Details of Disease

General Information of Disease (ID: DISMB65Y)

• Disease Name: Alcohol use disorder
• Synonyms: intoxication, chronic alcoholic; dependence, alcohol; chronic alcoholic intoxication; alcoholism; alcoholic intoxication, chronic; alcohol use disorder; alcohol dependence; alcohol addiction; addiction, alcohol; abuse, alcohol; ethanol abuse; alcohol abuse
• Disease Class: 6C40: Substance abuse
• Definition: The use of alcoholic beverages to excess, either on individual occasions ("binge drinking") or as a regular practice.
• Disease Hierarchy:
  DIS327VW: Substance abuse
  DIS3K4KK: Alcohol-related disorders
  DISMB65Y: Alcohol use disorder
• ICD Code: ICD-11: ICD-11: 6C40.2
• Disease Identifiers:
  MONDO ID: MONDO_0002046
  MESH ID: D000437
  UMLS CUI: C0085762
  MedGen ID: 39339
  SNOMED CT ID: 15167005

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Zonisamide	DM0DTF7	Approved	Small molecular drug	[1]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PT-150	DMJVPHA	Phase 1	Small molecule	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 49 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
APOE	TTKS9CB	Limited	Biomarker	[3]
CCKAR	TTCG0AL	Limited	Biomarker	[4]
COMT	TTKWFB8	Limited	Genetic Variation	[5]
CYP2E1	TTWVHQ5	Limited	Biomarker	[6]
GABRA2	TTBMV1G	Limited	Genetic Variation	[7]
GATA4	TT1VDN2	Limited	Biomarker	[8]
GHSR	TTWDC17	Limited	Therapeutic	[9]
HDAC2	TTSHTOI	Limited	Biomarker	[10]
MAOA	TT3WG5C	Limited	Biomarker	[11]
NPY	TT64REZ	Limited	Biomarker	[12]
SLC6A3	TTVBI8W	Limited	Biomarker	[13]
TLR2	TTY7ZHS	Limited	Biomarker	[14]
DRD3	TT4C8EA	moderate	Genetic Variation	[15]
HCRTR1	TT60Q8D	moderate	Biomarker	[16]
HTR1B	TTK8CXU	moderate	Biomarker	[17]
LDLR	TTH0DUS	moderate	Altered Expression	[18]
POMC	TT21AKM	moderate	Biomarker	[19]
TPH2	TT3KLDP	moderate	Genetic Variation	[20]
CHRNA5	TTH2QRX	Strong	Biomarker	[21]
CNR2	TTMSFAW	Strong	Biomarker	[22]
CRH	TTA7YIZ	Strong	Biomarker	[23]
DRD4	TTE0A2F	Strong	Genetic Variation	[24]
F2	TT6L509	Strong	Biomarker	[25]
FN1	TTPJ921	Strong	Altered Expression	[26]
FSHB	TT13GFV	Strong	Biomarker	[27]
FYN	TT2B9KF	Strong	Biomarker	[28]
GABRA1	TT1MPAY	Strong	Biomarker	[29]
GABRG2	TT06RH5	Strong	Biomarker	[30]
GAL	TTXZAJ5	Strong	Biomarker	[31]
GGT1	TTZVT7O	Strong	Biomarker	[32]
HTR1A	TTSQIFT	Strong	Biomarker	[33]
IGF1	TTT6LOU	Strong	Biomarker	[34]
IL17A	TTG0MT6	Strong	Biomarker	[35]
MMP2	TTLM12X	Strong	Biomarker	[36]
NPY2R	TTJ6WK9	Strong	Biomarker	[37]
NPY5R	TTY6EWA	Strong	Biomarker	[38]
OPRL1	TTNT7K8	Strong	Biomarker	[39]
OPRM1	TTKWM86	Strong	Genetic Variation	[40]
PDE4B	TTVIAT9	Strong	Biomarker	[41]
SIRT1	TTUF2HO	Strong	Biomarker	[42]
SLC6A4	TT3ROYC	Strong	Biomarker	[43]
SNCA	TT08OSU	Strong	Biomarker	[44]
TACR1	TTZPO1L	Strong	Biomarker	[45]
TACR3	TTBPGLU	Strong	Biomarker	[46]
TF	TT8WXAV	Strong	Biomarker	[47]
CTRC	TT3RMNA	Definitive	Genetic Variation	[48]
KCNJ6	TTTIBVP	Definitive	Genetic Variation	[49]
NPC1L1	TTPD1CN	Definitive	Biomarker	[50]
TKT	TT04R7I	Definitive	Biomarker	[51]

This Disease Is Related to 7 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ADH4	DEOCWU3	moderate	Biomarker	[52]
AKR1A1	DED2FW3	moderate	Biomarker	[53]
ALDH1A1	DE2JP1Y	moderate	Biomarker	[54]
ABO	DESIA7R	Strong	Biomarker	[55]
ADH1B	DEEN9RD	Strong	Genetic Variation	[56]
ADH1C	DEM1HNL	Strong	Genetic Variation	[57]
ADH5	DEIOH6A	Strong	Biomarker	[58]

This Disease Is Related to 29 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DDX53	OTHK3EGZ	Limited	Biomarker	[59]
HFE	OTDD93KB	Limited	Genetic Variation	[60]
CLOCK	OTNEOJY7	Disputed	Genetic Variation	[61]
SHBG	OTPWU5IW	moderate	Genetic Variation	[62]
ANXA4	OTUCRYXL	Strong	Biomarker	[63]
CDK20	OTOLNN68	Strong	Biomarker	[41]
CHRNA3	OTCZQY1U	Strong	Biomarker	[21]
ERCC1	OTNPYQHI	Strong	Biomarker	[64]
GABBR1	OTU5A52J	Strong	Biomarker	[30]
GALR3	OTXU6PKO	Strong	Biomarker	[65]
GPHN	OTAKK1SV	Strong	Biomarker	[30]
LHB	OT5GBOVJ	Strong	Biomarker	[27]
MCM5	OTAHLB62	Strong	Biomarker	[64]
MPDZ	OT9WY1QM	Strong	Biomarker	[66]
PDYN	OTEJ6430	Strong	Biomarker	[67]
PENK	OT8P3HMP	Strong	Biomarker	[68]
RPL18A	OTKBMVCX	Strong	Biomarker	[69]
SPI1	OTVCA1D0	Strong	Therapeutic	[70]
TAS2R16	OT67HLNS	Strong	Biomarker	[71]
TAS2R38	OTX5MM36	Strong	Biomarker	[71]
TBX19	OTXEMR2U	Strong	Biomarker	[41]
ANKK1	OT0OM1O0	Definitive	Biomarker	[72]
GABRB3	OT80C3D4	Definitive	Genetic Variation	[73]
GINS2	OT974IYI	Definitive	Altered Expression	[74]
HPX	OT14T7Q1	Definitive	Biomarker	[75]
MARCHF11	OTODNSYN	Definitive	Biomarker	[76]
NCAN	OT8OO6ZE	Definitive	Genetic Variation	[77]
SPACA9	OTVRFX49	Definitive	Biomarker	[78]
SPG21	OTMKJSYS	Definitive	Biomarker	[78]

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