Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNER5S)

• Drug Name: Bleomycin Drug Info
• Synonyms: BLM; Blenoxane; Bleo; Bleocin; Bleogin; Bleomicin; Bleomicina; Bleomycine; Bleomycins; Bleomycinum; Bleomycin sulfate; Bleomycin a2; Pingyangmyvin A2; Zhengguangmycin A2; Zhengguangmycin A2 [Chinese]; Blenoxane (TN); Bleomicina [INN-Spanish]; Bleomycin A(2); Bleomycin A2 & Bleomycin B2; Bleomycin B(2); Bleomycine [INN-French]; Bleomycinum [INN-Latin]; NDC 0015-3010; N(1)-[3-(dimethylsulfonio)propyl]bleomycinamide; N1-(3-(Dimethylsulfonio)propyl)bleomycinamide

Indication

Disease Entry	ICD 11	Status	REF
Cervical cancer	2C77.0	Approved	[1]
Head and neck cancer	2D42	Approved	[1]
Hodgkin lymphoma	2B30	Approved	[2]
Penile cancer		Approved	[1]
Testicular germ cell tumor		Approved	[1]
Classic Hodgkin lymphoma		Investigative	[1]
Follicular lymphoma	2A80	Investigative	[1]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 5360373
  CAS Number: CAS 11056-06-7
  TTD Drug ID: DMNER5S
  VARIDT Drug ID: DR00409
  INTEDE Drug ID: DR0217

Molecule-Related Drug Atlas

Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[13]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[14]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[15]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[16]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[17]
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[18]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[19]
Procarbazine	DMIK367	Hodgkin lymphoma	2B30	Approved	[20]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[21]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[22]

Drug(s) Affected By Bleomycin hydrolase (BLMH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[29]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[23]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Haloperidol	DM96SE0	Delirium		Approved	[33]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[34]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[37]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Haloperidol	DM96SE0	Delirium		Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[45]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[46]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Selenium	DM25CGV	N. A.	N. A.	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[53]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[55]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[61]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[63]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[72]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[73]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[76]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[77]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[78]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[79]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[80]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[82]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[86]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[85]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Selenium	DM25CGV	N. A.	N. A.	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]

Drug(s) Affected By Mucin-5AC (MUC5AC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[95]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[96]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[34]
Dihydroxyacetone	DMM1LG2	Sunburn	EJ40	Approved	[97]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[98]

Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]

Drug(s) Affected By Transmembrane protein 250 (TMEM250)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[5]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[5]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[109]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[110]

Drug(s) Affected By Suppressor of cytokine signaling 1 (SOCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[115]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[102]
Lomustine	DMMWSUL	Brain cancer	2A00	Approved	[116]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[117]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[121]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[122]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[123]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[124]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[125]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[127]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[128]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[129]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[130]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[131]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[132]
Fructose	DM43AN2	Vomiting	MD90	Approved	[33]
Ketoprofen	DMRKXPT	Bursitis		Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[135]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[136]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[140]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[85]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[51]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[142]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[143]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[146]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[149]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[152]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[156]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[157]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[160]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[161]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[52]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[162]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[82]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[163]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[141]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[168]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[169]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[171]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[172]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]

Drug(s) Affected By Cathepsin S (CTSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[11]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[115]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[181]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[183]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[186]

Drug(s) Affected By Max-interacting protein 1 (MXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[188]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[190]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[188]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[191]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[5]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[192]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[197]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]

Drug(s) Affected By Unconventional myosin-Ie (MYO1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[5]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[5]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[5]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[200]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[201]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[202]

Drug(s) Affected By Transcription intermediary factor 1-beta (TRIM28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Haloperidol	DM96SE0	Delirium		Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[190]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[203]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[203]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[212]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[213]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]

Drug(s) Affected By Structural maintenance of chromosomes protein 1A (SMC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[190]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Bortezomib	DMNO38U	Leukemia		Approved	[217]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]

Drug(s) Affected By 7SK snRNA methylphosphate capping enzyme (MEPCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[5]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[218]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[219]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[220]

Drug(s) Affected By Transmembrane protein 87A (TMEM87A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[191]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[5]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[200]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]

Drug(s) Affected By Terminal nucleotidyltransferase 4B (TENT4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[5]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[219]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[224]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[220]
Scriptaid	DM9JZ21	Solid tumour/cancer	2A00-2F9Z	Preclinical	[5]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[109]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[225]

Drug(s) Affected By Lipase member H (LIPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[5]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[5]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[201]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[228]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[229]

Drug(s) Affected By Abasic site processing protein HMCES (HMCES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[5]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[5]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[230]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[167]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[220]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[205]

Drug(s) Affected By Small integral membrane protein 14 (SMIM14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[5]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[190]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[5]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[49]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[5]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[221]

Drug(s) Affected By Kelch-like protein 42 (KLHL42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[231]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[5]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[232]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[233]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[219]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[5]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[234]

Drug(s) Affected By Inactive cell surface hyaluronidase CEMIP2 (CEMIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[190]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[235]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[5]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[221]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[5]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]

Drug(s) Affected By ERBB receptor feedback inhibitor 1 (ERRFI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[5]

Drug(s) Affected By Transmembrane and coiled-coil domain protein 3 (TMCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[231]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[238]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[5]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[234]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[238]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[234]
MGCD-0103	DM726HX	Non-small-cell lung cancer	2C25.Y	Phase 2	[5]

Drug(s) Affected By Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[5]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[239]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[231]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[201]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[5]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[240]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[241]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[242]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[245]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[246]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[247]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[248]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[249]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[250]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[252]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[210]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[254]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[255]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[258]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Breaker	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Bleomycin hydrolase (BLMH) Main DME	DECH1VP	BLMH_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
7SK snRNA methylphosphate capping enzyme (MEPCE)	OTRBQEYP	MEPCE_HUMAN	Gene/Protein Processing	[5]
Abasic site processing protein HMCES (HMCES)	OTVRDL6U	HMCES_HUMAN	Gene/Protein Processing	[5]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[6]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Drug Response	[7]
Bleomycin hydrolase (BLMH)	OT2QPWQJ	BLMH_HUMAN	Drug Response	[8]
C-X-C motif chemokine 2 (CXCL2)	OTEJCYMY	CXCL2_HUMAN	Gene/Protein Processing	[9]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Gene/Protein Processing	[10]
Cathepsin S (CTSS)	OT3PXIPM	CATS_HUMAN	Gene/Protein Processing	[11]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[12]
Ceramide glucosyltransferase	OTRT5P5I	CEGT_HUMAN	Gene/Protein Processing	[5]

References

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• [3] Bleomycin and talisomycin sequence-specific strand scission of DNA: a mechanism of double-strand cleavage. Cancer Res. 1982 Jul;42(7):2779-85.
• [4] The C-terminus of human bleomycin hydrolase is required for protection against bleomycin-induced chromosomal damage. Mutat Res. 1998 Oct 12;421(1):1-7.
• [5] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [6] Pulmonary fibrosis model using micro-CT analyzable human PSC-derived alveolar organoids containing alveolar macrophage-like cells. Cell Biol Toxicol. 2022 Aug;38(4):557-575. doi: 10.1007/s10565-022-09698-1. Epub 2022 Mar 10.
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• [8] Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity. Carcinogenesis. 2002 Jun;23(6):1003-8. doi: 10.1093/carcin/23.6.1003.
• [9] Agents associated with lung inflammation induce similar responses in NCI-H292 lung epithelial cells. Toxicol In Vitro. 2008 Oct;22(7):1782-8.
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• [16] Pharmacokinetics and metabolism of ifosfamide in relation to DNA damage assessed by the COMET assay in children with cancer. Br J Cancer. 2005 May 9;92(9):1626-35.
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• [19] DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect. Cancer Sci. 2004 May;95(5):454-8.
• [20] Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations... DNA Repair (Amst). 2009 Jan 1;8(1):72-86.
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