Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3Z6G4)

Drug Name
5S-HETE Drug Info
Synonyms
5-Hydroxyeicosatetraenoic acid; 5(S)-HETE; 5-Hete; 5-Hydroxyeicosatetraenoate; 5-Hydroxy-6,8,11,14-eicosatetraenoic acid; UNII-467RNW8T91; 70608-72-9; CHEMBL164813; CHEBI:28209; 5(S)-hydroxyeicosatetraenoic acid; 467RNW8T91; 6,8,11,14-Eicosatetraenoic acid, 5-hydroxy-, (S-(E,Z,Z,Z))-; (5S,6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetraenoic acid; 5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid; (6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid; 5-(S)-hydroxyeicosatetraenoic acid; AC1NQXIH; BSPBio_001443; 5-(S)-hydroxyeicosatetraenoic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5280733
ChEBI ID
CHEBI:28209
CAS Number
CAS 330796-62-8
TTD Drug ID
DM3Z6G4

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Arachidonate 5-lipoxygenase (5-LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [8]
Diethylcarbamazine DM1TJ8F Elephantiasis Approved [9]
Silymarin DMXBYQR N. A. N. A. Phase 4 [10]
3,4-Dihydroxycinnamic Acid DMVZL26 Thrombocytopenia 3B64 Phase 4 [11]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [12]
ABT-761 DM3FIC2 Asthma CA23 Phase 3 [13]
Tenidap DMHQRYE Rheumatoid arthritis FA20 Phase 3 [14]
FPL-62064 DMGF8MZ Inflammation 1A00-CA43.1 Phase 3 [15]
Flobufen DMPSG4D Rheumatoid arthritis FA20 Phase 3 [16]
Darbufelone DMYVKM5 Asthma CA23 Phase 2/3 [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Oxoeicosanoid receptor 1 (OXER1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
5S-HPETE DME1304 Discovery agent N.A. Investigative [3]
5-oxo-C20:3 DM6FSUW Discovery agent N.A. Investigative [18]
5-(6-chloro-2-hexyl-1H-indol-1-yl)-5-oxo-valeric acid DM0K7U5 Discovery agent N.A. Investigative [19]
5-oxo-12-HETE DMLABR9 Discovery agent N.A. Investigative [20]
5-oxo-15-HETE DM9ZC7B Discovery agent N.A. Investigative [21]
Gue1654 DM89KNT Discovery agent N.A. Investigative [22]
[3H]5-oxo-ETE DM50WFM Discovery agent N.A. Investigative [23]
5-oxo-ODE DM56TVA Discovery agent N.A. Investigative [24]
5-oxo-20-HETE DM493GU Discovery agent N.A. Investigative [21]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Targeting Transient receptor potential cation channel V1 (TRPV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capsaicin DMGMF6V Back pain ME84.Z Approved [25]
CNTX-4975 DMB4JPG Knee osteoarthritis FA01 Phase 3 [26]
XEN-D0501 DMG7PDY Overactive bladder GC50.0 Phase 2 [27]
Resiniferatoxin DMP62L5 Neuropathic pain 8E43.0 Phase 2 [28]
PAC-14028 DM3816P Atopic dermatitis EA80 Phase 2 [29]
GRC-15300 DMWXJSZ Pain MG30-MG3Z Phase 2 [30]
DWP-05195 DMQKU2F Neuropathic pain 8E43.0 Phase 2 [31]
SB-705498 DMRYHWI Rhinitis FA20 Phase 2 [32]
GRC-6211 DMZ0D3V Asthma CA23 Phase 1 [33]
ABT-102 DMJFWPR Chronic pain MG30 Phase 1 [32]
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Drug(s) Affected By Natriuretic peptides B (NPPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [34]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [38]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [42]
Ethanol DMDRQZU Chronic pain MG30 Approved [43]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [44]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [45]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [46]
Gefitinib DM15F0X Colon adenocarcinoma Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [51]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [54]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [57]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [58]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [60]
Gefitinib DM15F0X Colon adenocarcinoma Approved [61]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [64]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [55]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [65]
Paclitaxel DMLB81S Breast carcinoma Approved [66]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [67]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [54]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [68]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [57]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [58]
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Drug(s) Affected By Bifunctional epoxide hydrolase 2 (EPHX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Selenium DM25CGV N. A. N. A. Approved [71]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Leflunomide DMR8ONJ Arthritis FA20 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [76]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [76]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [77]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [78]
Selenium DM25CGV N. A. N. A. Approved [71]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [79]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [52]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [84]
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Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [87]
Fructose DM43AN2 Vomiting MD90 Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [91]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [77]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [92]
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Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Selenium DM25CGV N. A. N. A. Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [94]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [95]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [99]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [100]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [2]
Oxoeicosanoid receptor 1 (OXER1) TT7WBSV OXER1_HUMAN Agonist [3]
Transient receptor potential cation channel V1 (TRPV1) TTMI6F5 TRPV1_HUMAN Activator [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Regulation of Drug Effects [5]
Bifunctional epoxide hydrolase 2 (EPHX2) OTPTRCNW HYES_HUMAN Gene/Protein Processing [6]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [6]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [6]
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Gene/Protein Processing [6]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Gene/Protein Processing [6]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) OT7FOIK2 LOX5_HUMAN Biotransformations [7]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Gene/Protein Processing [6]

References

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