Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZGCEQ)

Drug Name
1,2,3,4-tetrahydroisoquinoline Drug Info
Synonyms
1,2,3,4-Tetrahydroisoquinoline; 91-21-4; Tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-isoquinoline; ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-; 1,2,3,4-Tetrahydro isoquinoline; EINECS 202-050-0; NSC 15312; 1,2,3,4-Tetrahydro-2-isoquinoline; 1,2,3,4-Tetrahydro-2-azanaphthalene; BRN 0116156; UNII-56W89FBX3E; CHEMBL14346; AI3-15931; 56W89FBX3E; UWYZHKAOTLEWKK-UHFFFAOYSA-N; MFCD00006896; 1,2,3,4-Tetrahydroisoquinoline, 95%; 3,4-dihydro-1H-isoquinoline; tetrahydroisoquinolin; tetrahyroisoquinoline; tetrahydro-isoquinoline; PubChem7253; AC1L1NVS
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
7046
ChEBI ID
CHEBI:125498
CAS Number
CAS 91-21-4
TTD Drug ID
DMZGCEQ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Adrenergic receptor alpha-2C (ADRA2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MOXONIDINE DMGFB0E Alcohol dependence 6C40.2 Approved [6]
Dihydroergocristine DM5SQ1G Alcohol dependence 6C40.2 Approved [7]
Brimonidine DMQLT4N Ocular hypertension 9C61.01 Approved [8]
Amosulalol DML8QSZ Hypertension BA00-BA04 Approved [9]
Amezinium DM6I2WQ Hypotension BA20-BA21 Approved [10]
Propylhexedrine DMTBW2O Obesity 5B81 Approved [11]
Tetrahydrozoline DMT57WC Ocular disease 1F00.1Z Approved [12]
Rilmenidine DM13PQW Hypertension BA00-BA04 Approved [13]
Xylometazoline DMKV32D Allergic rhinitis CA08.0 Phase 4 [14]
TNX-102 DMO1234 Fibromyalgia MG30.01 Phase 3 [15]
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Drug(s) Targeting Adrenergic receptor alpha-2A (ADRA2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lofexidine DM1WXA6 Heroin and opiate withdrawal 6C43 Approved [16]
MOXONIDINE DMGFB0E Alcohol dependence 6C40.2 Approved [6]
Connexyn DMF29Q5 Attention deficit hyperactivity disorder 6A05.Z Approved [17]
Guanfacine DMPN5IH Attention deficit hyperactivity disorder 6A05.Z Phase 4 [18]
A295 DM55GO2 Aggressive cancer 2A00-2F9Z IND submitted [19]
MEDETOMIDINE DMX9Y7V Pain MG30-MG3Z Phase 2 [20]
DSP-1200 DM4WSHG Depression 6A70-6A7Z Phase 1 [21]
MAZAPERTINE DMRHYAU N. A. N. A. Discontinued in Phase 2 [22]
NMI-870 DMU596F Sexual dysfunction HA00-HA01 Discontinued in Phase 2 [23]
SNAP-5089 DMROJEN Heart arrhythmia BC65 Terminated [24]
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Drug(s) Targeting Adrenergic receptor alpha-2B (ADRA2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MOXONIDINE DMGFB0E Alcohol dependence 6C40.2 Approved [6]
MEDETOMIDINE DMX9Y7V Pain MG30-MG3Z Phase 2 [20]
AGN-199981 DMP5Y1A Neuropathic pain 8E43.0 Phase 2 [25]
INDORAMIN DMNSJFD Hypertension BA00-BA04 Withdrawn from market [26]
MAZAPERTINE DMRHYAU N. A. N. A. Discontinued in Phase 2 [22]
SNAP-5089 DMROJEN Heart arrhythmia BC65 Terminated [24]
A-80426 DMBC3DG N. A. N. A. Terminated [27]
WB-4101 DMQU8B1 N. A. N. A. Terminated [28]
SK&F-104078 DMRADBU N. A. N. A. Terminated [26]
(+/-)-nantenine DM0L3GE Discovery agent N.A. Investigative [29]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Gefitinib DM15F0X Colon adenocarcinoma Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [33]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [34]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [35]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [34]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
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Drug(s) Affected By Amine oxidase B (MAOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [39]
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [41]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [42]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [43]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
BENZYL BENZOATE DMDPYI5 Infestations of lice and scabies 1G00.Z Approved [47]
Linezolid DMGFPU2 Bacteremia 1A73 Approved [48]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [49]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [50]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [51]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [52]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [53]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [54]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [55]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [59]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [50]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [60]
Paclitaxel DMLB81S Breast carcinoma Approved [61]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [62]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [49]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [52]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [53]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [65]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [66]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [68]
Gefitinib DM15F0X Colon adenocarcinoma Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [71]
Selenium DM25CGV N. A. N. A. Approved [72]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [73]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [74]
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Drug(s) Affected By D(3) dopamine receptor (DRD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Haloperidol DM96SE0 Delirium Approved [75]
Clozapine DMFC71L Schizophrenia 6A20 Approved [76]
Risperidone DMN6DXL Bipolar I disorder Approved [77]
Folic Acid DMEMBJC Colorectal carcinoma Approved [78]
Methamphetamine DMPM4SK Anxiety Approved [79]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [80]
Droperidol DM0DXA8 Nausea MD90 Approved [63]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [63]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [63]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [63]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [83]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [84]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [85]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [86]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [87]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [88]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [89]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [90]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [91]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [92]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [93]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [94]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [97]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [91]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor alpha-2A (ADRA2A) TTWG9A4 ADA2A_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2B (ADRA2B) TTWM4TY ADA2B_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2C (ADRA2C) TT2NUT5 ADA2C_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Amine oxidase B (MAOB) OTTDFM1O AOFB_HUMAN Gene/Protein Processing [2]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [3]
D(3) dopamine receptor (DRD3) OT0OFFKB DRD3_HUMAN Protein Interaction/Cellular Processes [4]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Drug Response [5]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [3]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [3]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [3]

References

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31 Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
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33 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
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36 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
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40 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
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46 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
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51 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
52 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
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58 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
59 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
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62 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
63 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
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65 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
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67 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
68 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
69 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
70 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
71 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
72 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
73 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
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