Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG2YBD)

Drug Name
Trifluridine Drug Info
Synonyms
Fluridine; TFDU; TRIFLUOROTHYMIDINE; Trifluoridine; Trifluoromethyldeoxyuridine; Trifluridina; Trifluridinum; Virophta; Viroptic; Trifluorothymine deoxyriboside; CF3dUrd; F3DThd; F3T; F3TDR; HS-0007; Trifluridina [INN-Spanish]; Trifluridine [USAN:INN]; Trifluridinum [INN-Latin]; Viroptic (TN); Trifluridine (USP/INN);Viroptic, Trifluorothymidine, Trifluridine; Alpha,alpha,alpha-Trifluorothymidine; 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione; 2'-Deoxy-5-(trifluoromethyl)uridine; 2'-Deoxy-5-trifluoromethyluridine; 5-(Trifluoromethyl)-2'-deoxyuridine; 5-(Trifluoromethyl)deoxyuridine; 5-Trifluoro-2'-deoxythymidine; 5-Trifluoromethyl-2'-deoxyuridine; 5-Trifluoromethyl-2-deoxyuridine; 5-Trifluorothymidine
Indication
Disease Entry ICD 11 Status REF
Herpetic keratitis 1F00.10 Approved [1]
Virus infection 1A24-1D9Z Approved [2]
Colon cancer 2B90.Z Investigative [1]
Therapeutic Class
Antiviral Agents
Cross-matching ID
PubChem CID
6256
ChEBI ID
CHEBI:75179
CAS Number
CAS 70-00-8
TTD Drug ID
DMG2YBD
VARIDT Drug ID
DR00096
INTEDE Drug ID
DR1643

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Candida Thymidylate synthase (Candi TMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [11]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [12]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [13]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [14]
Raltitrexed DMT9K8G Rectal adenocarcinoma 2B92 Approved [15]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [16]
Flucytosine DM13VTW Cryptococcal meningitis Approved [17]
Nolatrexed DMOF0CA Solid tumour/cancer 2A00-2F9Z Phase 3 [18]
Plevitrexed (R)-isomer DMTL39C Gastric adenocarcinoma 2B72 Phase 2 [19]
Plevitrexed DM7Y60I Gastric adenocarcinoma 2B72 Phase 2 [19]
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Drug(s) Transported By Organic anion transporter 1 (SLC22A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [22]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [23]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [23]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [23]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [24]
Olmesartan medoxomil DMWBHRY High blood pressure BA00 Approved [25]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [26]
FLUORESCEIN DMQTFAO Ocular disease 1F00.1Z Approved [27]
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Drug(s) Transported By Concentrative nucleoside transporter 1 (SLC28A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [28]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [29]
Uridine DMQTREB Depression 6A70-6A7Z Approved [30]
Drug(s) Transported By Equilibrative nucleoside transporter 1 (SLC29A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [31]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [32]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [28]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [33]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [34]
Clofarabine DMCVJ86 Acute lymphoblastic leukaemia 2A85 Approved [35]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [36]
Tecadenoson DM9T6MS Atrial fibrillation BC81.3 Discontinued in Phase 3 [37]
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Drug(s) Transported By Equilibrative nucleoside transporter 2 (SLC29A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [32]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [28]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [33]
Clofarabine DMCVJ86 Acute lymphoblastic leukaemia 2A85 Approved [35]
Drug(s) Metabolized By Thymidine phosphorylase (TYMP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [38]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [39]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [40]
Deoxythymidine DMR90HY Discovery agent N.A. Investigative [41]
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [10]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [10]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [42]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [43]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [44]
Etidronic acid DM1XHYJ Bone Paget disease Approved [10]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [10]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [10]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [45]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [46]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [51]
Paclitaxel DMLB81S Breast carcinoma Approved [52]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
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Drug(s) Affected By Cathepsin B (CTSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [58]
Selenium DM25CGV N. A. N. A. Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [64]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [65]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [66]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Gefitinib DM15F0X Colon adenocarcinoma Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [70]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [71]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [72]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [71]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [73]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [74]
Methotrexate DM2TEOL Anterior urethra cancer Approved [75]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [76]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [77]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [78]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [70]
Meloxicam DM2AR7L Arthritis FA20 Approved [81]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [82]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [83]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [84]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [86]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Gefitinib DM15F0X Colon adenocarcinoma Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [70]
Selenium DM25CGV N. A. N. A. Approved [59]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Verapamil DMA7PEW Angina pectoris BA40 Approved [90]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [92]
Selenium DM25CGV N. A. N. A. Approved [59]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [94]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [96]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Candida Thymidylate synthase (Candi TMP1) TTU6BFZ TYSY_CANAL Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Equilibrative nucleoside transporter 2 (SLC29A2) DTW78DQ S29A2_HUMAN Substrate [4]
Concentrative nucleoside transporter 1 (SLC28A1) DT0EQPW S28A1_HUMAN Substrate [4]
Equilibrative nucleoside transporter 1 (SLC29A1) DTXD1TQ S29A1_HUMAN Substrate [4]
Organic anion transporter 1 (SLC22A6) DTQ23VB S22A6_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Thymidine phosphorylase (TYMP) Main DME DE4HCYL TYPH_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Protein Interaction/Cellular Processes [7]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [7]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Protein Interaction/Cellular Processes [7]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [8]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Gene/Protein Processing [9]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [10]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [7]

References

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34 Effects of dipyridamole coadministration on the pharmacokinetics of ribavirin in healthy volunteers. Drug Metab Pharmacokinet. 2013;28(5):406-10.
35 Cytarabine-resistant leukemia cells are moderately sensitive to clofarabine in vitro. Anticancer Res. 2014 Apr;34(4):1657-62.
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37 Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1. Drug Metab Dispos. 2013 Apr;41(4):916-22.
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59 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
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61 Proton pump inhibitors interfere with the anti-tumor potency of RC48ADC. Toxicol In Vitro. 2022 Mar;79:105292. doi: 10.1016/j.tiv.2021.105292. Epub 2021 Dec 3.
62 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
63 Pyrimethamine induces apoptosis of melanoma cells via a caspase and cathepsin double-edged mechanism. Cancer Res. 2008 Jul 1;68(13):5291-300. doi: 10.1158/0008-5472.CAN-08-0222.
64 Synergistic effects of arsenic trioxide and silibinin on apoptosis and invasion in human glioblastoma U87MG cell line. Neurochem Res. 2012 Feb;37(2):370-80. doi: 10.1007/s11064-011-0620-1. Epub 2011 Oct 4.
65 Thyroid organotypic rat and human cultures used to investigate drug effects on thyroid function, hormone synthesis and release pathways. Toxicol Appl Pharmacol. 2012 Apr 1;260(1):81-8. doi: 10.1016/j.taap.2012.01.029. Epub 2012 Feb 8.
66 Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy. 2016 Nov;12(11):2213-2229. doi: 10.1080/15548627.2016.1213927. Epub 2016 Sep 16.
67 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
68 Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
69 Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
70 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
71 The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
72 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
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