Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME26RS)

Drug Name
LTB4 Drug Info
Synonyms
Leukotriene B4; LEUKOTRIENE B4; 5,12-Dihete; 71160-24-2; 5,12-Hete; UNII-1HGW4DR56D; (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid; 1HGW4DR56D; CHEMBL65061; 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid; CHEBI:15647; VNYSSYRCGWBHLG-AMOLWHMGSA-N; [5S,12R]-Dihydroxy-[6Z,8E,10E,14Z]-eicosatetraenoic acid; Leukotriene B; 5(S),12(R)-Dihydroxy-6-cis-8-trans-10-trans-14-cis-eicosatetraenoic Acid; (S-(R*,S*-(E,Z,E,Z)))-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid; 6,8,10,14-Eicosatetraenoic acid,; Leukotriene B4 agonist (HIV infection), LTB4 Sweden AB; LEUKOTRIENE_B4
Indication
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Phase 2 [1]
Cross-matching ID
PubChem CID
5280492
ChEBI ID
CHEBI:15647
CAS Number
CAS 71160-24-2
TTD Drug ID
DME26RS
INTEDE Drug ID
DR1851

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Leukotriene B4 receptor 2 (LTB4R2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Biomed 101 DMQ9KZW Kidney cancer 2C90.0 Phase 1 [3]
ONO-4057 DMNEA78 Inflammatory bowel disease DD72 Discontinued in Phase 2 [14]
CP-105696 DM1C4IN Inflammatory bowel disease DD72 Discontinued in Phase 1 [15]
LY-292728 DMU24HR N. A. N. A. Terminated [16]
LY-255283 DMFIR0S Asthma CA23 Terminated [17]
LY-282210 DMBSFDE Discovery agent N.A. Investigative [16]
(3S,4R)-3-Benzyl-7-isopropyl-chroman-4-ol DMET6IS Discovery agent N.A. Investigative [15]
12S-HETE DMBEZ09 Discovery agent N.A. Investigative [18]
ZK-158252 DMNMD0J Discovery agent N.A. Investigative [18]
[3H]LTB4 DMDOJVX Discovery agent N.A. Investigative [19]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [29]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [30]
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Drug(s) Targeting Leukotriene B4 receptor 1 (LTB4R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amelubant DMUMCB9 Pulmonary disease 1B10-1F85 Phase 2 [20]
Biomed 101 DMQ9KZW Kidney cancer 2C90.0 Phase 1 [21]
LY293111 DM03FHA Pancreatic cancer 2C10 Discontinued in Phase 2 [22]
SB-201993 DMIF4VJ Psoriasis vulgaris EA90 Discontinued in Phase 2 [23]
CI-949 DMN4QSW Asthma CA23 Discontinued in Phase 2 [24]
CP-195543 DM1OSUR Rheumatoid arthritis FA20 Discontinued in Phase 2 [25]
LTB 019 DM6G0PN Asthma CA23 Discontinued in Phase 2 [26]
LY-223982 DMWB7DO Asthma CA23 Discontinued in Phase 2 [27]
CP-105696 DM1C4IN Inflammatory bowel disease DD72 Discontinued in Phase 1 [15]
TAK-683 DMRD8HK Prostate cancer 2C82.0 Discontinued in Phase 1 [28]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [31]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [34]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [39]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [37]
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Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [46]
Ethanol DMDRQZU Chronic pain MG30 Approved [47]
Oxymetholone DMFXUT8 Aplastic anemia 3A70 Approved [48]
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Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Panobinostat DM58WKG Chronic graft versus host disease Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [53]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [54]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [55]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [56]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [42]
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Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [59]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [60]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [61]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [62]
Testosterone DM7HUNW Hot flushes GA30 Approved [63]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [64]
Acetylcholine DMDF79Z Cataract 9B10 Approved [65]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [66]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [67]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [68]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Verapamil DMA7PEW Angina pectoris BA40 Approved [70]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [71]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [72]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [73]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Meloxicam DM2AR7L Arthritis FA20 Approved [75]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [76]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [77]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [71]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [78]
Methotrexate DM2TEOL Anterior urethra cancer Approved [79]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [83]
Ethacrynic acid DM60QMR Edema MG29 Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [85]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [89]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [90]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [91]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [92]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [93]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [94]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Gefitinib DM15F0X Colon adenocarcinoma Approved [95]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [37]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [96]
Selenium DM25CGV N. A. N. A. Approved [97]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [98]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [99]
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Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [101]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [102]
Fructose DM43AN2 Vomiting MD90 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [107]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [108]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [109]
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Drug(s) Affected By Complement C5 (C5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [111]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [93]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [112]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [113]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [114]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [115]
Olanzapine DMPFN6Y Bipolar depression Approved [116]
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Drug(s) Affected By Leukotriene A-4 hydrolase (LTA4H)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [117]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [113]
Clozapine DMFC71L Schizophrenia 6A20 Approved [118]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [114]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [115]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [119]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [121]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leukotriene B4 receptor 1 (LTB4R) TTN53ZF LT4R1_HUMAN Agonist [2]
Leukotriene B4 receptor 2 (LTB4R2) TTVJX54 LT4R2_HUMAN Inhibitor [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Leukotriene B4 omega-hydroxylase (CYP4F3) Main DME DEFCMPI CP4F3_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Gene/Protein Processing [5]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [6]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [7]
Complement C5 (C5) OTSL3OIC CO5_HUMAN Regulation of Drug Effects [8]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Protein Interaction/Cellular Processes [9]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Gene/Protein Processing [7]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Regulation of Drug Effects [10]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [11]
Leukotriene A-4 hydrolase (LTA4H) OTWSZ0QT LKHA4_HUMAN Biotransformations [12]
Leukotriene B4 receptor 2 (LTB4R2) OTYRQR2T LT4R2_HUMAN Protein Interaction/Cellular Processes [13]

References

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21 Biomed 101, a leukotriene B4 inhibitor, may decrease IL-2 toxicity. 2003 ASCO Annual Meeting. 2003.
22 The Role of PPARgamma Receptors and Leukotriene B(4) Receptors in Mediating the Effects of LY293111 in Pancreatic Cancer. PPAR Res. 2008;2008:827096.
23 (E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist w... J Med Chem. 1996 Sep 13;39(19):3837-41.
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31 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
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33 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
34 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
35 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
36 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
37 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
38 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
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40 SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004;21(6):477-83.
41 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
42 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
43 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
44 Species-specific differences in the inhibition of human and zebrafish 11beta-hydroxysteroid dehydrogenase 2 by thiram and organotins. Toxicology. 2012 Nov 15;301(1-3):72-8.
45 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
46 Inhibition of 11-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole. Biochem Pharmacol. 2017 Apr 15;130:93-103. doi: 10.1016/j.bcp.2017.01.010. Epub 2017 Jan 25.
47 cAMP/PKA/EGR1 signaling mediates the molecular mechanism of ethanol-induced inhibition of placental 11beta-HSD2 expression. Toxicol Appl Pharmacol. 2018 Aug 1;352:77-86.
48 The anabolic androgenic steroid fluoxymesterone inhibits 11beta-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation. Toxicol Sci. 2012 Apr;126(2):353-61.
49 Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues. Toxicol Sci. 2016 Dec;154(2):354-367. doi: 10.1093/toxsci/kfw169. Epub 2016 Sep 7.
50 Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-/Smad signaling pathways. Cell Biol Toxicol. 2021 Jun;37(3):479-496. doi: 10.1007/s10565-020-09562-0. Epub 2020 Oct 17.
51 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
52 Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis. PLoS One. 2018 Nov 27;13(11):e0207915. doi: 10.1371/journal.pone.0207915. eCollection 2018.
53 Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway. J Cell Physiol. 2019 Mar;234(3):2606-2617. doi: 10.1002/jcp.27073. Epub 2018 Oct 14.
54 Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. J Pharmacol Exp Ther. 2014 Jun;349(3):480-6. doi: 10.1124/jpet.114.213520. Epub 2014 Apr 4.
55 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
56 Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
57 Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: a simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant. J Dermatol Sci. 2001 Jun;26(2):85-93. doi: 10.1016/s0923-1811(00)00165-1.
58 Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clin Exp Allergy. 2000 Apr;30(4):501-8. doi: 10.1046/j.1365-2222.2000.00768.x.
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