Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMK54YG)

Drug Name

Griseofulvin Drug Info

Synonyms

Amudane; Delmofulvina; Fulcin; Fulcine; Fulvicin; FulvicinUF; Fulvina; Fulvinil; Fulvistatin; Fungivin; Greosin;Gresfeed; Gricin; Grifulin; Grifulvin; GrisPEG; Grisactin; Griscofulvin; Grisefuline; Griseo; Griseofulvina; Griseofulvine; Griseofulvinum; Griseomix; Griseostatin; Grisetin; Grisofulvin; Grisovin; Grizeofulvin; Grysio; Guservin; Lamoryl; Likuden; Likunden; Murfulvin; Poncyl; Spirofulvin; Sporostatin; Xuanjing; Curling fact or; Curling factor; Fulvican grisactin; Fulvicin U F; Grifulvin V; Gris PEG; Grisactin Ultra; Grise ostatin; Griseofulvin forte; Grisovin FP; Interacts with polymerized microtubules and associated proteins; Sporostatin xan; Biogrisin-FP; FULVICIN P/G 165; FULVICIN P/G 330;Fulvicin Bolus (Veterinary); Fulvicin P/G; Fulvicin U/F; Fulvidex (Veterinary); GRISEOFULVIN, MICROCRYSTALLINE; GRISEOFULVIN, ULTRAMICROCRYSTALLINE; Gris-PEG; Griseofulvin and Alpha-IFN; Griseofulvin-forte; Griseofulvina [INN-Spanish]; Griseofulvine [INN-French]; Griseofulvinum [INN-Latin]; Grisovin (TN); NP-002466; Neo-Fulcin; ULTRAGRIS-165; ULTRAGRIS-330; USAF SC-2; Fulvicin-P/G; Fulvicin-U-F; Fulvicin-U/F; Fulvicin-U/F (Veterinary); Griseofulvin [USAN:INN:BAN:JAN]; (+)-Griseofulvin; 7-Chloro-4,6,2'-trimethoxy-6'-methylgris-2'-en-3,4'-dione

Indication

Disease Entry	ICD 11	Status	REF
Onychomycosis	EE12.1	Approved	[1]
Ringworm infection	1F28	Approved	[2]
Tinea corporis	1F28.Y	Approved	[1]
Tinea cruris	1F28.3	Approved	[1]
Tinea pedis	1F28.2	Investigative	[1]

Therapeutic Class

Antifungal Agents

Cross-matching ID

PubChem CID: 441140
ChEBI ID: CHEBI:27779
CAS Number: CAS 126-07-8
TTD Drug ID: DMK54YG
INTEDE Drug ID: DR0791
ACDINA Drug ID: D00306

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[10]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[11]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[13]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[14]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[16]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[17]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[18]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[19]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[20]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[21]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[23]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[25]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[26]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[27]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[28]
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Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Selenium	DM25CGV	N. A.	N. A.	Approved	[31]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
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Drug(s) Affected By L-selectin (SELL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[39]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[39]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[43]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[39]
Phenylbutazone	DMAYL0T	Chronic pain	MG30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
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Drug(s) Affected By Gap junction alpha-1 protein (GJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[50]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[51]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[45]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[52]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[53]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[55]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[56]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[57]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[58]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[60]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[62]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[63]
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Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[64]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[65]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[67]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[70]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[71]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[72]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[73]
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Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[74]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[5]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[5]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[5]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[5]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[5]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[5]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[5]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[5]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fungal Microtubule (Fung MicroTU)	TT7PBUD	NOUNIPROTAC	Inducer	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 1A2 (CYP1A2)^{Main DME}	DEJGDUW	CP1A2_HUMAN	Substrate	[4]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Gene/Protein Processing	[5]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[6]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Gene/Protein Processing	[6]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Gene/Protein Processing	[7]
Gap junction alpha-1 protein (GJA1)	OTT94MKL	CXA1_HUMAN	Gene/Protein Processing	[6]
Keratin, type I cytoskeletal 18 (KRT18)	OTVLQFIP	K1C18_HUMAN	Gene/Protein Processing	[8]
L-selectin (SELL)	OT6RAJZR	LYAM1_HUMAN	Gene/Protein Processing	[9]

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References

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