Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8SMD1)

Drug Name
Tazarotene Drug Info
Synonyms
Avage; Suretin; Tazaroteno; Tazarotenum; Tazorac; Tazoral; Zorac; AGN 190168; AGN-190168; Avage (TN); Tazarotene [USAN:INN]; Tazorac (TN); Zorac (TN); Tazarotene (JAN/USAN/INN); Tazorac, Avage, Zora, Tazarotene; Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate; Ethyl 6-(2-(4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate; Ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl]nicotinate; Ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl ester; 3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-,ethyl ester
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [1]
Psoriasis EA90 Approved [1]
Psoriasis vulgaris EA90 Approved [2]
Therapeutic Class
Dermatologic Agents
Cross-matching ID
PubChem CID
5381
ChEBI ID
CHEBI:32184
CAS Number
CAS 118292-40-3
TTD Drug ID
DM8SMD1
INTEDE Drug ID
DR1536

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Retinoic acid receptor gamma (RARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [10]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [11]
Trifarotene DMOL793 Acne vulgaris ED80 Approved [12]
Palovarotene DMAD2OZ Fibrodysplasia ossificans progressiva FB31.1 Approved [13]
PMID27336223-Compound-13 DMSZLYD N. A. N. A. Patented [14]
PMID27336223-Compound-12 DMT4P7K N. A. N. A. Patented [14]
PMID27336223-Compound-14 DMC41MA N. A. N. A. Patented [14]
PMID27336223-Compound-11 DMBN6KU N. A. N. A. Patented [14]
PMID27336223-Compound-15 DMIYCFE N. A. N. A. Patented [14]
PMID27336223-Compound-9 DM6V13W N. A. N. A. Patented [14]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [15]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [16]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [16]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [17]
Verapamil DMA7PEW Angina pectoris BA40 Approved [18]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [19]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [20]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [16]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [21]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [22]
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Drug(s) Affected By Steryl-sulfatase (STS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [27]
Danazol DML8KTN Menorrhagia GA20.50 Approved [28]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [9]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [23]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [29]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [30]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [31]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [33]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [34]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Verapamil DMA7PEW Angina pectoris BA40 Approved [36]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [37]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [38]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [39]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [42]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [43]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [44]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [45]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [46]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [47]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [48]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [49]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [30]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [49]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Verapamil DMA7PEW Angina pectoris BA40 Approved [36]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [50]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [51]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Meloxicam DM2AR7L Arthritis FA20 Approved [54]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [55]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [56]
Quinidine DMLPICK N. A. N. A. Approved [57]
Verapamil DMA7PEW Angina pectoris BA40 Approved [58]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [59]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [59]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [60]
Propranolol DM79NTF Angina pectoris BA40 Approved [61]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [62]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [63]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [59]
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Drug(s) Affected By Sodium/iodide cotransporter (SLC5A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [8]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [8]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [68]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [69]
Romidepsin DMT5GNL Cutaneous T-cell lymphoma 2B01 Approved [8]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Retinoic acid receptor gamma (RARG) TT1Q3IE RARG_HUMAN Binder [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2C8 (CYP2C8) Main DME DES5XRU CP2C8_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [5]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [5]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [6]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Gene/Protein Processing [7]
Sodium/iodide cotransporter (SLC5A5) OTU7E9G7 SC5A5_HUMAN Gene/Protein Processing [8]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Gene/Protein Processing [9]

References

1 Tazarotene FDA Label
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3 Recent developments in receptor-selective retinoids. Curr Pharm Des. 2000 Jun;6(9):919-31.
4 Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans. Drug Metab Dispos. 2003 Apr;31(4):476-81.
5 [Effects of all-trans-retinoic acid, acitretin and tazarotene on apoptosis and Bax/Bcl-2 expressions of human melanoma cells A375 and the significance]. Di Yi Jun Yi Da Xue Xue Bao. 2005 Aug;25(8):972-4, 978.
6 Effects of ATRA, acitretin and tazarotene on growth and apoptosis of Tca8113 cells. J Huazhong Univ Sci Technolog Med Sci. 2005;25(4):393-6. doi: 10.1007/BF02828205.
7 Why are most phospholipidosis inducers also hERG blockers?. Arch Toxicol. 2017 Dec;91(12):3885-3895. doi: 10.1007/s00204-017-1995-9. Epub 2017 May 27.
8 Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. Endocr Relat Cancer. 2006 Sep;13(3):797-826. doi: 10.1677/erc.1.01143.
9 Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. J Cell Biochem. 2006 Feb 1;97(2):327-50. doi: 10.1002/jcb.20579.
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30 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
31 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
32 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
33 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
34 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
35 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
36 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
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38 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
39 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
40 Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
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42 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
43 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
44 Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
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46 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
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49 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
50 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
51 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
52 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
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55 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
56 Comparison of the effects of metoclopramide and domperidone on HERG channels. Pharmacology. 2005 Apr;74(1):31-6. doi: 10.1159/000083234. Epub 2005 Jan 7.
57 Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol. 2005 Jan;16(1):54-8. doi: 10.1046/j.1540-8167.2005.04470.x.
58 Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds. Assay Drug Dev Technol. 2004 Oct;2(5):497-506. doi: 10.1089/adt.2004.2.497.
59 Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol Sci. 2013 Dec;136(2):581-94. doi: 10.1093/toxsci/kft205. Epub 2013 Sep 19.
60 Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs. Br J Pharmacol. 2008 Nov;155(6):957-66. doi: 10.1038/bjp.2008.325. Epub 2008 Aug 25.
61 Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. Br J Pharmacol. 2006 Mar;147(6):642-52. doi: 10.1038/sj.bjp.0706508.
62 Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels. Naunyn Schmiedebergs Arch Pharmacol. 1999 Mar;359(3):212-9. doi: 10.1007/pl00005344.
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64 Thyroid organotypic rat and human cultures used to investigate drug effects on thyroid function, hormone synthesis and release pathways. Toxicol Appl Pharmacol. 2012 Apr 1;260(1):81-8. doi: 10.1016/j.taap.2012.01.029. Epub 2012 Feb 8.
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67 Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
68 Amiodarone reversibly decreases sodium-iodide symporter mRNA expression at therapeutic concentrations and induces antioxidant responses at supraphysiological concentrations in cultured human thyroid follicles. Thyroid. 2007 Dec;17(12):1189-200. doi: 10.1089/thy.2007.0215.
69 Increased iodine uptake in thyroid carcinoma after treatment with sodium butyrate and decitabine (5-Aza-dC). Otolaryngol Head Neck Surg. 2007 Nov;137(5):722-8. doi: 10.1016/j.otohns.2007.07.030.