Details of Disease

General Information of Disease (ID: DISX9D54)

• Disease Name: Tourette syndrome
• Synonyms: GTS; chronic motor tics; Gilles De 50A Tourette syndrome; Tourette disorder; Gilles de la Tourette syndrome; Tourette disease; motor-verbal tic disorder; Guinon's disease; Tourette's syndrome; Tourette syndrome; psychogenic tics
• Disease Class: 8A05: Tic disorder
• Definition: A neurologic disorder caused by defective metabolism of the neurotransmitters in the brain. It is characterized by repeated involuntary movements (motor tics) and uncontrollable vocal sounds (vocal tics). The symptoms are usually manifested before the age of eighteen.
• Disease Hierarchy:
  DIS6SVEE: Syndromic disease
  DISD715V: Hereditary neurological disease
  DIS1CYA2: Convulsion
  DISOJJ2D: Movement disorder
  DISX9D54: Tourette syndrome
• ICD Code:
  ICD-11: ICD-11: 8A05.00
  ICD-10: ICD-10: F95.2
  Expand ICD-11: '8A05.00
  Expand ICD-10: 'F95.2
• Disease Identifiers:
  MONDO ID: MONDO_0007661
  MESH ID: D005879
  UMLS CUI: C0040517
  OMIM ID: 137580
  MedGen ID: 21219
  Orphanet ID: 856
  SNOMED CT ID: 5158005

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Haloperidol	DM96SE0	Approved	Small molecular drug	[1]
Pimozide	DMW83TP	Approved	Small molecular drug	[2]
Ingrezza	DMVPLNC	Phase 4	Small molecular drug	[3]

This Disease is Treated as An Indication in 7 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ecopipam	DMS9R43	Phase 3	Small molecular drug	[4]
Meningococcal vaccine groups A,C,Y,W-135 conjugate	DMEEDUK	Phase 3	NA	[5]
NBI-98854	DMVO1C0	Phase 3	Small molecular drug	[4]
THX-TS01	DM3DG5C	Phase 3	NA	[4]
CPP-115	DMK9NQI	Phase 2	Small molecular drug	[4]
Ecopipam hydrochloride	DMNV9TH	Phase 2	NA	[6]
ABX-1431	DM9SYVJ	Phase 1	NA	[4]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 124 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
UBAP1	OTTW6B2G	No Known	Unknown	[7]
UNKL	OTYN8S27	No Known	Unknown	[7]
USP1	OTKXT1D7	No Known	Unknown	[7]
WNT7B	OTF5JBMW	No Known	Unknown	[7]
ZC3H7A	OT2ZU1WI	No Known	Unknown	[7]
ZNF112	OT9HTNCA	No Known	Unknown	[7]
ZNF23	OTCQUB11	No Known	Unknown	[8]
ZNF37A	OTDVUUN0	No Known	Unknown	[8]
ZNF385A	OTM8CHUL	No Known	Unknown	[7]
ZNF799	OTAVJ57Y	No Known	Unknown	[8]
AADAC	OT8VACT2	No Known	Unknown	[37]
ARL8A	OTEYM6FA	No Known	Unknown	[7]
ATL2	OT93AUOO	No Known	Unknown	[7]
CCDC7	OTNCL9JR	No Known	Unknown	[7]
CDK12	OTZUDGNU	No Known	Unknown	[9]
COL24A1	OT2ZN672	No Known	Unknown	[7]
COLGALT2	OTV9EDZB	No Known	Unknown	[7]
CPEB3	OTP1GQCH	No Known	Unknown	[7]
DBX1	OTEBZXLT	No Known	Unknown	[7]
DENND5A	OT0QNNY1	No Known	Unknown	[8]
ETS1	OT4LVGDN	No Known	Unknown	[7]
EVPL	OTZIAFEK	No Known	Unknown	[7]
FBXO15	OTJHEFE5	No Known	Unknown	[38]
FPR1	OTFF9I6W	No Known	Unknown	[7]
GARIN4	OTQL4PP9	No Known	Unknown	[7]
GK2	OT0JGZPO	No Known	Unknown	[7]
GOPC	OTRBGH71	No Known	Unknown	[8]
HDAC5	OTWG387P	No Known	Unknown	[7]
HEPACAM2	OTQ90IG5	No Known	Unknown	[7]
ITPKB	OTSVVPAV	No Known	Unknown	[8]
KBTBD8	OTO8X1UF	No Known	Unknown	[7]
KDM5B	OT5DL94T	No Known	Unknown	[7]
KLHL9	OTRGEG3Z	No Known	Unknown	[39]
LCN12	OTHCV4G8	No Known	Unknown	[7]
LLGL1	OTAIQSXZ	No Known	Unknown	[7]
LRP8	OTZ71YV2	No Known	Unknown	[7]
LSM11	OTN9M7QG	No Known	Unknown	[7]
LYPD6	OTT45DF7	No Known	Unknown	[40]
ME2	OTO4LL76	No Known	Unknown	[7]
MGAM	OTVLMDUE	No Known	Unknown	[7]
MX2	OT05NF37	No Known	Unknown	[7]
NLRP11	OTAL4ADW	No Known	Unknown	[7]
NMRK1	OT0STQLV	No Known	Unknown	[7]
NUP85	OTB5ZHC8	No Known	Unknown	[8]
OR4M1	OTLGJKFF	No Known	Unknown	[7]
OR9I1	OTZP1O8O	No Known	Unknown	[7]
PDP1	OT82RTMT	No Known	Unknown	[7]
POM121L12	OTYUXICC	No Known	Unknown	[41]
PPWD1	OTA7CG42	No Known	Unknown	[8]
RFWD3	OTDUULBQ	No Known	Unknown	[7]
RICTOR	OTCC58QJ	No Known	Unknown	[10]
STRIP2	OTQLZ6Z7	No Known	Unknown	[10]
SYNDIG1	OT8P9T93	No Known	Unknown	[7]
THBS3	OTDKMUBD	No Known	Unknown	[7]
TIGD2	OTRXGZ1X	No Known	Unknown	[7]
TNPO1	OT7W2CM8	No Known	Unknown	[7]
TP53BP2	OTOWJ2Y4	No Known	Unknown	[8]
TPX2	OTWLJYH0	No Known	Unknown	[8]
ADAMTS6	OTSZE6L4	Limited	Unknown	[7]
ADD2	OTRCPCD2	Limited	Biomarker	[42]
AGPAT5	OTNY3VMD	Limited	Unknown	[7]
ANK3	OTJ3IRBP	Limited	Unknown	[7]
CD8A	OTDWQJXK	Limited	Biomarker	[43]
CNTN6	OTXVGVOR	Limited	Unknown	[44]
CSNK1G3	OTN1GGCN	Limited	Unknown	[8]
FAM120A	OTLAG3VN	Limited	Unknown	[7]
FSCB	OTTHS17E	Limited	Unknown	[45]
GLIS3	OTBC960E	Limited	Unknown	[7]
GRHL3	OT1V4ZEH	Limited	Biomarker	[46]
HDC	OT4WA5YQ	Limited	Autosomal dominant	[11]
HEXD	OTTMQKLM	Limited	Biomarker	[47]
HMGXB3	OTTZ1AS6	Limited	Unknown	[8]
HNRNPA0	OTCP792K	Limited	Unknown	[48]
ING2	OT6H0EWF	Limited	Biomarker	[43]
NCBP1	OTYBR927	Limited	Unknown	[7]
PABPC5	OTLUTQ02	Limited	Unknown	[49]
PEX13	OTXUAYEW	Limited	Genetic Variation	[50]
PNKD	OT6G9UXN	Limited	Autosomal dominant	[51]
RACK1	OTZBCQ1U	Limited	Unknown	[7]
RPGRIP1L	OT6Z069I	Limited	Biomarker	[52]
SHOX	OTE0YZJO	Limited	Biomarker	[53]
SLITRK1	OT1QQ7FR	Limited	Autosomal dominant	[11]
SPRY2	OTH0CRCZ	Limited	Unknown	[7]
TESC	OTI8C76M	Limited	Genetic Variation	[54]
TLN2	OT10QQBC	Limited	Unknown	[7]
COL27A1	OTQ5VDRH	moderate	Genetic Variation	[55]
CSMD3	OTAT75SW	moderate	Genetic Variation	[13]
LMO3	OTR7AJHN	moderate	Genetic Variation	[13]
SGCE	OT9F17JB	moderate	Genetic Variation	[34]
ACP1	OTJ9CKLU	Strong	Genetic Variation	[56]
ALG9	OT5V9PIR	Strong	Genetic Variation	[57]
AMELX	OTIN26MM	Strong	Biomarker	[58]
ANKK1	OT0OM1O0	Strong	Genetic Variation	[59]
APBA2	OTXD8ID1	Strong	Biomarker	[60]
ASH1L	OTUT5NLJ	Strong	Biomarker	[61]
BTBD9	OTWQ6GA3	Strong	Genetic Variation	[62]
CBLN2	OT29SSBE	Strong	Biomarker	[63]
CCT6A	OTCYWL5F	Strong	Biomarker	[64]
CELSR3	OT8P6QNJ	Strong	Genetic Variation	[65]
CHD2	OTRKL6YC	Strong	Biomarker	[66]
CHPT1	OT4FJ0K3	Strong	Biomarker	[67]
CNTNAP2	OT48T2ZP	Strong	Biomarker	[68]
COBLL1	OTQFN1TC	Strong	Biomarker	[28]
COL8A1	OTWBTED2	Strong	Genetic Variation	[69]
DHDDS	OTVLYBUS	Strong	Biomarker	[67]
DLGAP3	OT0GR2F6	Strong	Biomarker	[70]
DPP6	OTWW3H0K	Strong	Biomarker	[71]
EEF1A2	OT9Z23K5	Strong	Biomarker	[72]
GPC5	OT8NR7GC	Strong	Genetic Variation	[36]
IMMP2L	OT9WGAFD	Strong	Genetic Variation	[73]
LHX6	OT47UQZ5	Strong	Altered Expression	[74]
LHX8	OT0DFL7C	Strong	Altered Expression	[74]
MCF2L	OTEURA8N	Strong	Biomarker	[25]
MEIS1	OTH9DKAD	Strong	Genetic Variation	[26]
NLGN4X	OTDJGBK8	Strong	Genetic Variation	[75]
NRXN1	OTJN1JQA	Strong	Genetic Variation	[44]
NTN4	OTDRRMP3	Strong	Biomarker	[76]
OLFM1	OTOYPEWW	Strong	Biomarker	[77]
OLIG1	OTIMFI31	Strong	Biomarker	[78]
OLIG2	OTMCN6D3	Strong	Biomarker	[78]
PSD4	OTEFB87Z	Strong	Biomarker	[79]
SMN2	OT54RLO1	Strong	Biomarker	[32]
NECTIN1	OTTE5ZR6	Definitive	Genetic Variation	[80]
POU1F1	OTXT8A5C	Definitive	Genetic Variation	[80]

This Disease Is Related to 38 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CDK12	TTJ21A9	No Known	Unknown	[9]
ETS1	TTTGPSD	No Known	Unknown	[7]
FPR1	TT5Y4EM	No Known	Unknown	[7]
HDAC5	TTUELN5	No Known	Unknown	[7]
KDM5B	TTCLI75	No Known	Unknown	[7]
MGAM	TTXWASR	No Known	Unknown	[7]
RICTOR	TT143WL	No Known	Unknown	[10]
TPX2	TT0PHL4	No Known	Unknown	[8]
USP1	TTG9MT5	No Known	Unknown	[7]
CSNK1G3	TT34L5N	Limited	Unknown	[8]
HDC	TTV9GOF	Limited	Autosomal dominant	[11]
KCNK9	TTL4FMB	Limited	Genetic Variation	[12]
RACK1	TTJ10AL	Limited	Unknown	[7]
FLT3	TTGJCWZ	moderate	Genetic Variation	[13]
FPR3	TT16TM5	moderate	Genetic Variation	[13]
ADORA1	TTK25J1	Strong	Genetic Variation	[14]
ADRA2A	TTWG9A4	Strong	Biomarker	[15]
CHAT	TTKYFSB	Strong	Biomarker	[16]
CHM	TTOA18V	Strong	Genetic Variation	[17]
DBH	TTYIP79	Strong	Genetic Variation	[18]
DRD5	TTS2PH3	Strong	Genetic Variation	[19]
HMBS	TTT0HW3	Strong	Genetic Variation	[20]
HTR2C	TTWJBZ5	Strong	Genetic Variation	[21]
HTR7	TTO9X1H	Strong	Genetic Variation	[22]
KCNJ5	TTEO25X	Strong	Biomarker	[23]
LCT	TTA0OSE	Strong	Genetic Variation	[24]
LRP2	TTPH1AJ	Strong	Biomarker	[25]
MAP2K5	TTV3O87	Strong	Genetic Variation	[26]
ROBO4	TT3S9TY	Strong	Genetic Variation	[27]
SCN2A	TTLJTUF	Strong	Genetic Variation	[28]
SCN3A	TTAXZ0K	Strong	Genetic Variation	[28]
SLC1A1	TTG2A6F	Strong	Genetic Variation	[29]
SLC1A3	TT8WRDA	Strong	Altered Expression	[30]
SLC5A7	TTRV7W3	Strong	Biomarker	[31]
SMN1	TT8QL6X	Strong	Biomarker	[32]
TDP1	TT64IHJ	Strong	Biomarker	[33]
TOR1A	TTF85KW	Strong	Genetic Variation	[34]
TPH2	TT3KLDP	Strong	Genetic Variation	[35]

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC17A7	DTNK0FR	Strong	Altered Expression	[30]
SLC4A10	DT7RYVF	Strong	Genetic Variation	[36]

This Disease Is Related to 3 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
COLGALT2	DE8RIZD	No Known	Unknown	[7]
NMRK1	DENV24I	No Known	Unknown	[7]
MGST1	DEAPJSO	moderate	Genetic Variation	[13]

References

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