Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY8NC4)

Drug Name
Cefoxitin Drug Info
Synonyms
Cefoxitina; Cefoxitine; Cefoxitinum; Cefoxotin; Cenomycin; Mefoxin; Mefoxitin; Rephoxitin; cefoxitin; ceftoxitin; 35607-66-0; CEPHOXITIN; 4kow; 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-, (6R,7S)-; 6OEV9DX57Y; AK118716; CAS-35607-66-0; CFX; CHEBI:209807; CHEMBL996; DSSTox_CID_2764; DSSTox_GSID_22764; DSSTox_RID_76721; NCGC00183034-01; UNII-6OEV9DX57Y
Indication
Disease Entry ICD 11 Status REF
Acute gonococcal cervicitis Approved [1]
Bacteremia 1A73 Approved [1]
Bacterial infection 1A00-1C4Z Approved [2]
Endometritis Approved [1]
Lung abscess Approved [1]
Peritonitis Approved [1]
Staphylococcal pneumonia Approved [1]
Staphylococcus aureus infection Approved [1]
Pelvic inflammatory disease GA05 Investigative [1]
Cross-matching ID
PubChem CID
441199
ChEBI ID
CHEBI:209807
CAS Number
CAS 35607-66-0
TTD Drug ID
DMY8NC4
INTEDE Drug ID
DR2492

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial Penicillin binding protein (Bact PBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ampicillin DMHWE7P Acute epiglottitis Approved [13]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [14]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [15]
Ticarcillin DM4ME02 Aspiration pneumonia Approved [16]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [17]
Meropenem DM62UHC Bacterial infection 1A00-1C4Z Approved [15]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [18]
Clofarabine DMCVJ86 Acute lymphoblastic leukaemia 2A85 Approved [19]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [20]
Carbenicillin DMLEDNK Infection of the upper and lower urinary tract GC08 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Peptide transporter 1 (SLC15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [22]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [23]
Ampicillin DMHWE7P Acute epiglottitis Approved [24]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [25]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [26]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [4]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [27]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [23]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [25]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Beta-lactamase (blaB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cefazolin DMPDYFR Bacteremia 1A73 Approved [5]
Aztreonam DMDNJHG Bacterial infection 1A00-1C4Z Approved [5]
Levofloxacin DMS60RB Acute maxillary sinusitis Approved [5]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [5]
Cotrimoxazole DMSW5QP N. A. N. A. Phase 4 [5]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [6]
Aztreonam DMDNJHG Bacterial infection 1A00-1C4Z Approved [6]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [6] , [7]
Cefpirome DMJKWPZ N. A. N. A. Phase 4 [7]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [28]
Imipenem DMI9FBP Bacteremia 1A73 Approved [29]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [8]
Avibactam DM1AEH4 N. A. N. A. Approved [30] , [31]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [8] , [30]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [32]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [9]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [9]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [9]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [9]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [32]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [9]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [32]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [9] , [33]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [32]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [9]
Ertapenem DM4S3O8 Bacterial infection 1A00-1C4Z Approved [34]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [7]
Cefpirome DMJKWPZ N. A. N. A. Phase 4 [7]
Cefpodoxime DMJUNY5 Acute gonococcal cervicitis Approved [35]
Ticarcillin DM4ME02 Aspiration pneumonia Approved [10]
Carbenicillin DMLEDNK Infection of the upper and lower urinary tract GC08 Approved [10]
Cefotaxime DMEB837 Bacteremia 1A73 Approved [36]
⏷ Show the Full List of 32 Drug(s)
Drug(s) Affected By HLA class I histocompatibility antigen, A alpha chain (HLA-A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [37]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [38]
Allopurinol DMLPAOB Gout FA25 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [40]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [41]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [42]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [12]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [12]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [44]
Fluoxetine DM3PD2C Bipolar depression Approved [12]
Cinoxacin DM4EWNS Urinary tract infection GC08 Approved [12]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Testosterone DM7HUNW Hot flushes GA30 Approved [47]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [12]
Testosterone enanthate DMB6871 N. A. N. A. Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Penicillin binding protein (Bact PBP) TTJP4SM NOUNIPROTAC Binder [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Beta-lactamase (blaB) DEP0IWS A0A378EHS6_KLEPR Substrate [5]
Beta-lactamase (blaB) DEEAL81 BLA2_KLEPO Substrate [6] , [7]
Beta-lactamase (blaB) DE7IH52 AMPC_CITFR Substrate [8]
Beta-lactamase (blaB) DE5HV8P A0A4Q5I6I2_9BACE Substrate [9]
Beta-lactamase (blaB) DE47ARF B5WXV2_9BACT Substrate [9]
Beta-lactamase (blaB) DEG2PK9 B5WXV3_BACOV Substrate [9]
Beta-lactamase (blaB) DEWHJ7A B5WXV7_BACT4 Substrate [9]
Beta-lactamase (blaB) DEU1RXB BLAC_BACVU Substrate [9]
Beta-lactamase (blaB) DEMIUB2 BLAT_ECOLX Substrate [7]
Beta-lactamase (blaB) DEF01WC A0A3S4HKA9_CHRVL Substrate [10]
Beta-lactamase (blaB) DEHJVX4 A0A414C8Y0_9BACT Substrate [9]
Beta-lactamase (blaB) DEQAG48 A0A3Q9VXP1_CITAM Substrate [11]
Beta-lactamase (blaB) DE5AHG6 BLAC_CITKO Substrate [11]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
HLA class I histocompatibility antigen, A alpha chain (HLA-A) OTAH14LU HLAA_HUMAN Gene/Protein Processing [12]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1) OT7OG7Y2 DPA1_HUMAN Gene/Protein Processing [12]

References

1 Cefoxitin FDA Label
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4 Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9.
5 Analysis of the drug-resistant characteristics of Klebsiella pneumoniae isolated from the respiratory tract and CTX-M ESBL genes. Genet Mol Res. 2015 Oct 5;14(4):12043-8.
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9 Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74.
10 Beta-lactamase activity in Chromobacterium violaceum. J Infect Dis. 1976 Sep;134(3):290-3.
11 Citrobacter koseri and Citrobacter amalonaticus isolates carry highly divergent beta-lactamase genes despite having high levels of biochemical similarity and 16S rRNA sequence homology. J Antimicrob Chemother. 2004 Jun;53(6):1076-80.
12 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
13 Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci. Antimicrob Agents Chemother. 2002 May;46(5):1273-80.
14 Bacteriological characteristics of Staphylococcus aureus isolates from humans and bulk milk. J Dairy Sci. 2008 Feb;91(2):564-9.
15 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
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20 Relationship between penicillin-binding protein patterns and beta-lactamases in clinical isolates of Bacteroides fragilis with different susceptibility to beta-lactam antibiotics. J Med Microbiol. 2004 Mar;53(Pt 3):213-21.
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22 Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55.
23 Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18.
24 Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. Res Microbiol. 2017 Jun;168(5):443-449.
25 High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9.
26 The intestinal H+/peptide symporter PEPT1: structure-affinity relationships. Eur J Pharm Sci. 2004 Jan;21(1):53-60.
27 Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61.
28 Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24.
29 Antibiotic therapy for inducible AmpC beta-lactamase-producing Gram-negative bacilli: what are the alternatives to carbapenems, quinolones and aminoglycosides? Int J Antimicrob Agents. 2012 Oct;40(4):297-305.
30 Analyses of a ceftazidime-avibactam-resistant Citrobacter freundii isolate carrying blaKPC-2 reveals a heterogenous population and reversible genotype. mSphere. 2018 Sep 26;3(5). pii: e00408-18.
31 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.
32 Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13.
33 Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against beta-lactam antibiotics. J Antimicrob Chemother. 2015 Mar;70(3):701-9.
34 War wound treatment complications due to transfer of an IncN plasmid harboring bla(OXA-181) from Morganella morganii to CTX-M-27-producing sequence type 131 Escherichia coli. Antimicrob Agents Chemother. 2015;59(6):3556-62.
35 Low-virulence Citrobacter species encode resistance to multiple antimicrobials. Antimicrob Agents Chemother. 2002 Nov;46(11):3555-60.
36 Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate. Antimicrob Agents Chemother. 2005 Apr;49(4):1564-6.
37 HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med. 2011 Mar 24;364(12):1134-43. doi: 10.1056/NEJMoa1013297.
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39 Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans. Pharmacogenet Genomics. 2011 May;21(5):303-7. doi: 10.1097/FPC.0b013e32834282b8.
40 A study of HLA class I and class II 4-digit allele level in Stevens-Johnson syndrome and toxic epidermal necrolysis. Int J Immunogenet. 2011 Aug;38(4):303-9. doi: 10.1111/j.1744-313X.2011.01011.x. Epub 2011 May 4.
41 HLA alleles influence the clinical signature of amoxicillin-clavulanate hepatotoxicity. PLoS One. 2013 Jul 9;8(7):e68111. doi: 10.1371/journal.pone.0068111. Print 2013.
42 Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study. Pharmacogenomics J. 2008 Feb;8(1):29-33. doi: 10.1038/sj.tpj.6500442. Epub 2007 Mar 6.
43 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
44 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
45 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
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47 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
48 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
49 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.