Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG629M)

Drug Name
Rivastigmine Drug Info
Synonyms Rivastigmine (transdermal patch)
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Approved [1]
Cross-matching ID
PubChem CID
77991
ChEBI ID
CHEBI:8874
CAS Number
CAS 123441-03-2
TTD Drug ID
DMG629M
ACDINA Drug ID
D00602

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Acetylcholinesterase (AChE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [10]
Donepezil DMIYG7Z Advanced cancer 2A00-2F9Z Approved [2]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [11]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [12]
Huperzine A DMMAWLU Alzheimer disease 8A20 Approved [13]
Neostigmine DM6T2J3 Myasthenia gravis 8C6Y Approved [14]
YM443 DMNZCI1 Functional dyspepsia DD90.3 Approved [15]
Ambenonium DMOP0BL Myasthenia gravis 8C6Y Approved [16]
Demecarium bromide DMAYEU1 Open-angle glaucoma 9C61 Approved [17]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [18]
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Drug(s) Affected By Cholinesterase (BCHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [19]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [20]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [21]
Donepezil DMIYG7Z Advanced cancer 2A00-2F9Z Approved [22]
Succinylcholine DM2ET1M Plasma cell myeloma 2A83.1 Approved [23]
Ethopropazine DM0N3L7 Parkinson disease 8A00.0 Approved [20]
Dimenhydrinate DM264B3 Meniere disease AB31.0 Approved [24]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [25]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [26]
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Drug(s) Affected By Cocaine esterase (CES2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [27]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [28]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [6]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Testosterone enanthate DMB6871 N. A. N. A. Approved [34]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [35]
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Drug(s) Affected By Liver carboxylesterase 1 (CES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [36]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [29]
Selenium DM25CGV N. A. N. A. Approved [38]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [41]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [27]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [44]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [45]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [48]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [49]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [50]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [54]
Methotrexate DM2TEOL Anterior urethra cancer Approved [55]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [57]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [58]
Paclitaxel DMLB81S Breast carcinoma Approved [59]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [60]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [62]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
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Drug(s) Affected By Neuronal acetylcholine receptor subunit beta-2 (CHRNB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [8]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [8]
Scopolamine DMOM8AL Addictive disorder 6C50-6C5Z Approved [8]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [66]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [67]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [68]
CYTISINE DMUF0BJ Tobacco dependence 6C4A.2 Phase 3 [69]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [70]
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Drug(s) Affected By Acetylcholinesterase (ACHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetylcholine DMDF79Z Cataract 9B10 Approved [71]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [72]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [73]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [73]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [75]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [76]
Neostigmine DM6T2J3 Myasthenia gravis 8C6Y Approved [77]
Testosterone DM7HUNW Hot flushes GA30 Approved [78]
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Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Selenium DM25CGV N. A. N. A. Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [8]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [8]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [80]
Scopolamine DMOM8AL Addictive disorder 6C50-6C5Z Approved [8]
Arsenic DMTL2Y1 N. A. N. A. Approved [81]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [82]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [80]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [84]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [84]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [86]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [84]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [84]
Ethacrynic acid DM60QMR Edema MG29 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [84]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetylcholinesterase (AChE) TT1RS9F ACES_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acetylcholinesterase (ACHE) OT2H8HG6 ACES_HUMAN Gene/Protein Processing [3]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [4]
Cholinesterase (BCHE) OTOH3WQ9 CHLE_HUMAN Gene/Protein Processing [5]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Gene/Protein Processing [6]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Gene/Protein Processing [7]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Gene/Protein Processing [6]
Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) OT1H0ZXC ACHA4_HUMAN Protein Interaction/Cellular Processes [8]
Neuronal acetylcholine receptor subunit beta-2 (CHRNB2) OTNAT2M5 ACHB2_HUMAN Protein Interaction/Cellular Processes [8]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Gene/Protein Processing [9]

References

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2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465).
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84 A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
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86 Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.