238]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [239]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [184]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [240]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [241]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [242]
Arsenic DMTL2Y1 N. A. N. A. Approved [243]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [56]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor erythroid 2-related factor 3 (NFE2L3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [245]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [163]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [163]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [214]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [246]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphoribosylformylglycinamidine synthase (PFAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Testosterone DM7HUNW Hot flushes GA30 Approved [106]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [106]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [200]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [201]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [185]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [237]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [200]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [170]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [248]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [249]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [57]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [250]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibulin-1 (FBLN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [121]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Selenium DM25CGV N. A. N. A. Approved [176]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [128]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Progranulin (GRN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [200]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [170]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [133]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [242]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [171]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glypican-1 (GPC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Testosterone enanthate DMB6871 N. A. N. A. Approved [149]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [171]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [252]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [123]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Host cell factor 1 (HCFC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [237]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [253]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [170]
Arsenic DMTL2Y1 N. A. N. A. Approved [254]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [255]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [219]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Elongator complex protein 6 (ELP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [256]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Leflunomide DMR8ONJ Arthritis FA20 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [170]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [171]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [257]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [250]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protocadherin Fat 1 (FAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [259]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [260]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [261]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Putative PRAME family member 13 (PRAMEF13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Drug(s) Affected By C-Maf-inducing protein (CMIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [148]
Leflunomide DMR8ONJ Arthritis FA20 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [262]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [133]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [56]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [219]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prolyl 3-hydroxylase OGFOD1 (OGFOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [262]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [263]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [219]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [264]
Urethane DM7NSI0 N. A. N. A. Phase 4 [265]
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Drug(s) Affected By Autism susceptibility gene 2 protein (AUTS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [133]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [258]
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Drug(s) Affected By Ester hydrolase C11orf54 (C11ORF54)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [256]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [148]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [56]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [57]
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Drug(s) Affected By Ketosamine-3-kinase (FN3KRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [200]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [170]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [133]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [171]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [267]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [268]
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Drug(s) Affected By GPN-loop GTPase 1 (GPN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [219]
Urethane DM7NSI0 N. A. N. A. Phase 4 [265]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [269]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitochondrial import receptor subunit TOM7 homolog (TOMM7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [176]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [219]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [270]
AHPN DM8G6O4 Discovery agent N.A. Investigative [271]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [269]
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Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [272]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [273]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [175]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [274]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [275]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [174]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [189]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [276]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [277]
Diazepam DM08E9O Alcohol withdrawal Approved [278]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [135]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [279]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [277]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [280]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [277]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [281]
Testosterone DM7HUNW Hot flushes GA30 Approved [282]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [272]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [245]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [174]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [131]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [131]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [131]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [283]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [285]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [256]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [285]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [285]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [286]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Fluoxetine DM3PD2C Bipolar depression Approved [163]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [285]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [61]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [260]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [287]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [288]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [289]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [245]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [290]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [291]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [292]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [293]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin-binding sialoprotein (IBSP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [294]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [295]
Calcidiol DMN4CV5 Hypophosphatemia Approved [294]
Magnesium DMU4ORS Ischemic stroke 8B11.5Z Approved [296]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [297]
GSK2816126 DMJDVW4 Solid tumour/cancer 2A00-2F9Z Phase 1 [298]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [267]
EUGENOL DM7US1H Discovery agent N.A. Patented [299]
alpha-ketoglutaric acid DM5LFYN Discovery agent N.A. Investigative [300]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [287]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [301]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [302]
Quercetin DM3NC4M Obesity 5B81 Approved [303]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [291]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [139]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [148]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [304]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [116]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [305]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [306]
Methotrexate DM2TEOL Anterior urethra cancer Approved [307]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [308]
Quercetin DM3NC4M Obesity 5B81 Approved [309]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [175]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [245]
Panobinostat DM58WKG Chronic graft versus host disease Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [310]
Gefitinib DM15F0X Colon adenocarcinoma Approved [311]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [312]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [313]
Etretinate DM2CZFA Keratosis ED56 Approved [314]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [152]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [315]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [316]
Quercetin DM3NC4M Obesity 5B81 Approved [317]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [318]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenylate cyclase type 6 (ADCY6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [176]
Leflunomide DMR8ONJ Arthritis FA20 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Paclitaxel DMLB81S Breast carcinoma Approved [319]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [167]
Arsenic DMTL2Y1 N. A. N. A. Approved [254]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [320]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [167]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Forkhead box protein O3 (FOXO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [321]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [322]
Quercetin DM3NC4M Obesity 5B81 Approved [323]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [211]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [324]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [212]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [325]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [326]
Leflunomide DMR8ONJ Arthritis FA20 Approved [140]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superoxide dismutase (SOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [327]
Haloperidol DM96SE0 Delirium Approved [61]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [328]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [329]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [330]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [331]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [332]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Epinephrine DM3KJBC Acute asthma CA23 Approved [333]
Quercetin DM3NC4M Obesity 5B81 Approved [334]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [335]
Gefitinib DM15F0X Colon adenocarcinoma Approved [336]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [337]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [338]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [339]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [340]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [203]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [237]
Selenium DM25CGV N. A. N. A. Approved [341]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [342]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Verapamil DMA7PEW Angina pectoris BA40 Approved [344]
Selenium DM25CGV N. A. N. A. Approved [341]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [344]
Quercetin DM3NC4M Obesity 5B81 Approved [345]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [346]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [347]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [348]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Low-density lipoprotein receptor (LDLR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [349]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [135]
Desogestrel DM27U4Y Contraception QA21 Approved [349]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [350]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [351]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [346]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [175]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [209]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [287]
Diazepam DM08E9O Alcohol withdrawal Approved [352]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [328]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [288]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [353]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [354]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [355]
Quercetin DM3NC4M Obesity 5B81 Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apolipoprotein A-I (APOA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [357]
Quercetin DM3NC4M Obesity 5B81 Approved [358]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [346]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [359]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [77]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [360]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [361]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [362]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [363]
Quercetin DM3NC4M Obesity 5B81 Approved [364]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [365]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [275]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [366]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [367]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [330]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [368]
Haloperidol DM96SE0 Delirium Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [369]
Selenium DM25CGV N. A. N. A. Approved [370]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [371]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [372]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [373]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [374]
Selenium DM25CGV N. A. N. A. Approved [375]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [376]
Epinephrine DM3KJBC Acute asthma CA23 Approved [333]
Quercetin DM3NC4M Obesity 5B81 Approved [377]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [378]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [346]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [379]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [380]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione peroxidase 1 (GPX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [381]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Amlexanox DM0DQM5 Respiratory tract inflammation CA07 Approved [382]
Selenium DM25CGV N. A. N. A. Approved [383]
Methotrexate DM2TEOL Anterior urethra cancer Approved [384]
Quercetin DM3NC4M Obesity 5B81 Approved [385]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [386]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [387]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [388]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Sp1 (SP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [389]
Quercetin DM3NC4M Obesity 5B81 Approved [390]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [391]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [392]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [393]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [389]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [394]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [395]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [396]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [397]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [285]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [285]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [285]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [285]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [398]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [399]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [150]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [400]
Verapamil DMA7PEW Angina pectoris BA40 Approved [401]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [374]
Selenium DM25CGV N. A. N. A. Approved [402]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [403]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [404]
Methotrexate DM2TEOL Anterior urethra cancer Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [405]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [406]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [407]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [400]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [408]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [143]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [285]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [330]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [409]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [285]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [410]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [411]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [412]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [413]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [142]
Verapamil DMA7PEW Angina pectoris BA40 Approved [414]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [415]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [416]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [417]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Xaa-Pro dipeptidase (PEPD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [418]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [419]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Gentamicin DMKINJO Bacteremia 1A73 Approved [420]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [170]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [133]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [421]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [116]
Gefitinib DM15F0X Colon adenocarcinoma Approved [422]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [423]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [424]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [425]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [403]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [426]
Quercetin DM3NC4M Obesity 5B81 Approved [364]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivacaftor DMZC1HS Cystic fibrosis CA25 Approved [427]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [428]
Quercetin DM3NC4M Obesity 5B81 Approved [429]
Miglustat DM5J64S Niemann-Pick disease type C Approved [430]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [431]
Milrinone DM8TUPF Congestive heart failure BD10 Approved [428]
Oxidized glutathione DM9EQC0 Breast cancer 2C60-2C65 Approved [432]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [432]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [138]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [22]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [200]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [49]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [276]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Vascular endothelial growth factor receptor 1 (FLT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Panobinostat DM58WKG Chronic graft versus host disease Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [433]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [434]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Haloperidol DM96SE0 Delirium Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [435]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [201]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [436]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [437]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [417]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [438]
Gefitinib DM15F0X Colon adenocarcinoma Approved [336]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [439]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [440]
Selenium DM25CGV N. A. N. A. Approved [176]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [441]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [442]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [443]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [152]
Quercetin DM3NC4M Obesity 5B81 Approved [136]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [346]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [152]
Testosterone DM7HUNW Hot flushes GA30 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Menthol DMG2KW7 Back pain ME84.Z Approved [444]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [445]
Paclitaxel DMLB81S Breast carcinoma Approved [446]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [447]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [245]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [448]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [449]
Haloperidol DM96SE0 Delirium Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Clozapine DMFC71L Schizophrenia 6A20 Approved [168]
Menthol DMG2KW7 Back pain ME84.Z Approved [444]
Orlistat DMRJSP8 Obesity 5B81 Approved [450]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [304]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [451]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [452]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [453]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [454]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [455]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [456]
Quercetin DM3NC4M Obesity 5B81 Approved [457]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [132]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [458]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [459]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [460]
Quercetin DM3NC4M Obesity 5B81 Approved [323]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [128]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [174]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [216]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 6 (STAT6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [304]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Panobinostat DM58WKG Chronic graft versus host disease Approved [75]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [463]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [461]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [464]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [465]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [466]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [467]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [468]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [469]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [470]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [471]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [472]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [473]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor SOX-2 (SOX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [400]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [474]
Quercetin DM3NC4M Obesity 5B81 Approved [475]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [245]
Panobinostat DM58WKG Chronic graft versus host disease Approved [75]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [476]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [477]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [174]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [478]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Natural resistance-associated macrophage protein 2 (SLC11A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [479]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [49]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [260]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [480]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [481]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [328]
Selenium DM25CGV N. A. N. A. Approved [176]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [482]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [483]
Methotrexate DM2TEOL Anterior urethra cancer Approved [484]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [485]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Biotin--protein ligase (HLCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [152]
Quercetin DM3NC4M Obesity 5B81 Approved [486]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [122]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [152]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [184]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [487]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [133]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase omega-1 (GSTO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [488]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Menthol DMG2KW7 Back pain ME84.Z Approved [444]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [489]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [490]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C motif chemokine 6 (CXCL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [328]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [491]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [216]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Folic Acid DMEMBJC Colorectal carcinoma Approved [492]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [51]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [493]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [494]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [495]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [496]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peripheral myelin protein 22 (PMP22)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [245]
Testosterone DM7HUNW Hot flushes GA30 Approved [282]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [283]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [51]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [497]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Arsenic DMTL2Y1 N. A. N. A. Approved [498]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [474]
Quercetin DM3NC4M Obesity 5B81 Approved [499]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [500]
Panobinostat DM58WKG Chronic graft versus host disease Approved [75]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [476]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [501]
Testosterone DM7HUNW Hot flushes GA30 Approved [502]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [503]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [504]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transgelin (TAGLN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [151]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [491]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [505]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [151]
Methotrexate DM2TEOL Anterior urethra cancer Approved [506]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [151]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Fluoxetine DM3PD2C Bipolar depression Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [507]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [505]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Sp4 (SP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [389]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [245]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [389]
Testosterone DM7HUNW Hot flushes GA30 Approved [106]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [260]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [219]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [123]
Urethane DM7NSI0 N. A. N. A. Phase 4 [265]
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Drug(s) Affected By Transcription factor Sp3 (SP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [389]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [389]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [395]
Leflunomide DMR8ONJ Arthritis FA20 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [508]
Promegestone DMK4S8I Gynecological disease GA6Z Approved [509]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [489]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [510]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [511]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [219]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [61]
Selenium DM25CGV N. A. N. A. Approved [176]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [512]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [346]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [513]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [514]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [515]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [200]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-binding protein Ikaros (IKZF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Bortezomib DMNO38U Leukemia Approved [214]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [494]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [199]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [267]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [201]
Deguelin DMXT7WG Esophageal squamous cell carcinoma 2E60.1 Investigative [516]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [517]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [272]
Selenium DM25CGV N. A. N. A. Approved [176]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [209]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [518]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [131]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [131]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [519]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [520]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [521]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [522]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [523]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [304]
Gefitinib DM15F0X Colon adenocarcinoma Approved [524]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [525]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [313]
Selenium DM25CGV N. A. N. A. Approved [176]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [526]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [527]
Verapamil DMA7PEW Angina pectoris BA40 Approved [401]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [203]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [330]
Selenium DM25CGV N. A. N. A. Approved [176]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [528]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [529]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [376]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [530]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [531]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [532]
Prednisone DM2HG4X Acute asthma CA23 Approved [533]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [533]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [534]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [535]
Epinephrine DM3KJBC Acute asthma CA23 Approved [536]
Quercetin DM3NC4M Obesity 5B81 Approved [537]
Fluoxetine DM3PD2C Bipolar depression Approved [538]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [539]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plasma membrane ascorbate-dependent reductase CYBRD1 (CYBRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [540]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [170]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [219]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [123]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [250]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [121]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [283]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Proprotein convertase subtilisin/kexin type 9 (PCSK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [175]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [541]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [542]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [49]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [543]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [230]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [544]
Fructose DM43AN2 Vomiting MD90 Approved [545]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [546]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [547]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [548]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [549]
Leflunomide DMR8ONJ Arthritis FA20 Approved [140]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [549]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Haptoglobin (HP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [399]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [494]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [423]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [550]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [551]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [552]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [239]
Selenium DM25CGV N. A. N. A. Approved [176]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [553]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [129]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [554]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [555]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [213]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [556]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [557]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [558]
Paclitaxel DMLB81S Breast carcinoma Approved [559]
Allopurinol DMLPAOB Gout FA25 Approved [559]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [559]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [559]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [559]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [559]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [560]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase theta-1 (GSTT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [561]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [346]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [167]
Arsenic DMTL2Y1 N. A. N. A. Approved [254]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [56]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [562]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [255]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [563]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [564]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [565]
Ethanol DMDRQZU Chronic pain MG30 Approved [566]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [144]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [144]
Methyldopa DM5I621 Hypertension BA00-BA04 Approved [567]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Testosterone DM7HUNW Hot flushes GA30 Approved [106]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [106]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Collagen (CO) TTK982E NOUNIPROTAC Activator [10]
Solute carrier family 23 member 1 (SLC23A1) TT6XAGK S23A1_HUMAN Modulator [11]
Solute carrier family 23 member 2 (SLC23A2) TTOP832 S23A2_HUMAN Modulator [12]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Sodium-dependent vitamin C transporter 1 (SLC23A1) DT3KH2X S23A1_HUMAN Substrate [13]
Sodium-dependent vitamin C transporter 2 (SLC23A2) DTVY9PJ S23A2_HUMAN Substrate [14]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Thiopurine methyltransferase (TPMT) DEFQ8VO TPMT_HUMAN Substrate [15]
Prolyl 4-hydroxylase alpha-1 (P4HA1) DESO5ZY P4HA1_HUMAN Substrate [16]
Prolyl 4-hydroxylase alpha-2 (P4HA2) DE5EGK0 P4HA2_HUMAN Substrate [16]
HIF-prolyl hydroxylase 2 (EGLN1) DEWO724 EGLN1_HUMAN Substrate [17]
Prolyl 4-hydroxylase alpha-3 (P4HA3) DE2L4RX P4HA3_HUMAN Substrate [18]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) OTNAZVKB 3BHS1_HUMAN Gene/Protein Processing [19]
Adenylate cyclase type 6 (ADCY6) OTFOY4WW ADCY6_HUMAN Gene/Protein Processing [20]
Alanine--tRNA ligase, cytoplasmic (AARS1) OTW8D813 SYAC_HUMAN Gene/Protein Processing [21]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Post-Translational Modifications [22]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Gene/Protein Processing [23]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Gene/Protein Processing [23]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) OTG7J4BP PPBT_HUMAN Gene/Protein Processing [24]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Biotransformations [25]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Gene/Protein Processing [26]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [27]

References

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55 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
56 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
57 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
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67 Fructose induces the inflammatory molecule ICAM-1 in endothelial cells. J Am Soc Nephrol. 2008 Sep;19(9):1712-20.
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70 Beneficial effect of oleoylated lipids on paraoxonase 1: protection against oxidative inactivation and stabilization. Biochem J. 2003 Oct 15;375(Pt 2):275-85.
71 Serum paraoxonase activity before and after treatment of thyrotoxicosis. Clin Endocrinol (Oxf). 2004 Jan;60(1):75-80.
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