General Information of Disease (ID: DISUGBZL)

Disease Name Idiopathic cardiomyopathy
Definition A disease of the heart muscle or myocardium proper whose cause is unknown.
Disease Hierarchy
DISUPZRG: Cardiomyopathy
DISBBY0S: Idiopathic disease
DISUGBZL: Idiopathic cardiomyopathy
Disease Identifiers
MONDO ID
MONDO_0005110
MESH ID
D009202
UMLS CUI
C0033141
MedGen ID
18634
SNOMED CT ID
89461002

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 64 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
FAS TT7LTUJ Limited Biomarker [1]
FASLG TTO7014 Limited Biomarker [1]
PDE2A TTJGW1Z Limited Biomarker [2]
ADAM10 TTVXEGU Strong Biomarker [3]
ADCY5 TTN64VU Strong Biomarker [4]
ADCYAP1 TTW4LYC Strong Therapeutic [5]
ADORA2A TTM2AOE Strong Therapeutic [6]
ADRB2 TTG8ZWP Strong Biomarker [7]
AGT TT5C0UB Strong Biomarker [8]
AKT1 TTWTSCV Strong Biomarker [9]
APP TTE4KHA Strong Biomarker [10]
ATF3 TTCE793 Strong Therapeutic [11]
AVP TTJ8EWH Strong Biomarker [8]
AVPR2 TTK8R02 Strong Biomarker [8]
BDKRB2 TTGY8IW Strong Biomarker [12]
CASR TTBUYHA Strong Biomarker [13]
CAT TTPS279 Strong Therapeutic [14]
CBR1 TTVG0SN Strong Biomarker [15]
CS TTZA6B3 Strong Biomarker [16]
CYP2C9 TTR40YJ Strong Biomarker [17]
DMD TTWLFXU Strong Biomarker [18]
EDN1 TTJR60Z Strong Biomarker [19]
EPO TTQG4NR Strong Therapeutic [20]
GOT1 TTU507L Strong Biomarker [21]
GRK2 TTAZ3MN Strong Therapeutic [22]
HGF TT4V2JM Strong Therapeutic [23]
HSPD1 TT9HL5R Strong Therapeutic [24]
HSPE1 TTWYMFE Strong Therapeutic [24]
IGF1R TTQFBMY Strong Biomarker [25]
IL1A TTPM6HI Strong Biomarker [26]
IL4 TTLGTKB Strong Biomarker [27]
ITGB1 TTBVIQC Strong Biomarker [28]
LDHA TTW76JE Strong Biomarker [29]
LPL TTOF3WZ Strong Biomarker [30]
MAP3K5 TTOQCD8 Strong Biomarker [31]
MAPK1 TT4TQBX Strong Therapeutic [32]
MAPK11 TT73U6C Strong Therapeutic [32]
MAPK14 TTQBR95 Strong Biomarker [32]
MAPK3 TT1MG9E Strong Therapeutic [32]
MAPT TTS87KH Strong Biomarker [10]
MIF TT6804T Strong Biomarker [33]
MYBPC3 TT9WOBN Strong Biomarker [34]
MYH7 TTNIMDP Strong Biomarker [35]
NOS1 TTZUFI5 Strong Biomarker [36]
NPPB TTY63XT Strong Biomarker [37]
OLR1 TTKSND3 Strong Biomarker [38]
PARP1 TTVDSZ0 Strong Biomarker [39]
PDK2 TTJGCKM Strong Biomarker [40]
PPARD TT2JWF6 Strong Biomarker [41]
PRKCE TT57MT2 Strong Biomarker [42]
PSEN1 TTZ3S8C Strong Biomarker [10]
RAD51 TTC0G1L Strong Therapeutic [43]
SGCB TTEDCQ0 Strong Biomarker [40]
STAT3 TTHJT3X Strong Biomarker [9]
THPO TTCG5PE Strong Therapeutic [44]
TLR2 TTY7ZHS Strong Biomarker [45]
TNF TTF8CQI Strong Therapeutic [46]
TNNI3 TTNLDK6 Strong Biomarker [47]
TNNT2 TTWAS18 Strong Biomarker [48]
TXN TTZJ5U9 Strong Therapeutic [49]
UTS2 TTERU0T Strong Biomarker [50]
UTS2R TTW5UDX Strong Biomarker [50]
XDH TT7RJY8 Strong Therapeutic [51]
YWHAH TTADIOY Strong Therapeutic [31]
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⏷ Show the Full List of 64 DTT(s)
This Disease Is Related to 1 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
NDUFS2 DEKX5CD Definitive Biomarker [52]
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This Disease Is Related to 18 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
MYOT OTCEW5XW Limited Biomarker [53]
AQP2 OTQLBKK6 Strong Biomarker [8]
ATP5F1B OTLFZUQK Strong Therapeutic [54]
COX1 OTG3O9BN Strong Biomarker [16]
DSG2 OTJPB2TO Strong Altered Expression [55]
EPG5 OT3P5HQD Strong Biomarker [56]
FKBP1B OT8CMPB2 Strong Biomarker [57]
ITGA7 OTTBTAYW Strong Therapeutic [58]
PPP1R1A OTGTAGCV Strong Biomarker [59]
PRKAA2 OTU1KZPV Strong Biomarker [40]
RHOJ OTWI65OA Strong Biomarker [40]
SCO2 OTJQQDRS Strong Biomarker [60]
SGCD OTRBL3NQ Strong Biomarker [61]
SMR3B OTL5HNM8 Strong Biomarker [62]
TIMP2 OT8S1RRP Strong Biomarker [63]
TMEM70 OTLTKYXG Strong Biomarker [64]
TRIM63 OTUSWA74 Strong Therapeutic [65]
NDUFV2 OTSZF7D6 Definitive Biomarker [52]
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⏷ Show the Full List of 18 DOT(s)

References

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2 An abnormal gene expression of the beta-adrenergic system contributes to the pathogenesis of cardiomyopathy in cirrhotic rats.Hepatology. 2008 Dec;48(6):1913-23. doi: 10.1002/hep.22533.
3 Interrelation between Expression of ADAM 10 and MMP 9 and Synthesis of Peroxynitrite in Doxorubicin Induced Cardiomyopathy.Biomol Ther (Seoul). 2013 Sep 30;21(5):371-80. doi: 10.4062/biomolther.2013.034.
4 Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway.Circulation. 2013 Apr 23;127(16):1692-701. doi: 10.1161/CIRCULATIONAHA.112.001212. Epub 2013 Mar 27.
5 Cardioprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on Doxorubicin-induced cardiomyopathy in mice.Circ J. 2010 Jun;74(6):1183-90. doi: 10.1253/circj.cj-09-1024. Epub 2010 Apr 6.
6 Effects of cardiac-restricted overexpression of the A(2A) adenosine receptor on adriamycin-induced cardiotoxicity.Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1738-47. doi: 10.1152/ajpheart.00688.2009. Epub 2010 Apr 2.
7 Disruption of type 5 adenylyl cyclase prevents -adrenergic receptor cardiomyopathy: a novel approach to -adrenergic receptor blockade.Am J Physiol Heart Circ Physiol. 2014 Nov 15;307(10):H1521-8. doi: 10.1152/ajpheart.00491.2014. Epub 2014 Sep 5.
8 Upregulation of vasopressin V2 and aquaporin 2 in the inner medullary collecting duct of cardiomyopathic hamsters is attenuated by enalapril treatment.Metabolism. 2002 Aug;51(8):970-5. doi: 10.1053/meta.2002.34015.
9 Opposing roles of Akt and STAT3 in the protection of the maternal heart from peripartum stress.Cardiovasc Res. 2014 Mar 15;101(4):587-96. doi: 10.1093/cvr/cvu010. Epub 2014 Jan 20.
10 The preventive effects of edible folic acid on cardiomyocyte apoptosis and survival in early onset triple-transgenic Alzheimer's disease model mice.Environ Toxicol. 2018 Jan;33(1):83-92. doi: 10.1002/tox.22498. Epub 2017 Oct 25.
11 Characterization of the regulatory mechanisms of activating transcription factor 3 by hypertrophic stimuli in rat cardiomyocytes.PLoS One. 2014 Aug 19;9(8):e105168. doi: 10.1371/journal.pone.0105168. eCollection 2014.
12 Altered baroreflex control of heart rate in bradykinin B2-receptor knockout mice.Immunopharmacology. 1999 Dec;45(1-3):21-7. doi: 10.1016/s0162-3109(99)00053-3.
13 Interstitial fibrosis and microvascular disease of the heart in uremia: amelioration by a calcimimetic.Lab Invest. 2009 May;89(5):520-30. doi: 10.1038/labinvest.2009.7. Epub 2009 Feb 2.
14 Inhibition of doxorubicin chronic toxicity in catalase-overexpressing transgenic mouse hearts.Chem Res Toxicol. 2002 Jan;15(1):1-6. doi: 10.1021/tx015532n.
15 Human carbonyl reductase overexpression in the heart advances the development of doxorubicin-induced cardiotoxicity in transgenic mice.Cancer Res. 2000 Sep 15;60(18):5158-64.
16 Time-dependent and tissue-specific accumulation of mtDNA and respiratory chain defects in chronic doxorubicin cardiomyopathy.Circulation. 2003 Nov 11;108(19):2423-9. doi: 10.1161/01.CIR.0000093196.59829.DF. Epub 2003 Oct 20.
17 Left ventricular non-compaction associated with a genetic variant of the CYP2C9 gene.Heart Lung Circ. 2006 Aug;15(4):269-71. doi: 10.1016/j.hlc.2006.02.007. Epub 2006 Apr 3.
18 Intolerance to -blockade in a mouse model of -sarcoglycan-deficient muscular dystrophy cardiomyopathy.Eur J Heart Fail. 2010 Nov;12(11):1163-70. doi: 10.1093/eurjhf/hfq129. Epub 2010 Jul 30.
19 Increased plasma endothelin-1 and cardiac nitric oxide during doxorubicin-induced cardiomyopathy.Pharmacol Toxicol. 2001 Sep;89(3):140-4. doi: 10.1034/j.1600-0773.2001.d01-148.x.
20 Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent pathway.J Pharmacol Exp Ther. 2008 Jan;324(1):160-9. doi: 10.1124/jpet.107.125773. Epub 2007 Oct 10.
21 Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats.Lab Invest. 2011 Jan;91(1):12-23. doi: 10.1038/labinvest.2010.156. Epub 2010 Aug 23.
22 Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling.Circ Res. 2006 Oct 27;99(9):996-1003. doi: 10.1161/01.RES.0000247932.71270.2c. Epub 2006 Sep 28.
23 Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy.Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H1048-57. doi: 10.1152/ajpheart.01102.2007. Epub 2007 Dec 14.
24 Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells.J Mol Cell Cardiol. 2003 Sep;35(9):1135-43. doi: 10.1016/s0022-2828(03)00229-3.
25 [The relationship of blood glucose and the expression of insulin-like growth factor-1 receptor mRNA in diabetic cardiomyopathy: a preliminary study with rats].Zhonghua Yi Xue Za Zhi. 2007 May 15;87(18):1249-51.
26 Cytokine expression in the muscle of HIV-infected patients: evidence for interleukin-1 alpha accumulation in mitochondria of AZT fibers. Ann Neurol. 1994 Nov;36(5):752-8. doi: 10.1002/ana.410360511.
27 Cardiotoxicity and cardioprotection during chemotherapy.Curr Opin Oncol. 1995 Jul;7(4):304-9. doi: 10.1097/00001622-199507000-00002.
28 Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification.Circ Res. 2008 May 9;102(9):1109-17. doi: 10.1161/CIRCRESAHA.108.173153. Epub 2008 Mar 13.
29 Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4.J Pharm Pharmacol. 2004 Jun;56(6):757-68. doi: 10.1211/0022357023565.
30 Lipolysis is an important determinant of isoproterenol-induced myocardial necrosis.Cardiovasc Pathol. 1999 Sep-Oct;8(5):255-61. doi: 10.1016/s1054-8807(99)00017-4.
31 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy.Biochem Pharmacol. 2008 May 1;75(9):1797-806. doi: 10.1016/j.bcp.2008.02.003. Epub 2008 Feb 12.
32 Cocaine and apoptosis in myocardial cells.Anat Rec. 1999 Dec 15;257(6):208-16. doi: 10.1002/(SICI)1097-0185(19991215)257:6<208::AID-AR6>3.0.CO;2-0.
33 Endotoxin-induced myocardial dysfunction: effects of macrophage migration inhibitory factor neutralization.Circ Res. 2005 May 27;96(10):1095-102. doi: 10.1161/01.RES.0000168327.22888.4d. Epub 2005 May 5.
34 A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia.Nat Genet. 2009 Feb;41(2):187-91. doi: 10.1038/ng.309. Epub 2009 Jan 18.
35 Clinical diversity of MYH7-related cardiomyopathies: Insights into genotype-phenotype correlations.Am J Med Genet A. 2019 Mar;179(3):365-372. doi: 10.1002/ajmg.a.61017. Epub 2018 Dec 27.
36 Altered contractile response due to increased beta3-adrenoceptor stimulation in diabetic cardiomyopathy: the role of nitric oxide synthase 1-derived nitric oxide.Anesthesiology. 2007 Sep;107(3):452-60. doi: 10.1097/01.anes.0000278909.40408.24.
37 Plasma concentrations of NT-pro-BNP and cardiac troponin-I in relation to doxorubicin-induced cardiomyopathy and cardiac function in childhood malignancy.Saudi Med J. 2005 Aug;26(8):1197-202.
38 Doxorubicin-induced expression of LOX-1 in H9c2 cardiac muscle cells and its role in apoptosis.Biochem Biophys Res Commun. 2005 Sep 16;335(1):188-96. doi: 10.1016/j.bbrc.2005.07.064.
39 Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1.Mech Ageing Dev. 2010 Jun;131(6):389-404. doi: 10.1016/j.mad.2010.05.005. Epub 2010 Jun 8.
40 Comparative phenotypic assessment of cardiac pathology, physiology, and gene expression in C3H/HeJ, C57BL/6J, and B6C3F1/J mice.Toxicol Pathol. 2010 Oct;38(6):923-42. doi: 10.1177/0192623310382864.
41 Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart.Circ Res. 2010 Mar 19;106(5):911-9. doi: 10.1161/CIRCRESAHA.109.206185. Epub 2010 Jan 14.
42 Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure.Circ Res. 2004 Aug 20;95(4):424-32. doi: 10.1161/01.RES.0000138299.85648.92. Epub 2004 Jul 8.
43 Disparate impact of butyroyloxymethyl diethylphosphate (AN-7), a histone deacetylase inhibitor, and doxorubicin in mice bearing a mammary tumor.PLoS One. 2012;7(2):e31393. doi: 10.1371/journal.pone.0031393. Epub 2012 Feb 23.
44 Thrombopoietin protects against in vitro and in vivo cardiotoxicity induced by doxorubicin.Circulation. 2006 May 9;113(18):2211-20. doi: 10.1161/CIRCULATIONAHA.105.560250. Epub 2006 May 1.
45 Modulation of doxorubicin-induced cardiac dysfunction in toll-like receptor-2-knockout mice.Circulation. 2004 Nov 2;110(18):2869-74. doi: 10.1161/01.CIR.0000146889.46519.27. Epub 2004 Oct 25.
46 Antioxidants and tumor necrosis factor alpha-inhibiting activity of sesame oil against doxorubicin-induced cardiotoxicity.Ther Adv Cardiovasc Dis. 2014 Feb;8(1):4-11. doi: 10.1177/1753944713516532. Epub 2014 Jan 17.
47 Targeted panel sequencing in pediatric primary cardiomyopathy supports a critical role of TNNI3.Clin Genet. 2019 Dec;96(6):549-559. doi: 10.1111/cge.13645. Epub 2019 Oct 22.
48 In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity.Toxicology. 2007 Jul 31;237(1-3):218-228. doi: 10.1016/j.tox.2007.05.016. Epub 2007 May 24.
49 Overexpression of thioredoxin-1 in transgenic mice attenuates adriamycin-induced cardiotoxicity.Circulation. 2002 Sep 10;106(11):1403-9. doi: 10.1161/01.cir.0000027817.55925.b4.
50 Elevated expression of urotensin II and its receptor in diabetic cardiomyopathy.J Diabetes Complications. 2008 Mar-Apr;22(2):137-43. doi: 10.1016/j.jdiacomp.2006.10.008.
51 Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system.J Transl Med. 2015 Mar 6;13:82. doi: 10.1186/s12967-015-0445-9.
52 Mutant NDUFS3 subunit of mitochondrial complex I causes Leigh syndrome. J Med Genet. 2004 Jan;41(1):14-7. doi: 10.1136/jmg.2003.014316.
53 Mutations in myotilin cause myofibrillar myopathy.Neurology. 2004 Apr 27;62(8):1363-71. doi: 10.1212/01.wnl.0000123576.74801.75.
54 [Screening of differentially expressed genes in rats with cardiomyopathy after bone marrow mesenchymal stem cell transplantation].Zhonghua Er Ke Za Zhi. 2006 Oct;44(10):787-91.
55 Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy.Physiol Genomics. 2018 Sep 1;50(9):680-687. doi: 10.1152/physiolgenomics.00143.2017. Epub 2018 May 18.
56 Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy. Nat Genet. 2013 Jan;45(1):83-7. doi: 10.1038/ng.2497. Epub 2012 Dec 9.
57 Total triterpene acids, active ingredients from Fructus Corni, attenuate diabetic cardiomyopathy by normalizing ET pathway and expression of FKBP12.6 and SERCA2a in streptozotocin-rats.J Pharm Pharmacol. 2008 Dec;60(12):1687-94. doi: 10.1211/jpp/60.12.0016.
58 Transgenic expression of {alpha}7{beta}1 integrin maintains muscle integrity, increases regenerative capacity, promotes hypertrophy, and reduces cardiomyopathy in dystrophic mice.Am J Pathol. 2005 Jan;166(1):253-63. doi: 10.1016/s0002-9440(10)62249-3.
59 Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging.J Clin Invest. 2010 Feb;120(2):617-26. doi: 10.1172/JCI40545. Epub 2010 Jan 11.
60 Retrospective, multicentric study of 180 children with cytochrome C oxidase deficiency.Pediatr Res. 2006 Jan;59(1):21-6. doi: 10.1203/01.pdr.0000190572.68191.13. Epub 2005 Dec 2.
61 Hydrogen gas attenuates embryonic gene expression and prevents left ventricular remodeling induced by intermittent hypoxia in cardiomyopathic hamsters.Am J Physiol Heart Circ Physiol. 2014 Dec 1;307(11):H1626-33. doi: 10.1152/ajpheart.00228.2014. Epub 2014 Oct 3.
62 Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling.Biochem Biophys Res Commun. 2001 May 25;283(5):1061-8. doi: 10.1006/bbrc.2001.4881.
63 The roles of MMP-2/TIMP-2 in extracellular matrix remodelling in the hearts of STZ-induced diabetic rats.Acta Cardiol. 2007 Oct;62(5):485-91. doi: 10.2143/AC.62.5.2023412.
64 TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy. Nat Genet. 2008 Nov;40(11):1288-90. doi: 10.1038/ng.246. Epub 2008 Oct 26.
65 Muscle ring finger 1 mediates cardiac atrophy in vivo.Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H997-H1006. doi: 10.1152/ajpheart.00660.2008. Epub 2009 Jan 23.