Details of the Drug Combination

General Information of Drug Combination (ID: DCN39RC)

• Drug Combination Name: Resveratrol + Losartan
• Indication: Diabetic Nephropathy; Status: Phase 1 [1]
• Component Drugs:
  Resveratrol (DM3RWXL): Small molecular drug
  Losartan (DM72JXH): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Resveratrol

Disease Entry	ICD 11	Status	REF
Giant cell arteritis	4A44.2	Phase 3	[2]
Rheumatoid arthritis	FA20	Phase 3	[2]
Systemic sclerosis	4A42	Phase 3	[2]
Colorectal cancer	2B91.Z	Discontinued in Phase 2	[3]
Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[4]

Resveratrol Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
NAD-dependent deacetylase sirtuin-1 (SIRT1)	TTUF2HO	SIR1_HUMAN	Inhibitor	[52]
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Modulator	[53]

Resveratrol Interacts with 3 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[54]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[55]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[54]

Resveratrol Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[56]
Sulfotransferase 1C2 (SULT1C2)	DEYMAD4	ST1C2_HUMAN	Metabolism	[57]
NADPH-dependent curcumin reductase (curA)	DEZWDKE	CURA_ECOLI	Metabolism	[58]

Resveratrol Interacts with 1110 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Decreases Activity	[59]
Sulfotransferase 1C2 (SULT1C2)	OT07MMZS	ST1C2_HUMAN	Increases Expression	[60]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Decreases Expression	[36]
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Decreases Response To Substance	[61]
Multidrug resistance-associated protein 1 (ABCC1)	OTGUN89S	MRP1_HUMAN	Decreases Response To Substance	[61]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Decreases Expression	[62]
DNA fragmentation factor subunit alpha (DFFA)	OTFPFMT8	DFFA_HUMAN	Decreases Expression	[8]
cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A)	OTZESF4H	PDE2A_HUMAN	Decreases Expression	[8]
Interferon-related developmental regulator 1 (IFRD1)	OT4SQMLQ	IFRD1_HUMAN	Decreases Expression	[8]
Nucleolar protein 56 (NOP56)	OTT67SRZ	NOP56_HUMAN	Decreases Expression	[8]
Ectoderm-neural cortex protein 1 (ENC1)	OTJEUB6U	ENC1_HUMAN	Decreases Expression	[8]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Decreases Expression	[8]
Glutathione S-transferase A4 (GSTA4)	OTZ1USIA	GSTA4_HUMAN	Increases Expression	[8]
Fatty acid-binding protein, brain (FABP7)	OTRE2H4G	FABP7_HUMAN	Increases Expression	[8]
Mitotic checkpoint protein BUB3 (BUB3)	OTU91HAU	BUB3_HUMAN	Increases Expression	[8]
Translation initiation factor eIF2 assembly protein (CDC123)	OTDGV8X3	CD123_HUMAN	Decreases Expression	[8]
Flotillin-1 (FLOT1)	OT0JPPJZ	FLOT1_HUMAN	Increases Expression	[8]
Glutathione reductase, mitochondrial (GSR)	OTM2TUYM	GSHR_HUMAN	Increases Expression	[8]
GTPase KRas (KRAS)	OT78QCN8	RASK_HUMAN	Decreases Expression	[8]
Platelet-derived growth factor subunit B (PDGFB)	OTMFMFC3	PDGFB_HUMAN	Increases Expression	[8]
Glutathione S-transferase P (GSTP1)	OTLP0A0Y	GSTP1_HUMAN	Increases Expression	[8]
Fibroblast growth factor receptor 1 (FGFR1)	OT4GLCXW	FGFR1_HUMAN	Increases Expression	[8]
Cation-independent mannose-6-phosphate receptor (IGF2R)	OTDXPQVX	MPRI_HUMAN	Increases Expression	[8]
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)	OT18H1B0	ERF3A_HUMAN	Decreases Expression	[8]
Neuromodulin (GAP43)	OT2OTGGV	NEUM_HUMAN	Decreases Expression	[8]
Insulin-like growth factor-binding protein 2 (IGFBP2)	OTG1P60E	IBP2_HUMAN	Increases Expression	[8]
Bone morphogenetic protein 6 (BMP6)	OT9WN536	BMP6_HUMAN	Decreases Expression	[8]
Embryonic growth/differentiation factor 1 (GDF1)	OTZ1VRBH	GDF1_HUMAN	Decreases Expression	[8]
Calreticulin (CALR)	OTYD2TR1	CALR_HUMAN	Decreases Expression	[8]
Transcription initiation factor IIE subunit beta (GTF2E2)	OTDHCCCR	T2EB_HUMAN	Increases Expression	[8]
Cellular retinoic acid-binding protein 2 (CRABP2)	OTY01V9G	RABP2_HUMAN	Increases Expression	[8]
Protein DEK (DEK)	OTYCJ5H6	DEK_HUMAN	Decreases Expression	[8]
B-cell lymphoma 6 protein (BCL6)	OTQAWWO1	BCL6_HUMAN	Increases Expression	[8]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Increases Expression	[8]
Epidermal growth factor receptor substrate 15 (EPS15)	OT7NPP8U	EPS15_HUMAN	Increases Expression	[8]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Decreases Expression	[8]
Protein PRRC2A (PRRC2A)	OTBX6FM5	PRC2A_HUMAN	Increases Expression	[8]
LIM/homeobox protein Lhx2 (LHX2)	OTK61NP8	LHX2_HUMAN	Increases Expression	[8]
Hepatoma-derived growth factor (HDGF)	OT16PTBC	HDGF_HUMAN	Decreases Expression	[8]
GTP-binding nuclear protein Ran (RAN)	OT2TER5M	RAN_HUMAN	Decreases Expression	[8]
Growth factor receptor-bound protein 2 (GRB2)	OTOP7LTE	GRB2_HUMAN	Decreases Expression	[8]
Phosphatidylinositol-glycan-specific phospholipase D (GPLD1)	OTUUQOVY	PHLD_HUMAN	Decreases Expression	[8]
Transcription factor A, mitochondrial (TFAM)	OTXXV5V7	TFAM_HUMAN	Decreases Expression	[8]
Transcription initiation factor IIB (GTF2B)	OTAH5NSO	TF2B_HUMAN	Decreases Expression	[8]
Nuclear factor NF-kappa-B p100 subunit (NFKB2)	OTS231V7	NFKB2_HUMAN	Decreases Expression	[8]
Interferon regulatory factor 9 (IRF9)	OTK4MYQJ	IRF9_HUMAN	Increases Expression	[8]
Pro-neuregulin-1, membrane-bound isoform (NRG1)	OTZO6F1X	NRG1_HUMAN	Decreases Expression	[8]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Decreases Expression	[8]
Proteolipid protein 2 (PLP2)	OTEZ4LOV	PLP2_HUMAN	Increases Expression	[8]
Myocyte-specific enhancer factor 2C (MEF2C)	OTZGF1Y5	MEF2C_HUMAN	Increases Expression	[8]
Baculoviral IAP repeat-containing protein 1 (NAIP)	OTLA925F	BIRC1_HUMAN	Decreases Expression	[8]
Metal regulatory transcription factor 1 (MTF1)	OTJWVLLF	MTF1_HUMAN	Increases Expression	[8]
Nuclear factor 1 X-type (NFIX)	OT1DPZAE	NFIX_HUMAN	Increases Expression	[8]
MAD2L1-binding protein (MAD2L1BP)	OT2O2IUJ	MD2BP_HUMAN	Decreases Expression	[8]
Monocyte to macrophage differentiation factor (MMD)	OTB5I4OC	PAQRB_HUMAN	Increases Expression	[8]
Methylsterol monooxygenase 1 (MSMO1)	OTKV62RZ	MSMO1_HUMAN	Increases Expression	[8]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Expression	[8]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Decreases Expression	[8]
Transcription factor E4F1 (E4F1)	OTL5ESAC	E4F1_HUMAN	Increases Expression	[8]
MAP kinase-activating death domain protein (MADD)	OTUFYVGG	MADD_HUMAN	Decreases Expression	[8]
Transcription factor IIIA (GTF3A)	OTVROUVQ	TF3A_HUMAN	Decreases Expression	[8]
General transcription factor IIH subunit 4 (GTF2H4)	OTPD1DIU	TF2H4_HUMAN	Increases Expression	[8]
Histone-lysine N-methyltransferase EZH1 (EZH1)	OTFLUU94	EZH1_HUMAN	Increases Expression	[8]
Transcription factor IIIB 90 kDa subunit (BRF1)	OTQC6DMG	TF3B_HUMAN	Decreases Expression	[8]
Transcription factor 12 (TCF12)	OTZVONNU	HTF4_HUMAN	Increases Expression	[8]
Neuronal PAS domain-containing protein 2 (NPAS2)	OTMRT2TS	NPAS2_HUMAN	Increases Expression	[8]
Immediate early response gene 2 protein (IER2)	OT5OY8BO	IER2_HUMAN	Increases Expression	[8]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Increases Expression	[8]
Death domain-associated protein 6 (DAXX)	OTX6O7PL	DAXX_HUMAN	Decreases Expression	[8]
COP9 signalosome complex subunit 3 (COPS3)	OTZWPJ24	CSN3_HUMAN	Increases Expression	[8]
Rho family-interacting cell polarization regulator 2 (RIPOR2)	OTXB6LIR	RIPR2_HUMAN	Decreases Expression	[8]
Insulin-like growth factor-binding protein 1 (IGFBP1)	OT6UQV2K	IBP1_HUMAN	Increases Expression	[9]
Interleukin-7 receptor subunit alpha (IL7R)	OTBMFLQQ	IL7RA_HUMAN	Increases Expression	[9]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Increases Expression	[9]
Ephrin type-A receptor 1 (EPHA1)	OTGJMRZ0	EPHA1_HUMAN	Increases Expression	[9]
CCHC-type zinc finger nucleic acid binding protein (CNBP)	OTTGM9NK	CNBP_HUMAN	Increases Expression	[9]
Dynein light chain 1, cytoplasmic (DYNLL1)	OTR69LHT	DYL1_HUMAN	Increases Expression	[9]
Cyclin-A1 (CCNA1)	OTX4HD45	CCNA1_HUMAN	Increases Expression	[9]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)	OT4Y9NQI	MP2K1_HUMAN	Increases Expression	[9]
SH2 domain-containing adapter protein B (SHB)	OTF2HSC0	SHB_HUMAN	Increases Expression	[9]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Decreases Activity	[63]
Forkhead box protein N3 (FOXN3)	OTOJYJZP	FOXN3_HUMAN	Decreases Expression	[10]
Actin-binding LIM protein 1 (ABLIM1)	OTHXEK3E	ABLM1_HUMAN	Increases Expression	[10]
Etoposide-induced protein 2.4 homolog (EI24)	OTD4NOYS	EI24_HUMAN	Increases Expression	[10]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[10]
Regulator of G-protein signaling 5 (RGS5)	OTUY0Q2I	RGS5_HUMAN	Decreases Expression	[10]
Prostate-specific antigen (KLK3)	OTFGSBFJ	KLK3_HUMAN	Decreases Expression	[10]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Decreases Expression	[10]
Microtubule-associated protein tau (MAPT)	OTMTP2Z7	TAU_HUMAN	Decreases Expression	[10]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Decreases Expression	[10]
Receptor-type tyrosine-protein phosphatase alpha (PTPRA)	OTZA82J1	PTPRA_HUMAN	Decreases Expression	[10]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)	OTSBQR6D	PLCG1_HUMAN	Decreases Expression	[10]
Replication protein A 70 kDa DNA-binding subunit (RPA1)	OT76POLP	RFA1_HUMAN	Decreases Expression	[10]
Microtubule-associated protein 4 (MAP4)	OT78YX9J	MAP4_HUMAN	Decreases Expression	[10]
AT-rich interactive domain-containing protein 4A (ARID4A)	OT1XKBZ0	ARI4A_HUMAN	Decreases Expression	[10]
Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4)	OT1H0ZXC	ACHA4_HUMAN	Increases Expression	[10]
Serine--tRNA ligase, cytoplasmic (SARS1)	OTFKXQ1O	SYSC_HUMAN	Increases Expression	[10]
Cyclin-dependent kinase inhibitor 1C (CDKN1C)	OTASTJ3Q	CDN1C_HUMAN	Increases Expression	[10]
Hsc70-interacting protein (ST13)	OTNML6UP	F10A1_HUMAN	Increases Expression	[10]
Ephrin type-A receptor 4 (EPHA4)	OT3AMK0C	EPHA4_HUMAN	Increases Expression	[10]
E3 ubiquitin-protein ligase RNF4 (RNF4)	OTCMXQRE	RNF4_HUMAN	Decreases Expression	[10]
Microtubule-associated protein 1A (MAP1A)	OTHO8K43	MAP1A_HUMAN	Decreases Expression	[10]
Insulinoma-associated protein 1 (INSM1)	OTG8RV8E	INSM1_HUMAN	Decreases Expression	[10]
Activated CDC42 kinase 1 (TNK2)	OTRGG0T8	ACK1_HUMAN	Increases Expression	[10]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2)	OTVZD4H6	BNIP2_HUMAN	Increases Expression	[10]
PR domain zinc finger protein 2 (PRDM2)	OT8L7CGX	PRDM2_HUMAN	Decreases Expression	[10]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Increases Expression	[10]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)	OTPLXCDN	DYR1A_HUMAN	Decreases Expression	[10]
Programmed cell death protein 2 (PDCD2)	OTUOGSDJ	PDCD2_HUMAN	Increases Expression	[10]
Secreted frizzled-related protein 1 (SFRP1)	OT0U9G41	SFRP1_HUMAN	Decreases Expression	[10]
Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1)	OTS8G0EN	BAP1_HUMAN	Decreases Expression	[10]
Unconventional myosin-XVIIIa (MYO18A)	OT2YPT7O	MY18A_HUMAN	Decreases Expression	[10]
Receptor-type tyrosine-protein phosphatase N2 (PTPRN2)	OTL6SH28	PTPR2_HUMAN	Increases Expression	[10]
Apoptosis inhibitor 5 (API5)	OTYX9YCZ	API5_HUMAN	Decreases Expression	[10]
Serum paraoxonase/arylesterase 1 (PON1)	OTD0Z2XO	PON1_HUMAN	Increases Expression	[64]
cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A)	OTT8Q1AP	PDE5A_HUMAN	Decreases Activity	[65]
Neprilysin (MME)	OT5Q39P8	NEP_HUMAN	Increases Activity	[66]
Nitric oxide synthase 3 (NOS3)	OTLDT7NR	NOS3_HUMAN	Decreases Expression	[67]
Protein-glutamine gamma-glutamyltransferase 5 (TGM5)	OTHI37BJ	TGM5_HUMAN	Increases Expression	[68]
Protein-glutamine gamma-glutamyltransferase K (TGM1)	OTB8URRI	TGM1_HUMAN	Increases Expression	[68]
Protein-glutamine gamma-glutamyltransferase E (TGM3)	OTNGRUDT	TGM3_HUMAN	Increases Expression	[68]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[69]
Glutathione peroxidase 2 (GPX2)	OTXI2NTI	GPX2_HUMAN	Increases Expression	[69]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[11]
Glutathione peroxidase 1 (GPX1)	OTE2O72Q	GPX1_HUMAN	Increases Expression	[11]
Protein NDRG1 (NDRG1)	OTVO66BO	NDRG1_HUMAN	Increases Expression	[11]
Selenide, water dikinase 2 (SEPHS2)	OTTFXROR	SPS2_HUMAN	Increases Expression	[11]
Sulfotransferase 1E1 (SULT1E1)	OTGPJ517	ST1E1_HUMAN	Increases Expression	[12]
Cytochrome P450 2D6 (CYP2D6)	OTZJC802	CP2D6_HUMAN	Decreases Activity	[70]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Decreases Activity	[70]
Inositol polyphosphate 4-phosphatase type II (INPP4B)	OTLROA7G	INP4B_HUMAN	Decreases Expression	[13]
Transmembrane protease serine 2 (TMPRSS2)	OTN44YQ5	TMPS2_HUMAN	Decreases Expression	[13]
Transcription factor Maf (MAF)	OT1GR3IZ	MAF_HUMAN	Decreases Expression	[13]
Cholinesterase (BCHE)	OTOH3WQ9	CHLE_HUMAN	Increases Expression	[13]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Decreases Expression	[13]
Kallikrein-2 (KLK2)	OT9RE37R	KLK2_HUMAN	Decreases Expression	[13]
Aromatic-L-amino-acid decarboxylase (DDC)	OT0TSW09	DDC_HUMAN	Increases Expression	[13]
Retinaldehyde dehydrogenase 3 (ALDH1A3)	OT1C9NKQ	AL1A3_HUMAN	Decreases Expression	[13]
Cyclin-dependent kinase 8 (CDK8)	OTMC3CWX	CDK8_HUMAN	Increases Expression	[13]
Hepatocyte nuclear factor 3-gamma (FOXA3)	OTRGT2OT	FOXA3_HUMAN	Affects Expression	[13]
Growth factor receptor-bound protein 10 (GRB10)	OTCKXGRC	GRB10_HUMAN	Increases Expression	[13]
Ras GTPase-activating-like protein IQGAP2 (IQGAP2)	OTX2UA7P	IQGA2_HUMAN	Decreases Expression	[13]
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)	OTXGJ8N1	P55G_HUMAN	Affects Expression	[13]
Protein TMEPAI (PMEPA1)	OTY8Z9UF	PMEPA_HUMAN	Decreases Expression	[13]
Homeobox protein Nkx-3.1 (NKX3-1)	OT0DO6ZU	NKX31_HUMAN	Decreases Expression	[13]
Homer protein homolog 2 (HOMER2)	OT4JGKJF	HOME2_HUMAN	Decreases Expression	[13]
STE20/SPS1-related proline-alanine-rich protein kinase (STK39)	OTXHT5FR	STK39_HUMAN	Increases Expression	[13]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[71]
Serine/threonine-protein kinase RIO3 (RIOK3)	OTZYZVIX	RIOK3_HUMAN	Decreases Expression	[14]
Aurora kinase A (AURKA)	OTMX0HYT	AURKA_HUMAN	Increases Expression	[14]
NEDD4-binding protein 1 (N4BP1)	OTN2TL6N	N4BP1_HUMAN	Decreases Expression	[14]
Adapter SH3BGRL (SH3BGRL)	OTUOCTMT	SH3L1_HUMAN	Decreases Expression	[14]
PC4 and SFRS1-interacting protein (PSIP1)	OT4YAFUS	PSIP1_HUMAN	Increases Expression	[14]
Ribonuclease H2 subunit A (RNASEH2A)	OT8G3G7K	RNH2A_HUMAN	Increases Expression	[14]
Centrosomal protein of 152 kDa (CEP152)	OTOKZR9B	CE152_HUMAN	Increases Expression	[14]
Serine protease 23 (PRSS23)	OT6DQAM1	PRS23_HUMAN	Decreases Expression	[14]
Kinesin-like protein KIF20A (KIF20A)	OTXOQHE0	KI20A_HUMAN	Increases Expression	[14]
RAS guanyl-releasing protein 1 (RASGRP1)	OTX9WN2E	GRP1_HUMAN	Decreases Expression	[14]
Histidine protein methyltransferase 1 homolog (METTL18)	OT7NDLYO	MET18_HUMAN	Increases Expression	[14]
Claudin-1 (CLDN1)	OT27KV99	CLD1_HUMAN	Decreases Expression	[14]
Securin (PTTG1)	OTIMYS4W	PTTG1_HUMAN	Increases Expression	[14]
Acylphosphatase-1 (ACYP1)	OTR77NZD	ACYP1_HUMAN	Increases Expression	[14]
Myb-related protein B (MYBL2)	OTZ3JX8Q	MYBB_HUMAN	Increases Expression	[14]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Decreases Expression	[14]
Collagen alpha-1(V) chain (COL5A1)	OT24078H	CO5A1_HUMAN	Decreases Expression	[14]
RNA-binding motif, single-stranded-interacting protein 1 (RBMS1)	OTD13PJN	RBMS1_HUMAN	Decreases Expression	[14]
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)	OTRA8ZVE	PPIF_HUMAN	Increases Expression	[14]
S-adenosylmethionine synthase isoform type-2 (MAT2A)	OTFJMIQR	METK2_HUMAN	Increases Expression	[14]
Transcription factor 7 (TCF7)	OT1ID822	TCF7_HUMAN	Decreases Expression	[14]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Decreases Expression	[14]
Microtubule-associated protein 1B (MAP1B)	OTVXW089	MAP1B_HUMAN	Decreases Expression	[14]
Eukaryotic translation initiation factor 5 (EIF5)	OT79PQUN	IF5_HUMAN	Decreases Expression	[14]
Sestrin-2 (SESN2)	OT889IXY	SESN2_HUMAN	Decreases Expression	[14]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1)	OTLL7L74	GBB1_HUMAN	Decreases Expression	[14]
G-protein-signaling modulator 2 (GPSM2)	OT6RPMRM	GPSM2_HUMAN	Increases Expression	[14]
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11)	OT7EVFBK	M2OM_HUMAN	Increases Expression	[14]
Trefoil factor 3 (TFF3)	OTJJDRTU	TFF3_HUMAN	Increases Expression	[14]
Forkhead box protein M1 (FOXM1)	OT5887KR	FOXM1_HUMAN	Increases Expression	[14]
Mitotic-spindle organizing protein 1 (MZT1)	OTO4IVND	MZT1_HUMAN	Increases Expression	[14]
Maternal embryonic leucine zipper kinase (MELK)	OTEY2UQA	MELK_HUMAN	Increases Expression	[14]
DNA replication complex GINS protein PSF1 (GINS1)	OTVQZMMQ	PSF1_HUMAN	Increases Expression	[14]
PCNA-associated factor (PCLAF)	OTMVIOUU	PAF15_HUMAN	Increases Expression	[14]
Pachytene checkpoint protein 2 homolog (TRIP13)	OTFM3TI9	PCH2_HUMAN	Increases Expression	[14]
Cyclin-dependent kinase inhibitor 3 (CDKN3)	OTBE3H07	CDKN3_HUMAN	Increases Expression	[14]
Borealin (CDCA8)	OT17D55D	BOREA_HUMAN	Increases Expression	[14]
Shugoshin 2 (SGO2)	OTNGJDS8	SGO2_HUMAN	Increases Expression	[14]
Fidgetin-like protein 1 (FIGNL1)	OTKII63K	FIGL1_HUMAN	Increases Expression	[14]
ATPase family AAA domain-containing protein 2 (ATAD2)	OT8MCRNY	ATAD2_HUMAN	Increases Expression	[14]
G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)	OT06BFRQ	G2E3_HUMAN	Increases Expression	[14]
Centrosomal protein of 57 kDa (CEP57)	OTPOHLIX	CEP57_HUMAN	Increases Expression	[14]
Protein FAM43A (FAM43A)	OT5RPQRE	FA43A_HUMAN	Decreases Expression	[14]
Protein PHTF2 (PHTF2)	OTBLTYRJ	PHTF2_HUMAN	Increases Expression	[14]
Protein FAM222B (FAM222B)	OTV9TL5C	F222B_HUMAN	Decreases Expression	[14]
Synaptotagmin-like protein 4 (SYTL4)	OT7MX5IK	SYTL4_HUMAN	Increases Expression	[14]
Formin-like protein 2 (FMNL2)	OT9OVWCV	FMNL2_HUMAN	Decreases Expression	[14]
Condensin complex subunit 3 (NCAPG)	OT1AI9EO	CND3_HUMAN	Increases Expression	[14]
Transmembrane 6 superfamily member 1 (TM6SF1)	OTQR4I2N	TM6S1_HUMAN	Decreases Expression	[14]
Protein FAM107B (FAM107B)	OT5RG4J0	F107B_HUMAN	Decreases Expression	[14]
Rac GTPase-activating protein 1 (RACGAP1)	OTQE8IEH	RGAP1_HUMAN	Increases Expression	[14]
Thioredoxin-related transmembrane protein 1 (TMX1)	OTX4FHYQ	TMX1_HUMAN	Increases Expression	[14]
Kinetochore protein Spc25 (SPC25)	OTCAS0OH	SPC25_HUMAN	Increases Expression	[14]
Centromere protein M (CENPM)	OTYK9KOX	CENPM_HUMAN	Increases Expression	[14]
Nuclear distribution protein nudE homolog 1 (NDE1)	OT2N8Q17	NDE1_HUMAN	Increases Expression	[14]
Protein downstream neighbor of Son (DONSON)	OTN5HE0W	DONS_HUMAN	Increases Expression	[14]
ERBB receptor feedback inhibitor 1 (ERRFI1)	OT7VZ2IZ	ERRFI_HUMAN	Decreases Expression	[14]
Targeting protein for Xklp2 (TPX2)	OTWLJYH0	TPX2_HUMAN	Increases Expression	[14]
Protein timeless homolog (TIMELESS)	OTD8DCBJ	TIM_HUMAN	Increases Expression	[14]
Ninein-like protein (NINL)	OTWIK6HT	NINL_HUMAN	Decreases Expression	[14]
Espin (ESPN)	OT7Z6LX2	ESPN_HUMAN	Increases Expression	[15]
Left-right determination factor 2 (LEFTY2)	OT3RX4QF	LFTY2_HUMAN	Decreases Expression	[15]
Suppressor of cytokine signaling 2 (SOCS2)	OTBPNKJQ	SOCS2_HUMAN	Decreases Expression	[15]
Calpain-9 (CAPN9)	OTE4IU5U	CAN9_HUMAN	Increases Expression	[15]
NPC intracellular cholesterol transporter 1 (NPC1)	OTRIPICX	NPC1_HUMAN	Increases Expression	[15]
Mitogen-activated protein kinase 13 (MAPK13)	OT0W9GE7	MK13_HUMAN	Decreases Expression	[15]
High affinity copper uptake protein 1 (SLC31A1)	OTXLRTUB	COPT1_HUMAN	Increases Expression	[15]
Protein sprouty homolog 1 (SPRY1)	OT764FXI	SPY1_HUMAN	Decreases Expression	[15]
Short-chain dehydrogenase/reductase 3 (DHRS3)	OTSK1DTP	DHRS3_HUMAN	Increases Expression	[15]
Importin-13 (IPO13)	OT887N3O	IPO13_HUMAN	Increases Expression	[15]
Mitofusin-2 (MFN2)	OTPYN8A3	MFN2_HUMAN	Increases Expression	[15]
Tetraspanin-12 (TSPAN12)	OTF9I3CX	TSN12_HUMAN	Decreases Expression	[15]
Actin-associated protein FAM107A (FAM107A)	OTBG61YZ	F107A_HUMAN	Decreases Expression	[15]
Apolipoprotein E (APOE)	OTFOWL2H	APOE_HUMAN	Increases Expression	[15]
Non-histone chromosomal protein HMG-17 (HMGN2)	OTN20MEF	HMGN2_HUMAN	Decreases Expression	[15]
Hepatocyte growth factor receptor (MET)	OT7K55MU	MET_HUMAN	Increases Expression	[15]
Galectin-1 (LGALS1)	OT8LDFWR	LEG1_HUMAN	Decreases Expression	[15]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)	OTPG0K7E	IMDH2_HUMAN	Increases Expression	[15]
cAMP-dependent protein kinase type II-alpha regulatory subunit (PRKAR2A)	OTZ7P17Z	KAP2_HUMAN	Increases Expression	[15]
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3)	OTVAW3P1	ERCC3_HUMAN	Increases Expression	[15]
Casein kinase II subunit alpha' (CSNK2A2)	OT7MA2LV	CSK22_HUMAN	Increases Expression	[15]
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Decreases Expression	[15]
Receptor tyrosine-protein kinase erbB-3 (ERBB3)	OTRSST0A	ERBB3_HUMAN	Decreases Expression	[15]
Homeobox protein cut-like 1 (CUX1)	OTU1LCNJ	CUX1_HUMAN	Decreases Expression	[15]
Tissue factor pathway inhibitor 2 (TFPI2)	OTZCRWOR	TFPI2_HUMAN	Increases Expression	[15]
Nuclear autoantigenic sperm protein (NASP)	OTNE4THC	NASP_HUMAN	Decreases Expression	[15]
Cysteine-rich protein 1 (CRIP1)	OT0EICG3	CRIP1_HUMAN	Decreases Expression	[15]
E3 ubiquitin-protein ligase RNF144A (RNF144A)	OTCG27CT	R144A_HUMAN	Decreases Expression	[15]
B-cell receptor-associated protein 31 (BCAP31)	OTKSACR4	BAP31_HUMAN	Increases Expression	[15]
Histone H2B type 1-D (H2BC5)	OTXDTDHN	H2B1D_HUMAN	Decreases Expression	[15]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Decreases Expression	[15]
Reelin (RELN)	OTLKMW1O	RELN_HUMAN	Increases Expression	[15]
Vesicle transport protein SEC20 (BNIP1)	OT7USYCY	SEC20_HUMAN	Increases Expression	[15]
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Decreases Expression	[15]
Squalene monooxygenase (SQLE)	OT0GGRDO	ERG1_HUMAN	Decreases Expression	[15]
TSC22 domain family protein 1 (TSC22D1)	OTN4GFWD	T22D1_HUMAN	Decreases Expression	[15]
Neutral amino acid transporter B(0) (SLC1A5)	OTE2H26Q	AAAT_HUMAN	Increases Expression	[15]
Forkhead box protein D1 (FOXD1)	OT80PRHS	FOXD1_HUMAN	Increases Expression	[15]
Histone H2B type 2-E (H2BC21)	OT0FDCUC	H2B2E_HUMAN	Decreases Expression	[15]
Histone-lysine N-methyltransferase SETMAR (SETMAR)	OTE2MIMZ	SETMR_HUMAN	Decreases Expression	[15]
Anoctamin-1 (ANO1)	OTSREUNI	ANO1_HUMAN	Increases Expression	[15]
SPRY domain-containing SOCS box protein 3 (SPSB3)	OTHGEE2K	SPSB3_HUMAN	Decreases Expression	[15]
Plexin domain-containing protein 2 (PLXDC2)	OTS1FUV6	PXDC2_HUMAN	Increases Expression	[15]
Protein ABHD15 (ABHD15)	OTG98AB1	ABH15_HUMAN	Increases Expression	[15]
Protein Bop (RTL10)	OTHGB81W	BOP_HUMAN	Increases Expression	[15]
BTB/POZ domain-containing protein KCTD20 (KCTD20)	OTJLEFX1	KCD20_HUMAN	Increases Expression	[15]
Probable G-protein coupled receptor 142 (GPR142)	OT6UFQCL	GP142_HUMAN	Increases Expression	[15]
Patatin-like phospholipase domain-containing protein 5 (PNPLA5)	OTZ1GP03	PLPL5_HUMAN	Increases Expression	[15]
E3 ubiquitin-protein ligase SIAH1 (SIAH1)	OT29A838	SIAH1_HUMAN	Decreases Expression	[15]
Leucine-rich repeat-containing protein 49 (LRRC49)	OT9SOV66	LRC49_HUMAN	Decreases Expression	[15]
Uncharacterized protein C9orf40 (C9ORF40)	OT9MG9IS	CI040_HUMAN	Decreases Expression	[15]
IQ domain-containing protein K (IQCK)	OT4QNL67	IQCK_HUMAN	Decreases Expression	[15]
Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4)	OT6WKC13	GALT4_HUMAN	Increases Expression	[15]
Programmed cell death protein 7 (PDCD7)	OTK5YO7J	PDCD7_HUMAN	Increases Expression	[15]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Decreases Expression	[15]
Docking protein 4 (DOK4)	OTUEWLG8	DOK4_HUMAN	Increases Expression	[15]
Glycerophosphodiester phosphodiesterase domain-containing protein 5 (GDPD5)	OTUM65JL	GDPD5_HUMAN	Increases Expression	[15]
Solute carrier organic anion transporter family member 2A1 (SLCO2A1)	OT3062CA	SO2A1_HUMAN	Increases Expression	[15]
Endonuclease 8-like 2 (NEIL2)	OTV6JEON	NEIL2_HUMAN	Increases Expression	[15]
RecQ-mediated genome instability protein 2 (RMI2)	OTA0HP4S	RMI2_HUMAN	Decreases Expression	[15]
E3 ubiquitin-protein ligase RNFT2 (RNFT2)	OTGIY43B	RNFT2_HUMAN	Decreases Expression	[15]
Phospholipid phosphatase-related protein type 2 (PLPPR2)	OTB2HQ4S	PLPR2_HUMAN	Increases Expression	[15]
Solute carrier family 41 member 3 (SLC41A3)	OTCABXH9	S41A3_HUMAN	Decreases Expression	[15]
Protein arginine N-methyltransferase 6 (PRMT6)	OT5V3XIN	ANM6_HUMAN	Decreases Expression	[15]
Sphingosine 1-phosphate receptor 3 (S1PR3)	OTXBIYO8	S1PR3_HUMAN	Increases Expression	[15]
Noelin (OLFM1)	OTOYPEWW	NOE1_HUMAN	Decreases Expression	[15]
TERF1-interacting nuclear factor 2 (TINF2)	OT861N2N	TINF2_HUMAN	Decreases Expression	[15]
Splicing factor 3B subunit 5 (SF3B5)	OTUXTOSF	SF3B5_HUMAN	Increases Expression	[15]
Transcription factor SOX-17 (SOX17)	OT9H4WWE	SOX17_HUMAN	Decreases Expression	[15]
Alpha-1,2-mannosyltransferase ALG9 (ALG9)	OT5V9PIR	ALG9_HUMAN	Decreases Expression	[15]
MANSC domain-containing protein 1 (MANSC1)	OTE5CMEP	MANS1_HUMAN	Decreases Expression	[15]
Olfactomedin-like protein 3 (OLFML3)	OTDN45FN	OLFL3_HUMAN	Increases Expression	[15]
Glutaredoxin-2, mitochondrial (GLRX2)	OT4LIRBC	GLRX2_HUMAN	Increases Expression	[15]
Ethanolamine kinase 2 (ETNK2)	OT5S1Z75	EKI2_HUMAN	Increases Expression	[15]
Adaptin ear-binding coat-associated protein 2 (NECAP2)	OTLH23GP	NECP2_HUMAN	Increases Expression	[15]
TBC1 domain family member 7 (TBC1D7)	OT1ALJ63	TBCD7_HUMAN	Increases Expression	[15]
Translation initiation factor eIF2B subunit delta (EIF2B4)	OTTM5SX1	EI2BD_HUMAN	Increases Expression	[15]
Coronin-1C (CORO1C)	OTXDF9T3	COR1C_HUMAN	Increases Expression	[15]
Nitric oxide synthase 1 (NOS1)	OT7M8XVG	NOS1_HUMAN	Increases Expression	[72]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Increases Expression	[73]
NADPH oxidase 4 (NOX4)	OTTYQ097	NOX4_HUMAN	Decreases Expression	[73]
GTP cyclohydrolase 1 (GCH1)	OTOZ6NSL	GCH1_HUMAN	Increases Expression	[74]
Telomerase reverse transcriptase (TERT)	OT085VVA	TERT_HUMAN	Decreases Expression	[16]
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3)	OTT00T7Q	PLOD3_HUMAN	Increases Expression	[16]
Cytochrome c oxidase subunit 1 (COX1)	OTG3O9BN	COX1_HUMAN	Increases Expression	[16]
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Decreases Expression	[16]
Insulin-like growth factor I (IGF1)	OTIIZR61	IGF1_HUMAN	Decreases Expression	[16]
Fibroblast growth factor 1 (FGF1)	OT8I64X8	FGF1_HUMAN	Increases Expression	[16]
Extracellular superoxide dismutase (SOD3)	OTIOZQAB	SODE_HUMAN	Decreases Expression	[16]
Retinoic acid receptor alpha (RARA)	OT192V9V	RARA_HUMAN	Increases Expression	[16]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[16]
Keratin, type II cytoskeletal 5 (KRT5)	OTVGI9HT	K2C5_HUMAN	Increases Expression	[16]
Translationally-controlled tumor protein (TPT1)	OTHMTRJU	TCTP_HUMAN	Increases Expression	[16]
Progranulin (GRN)	OTXXSJ53	GRN_HUMAN	Increases Expression	[16]
Aquaporin-1 (AQP1)	OTX5MYX9	AQP1_HUMAN	Increases Expression	[16]
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)	OTTG0NFD	S5A2_HUMAN	Decreases Expression	[16]
Prostaglandin E2 receptor EP1 subtype (PTGER1)	OT978JZW	PE2R1_HUMAN	Decreases Expression	[16]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Decreases Expression	[16]
ATP-citrate synthase (ACLY)	OTRL9ZRP	ACLY_HUMAN	Increases Expression	[16]
Melanocyte-stimulating hormone receptor (MC1R)	OTB95LIK	MSHR_HUMAN	Decreases Expression	[16]
Cytoglobin (CYGB)	OTX153DQ	CYGB_HUMAN	Decreases Expression	[16]
Aquaporin-3 (AQP3)	OT2J7JPD	AQP3_HUMAN	Increases Expression	[16]
Hyaluronan synthase 1 (HAS1)	OTJIAG1W	HYAS1_HUMAN	Decreases Expression	[16]
Klotho (KL)	OTD4VWU6	KLOT_HUMAN	Decreases Expression	[16]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Decreases Expression	[75]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Decreases Expression	[75]
Prostaglandin G/H synthase 1 (PTGS1)	OTHCRLEC	PGH1_HUMAN	Decreases Expression	[75]
Occludin (OCLN)	OTSUTVWL	OCLN_HUMAN	Decreases Expression	[75]
Fibronectin (FN1)	OTB5ZN4Q	FINC_HUMAN	Decreases Expression	[17]
Heat shock protein beta-1 (HSPB1)	OTHFZ8ED	HSPB1_HUMAN	Decreases Expression	[17]
E-selectin (SELE)	OT33RZWY	LYAM2_HUMAN	Decreases Expression	[17]
Homeobox protein CDX-1 (CDX1)	OTOHTMJE	CDX1_HUMAN	Decreases Expression	[17]
Fatty acid synthase (FASN)	OTFII9KG	FAS_HUMAN	Decreases Expression	[17]
Homeobox protein Hox-A1 (HOXA1)	OTMSOJ7D	HXA1_HUMAN	Decreases Expression	[17]
Homeobox protein engrailed-1 (EN1)	OT2DKIDK	HME1_HUMAN	Decreases Expression	[17]
Protein patched homolog 1 (PTCH1)	OTMG07H5	PTC1_HUMAN	Increases Expression	[17]
Quinone oxidoreductase PIG3 (TP53I3)	OTSCM68G	QORX_HUMAN	Decreases Expression	[17]
Hedgehog-interacting protein (HHIP)	OT77RQYS	HHIP_HUMAN	Decreases Expression	[17]
Hepatocyte nuclear factor 3-beta (FOXA2)	OTJOCVOY	FOXA2_HUMAN	Decreases Expression	[17]
Cytochrome P450 4F2 (CYP4F2)	OTKILAER	CP4F2_HUMAN	Increases Expression	[76]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Decreases Expression	[18]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Decreases Expression	[18]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Decreases Expression	[18]
C-X-C motif chemokine 10 (CXCL10)	OTTLQ6S0	CXL10_HUMAN	Decreases Expression	[77]
Aryl hydrocarbon receptor nuclear translocator (ARNT)	OTMSIEZY	ARNT_HUMAN	Increases Localization	[77]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Decreases Expression	[78]
N-glycosylase/DNA lyase (OGG1)	OTJ97TF3	OGG1_HUMAN	Increases Expression	[19]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Increases Expression	[19]
Sulfotransferase 1A1 (SULT1A1)	OT0K7JIE	ST1A1_HUMAN	Increases Expression	[60]
Sulfotransferase 4A1 (SULT4A1)	OT7AL3KJ	ST4A1_HUMAN	Increases Expression	[60]
Egl nine homolog 1 (EGLN1)	OT5QODDK	EGLN1_HUMAN	Decreases Expression	[79]
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)	OT2NV3AN	CP11A_HUMAN	Decreases Acetylation	[80]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Increases Expression	[81]
Platelet glycoprotein 4 (CD36)	OT5CZWKY	CD36_HUMAN	Increases Expression	[82]
Sterol 26-hydroxylase, mitochondrial (CYP27A1)	OT649C01	CP27A_HUMAN	Increases Expression	[82]
Scavenger receptor class B member 1 (SCARB1)	OTAE1UA1	SCRB1_HUMAN	Increases Expression	[82]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Decreases Expression	[83]
Frataxin, mitochondrial (FXN)	OTE9U09A	FRDA_HUMAN	Increases Expression	[84]
Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)	OTOEEEXG	HPRT_HUMAN	Decreases Expression	[85]
Peroxiredoxin-6 (PRDX6)	OTS8KC8A	PRDX6_HUMAN	Decreases Expression	[85]
Stress-induced-phosphoprotein 1 (STIP1)	OT7TXLOX	STIP1_HUMAN	Decreases Expression	[85]
Triosephosphate isomerase (TPI1)	OT14KP4B	TPIS_HUMAN	Increases Expression	[85]
Pyridoxine-5'-phosphate oxidase (PNPO)	OTOUBD05	PNPO_HUMAN	Decreases Expression	[85]
Gamma-aminobutyric acid receptor-associated protein (GABARAP)	OTAQUX6E	GBRAP_HUMAN	Increases Expression	[86]
Annexin A2 (ANXA2)	OTFNS0CC	ANXA2_HUMAN	Increases Expression	[86]
Metallothionein-1X (MT1X)	OT9AKFVS	MT1X_HUMAN	Increases Expression	[86]
Cyclin-dependent kinase 6 (CDK6)	OTR95N0X	CDK6_HUMAN	Decreases Expression	[86]
Cell cycle checkpoint control protein RAD9B (RAD9B)	OTEFWVVE	RAD9B_HUMAN	Decreases Expression	[86]
Angiomotin-like protein 1 (AMOTL1)	OT40G45S	AMOL1_HUMAN	Increases Expression	[86]
DNA damage-regulated autophagy modulator protein 1 (DRAM1)	OTIJTXEN	DRAM1_HUMAN	Increases Expression	[86]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Increases Expression	[86]
Ubiquitin-like-conjugating enzyme ATG3 (ATG3)	OT28VBVK	ATG3_HUMAN	Decreases Expression	[86]
Myocardin-related transcription factor B (MRTFB)	OT9OXGS9	MRTFB_HUMAN	Decreases Expression	[86]
ELAV-like protein 1 (ELAVL1)	OTY55PLY	ELAV1_HUMAN	Increases Expression	[87]
Methionine adenosyltransferase 2 subunit beta (MAT2B)	OT4Y7T9L	MAT2B_HUMAN	Increases Expression	[87]
NADH dehydrogenase iron-sulfur protein 3, mitochondrial (NDUFS3)	OTX61TQQ	NDUS3_HUMAN	Increases Expression	[20]
Cytochrome c oxidase subunit 2 (COX2)	OTTMVBJJ	COX2_HUMAN	Increases Expression	[20]
NADH-ubiquinone oxidoreductase chain 1 (ND1)	OTCLGIXV	NU1M_HUMAN	Increases Expression	[20]
Steroid hormone receptor ERR1 (ESRRA)	OTTDTUSP	ERR1_HUMAN	Increases Expression	[20]
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2)	OTSZF7D6	NDUV2_HUMAN	Increases Expression	[20]
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB)	OTRE1M1T	SDHB_HUMAN	Increases Expression	[20]
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1)	OTTIZDFR	NDUS1_HUMAN	Increases Expression	[20]
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1)	OTEVK4WW	NDUV1_HUMAN	Increases Expression	[20]
Surfeit locus protein 1 (SURF1)	OTAINRSS	SURF1_HUMAN	Increases Expression	[20]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Decreases Expression	[88]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Activity	[88]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Increases Expression	[89]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)	OTZKVLVJ	CP17A_HUMAN	Decreases Expression	[90]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Increases Expression	[90]
Interleukin-4 (IL4)	OTOXBWAU	IL4_HUMAN	Decreases Expression	[91]
Beta-hexosaminidase subunit beta (HEXB)	OTROYLCR	HEXB_HUMAN	Decreases Secretion	[91]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Phosphorylation	[91]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Phosphorylation	[91]
Tyrosine-protein kinase SYK (SYK)	OTQID87L	KSYK_HUMAN	Decreases Phosphorylation	[91]
Serine/threonine-protein kinase D1 (PRKD1)	OTXIOYD2	KPCD1_HUMAN	Decreases Phosphorylation	[91]
Steroid 21-hydroxylase (CYP21A2)	OTN0UDVP	CP21A_HUMAN	Decreases Expression	[92]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)	OT1QHOS2	NF2L1_HUMAN	Increases Expression	[93]
Nuclear factor erythroid 2-related factor 3 (NFE2L3)	OT1MGXT0	NF2L3_HUMAN	Decreases Expression	[93]
LYR motif-containing protein 9 (LYRM9)	OT1MILTK	LYRM9_HUMAN	Increases Expression	[21]
PTPN13-like protein, Y-linked (PRY)	OTO6GHZU	PRY_HUMAN	Increases Expression	[21]
Formimidoyltransferase-cyclodeaminase (FTCD)	OTX9HZT5	FTCD_HUMAN	Increases Expression	[21]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Decreases Expression	[21]
Protein PML (PML)	OT6SM2GD	PML_HUMAN	Increases Expression	[21]
Bifunctional epoxide hydrolase 2 (EPHX2)	OTPTRCNW	HYES_HUMAN	Increases Expression	[21]
Caspase-2 (CASP2)	OTUDYSPP	CASP2_HUMAN	Increases Expression	[21]
G protein-regulated inducer of neurite outgrowth 1 (GPRIN1)	OT9CE9FU	GRIN1_HUMAN	Increases Expression	[21]
Plexin domain-containing protein 1 (PLXDC1)	OT2X0IFQ	PLDX1_HUMAN	Increases Expression	[21]
Caspase-10 (CASP10)	OTE6J88E	CASPA_HUMAN	Increases Expression	[21]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Increases Expression	[21]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3)	OTZM6MHU	NLRP3_HUMAN	Increases Expression	[21]
CDK5 regulatory subunit-associated protein 2 (CDK5RAP2)	OTRKEVTY	CK5P2_HUMAN	Increases Expression	[21]
NACHT, LRR and PYD domains-containing protein 1 (NLRP1)	OT4BNNOS	NLRP1_HUMAN	Increases Expression	[21]
ABC-type oligopeptide transporter ABCB9 (ABCB9)	OTSOBOL5	ABCB9_HUMAN	Increases Expression	[21]
5'(3')-deoxyribonucleotidase, mitochondrial (NT5M)	OTJF73BA	NT5M_HUMAN	Increases Expression	[21]
Solute carrier family 12 member 4 (SLC12A4)	OT21JMDH	S12A4_HUMAN	Increases Expression	[21]
U6 snRNA-associated Sm-like protein LSm4 (LSM4)	OTLKJB3A	LSM4_HUMAN	Increases Expression	[21]
Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L)	OT7QO47I	RBG10_HUMAN	Decreases Expression	[22]
Prostaglandin E synthase (PTGES)	OTB7YQFU	PTGES_HUMAN	Increases Expression	[22]
Transmembrane 4 L6 family member 5 (TM4SF5)	OTPAV531	T4S5_HUMAN	Increases Expression	[22]
Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)	OTQKQ346	KCNN4_HUMAN	Increases Expression	[22]
Lysine-specific demethylase hairless (HR)	OTHEZWPW	HAIR_HUMAN	Increases Expression	[22]
Probable phospholipid-transporting ATPase IIB (ATP9B)	OTRTYQOK	ATP9B_HUMAN	Increases Expression	[22]
Microphthalmia-associated transcription factor (MITF)	OT6XJCZH	MITF_HUMAN	Increases Expression	[22]
Tight junction protein ZO-3 (TJP3)	OTC1K8HC	ZO3_HUMAN	Increases Expression	[22]
Potassium voltage-gated channel subfamily H member 1 (KCNH1)	OTZZXWER	KCNH1_HUMAN	Decreases Expression	[22]
Alpha-1-antitrypsin (SERPINA1)	OTACYW9J	A1AT_HUMAN	Increases Expression	[22]
Complement C3 (C3)	OTCH5GS0	CO3_HUMAN	Increases Expression	[22]
Apolipoprotein C-I (APOC1)	OTA58CED	APOC1_HUMAN	Increases Expression	[22]
Secretogranin-1 (CHGB)	OT7SAQT2	SCG1_HUMAN	Increases Expression	[22]
Integrin beta-2 (ITGB2)	OTEKPEPR	ITB2_HUMAN	Increases Expression	[22]
Thyroid hormone receptor beta (THRB)	OTBBIRHZ	THB_HUMAN	Increases Expression	[22]
Bone morphogenetic protein 4 (BMP4)	OTPZMDFH	BMP4_HUMAN	Increases Expression	[22]
Gamma-interferon-inducible lysosomal thiol reductase (IFI30)	OT9DERT1	GILT_HUMAN	Increases Expression	[22]
Junction plakoglobin (JUP)	OTUH7VMO	PLAK_HUMAN	Increases Expression	[22]
Keratin, type I cytoskeletal 15 (KRT15)	OTS6WLF7	K1C15_HUMAN	Increases Expression	[22]
Endothelin-2 (EDN2)	OTQ7RCPI	EDN2_HUMAN	Increases Expression	[22]
C4b-binding protein beta chain (C4BPB)	OTJ70B0K	C4BPB_HUMAN	Increases Expression	[22]
NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR)	OTPDCK1F	ADRO_HUMAN	Increases Expression	[22]
Diacylglycerol kinase alpha (DGKA)	OTTBVNEZ	DGKA_HUMAN	Increases Expression	[22]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Increases Expression	[22]
Gap junction beta-2 protein (GJB2)	OTBKLEYB	CXB2_HUMAN	Increases Expression	[22]
Caspase-1 (CASP1)	OTZ3YQFU	CASP1_HUMAN	Increases Expression	[22]
Protein phosphatase 1A (PPM1A)	OT1U770U	PPM1A_HUMAN	Decreases Expression	[22]
Macrophage-capping protein (CAPG)	OTJ86KI6	CAPG_HUMAN	Increases Expression	[22]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B)	OTAG24N1	CDN2B_HUMAN	Increases Expression	[22]
Cell surface glycoprotein MUC18 (MCAM)	OTT8XKGE	MUC18_HUMAN	Increases Expression	[22]
Troponin T, cardiac muscle (TNNT2)	OT80NN7R	TNNT2_HUMAN	Increases Expression	[22]
Transcriptional regulator ATRX (ATRX)	OT77RSQW	ATRX_HUMAN	Decreases Expression	[22]
Tryptophan 2,3-dioxygenase (TDO2)	OTV5HKJ4	T23O_HUMAN	Increases Expression	[22]
PMS1 protein homolog 1 (PMS1)	OTOGFMI6	PMS1_HUMAN	Decreases Expression	[22]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)	OT1SLUZH	TSG6_HUMAN	Increases Expression	[22]
Prolow-density lipoprotein receptor-related protein 1 (LRP1)	OTHTEH4G	LRP1_HUMAN	Increases Expression	[22]
Aspartyl/asparaginyl beta-hydroxylase (ASPH)	OT3KGDEE	ASPH_HUMAN	Decreases Expression	[22]
Semaphorin-3B (SEMA3B)	OTCZCPMS	SEM3B_HUMAN	Increases Expression	[22]
Raftlin (RFTN1)	OT8875JE	RFTN1_HUMAN	Increases Expression	[22]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI)	OTR443C5	BGH3_HUMAN	Decreases Expression	[22]
2'-5'-oligoadenylate synthase-like protein (OASL)	OTZ05YRP	OASL_HUMAN	Increases Expression	[22]
NT-3 growth factor receptor (NTRK3)	OTII30MY	NTRK3_HUMAN	Decreases Expression	[22]
Bcl-2-related protein A1 (BCL2A1)	OTWRYSNA	B2LA1_HUMAN	Increases Expression	[22]
Uncharacterized protein C11orf91 (C11ORF91)	OTNHO5HP	CK091_HUMAN	Decreases Expression	[22]
Caspase recruitment domain-containing protein 16 (CARD16)	OT4NUHWB	CAR16_HUMAN	Increases Expression	[22]
NADH-cytochrome b5 reductase 2 (CYB5R2)	OTTLM7XN	NB5R2_HUMAN	Increases Expression	[22]
Dermokine (DMKN)	OTRIGZMK	DMKN_HUMAN	Increases Expression	[22]
Aftiphilin (AFTPH)	OTDUYPRS	AFTIN_HUMAN	Decreases Expression	[22]
Coiled-coil domain-containing protein 80 (CCDC80)	OTOZSYEM	CCD80_HUMAN	Decreases Expression	[22]
Serine/threonine-protein kinase MARK2 (MARK2)	OTJWGLUZ	MARK2_HUMAN	Increases Expression	[22]
Metalloprotease TIKI1 (TRABD2A)	OTVMA26J	TIKI1_HUMAN	Increases Expression	[22]
Extracellular sulfatase Sulf-2 (SULF2)	OTIXMUVL	SULF2_HUMAN	Increases Expression	[22]
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (PYROXD2)	OTJIX22S	PYRD2_HUMAN	Increases Expression	[22]
Nesprin-1 (SYNE1)	OTSBSLUH	SYNE1_HUMAN	Decreases Expression	[22]
Neurobeachin (NBEA)	OTYLY5TY	NBEA_HUMAN	Decreases Expression	[22]
DNA damage-binding protein 2 (DDB2)	OTO8HVVB	DDB2_HUMAN	Increases Expression	[22]
TBC1 domain family member 5 (TBC1D5)	OTNHLLAX	TBCD5_HUMAN	Decreases Expression	[22]
Lipoma-preferred partner (LPP)	OT6TU8SE	LPP_HUMAN	Decreases Expression	[22]
Major histocompatibility complex class I-related gene protein (MR1)	OTZU3XX7	HMR1_HUMAN	Increases Expression	[22]
F-box only protein 32 (FBXO32)	OTUE978R	FBX32_HUMAN	Decreases Expression	[22]
Collagen triple helix repeat-containing protein 1 (CTHRC1)	OTV88X2G	CTHR1_HUMAN	Increases Expression	[22]
StAR-related lipid transfer protein 4 (STARD4)	OTPQ0BFY	STAR4_HUMAN	Increases Expression	[22]
Sorting nexin-18 (SNX18)	OT68KT3X	SNX18_HUMAN	Increases Expression	[22]
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)	OTT3DOOL	M3K14_HUMAN	Decreases Expression	[22]
Metalloproteinase inhibitor 4 (TIMP4)	OT8A68SW	TIMP4_HUMAN	Increases Expression	[22]
Specifically androgen-regulated gene protein (C1ORF116)	OTPYEXDM	SARG_HUMAN	Increases Expression	[22]
Sperm protein associated with the nucleus on the X chromosome D (SPANXD)	OTMM6ANB	SPNXD_HUMAN	Increases Expression	[22]
TBC1 domain family member 2A (TBC1D2)	OTSGHPD0	TBD2A_HUMAN	Increases Expression	[22]
Cadherin-23 (CDH23)	OTOJGQ7S	CAD23_HUMAN	Increases Expression	[22]
Thiol S-methyltransferase TMT1A (TMT1A)	OT4IAAZP	TMT1A_HUMAN	Increases Expression	[22]
Fibulin-5 (FBLN5)	OTLVNZ8U	FBLN5_HUMAN	Increases Expression	[22]
Hydroxyproline dehydrogenase (PRODH2)	OTHO2TO0	HYPDH_HUMAN	Increases Expression	[22]
C-C motif chemokine 26 (CCL26)	OT2B7HR9	CCL26_HUMAN	Increases Expression	[22]
Sorting nexin-5 (SNX5)	OT6ZOWMU	SNX5_HUMAN	Increases Expression	[22]
Glypican-6 (GPC6)	OTNJBESF	GPC6_HUMAN	Decreases Expression	[22]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases Expression	[94]
RAC-beta serine/threonine-protein kinase (AKT2)	OTBB632K	AKT2_HUMAN	Decreases Expression	[94]
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A)	OTPMGIU4	MLP3A_HUMAN	Decreases Expression	[94]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Expression	[95]
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Decreases Activity	[96]
Calcium-activated chloride channel regulator 1 (CLCA1)	OTL9LPSI	CLCA1_HUMAN	Decreases Expression	[97]
Toll-like receptor 4 (TLR4)	OTP7ML3S	TLR4_HUMAN	Decreases Activity	[98]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)	OTBPCU2O	TR10A_HUMAN	Increases Expression	[46]
Forkhead box protein E1 (FOXE1)	OT5IR5IT	FOXE1_HUMAN	Increases Expression	[99]
GDNF family receptor alpha-2 (GFRA2)	OT34CXNN	GFRA2_HUMAN	Decreases Expression	[100]
C-C motif chemokine 22 (CCL22)	OTT3QJC2	CCL22_HUMAN	Decreases Expression	[48]
Transcription factor E2F3 (E2F3)	OT5VQMWY	E2F3_HUMAN	Decreases Expression	[101]
Acetyl-CoA carboxylase 2 (ACACB)	OT96UIP1	ACACB_HUMAN	Decreases Phosphorylation	[102]
Suppressor of cytokine signaling 3 (SOCS3)	OTY183WJ	SOCS3_HUMAN	Increases Expression	[103]
Citron Rho-interacting kinase (CIT)	OTOZDKPG	CTRO_HUMAN	Decreases Expression	[40]
AP-3 complex subunit delta-1 (AP3D1)	OTJLI0IM	AP3D1_HUMAN	Decreases Expression	[40]
Serine/threonine-protein kinase Chk1 (CHEK1)	OTTTI622	CHK1_HUMAN	Decreases Expression	[40]
Kinetochore protein NDC80 homolog (NDC80)	OTS7D306	NDC80_HUMAN	Decreases Expression	[24]
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C)	OTVHOL9B	TR10C_HUMAN	Increases Expression	[46]
Krueppel-like factor 11 (KLF11)	OTKVQDJD	KLF11_HUMAN	Decreases Expression	[40]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)	OT9RDS3H	IKKB_HUMAN	Decreases Phosphorylation	[104]
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23)	OTAAS85T	TIM23_HUMAN	Decreases Expression	[40]
ERC protein 2 (ERC2)	OTFEDI56	ERC2_HUMAN	Decreases Phosphorylation	[45]
Mothers against decapentaplegic homolog 7 (SMAD7)	OTSLHWF4	SMAD7_HUMAN	Increases Expression	[40]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)	OTLF4ZB1	IKKA_HUMAN	Decreases Phosphorylation	[104]
BET1 homolog (BET1)	OTGX2557	BET1_HUMAN	Increases Expression	[40]
Mothers against decapentaplegic homolog 9 (SMAD9)	OTK4M1H8	SMAD9_HUMAN	Increases Phosphorylation	[105]
Tumor protein p73 (TP73)	OT0LUO47	P73_HUMAN	Increases Expression	[106]
Histone deacetylase 3 (HDAC3)	OTC6GUV3	HDAC3_HUMAN	Increases Expression	[24]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Decreases Cleavage	[107]
Suppressor of cytokine signaling 1 (SOCS1)	OTWA9KFU	SOCS1_HUMAN	Increases Expression	[108]
SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3)	OT9ZS72C	SRGP3_HUMAN	Increases Expression	[109]
RNA-binding protein Musashi homolog 1 (MSI1)	OTAN4FSC	MSI1H_HUMAN	Decreases Expression	[110]
Krueppel-like factor 4 (KLF4)	OT4O9RQW	KLF4_HUMAN	Increases Expression	[111]
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Increases Expression	[112]
Neuronal migration protein doublecortin (DCX)	OTISR7K3	DCX_HUMAN	Increases Expression	[40]
Zinc finger protein SNAI2 (SNAI2)	OT7Y8EJ2	SNAI2_HUMAN	Decreases Expression	[36]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)	OT80DZMT	BUB1_HUMAN	Decreases Expression	[24]
Calumenin (CALU)	OTSYQN71	CALU_HUMAN	Affects Secretion	[113]
Dynamin-like 120 kDa protein, mitochondrial (OPA1)	OTJGNWPW	OPA1_HUMAN	Decreases Expression	[40]
Long-chain-fatty-acid--CoA ligase 4 (ACSL4)	OTI71MUJ	ACSL4_HUMAN	Increases Expression	[114]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)	OT8KME51	BUB1B_HUMAN	Decreases Expression	[24]
Toll-like receptor 2 (TLR2)	OTGO5P4R	TLR2_HUMAN	Decreases Activity	[115]
Tyrosine-protein kinase JAK2 (JAK2)	OTBIDOOR	JAK2_HUMAN	Decreases Phosphorylation	[116]
85/88 kDa calcium-independent phospholipase A2 (PLA2G6)	OT5FL0WU	PLPL9_HUMAN	Increases Expression	[24]
Nibrin (NBN)	OT73B5MD	NBN_HUMAN	Decreases Expression	[117]
Citrate synthase, mitochondrial (CS)	OTYLYXMO	CISY_HUMAN	Increases Activity	[118]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)	OTY9R6FZ	ERN1_HUMAN	Increases Expression	[119]
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5)	OTMVHF9E	LGR5_HUMAN	Decreases Expression	[120]
Serine/threonine-protein kinase 17B (STK17B)	OT4NYNO8	ST17B_HUMAN	Decreases Expression	[24]
PHD finger protein 14 (PHF14)	OTZT3GV1	PHF14_HUMAN	Increases Phosphorylation	[45]
Nuclear factor of activated T-cells 5 (NFAT5)	OTKIE59S	NFAT5_HUMAN	Decreases Expression	[49]
G2/mitotic-specific cyclin-B2 (CCNB2)	OTIEXTDK	CCNB2_HUMAN	Decreases Expression	[24]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)	OT8V1J4M	GA45G_HUMAN	Increases Expression	[121]
Phospholipid-transporting ATPase ABCA1 (ABCA1)	OT94G6BQ	ABCA1_HUMAN	Increases Expression	[122]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Increases Secretion	[123]
Zinc finger protein SNAI1 (SNAI1)	OTDPYAMC	SNAI1_HUMAN	Decreases Expression	[36]
Chromobox protein homolog 7 (CBX7)	OTNELDIB	CBX7_HUMAN	Decreases Expression	[124]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)	OT9QIHEQ	RECK_HUMAN	Decreases Expression	[40]
Serine/threonine-protein kinase Chk2 (CHEK2)	OT8ZPCNS	CHK2_HUMAN	Increases Phosphorylation	[125]
G1/S-specific cyclin-E2 (CCNE2)	OTBBUKQQ	CCNE2_HUMAN	Decreases Expression	[24]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Decreases Activity	[26]
Cytochrome c oxidase subunit 3 (COX3)	OTNNGBYJ	COX3_HUMAN	Increases Expression	[49]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Decreases Expression	[49]
Phosphoglycerate kinase 1 (PGK1)	OT6V1ICH	PGK1_HUMAN	Increases Expression	[126]
Complement factor D (CFD)	OTLNRXB6	CFAD_HUMAN	Affects Secretion	[113]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Decreases Expression	[127]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Increases Expression	[128]
Argininosuccinate synthase (ASS1)	OT4ZMG0Q	ASSY_HUMAN	Increases Expression	[40]
Angiotensinogen (AGT)	OTBZLYR3	ANGT_HUMAN	Decreases Response To Substance	[129]
Complement C5 (C5)	OTSL3OIC	CO5_HUMAN	Decreases Response To Substance	[130]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Decreases Expression	[131]
Cystatin-S (CST4)	OTXXM8EH	CYTS_HUMAN	Increases Expression	[43]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[132]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[133]
GTPase HRas (HRAS)	OTWQN0DP	RASH_HUMAN	Affects Expression	[134]
Low-density lipoprotein receptor (LDLR)	OTH559LU	LDLR_HUMAN	Increases Expression	[135]
Pro-epidermal growth factor (EGF)	OTANRJ0L	EGF_HUMAN	Decreases Activity	[136]
Protransforming growth factor alpha (TGFA)	OTPD1LL9	TGFA_HUMAN	Increases Expression	[137]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Decreases Expression	[138]
Natriuretic peptides A (NPPA)	OTMQNTNX	ANF_HUMAN	Decreases Expression	[48]
Insulin-like growth factor II (IGF2)	OTJ4O6MW	IGF2_HUMAN	Decreases Secretion	[139]
Gastrin (GAST)	OTD0IP9N	GAST_HUMAN	Decreases Expression	[48]
Lymphotoxin-alpha (LTA)	OTUC3S76	TNFB_HUMAN	Decreases Expression	[48]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Decreases Expression	[140]
Interferon beta (IFNB1)	OTYQGUB5	IFNB_HUMAN	Decreases Expression	[48]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Decreases Expression	[141]
Collagen alpha-1(II) chain (COL2A1)	OT5E59C8	CO2A1_HUMAN	Increases Expression	[142]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Decreases Expression	[143]
Prelamin-A/C (LMNA)	OT3SG7ZR	LMNA_HUMAN	Increases Cleavage	[144]
Glycophorin-A (GYPA)	OTABU4YV	GLPA_HUMAN	Increases Expression	[145]
Band 3 anion transport protein (SLC4A1)	OT3EFUK8	B3AT_HUMAN	Increases Expression	[145]
C-reactive protein (CRP)	OT0RFT8F	CRP_HUMAN	Decreases Expression	[146]
Alpha-2-HS-glycoprotein (AHSG)	OTUG0LEA	FETUA_HUMAN	Decreases Phosphorylation	[45]
Transferrin receptor protein 1 (TFRC)	OT8ZPBDL	TFR1_HUMAN	Decreases Expression	[49]
Serotransferrin (TF)	OT41PEMS	TRFE_HUMAN	Affects Secretion	[113]
Ferritin heavy chain (FTH1)	OT6IFS0O	FRIH_HUMAN	Increases Expression	[147]
Osteocalcin (BGLAP)	OTK1YLWQ	OSTCN_HUMAN	Increases Expression	[148]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Decreases Expression	[133]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Increases Expression	[112]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Decreases Expression	[40]
Apolipoprotein B-100 (APOB)	OTH0UOCZ	APOB_HUMAN	Decreases Secretion	[149]
Granulocyte-macrophage colony-stimulating factor (CSF2)	OT1M7D28	CSF2_HUMAN	Increases Expression	[100]
Glucocorticoid receptor (NR3C1)	OTCI2YDI	GCR_HUMAN	Decreases Expression	[40]
Trefoil factor 1 (TFF1)	OTCYQH4F	TFF1_HUMAN	Increases Expression	[132]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Decreases Expression	[150]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[151]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Expression	[152]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Decreases Expression	[125]
Integrin beta-3 (ITGB3)	OTWCK1K6	ITB3_HUMAN	Affects Localization	[153]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Decreases Expression	[154]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Increases Phosphorylation	[31]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Decreases Expression	[155]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Decreases Expression	[156]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Affects Localization	[153]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Decreases Phosphorylation	[157]
Progesterone receptor (PGR)	OT0FZ3QE	PRGR_HUMAN	Increases Expression	[132]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Expression	[24]
Alpha-enolase (ENO1)	OTB1KWJS	ENOA_HUMAN	Decreases Expression	[126]
Lipoprotein lipase (LPL)	OTTW0267	LIPL_HUMAN	Decreases Expression	[122]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Increases Expression	[152]
L-lactate dehydrogenase B chain (LDHB)	OT9B1CT3	LDHB_HUMAN	Affects Secretion	[113]
Thrombomodulin (THBD)	OT8VHLKY	TRBM_HUMAN	Increases Expression	[158]
Vitamin K-dependent protein S (PROS1)	OTXQWNOI	PROS_HUMAN	Decreases Expression	[159]
Cathepsin D (CTSD)	OTQZ36F3	CATD_HUMAN	Increases Expression	[132]
Pulmonary surfactant-associated protein B (SFTPB)	OTOHS07E	PSPB_HUMAN	Decreases Expression	[48]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Decreases Acetylation	[25]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Affects Secretion	[113]
Tumor necrosis factor receptor superfamily member 16 (NGFR)	OTPKSM49	TNR16_HUMAN	Increases Expression	[160]
Zinc finger protein GLI1 (GLI1)	OT1BTAJO	GLI1_HUMAN	Decreases Activity	[161]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Expression	[162]
ATP-dependent 6-phosphofructokinase, muscle type (PFKM)	OT1QY9JM	PFKAM_HUMAN	Decreases Activity	[163]
Synaptophysin (SYP)	OTFJKMO4	SYPH_HUMAN	Increases Expression	[164]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Decreases Expression	[165]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1)	OTGEU8IK	ODPA_HUMAN	Decreases Expression	[126]
Monocyte differentiation antigen CD14 (CD14)	OT83GJ47	CD14_HUMAN	Increases Expression	[166]
Fibroblast growth factor 4 (FGF4)	OTNVV3ZG	FGF4_HUMAN	Decreases Expression	[156]
Tyrosine-protein kinase HCK (HCK)	OTRL6OSI	HCK_HUMAN	Decreases Expression	[100]
Integrin alpha-5 (ITGA5)	OT3RCI67	ITA5_HUMAN	Decreases Expression	[40]
Interleukin-3 (IL3)	OT0CQ35N	IL3_HUMAN	Decreases Expression	[48]
Annexin A5 (ANXA5)	OTZS877V	ANXA5_HUMAN	Increases Expression	[167]
Fibroblast growth factor 2 (FGF2)	OT7YUJ9F	FGF2_HUMAN	Decreases Expression	[168]
Gamma-enolase (ENO2)	OTRODL0T	ENOG_HUMAN	Decreases Expression	[126]
Matrilysin (MMP7)	OTVT3SEJ	MMP7_HUMAN	Decreases Expression	[169]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Decreases Expression	[170]
SPARC (SPARC)	OTPN90H0	SPRC_HUMAN	Decreases Expression	[165]
Clathrin light chain A (CLTA)	OTLHOXMQ	CLCA_HUMAN	Affects Secretion	[113]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[171]
Dihydrolipoyl dehydrogenase, mitochondrial (DLD)	OT378CU9	DLDH_HUMAN	Increases Expression	[126]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[140]
DNA polymerase alpha catalytic subunit (POLA1)	OT1WXFVY	DPOLA_HUMAN	Decreases Expression	[24]
Fructose-bisphosphate aldolase C (ALDOC)	OTEC13I5	ALDOC_HUMAN	Increases Expression	[126]
Heat shock 70 kDa protein 1A (HSPA1A)	OTKGIE76	HS71A_HUMAN	Decreases Expression	[40]
Choriogonadotropin subunit beta 3 (CGB3)	OTVM2SU3	CGB3_HUMAN	Increases Expression	[100]
Ras-related protein Rap-2a (RAP2A)	OT0JB5S4	RAP2A_HUMAN	Increases Expression	[40]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Decreases Expression	[140]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Decreases Expression	[48]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Decreases Expression	[172]
Serine/threonine-protein kinase A-Raf (ARAF)	OTZJ0FNO	ARAF_HUMAN	Increases Expression	[40]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[173]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Increases Expression	[148]
Chromogranin-A (CHGA)	OTXYX5JH	CMGA_HUMAN	Decreases Expression	[174]
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Decreases Expression	[175]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Increases Expression	[160]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Decreases Expression	[176]
Laminin subunit gamma-1 (LAMC1)	OTIG527N	LAMC1_HUMAN	Affects Secretion	[113]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)	OTA675TJ	GTR1_HUMAN	Affects Binding	[177]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)	OTBL2W7R	GTR2_HUMAN	Increases Expression	[178]
Acetylcholine receptor subunit beta (CHRNB1)	OTTJXD24	ACHB_HUMAN	Decreases Expression	[40]
Serine/threonine-protein kinase pim-1 (PIM1)	OTWEKXTU	PIM1_HUMAN	Increases Expression	[179]
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM)	OTA4P0FC	ACADM_HUMAN	Increases Expression	[180]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Expression	[24]
Ornithine decarboxylase (ODC1)	OTNDAGRR	DCOR_HUMAN	Decreases Expression	[181]
Neurofilament heavy polypeptide (NEFH)	OTMSCW5I	NFH_HUMAN	Increases Expression	[110]
Collagen alpha-1(VI) chain (COL6A1)	OTYKSCOB	CO6A1_HUMAN	Affects Secretion	[113]
Collagen alpha-2(VI) chain (COL6A2)	OTQC6PPO	CO6A2_HUMAN	Affects Secretion	[113]
Annexin A3 (ANXA3)	OTDD8OI7	ANXA3_HUMAN	Increases Cleavage	[182]
Bone morphogenetic protein 2 (BMP2)	OT23T37S	BMP2_HUMAN	Increases Expression	[183]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Decreases Phosphorylation	[184]
Cystic fibrosis transmembrane conductance regulator (CFTR)	OT6B22QH	CFTR_HUMAN	Increases Activity	[185]
Elongation factor 2 (EEF2)	OTZ7SZ39	EF2_HUMAN	Decreases Expression	[186]
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)	OTPWI88U	CEAM1_HUMAN	Increases Expression	[100]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Decreases Expression	[187]
Beta-enolase (ENO3)	OT3HYKYI	ENOB_HUMAN	Decreases Expression	[126]
Glial fibrillary acidic protein (GFAP)	OTQ01ZAS	GFAP_HUMAN	Increases Expression	[188]
Hepatocyte growth factor (HGF)	OTGHUA23	HGF_HUMAN	Decreases Expression	[100]
Perforin-1 (PRF1)	OTFVXD7H	PERF_HUMAN	Increases Expression	[189]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Decreases Expression	[109]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Decreases Expression	[190]
Indoleamine 2,3-dioxygenase 1 (IDO1)	OT91DBN7	I23O1_HUMAN	Affects Activity	[191]
Leukemia inhibitory factor (LIF)	OTO46S5S	LIF_HUMAN	Increases Expression	[164]
Serine/threonine-protein kinase B-raf (BRAF)	OT7S81XQ	BRAF_HUMAN	Decreases Expression	[192]
Fatty acid-binding protein, adipocyte (FABP4)	OT3DKFOU	FABP4_HUMAN	Decreases Expression	[193]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2)	OTNIZPEA	ATF2_HUMAN	Increases Activity	[194]
Mucin-1 (MUC1)	OTHQI7IY	MUC1_HUMAN	Decreases Expression	[100]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Decreases Expression	[26]
Ribosyldihydronicotinamide dehydrogenase (NQO2)	OTGDAJRZ	NQO2_HUMAN	Decreases Activity	[195]
Cyclic AMP-responsive element-binding protein 1 (CREB1)	OT1MDLA1	CREB1_HUMAN	Decreases Phosphorylation	[196]
Platelet endothelial cell adhesion molecule (PECAM1)	OTXOM4D9	PECA1_HUMAN	Decreases Expression	[197]
Fumarylacetoacetase (FAH)	OTGZA1YR	FAAA_HUMAN	Affects Splicing	[198]
Stathmin (STMN1)	OTDJ4RV0	STMN1_HUMAN	Decreases Expression	[40]
Protein kinase C alpha type (PRKCA)	OT5UWNRD	KPCA_HUMAN	Decreases Activity	[199]
Integrin alpha-2 (ITGA2)	OTPFL017	ITA2_HUMAN	Increases Expression	[40]
Transcription factor JunD (JUND)	OTNKACJD	JUND_HUMAN	Increases Expression	[24]
S-adenosylmethionine decarboxylase proenzyme (AMD1)	OTKAGZY3	DCAM_HUMAN	Decreases Activity	[181]
Vascular endothelial growth factor receptor 1 (FLT1)	OTT0OGYS	VGFR1_HUMAN	Decreases Expression	[200]
Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12)	OTFL5KR5	LOX12_HUMAN	Decreases Activity	[201]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Increases Expression	[202]
Phosphoglycerate mutase 1 (PGAM1)	OTZ5DB06	PGAM1_HUMAN	Decreases Expression	[126]
Cyclic AMP-dependent transcription factor ATF-1 (ATF1)	OT251CI0	ATF1_HUMAN	Increases Phosphorylation	[125]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)	OTAFHAVI	ATF6A_HUMAN	Increases Expression	[119]
Cadherin-2 (CDH2)	OTH0Y56P	CADH2_HUMAN	Decreases Expression	[26]
ETS domain-containing protein Elk-1 (ELK1)	OTH9MXD6	ELK1_HUMAN	Increases Activity	[203]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	OT2D9DOV	TNR1A_HUMAN	Decreases Expression	[140]
Sodium/hydrogen exchanger 1 (SLC9A1)	OT6HNHFV	SL9A1_HUMAN	Increases Expression	[204]
C-X-C motif chemokine 2 (CXCL2)	OTEJCYMY	CXCL2_HUMAN	Decreases Expression	[48]
Follistatin (FST)	OTRIVK9Y	FST_HUMAN	Increases Expression	[43]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Increases Expression	[132]
Pro-thyrotropin-releasing hormone (TRH)	OT02UY2V	TRH_HUMAN	Decreases Expression	[48]
Lamin-B1 (LMNB1)	OT100T3P	LMNB1_HUMAN	Increases Cleavage	[205]
Hepatocyte nuclear factor 1-alpha (HNF1A)	OT9DOUKL	HNF1A_HUMAN	Increases Expression	[178]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Increases Expression	[100]
Macrophage scavenger receptor types I and II (MSR1)	OTHANJ7A	MSRE_HUMAN	Decreases Expression	[122]
Methylmalonyl-CoA mutase, mitochondrial (MMUT)	OTBBBV70	MUTA_HUMAN	Increases Expression	[40]
Interleukin-10 (IL10)	OTIRFRXC	IL10_HUMAN	Decreases Secretion	[206]
E3 ubiquitin-protein ligase CBL (CBL)	OTTKELCU	CBL_HUMAN	Decreases Expression	[49]
Insulin-like growth factor-binding protein 4 (IGFBP4)	OT2HZRBD	IBP4_HUMAN	Decreases Expression	[48]
Ribosomal protein S6 kinase beta-1 (RPS6KB1)	OTAELNGX	KS6B1_HUMAN	Decreases Activity	[30]
Tyrosine-protein kinase JAK1 (JAK1)	OT0X3D17	JAK1_HUMAN	Decreases Expression	[49]
Receptor-type tyrosine-protein phosphatase epsilon (PTPRE)	OTOD5NID	PTPRE_HUMAN	Increases Expression	[207]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG)	OT9N2WOF	PTPRG_HUMAN	Decreases Expression	[208]
Adenosylhomocysteinase (AHCY)	OT8UC40I	SAHH_HUMAN	Affects Expression	[32]
Cofilin-1 (CFL1)	OTT6D5MH	COF1_HUMAN	Decreases Expression	[186]
C-type natriuretic peptide (NPPC)	OTYJ0LMA	ANFC_HUMAN	Increases Expression	[158]
Eukaryotic translation initiation factor 4B (EIF4B)	OTE8TXA8	IF4B_HUMAN	Decreases Phosphorylation	[45]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[133]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[100]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Decreases Expression	[100]
G1/S-specific cyclin-E1 (CCNE1)	OTLD7UID	CCNE1_HUMAN	Decreases Expression	[209]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Decreases Expression	[109]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[140]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Expression	[210]
DNA cytosine-5)-methyltransferase 1 (DNMT1)	OTM2DGTK	DNMT1_HUMAN	Decreases Expression	[211]
Protein S100-A4 (S100A4)	OTLRGFSQ	S10A4_HUMAN	Decreases Expression	[23]
High mobility group protein B2 (HMGB2)	OTGEGAOK	HMGB2_HUMAN	Decreases Expression	[24]
NKG2-D type II integral membrane protein (KLRK1)	OTQWXK71	NKG2D_HUMAN	Increases Expression	[189]
G0/G1 switch protein 2 (G0S2)	OT8FL49L	G0S2_HUMAN	Increases Expression	[43]
Ceramide synthase 1 (CERS1)	OT6EYRM3	CERS1_HUMAN	Increases Expression	[44]
DNA repair nuclease/redox regulator APEX1 (APEX1)	OT53OI14	APEX1_HUMAN	Decreases Activity	[212]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)	OT5BZ1J9	P85A_HUMAN	Increases Expression	[40]
Proteasome subunit beta type-5 (PSMB5)	OTOZXAS6	PSB5_HUMAN	Decreases Expression	[213]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)	OTG0TTX7	CD38_HUMAN	Increases Expression	[40]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Decreases Expression	[48]
Phosphatidylethanolamine-binding protein 1 (PEBP1)	OTQ5FEI0	PEBP1_HUMAN	Affects Secretion	[113]
Protein disulfide-isomerase A3 (PDIA3)	OTHPQ0Q3	PDIA3_HUMAN	Affects Expression	[214]
Cell division cycle protein 27 homolog (CDC27)	OTDT45XJ	CDC27_HUMAN	Decreases Expression	[24]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Decreases Expression	[106]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Decreases Expression	[40]
M-phase inducer phosphatase 2 (CDC25B)	OT12MSRY	MPIP2_HUMAN	Decreases Expression	[40]
M-phase inducer phosphatase 3 (CDC25C)	OTPQI71S	MPIP3_HUMAN	Increases Phosphorylation	[215]
B2 bradykinin receptor (BDKRB2)	OTOA9D3W	BKRB2_HUMAN	Decreases Expression	[40]
HLA class I histocompatibility antigen, alpha chain F (HLA-F)	OT76CM19	HLAF_HUMAN	Increases Expression	[43]
Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA)	OTOJ8QFF	SDHA_HUMAN	Decreases Acetylation	[216]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Decreases Expression	[24]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Expression	[217]
Peroxiredoxin-2 (PRDX2)	OTLWCY9T	PRDX2_HUMAN	Affects Secretion	[113]
Cadherin-5 (CDH5)	OTVX0E1Q	CADH5_HUMAN	Affects Localization	[218]
Cyclin-dependent kinases regulatory subunit 2 (CKS2)	OTPTMHIV	CKS2_HUMAN	Decreases Expression	[24]
Dual specificity protein kinase TTK (TTK)	OTBY1Z5H	TTK_HUMAN	Decreases Expression	[24]
DNA replication licensing factor MCM4 (MCM4)	OT19PNNG	MCM4_HUMAN	Decreases Expression	[24]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Decreases Expression	[106]
Interleukin-13 (IL13)	OTI4YS3Y	IL13_HUMAN	Decreases Expression	[48]
Replication factor C subunit 4 (RFC4)	OTWALD2R	RFC4_HUMAN	Decreases Expression	[24]
Pro-adrenomedullin (ADM)	OT7T0TA4	ADML_HUMAN	Decreases Secretion	[219]
Hexokinase-4 (GCK)	OTR3Q0NN	HXK4_HUMAN	Increases Expression	[178]
Insulin receptor substrate 1 (IRS1)	OTNO82CU	IRS1_HUMAN	Decreases Expression	[40]
Basigin (BSG)	OTD0CVEC	BASI_HUMAN	Decreases Expression	[220]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[221]
Hepatocyte nuclear factor 1-beta (HNF1B)	OTSYIC3T	HNF1B_HUMAN	Decreases Expression	[100]
Keratin, type I cytoskeletal 20 (KRT20)	OT4RB40L	K1C20_HUMAN	Increases Expression	[222]
Vascular endothelial growth factor receptor 2 (KDR)	OT15797V	VGFR2_HUMAN	Decreases Expression	[223]
Chitinase-3-like protein 1 (CHI3L1)	OT2Z7VJH	CH3L1_HUMAN	Decreases Expression	[224]
TGF-beta receptor type-1 (TGFBR1)	OT40S1SJ	TGFR1_HUMAN	Increases Expression	[225]
Serpin B5 (SERPINB5)	OTSMXQRJ	SPB5_HUMAN	Increases Expression	[226]
Pigment epithelium-derived factor (SERPINF1)	OTWZH98J	PEDF_HUMAN	Affects Secretion	[113]
Sterol regulatory element-binding protein 1 (SREBF1)	OTWBRPAI	SRBP1_HUMAN	Decreases Expression	[227]
Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)	OTRAFFX2	GPX4_HUMAN	Increases Expression	[114]
TGF-beta receptor type-2 (TGFBR2)	OT3P7GZP	TGFR2_HUMAN	Increases Expression	[225]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Increases Expression	[228]
Squalene synthase (FDFT1)	OTGDISIT	FDFT_HUMAN	Increases Expression	[135]
Transaldolase (TALDO1)	OTDKV2S2	TALDO_HUMAN	Affects Expression	[32]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Increases Degradation	[229]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Increases Expression	[230]
Collagen alpha-1(XVIII) chain (COL18A1)	OTJFUH6O	COIA1_HUMAN	Decreases Expression	[48]
Adenylyl cyclase-associated protein 2 (CAP2)	OTC1WFNO	CAP2_HUMAN	Decreases Expression	[100]
L-dopachrome tautomerase (DCT)	OTYVNTBG	TYRP2_HUMAN	Decreases Expression	[29]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Decreases Expression	[164]
DNA-binding protein inhibitor ID-1 (ID1)	OTKGNZN5	ID1_HUMAN	Decreases Expression	[231]
Leptin (LEP)	OT5Q7ODW	LEP_HUMAN	Decreases Expression	[232]
Protein phosphatase inhibitor 2 (PPP1R2)	OTNLOUQR	IPP2_HUMAN	Increases Expression	[40]
C-C chemokine receptor type 2 (CCR2)	OTQ7T10J	CCR2_HUMAN	Decreases Expression	[233]
Protein kinase C iota type (PRKCI)	OTKBAVT3	KPCI_HUMAN	Decreases Expression	[40]
T-lymphocyte activation antigen CD86 (CD86)	OTJCSBPC	CD86_HUMAN	Increases Expression	[166]
Lamina-associated polypeptide 2, isoform alpha (TMPO)	OTL68EL4	LAP2A_HUMAN	Decreases Phosphorylation	[45]
Signal transducer and activator of transcription 1-alpha/beta (STAT1)	OTLMBUZ6	STAT1_HUMAN	Decreases Expression	[40]
Signal transducer and activator of transcription 6 (STAT6)	OTCKMP49	STAT6_HUMAN	Decreases Expression	[234]
Signal transducer and activator of transcription 5A (STAT5A)	OTBSJGN3	STA5A_HUMAN	Affects Localization	[207]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)	OTO8JQJA	PK3CB_HUMAN	Decreases Expression	[49]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Decreases Expression	[41]
Endothelin-converting enzyme 1 (ECE1)	OTPFHC6F	ECE1_HUMAN	Decreases Expression	[235]
ETS translocation variant 4 (ETV4)	OT8C98UZ	ETV4_HUMAN	Decreases Activity	[236]
Nicotinamide phosphoribosyltransferase (NAMPT)	OTVJR3GL	NAMPT_HUMAN	Increases Expression	[237]
Homeobox protein Nkx-2.1 (NKX2-1)	OTCMEJTA	NKX21_HUMAN	Increases Expression	[99]
Collagenase 3 (MMP13)	OTY8BZIE	MMP13_HUMAN	Decreases Secretion	[238]
ATP-binding cassette sub-family G member 1 (ABCG1)	OT5BG6MK	ABCG1_HUMAN	Increases Expression	[122]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Decreases Activity	[239]
Mitogen-activated protein kinase 9 (MAPK9)	OTCEVJ9E	MK09_HUMAN	Decreases Phosphorylation	[240]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[24]
Solute carrier family 15 member 1 (SLC15A1)	OT1P16B5	S15A1_HUMAN	Increases Expression	[241]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Increases Expression	[242]
Neurogenic locus notch homolog protein 1 (NOTCH1)	OTI1WADQ	NOTC1_HUMAN	Decreases Expression	[27]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Expression	[140]
Melatonin receptor type 1A (MTNR1A)	OTYYV8JK	MTR1A_HUMAN	Affects Binding	[243]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Increases Expression	[244]
DNA-binding protein RFX2 (RFX2)	OTK6VQ1B	RFX2_HUMAN	Increases Phosphorylation	[45]
Transcription factor SOX-2 (SOX2)	OTFAWCAU	SOX2_HUMAN	Decreases Expression	[36]
Transcription factor SOX-9 (SOX9)	OTVDJFGN	SOX9_HUMAN	Increases Expression	[142]
Glutamate--cysteine ligase catalytic subunit (GCLC)	OTESDI4D	GSH1_HUMAN	Increases Expression	[245]
Glutathione synthetase (GSS)	OTVSBEIW	GSHB_HUMAN	Increases Expression	[114]
Neuromedin-U (NMU)	OTW9X7BQ	NMU_HUMAN	Increases Expression	[43]
Nestin (NES)	OTZ9PZ14	NEST_HUMAN	Decreases Expression	[26]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)	OT3FAU4Y	PK3CG_HUMAN	Decreases Activity	[246]
Sodium/hydrogen exchanger 3 (SLC9A3)	OTZ7PFVT	SL9A3_HUMAN	Increases Expression	[204]
Adhesion G protein-coupled receptor E5 (ADGRE5)	OTTSB84Q	AGRE5_HUMAN	Decreases Expression	[247]
Melatonin receptor type 1B (MTNR1B)	OT6VFHX9	MTR1B_HUMAN	Affects Binding	[243]
Centromere protein F (CENPF)	OT7AG0SW	CENPF_HUMAN	Decreases Expression	[24]
DNA primase small subunit (PRIM1)	OTWWP8Y6	PRI1_HUMAN	Decreases Expression	[24]
Caspase-4 (CASP4)	OTVQTV1L	CASP4_HUMAN	Increases Activity	[176]
CCAAT/enhancer-binding protein delta (CEBPD)	OTNBIPMY	CEBPD_HUMAN	Decreases Expression	[100]
Placenta growth factor (PGF)	OT5MF5DJ	PLGF_HUMAN	Decreases Expression	[48]
Presenilin-2 (PSEN2)	OTOW778B	PSN2_HUMAN	Decreases Expression	[248]
Tuberin (TSC2)	OT47LWI9	TSC2_HUMAN	Increases Expression	[249]
Glycogen synthase kinase-3 alpha (GSK3A)	OT0F6DWV	GSK3A_HUMAN	Decreases Phosphorylation	[250]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Decreases Activity	[251]
Cathelicidin antimicrobial peptide (CAMP)	OT3Y8011	CAMP_HUMAN	Increases Expression	[252]
Double-strand break repair protein MRE11 (MRE11)	OTGU8TZM	MRE11_HUMAN	Decreases Expression	[117]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Increases Expression	[253]
Serpin H1 (SERPINH1)	OTKGI7BS	SERPH_HUMAN	Decreases Expression	[141]
Achaete-scute homolog 1 (ASCL1)	OTI4X44G	ASCL1_HUMAN	Decreases Expression	[174]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Increases Expression	[254]
Biotin--protein ligase (HLCS)	OTPDUX30	BPL1_HUMAN	Decreases Activity	[255]
Annexin A11 (ANXA11)	OT8SRY1C	ANX11_HUMAN	Decreases Expression	[40]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (PLCD1)	OT6WFVXZ	PLCD1_HUMAN	Increases Expression	[40]
Dual specificity protein phosphatase 3 (DUSP3)	OTPJX9B4	DUS3_HUMAN	Decreases Expression	[40]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2)	OT4DJFFU	DNA2_HUMAN	Decreases Expression	[24]
Breast cancer type 2 susceptibility protein (BRCA2)	OTF1XSV1	BRCA2_HUMAN	Decreases Expression	[49]
Methyl-CpG-binding protein 2 (MECP2)	OTREZK68	MECP2_HUMAN	Decreases Expression	[256]
Eotaxin (CCL11)	OT3BIFPK	CCL11_HUMAN	Decreases Expression	[234]
Signal transducer and activator of transcription 5B (STAT5B)	OTZVPEBT	STA5B_HUMAN	Affects Localization	[207]
Serine/threonine-protein kinase Nek2 (NEK2)	OT1H27HO	NEK2_HUMAN	Decreases Expression	[24]
Importin subunit alpha-1 (KPNA2)	OTU7FOE6	IMA1_HUMAN	Decreases Expression	[24]
Rho GDP-dissociation inhibitor 1 (ARHGDIA)	OTEXWJDO	GDIR1_HUMAN	Decreases Expression	[49]
DNA mismatch repair protein Msh6 (MSH6)	OT46FP09	MSH6_HUMAN	Decreases Expression	[40]
Kinesin-like protein KIF11 (KIF11)	OTHRGLCQ	KIF11_HUMAN	Decreases Expression	[24]
Hexokinase-2 (HK2)	OTC0GCQO	HXK2_HUMAN	Decreases Expression	[257]
Pancreas/duodenum homeobox protein 1 (PDX1)	OTX1DKRA	PDX1_HUMAN	Increases Expression	[178]
Serine/threonine-protein kinase PLK1 (PLK1)	OTRZX45T	PLK1_HUMAN	Decreases Expression	[24]
Death-associated protein kinase 1 (DAPK1)	OTNCNUCO	DAPK1_HUMAN	Increases Expression	[258]
LIM domain kinase 1 (LIMK1)	OTFZ8MZ0	LIMK1_HUMAN	Decreases Expression	[210]
Telomeric repeat-binding factor 1 (TERF1)	OTIJCMGB	TERF1_HUMAN	Affects Localization	[42]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)	OTU1KZPV	AAPK2_HUMAN	Increases Phosphorylation	[259]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Activity	[197]
Caspase-6 (CASP6)	OTXLD3EC	CASP6_HUMAN	Increases Activity	[260]
Hepatocyte nuclear factor 3-alpha (FOXA1)	OTEBY0TD	FOXA1_HUMAN	Increases Phosphorylation	[45]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Decreases Expression	[176]
Claudin-2 (CLDN2)	OTRF3D6Y	CLD2_HUMAN	Increases Expression	[261]
Myotrophin (MTPN)	OT5N60RU	MTPN_HUMAN	Decreases Expression	[40]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Decreases Expression	[262]
Interleukin-2 (IL2)	OTGI4NSA	IL2_HUMAN	Decreases Expression	[263]
Ras-related C3 botulinum toxin substrate 3 (RAC3)	OT2RE7A7	RAC3_HUMAN	Decreases Expression	[41]
Destrin (DSTN)	OTMXO4YB	DEST_HUMAN	Affects Expression	[32]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Decreases Expression	[100]
Small ribosomal subunit protein eS1 (RPS3A)	OTUEP7CL	RS3A_HUMAN	Decreases Expression	[40]
NPC intracellular cholesterol transporter 2 (NPC2)	OTE9UEJC	NPC2_HUMAN	Increases Expression	[43]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Decreases Expression	[141]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Decreases Activity	[264]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Increases Expression	[43]
Histone H2B type 1-C/E/F/G/I (H2BC10)	OTLQH0D6	H2B1C_HUMAN	Increases Expression	[43]
Ras-related C3 botulinum toxin substrate 1 (RAC1)	OTKRO61U	RAC1_HUMAN	Affects Localization	[265]
Eukaryotic translation initiation factor 5A-1 (EIF5A)	OTQ8DJX5	IF5A1_HUMAN	Decreases Acetylation	[186]
Histone H3.1 (H3C1)	OTGBGOZW	H31_HUMAN	Decreases Expression	[109]
Hemoglobin subunit beta (HBB)	OT514IKQ	HBB_HUMAN	Increases Expression	[145]
Hemoglobin subunit gamma-2 (HBG2)	OT4J48JJ	HBG2_HUMAN	Increases Expression	[145]
Hemoglobin subunit alpha (HBA1)	OTW2BQF4	HBA_HUMAN	Increases Expression	[145]
Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2)	OTEO98CR	IF4G2_HUMAN	Decreases Expression	[40]
T-complex protein 1 subunit beta (CCT2)	OTW1VV4E	TCPB_HUMAN	Affects Expression	[214]
Fractalkine (CX3CL1)	OTPLGI0E	X3CL1_HUMAN	Decreases Expression	[48]
C-X-C motif chemokine 6 (CXCL6)	OTFTCQ4O	CXCL6_HUMAN	Decreases Expression	[48]
Mothers against decapentaplegic homolog 3 (SMAD3)	OTNA96MR	SMAD3_HUMAN	Decreases Expression	[138]
Large ribosomal subunit protein eL19 (RPL19)	OT33LM66	RL19_HUMAN	Affects Expression	[214]
Mucin-5AC (MUC5AC)	OTJV8O04	MUC5A_HUMAN	Decreases Expression	[97]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Increases Activity	[266]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Decreases Expression	[267]
Transcription factor RelB (RELB)	OTU3QYEF	RELB_HUMAN	Increases Expression	[100]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Increases Expression	[135]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Decreases Expression	[36]
Centromere-associated protein E (CENPE)	OTQ7AP04	CENPE_HUMAN	Decreases Expression	[24]
Kinesin-like protein KIF23 (KIF23)	OTY850JC	KIF23_HUMAN	Decreases Expression	[24]
Desmoglein-1 (DSG1)	OT11HC3A	DSG1_HUMAN	Decreases Expression	[40]
Nucleobindin-1 (NUCB1)	OT5Z6YU4	NUCB1_HUMAN	Affects Secretion	[113]
Peroxisome proliferator-activated receptor delta (PPARD)	OTI4WTOP	PPARD_HUMAN	Increases Expression	[228]
Urokinase plasminogen activator surface receptor (PLAUR)	OTIRKKEQ	UPAR_HUMAN	Decreases Expression	[127]
Neurogenic locus notch homolog protein 2 (NOTCH2)	OTQ3Y9PA	NOTC2_HUMAN	Decreases Expression	[27]
Lactoylglutathione lyase (GLO1)	OTXFS5B3	LGUL_HUMAN	Increases Expression	[268]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Decreases Expression	[40]
Elongation factor 1-alpha 2 (EEF1A2)	OT9Z23K5	EF1A2_HUMAN	Decreases Expression	[197]
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)	OTFH9M73	PTN11_HUMAN	Increases Expression	[207]
DNA repair protein RAD51 homolog 1 (RAD51)	OTNVWGC1	RAD51_HUMAN	Increases Expression	[230]
Paired box protein Pax-8 (PAX8)	OTRPD9MI	PAX8_HUMAN	Increases Expression	[99]
Peroxiredoxin-1 (PRDX1)	OTZ3BEC4	PRDX1_HUMAN	Affects Secretion	[113]
Early activation antigen CD69 (CD69)	OTGJHSVP	CD69_HUMAN	Increases Expression	[269]
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1)	OT5GO2PL	KHDR1_HUMAN	Increases Expression	[40]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Decreases Expression	[267]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[270]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[271]
Peroxisome proliferator-activated receptor alpha (PPARA)	OTK095PP	PPARA_HUMAN	Increases Expression	[228]
Lactadherin (MFGE8)	OTQKE41R	MFGM_HUMAN	Affects Response To Substance	[272]
Histone acetyltransferase p300 (EP300)	OTL8QJDX	EP300_HUMAN	Decreases Expression	[273]
Bone marrow stromal antigen 2 (BST2)	OTU4LCJV	BST2_HUMAN	Decreases Expression	[274]
Sterol regulatory element-binding protein 2 (SREBF2)	OTBXUNPL	SRBP2_HUMAN	Increases Expression	[135]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)	OTZVUOOB	FBLN3_HUMAN	Affects Secretion	[113]
Ileal sodium/bile acid cotransporter (SLC10A2)	OTIHSXO8	NTCP2_HUMAN	Decreases Expression	[275]
TNF receptor-associated factor 2 (TRAF2)	OT1MEZZN	TRAF2_HUMAN	Decreases Expression	[276]
Interleukin-24 (IL24)	OT4VUWH1	IL24_HUMAN	Decreases Expression	[48]
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1)	OTA0UNHM	ECH1_HUMAN	Affects Secretion	[113]
Rho GTPase-activating protein 5 (ARHGAP5)	OTOQELUN	RHG05_HUMAN	Decreases Expression	[40]
TNF receptor-associated factor 1 (TRAF1)	OTTLM5RU	TRAF1_HUMAN	Increases Expression	[100]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Increases Phosphorylation	[259]
PDZK1-interacting protein 1 (PDZK1IP1)	OTWA6M5K	PDZ1I_HUMAN	Increases Expression	[43]
RE1-silencing transcription factor (REST)	OTLL92LQ	REST_HUMAN	Decreases Expression	[277]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)	OT7TNF0L	AAPK1_HUMAN	Increases Phosphorylation	[125]
Oxysterols receptor LXR-alpha (NR1H3)	OT54YZ9I	NR1H3_HUMAN	Increases Expression	[122]
Serine/threonine-protein kinase PAK 1 (PAK1)	OT17LZNZ	PAK1_HUMAN	Decreases Activity	[278]
Mitogen-activated protein kinase 7 (MAPK7)	OTF7H7L7	MK07_HUMAN	Increases Phosphorylation	[180]
Dual specificity protein phosphatase 8 (DUSP8)	OTPLMPG9	DUS8_HUMAN	Increases Expression	[100]
Pappalysin-1 (PAPPA)	OTTTG9PG	PAPP1_HUMAN	Decreases Expression	[279]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)	OTXNGZCG	MD2L1_HUMAN	Decreases Expression	[24]
Transcription intermediary factor 1-beta (TRIM28)	OTE38OBF	TIF1B_HUMAN	Increases Phosphorylation	[280]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Increases Acetylation	[34]
Metastasis-associated protein MTA1 (MTA1)	OTBHW3S9	MTA1_HUMAN	Decreases Expression	[281]
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)	OT70Z4II	ADAM9_HUMAN	Increases Expression	[40]
Rho-associated protein kinase 1 (ROCK1)	OTSXYVW1	ROCK1_HUMAN	Decreases Expression	[40]
Mothers against decapentaplegic homolog 4 (SMAD4)	OTWQWCKG	SMAD4_HUMAN	Decreases Expression	[40]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Decreases Expression	[282]
Sequestosome-1 (SQSTM1)	OTGY5D5J	SQSTM_HUMAN	Decreases Expression	[283]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)	OTHBQVD5	4EBP1_HUMAN	Decreases Activity	[30]
Histone deacetylase 1 (HDAC1)	OTQDNOXZ	HDAC1_HUMAN	Decreases Expression	[256]
Apoptosis-stimulating of p53 protein 2 (TP53BP2)	OTOWJ2Y4	ASPP2_HUMAN	Decreases Expression	[40]
Nuclear receptor coactivator 4 (NCOA4)	OTRVU0UA	NCOA4_HUMAN	Decreases Expression	[172]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Increases Expression	[284]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)	OT6VY3A3	SPTN1_HUMAN	Increases Cleavage	[285]
Runt-related transcription factor 2 (RUNX2)	OT97RQQM	RUNX2_HUMAN	Increases Expression	[286]
Ras-specific guanine nucleotide-releasing factor 1 (RASGRF1)	OTNWJ7EN	RGRF1_HUMAN	Decreases Expression	[41]
Nidogen-2 (NID2)	OTHC33FF	NID2_HUMAN	Affects Secretion	[113]
Dystroglycan 1 (DAG1)	OT6QBA05	DAG1_HUMAN	Decreases Expression	[40]
ARF GTPase-activating protein GIT2 (GIT2)	OTQ2EQJ1	GIT2_HUMAN	Decreases Expression	[40]
Dynactin subunit 1 (DCTN1)	OT5B51FJ	DCTN1_HUMAN	Affects Expression	[32]
Eukaryotic initiation factor 4A-II (EIF4A2)	OT08H03R	IF4A2_HUMAN	Decreases Expression	[24]
Endonuclease G, mitochondrial (ENDOG)	OT5IM7B3	NUCG_HUMAN	Affects Localization	[287]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Increases Expression	[288]
Transcription factor HES-1 (HES1)	OT8P19W2	HES1_HUMAN	Decreases Expression	[289]
DNA replication licensing factor MCM6 (MCM6)	OTKLIAWT	MCM6_HUMAN	Decreases Expression	[24]
Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3)	OTGQ2AOJ	ITPR3_HUMAN	Increases Phosphorylation	[45]
Indian hedgehog protein (IHH)	OT1DWGXC	IHH_HUMAN	Decreases Expression	[290]
Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)	OTX7MWW1	ITPR1_HUMAN	Increases Expression	[109]
Structural maintenance of chromosomes protein 1A (SMC1A)	OT9ZMRK9	SMC1A_HUMAN	Increases Phosphorylation	[280]
Phosphatidate phosphatase LPIN1 (LPIN1)	OTQ75KF2	LPIN1_HUMAN	Increases Expression	[291]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Expression	[292]
Nuclear receptor subfamily 1 group I member 3 (NR1I3)	OTS3SGH7	NR1I3_HUMAN	Increases Activity	[293]
Condensin complex subunit 2 (NCAPH)	OTXOS97C	CND2_HUMAN	Increases Phosphorylation	[45]
TNFAIP3-interacting protein 1 (TNIP1)	OTRAOTEW	TNIP1_HUMAN	Increases Expression	[43]
116 kDa U5 small nuclear ribonucleoprotein component (EFTUD2)	OT3X7QG2	U5S1_HUMAN	Increases Phosphorylation	[45]
Advanced glycosylation end product-specific receptor (AGER)	OTPY0IH7	RAGE_HUMAN	Decreases Expression	[294]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PPP2R5A)	OTZBCRGI	2A5A_HUMAN	Decreases Expression	[40]
Nicotinate-nucleotide pyrophosphorylase (QPRT)	OT6SKKLL	NADC_HUMAN	Increases Expression	[186]
Ras GTPase-activating protein 2 (RASA2)	OTL06RG2	RASA2_HUMAN	Increases Expression	[40]
Ribosomal protein S6 kinase alpha-1 (RPS6KA1)	OTDOTWU4	KS6A1_HUMAN	Decreases Phosphorylation	[257]
Sonic hedgehog protein (SHH)	OTOG2BXF	SHH_HUMAN	Decreases Expression	[48]
Nuclear receptor subfamily 0 group B member 2 (NR0B2)	OT7UVICX	NR0B2_HUMAN	Increases Expression	[295]
SCL-interrupting locus protein (STIL)	OT9799VN	STIL_HUMAN	Decreases Expression	[24]
Translin (TSN)	OTOFAQ2Z	TSN_HUMAN	Decreases Expression	[24]
Mothers against decapentaplegic homolog 2 (SMAD2)	OTC6VB4K	SMAD2_HUMAN	Decreases Expression	[40]
Mothers against decapentaplegic homolog 1 (SMAD1)	OTQSHR25	SMAD1_HUMAN	Increases Phosphorylation	[105]
Serine/threonine-protein kinase STK11 (STK11)	OT1YZSP3	STK11_HUMAN	Decreases Acetylation	[296]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Increases Expression	[48]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Decreases Expression	[49]
Serine/threonine-protein kinase N2 (PKN2)	OTW0SOID	PKN2_HUMAN	Decreases Expression	[40]
Mitogen-activated protein kinase 14 (MAPK14)	OT5TCO3O	MK14_HUMAN	Decreases Expression	[40]
Interleukin-17A (IL17A)	OTY72FT2	IL17_HUMAN	Decreases Expression	[48]
Survival motor neuron protein (SMN2)	OT54RLO1	SMN_HUMAN	Increases Expression	[297]
kinase isozyme 4, mitochondrial (PDK4)	OTCMHMBZ	PDK4_HUMAN	Increases Expression	[253]
Nuclear respiratory factor 1 (NRF1)	OTOXWNV8	NRF1_HUMAN	Increases Expression	[298]
Melanoma-derived growth regulatory protein (MIA)	OTG5FN5S	MIA_HUMAN	Decreases Expression	[48]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Expression	[152]
Discoidin domain-containing receptor 2 (DDR2)	OT9IHOGZ	DDR2_HUMAN	Decreases Expression	[49]
MHC class I polypeptide-related sequence B (MICB)	OTS2DVDW	MICB_HUMAN	Increases Expression	[46]
MHC class I polypeptide-related sequence A (MICA)	OTPEIEAR	MICA_HUMAN	Increases Expression	[46]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)	OTN7XAUD	LRRF1_HUMAN	Increases Expression	[40]
Erythroid differentiation-related factor 1 (EDRF1)	OTM7TWJZ	EDRF1_HUMAN	Increases Expression	[43]
Protein GREB1 (GREB1)	OTU6ZA26	GREB1_HUMAN	Increases Expression	[299]
Programmed cell death protein 4 (PDCD4)	OTZ6NXUX	PDCD4_HUMAN	Increases Expression	[24]
Type-1 angiotensin II receptor-associated protein (AGTRAP)	OT02N7LD	ATRAP_HUMAN	Decreases Activity	[300]
Inactive caspase-12 (CASP12)	OTY2W6FG	CASPC_HUMAN	Increases Expression	[119]
Myosin phosphatase Rho-interacting protein (MPRIP)	OT5FV5NS	MPRIP_HUMAN	Increases Expression	[40]
Ceramide synthase 6 (CERS6)	OTOP4GV1	CERS6_HUMAN	Increases Expression	[44]
Histone H3.2 (H3C13)	OT97FS6C	H32_HUMAN	Decreases Expression	[109]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)	OTE8GBUR	RIR2B_HUMAN	Increases Expression	[24]
Basic helix-loop-helix transcription factor scleraxis (SCX)	OT5VBXC7	SCX_HUMAN	Increases Expression	[301]
Protein lifeguard 1 (GRINA)	OTMC1O66	LFG1_HUMAN	Increases Expression	[43]
Serine/threonine-protein kinase tousled-like 2 (TLK2)	OTZ09CG8	TLK2_HUMAN	Increases Phosphorylation	[45]
Mitofusin-1 (MFN1)	OTCBXQZF	MFN1_HUMAN	Increases Expression	[302]
NAD-dependent protein deacetylase sirtuin-2 (SIRT2)	OT5Q6SVK	SIR2_HUMAN	Decreases Expression	[303]
Proline-, glutamic acid- and leucine-rich protein 1 (PELP1)	OTVXQNOT	PELP1_HUMAN	Increases Expression	[304]
Regulatory-associated protein of mTOR (RPTOR)	OT4TQZ9F	RPTOR_HUMAN	Increases Phosphorylation	[288]
NAD-dependent protein deacylase sirtuin-6 (SIRT6)	OTF755ZO	SIR6_HUMAN	Increases Expression	[34]
Proprotein convertase subtilisin/kexin type 9 (PCSK9)	OTI0DU9Y	PCSK9_HUMAN	Increases Expression	[135]
Transcription factor Sp7 (SP7)	OT07ETZT	SP7_HUMAN	Increases Expression	[286]
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2)	OTCA9WCM	RSAD2_HUMAN	Increases Expression	[43]
DNA topoisomerase 2-binding protein 1 (TOPBP1)	OT6UPZPD	TOPB1_HUMAN	Decreases Expression	[24]
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (DHX38)	OTBVB3W5	PRP16_HUMAN	Decreases Expression	[40]
Estrogen receptor beta (ESR2)	OTXNR2WQ	ESR2_HUMAN	Increases Expression	[133]
Histone deacetylase 2 (HDAC2)	OTUYVFKN	HDAC2_HUMAN	Increases Metabolism	[305]
CREB-binding protein (CREBBP)	OTPA4QGM	CBP_HUMAN	Increases Expression	[230]
Type II iodothyronine deiodinase (DIO2)	OTGPNSLH	IOD2_HUMAN	Decreases Activity	[306]
Histone acetyltransferase KAT2B (KAT2B)	OTWQITWK	KAT2B_HUMAN	Increases Expression	[24]
Bcl-2-like protein 2 (BCL2L2)	OTMKVO0J	B2CL2_HUMAN	Increases Expression	[103]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Decreases Expression	[241]
Sodium/iodide cotransporter (SLC5A5)	OTU7E9G7	SC5A5_HUMAN	Increases Expression	[247]
Histone acetyltransferase KAT5 (KAT5)	OTL7257A	KAT5_HUMAN	Increases Acetylation	[34]
Cullin-5 (CUL5)	OTMTZD47	CUL5_HUMAN	Increases Expression	[307]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1)	OT2363Z9	T53I1_HUMAN	Increases Expression	[24]
SOSS complex subunit B2 (NABP1)	OTFTNFHW	SOSB2_HUMAN	Increases Expression	[43]
RAD51-associated protein 1 (RAD51AP1)	OTXM7UTD	R51A1_HUMAN	Decreases Expression	[24]
Proline-rich AKT1 substrate 1 (AKT1S1)	OT4JHN4Y	AKTS1_HUMAN	Decreases Phosphorylation	[45]
Baculoviral IAP repeat-containing protein 7 (BIRC7)	OTITCGHB	BIRC7_HUMAN	Decreases Expression	[308]
RalBP1-associated Eps domain-containing protein 1 (REPS1)	OTX4ERRK	REPS1_HUMAN	Decreases Expression	[40]
p53 apoptosis effector related to PMP-22 (PERP)	OTP0YL53	PERP_HUMAN	Increases Expression	[24]
Ceramide synthase 2 (CERS2)	OTRAHYYP	CERS2_HUMAN	Increases Expression	[44]
Lymphokine-activated killer T-cell-originated protein kinase (PBK)	OT5Z27TW	TOPK_HUMAN	Decreases Expression	[24]
FYVE, RhoGEF and PH domain-containing protein 4 (FGD4)	OTYXJQCW	FGD4_HUMAN	Increases Expression	[40]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Increases Expression	[284]
SRSF protein kinase 1 (SRPK1)	OTPI7DAV	SRPK1_HUMAN	Decreases Expression	[40]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)	OTQR6ENW	M3K5_HUMAN	Increases Activity	[309]
Mothers against decapentaplegic homolog 5 (SMAD5)	OTQNSVCQ	SMAD5_HUMAN	Increases Phosphorylation	[105]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)	OTT5JX1F	LITAF_HUMAN	Decreases Expression	[40]
Cell division control protein 6 homolog (CDC6)	OTX93FE7	CDC6_HUMAN	Decreases Expression	[24]
Tumor susceptibility gene 101 protein (TSG101)	OT97UIXC	TS101_HUMAN	Increases Expression	[24]
Protein smoothened (SMO)	OTXXE208	SMO_HUMAN	Decreases Expression	[290]
Myeloid differentiation primary response protein MyD88 (MYD88)	OTB4D6FL	MYD88_HUMAN	Decreases Activity	[115]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Increases Expression	[310]
Myb-binding protein 1A (MYBBP1A)	OTIVEMIU	MBB1A_HUMAN	Decreases Expression	[40]
Pygopus homolog 2 (PYGO2)	OTZHB2OI	PYGO2_HUMAN	Decreases Expression	[120]
Acireductone dioxygenase (ADI1)	OT8IOD03	MTND_HUMAN	Increases Expression	[186]
NF-kappa-B inhibitor zeta (NFKBIZ)	OTU728KS	IKBZ_HUMAN	Decreases Expression	[210]
Normal mucosa of esophagus-specific gene 1 protein (C15ORF48)	OT85J32K	NMES1_HUMAN	Increases Expression	[43]
Tenomodulin (TNMD)	OTHLVA9G	TNMD_HUMAN	Increases Expression	[301]
Tumor protein 63 (TP63)	OT0WOOKQ	P63_HUMAN	Increases Expression	[106]
Rho-related GTP-binding protein RhoJ (RHOJ)	OTWI65OA	RHOJ_HUMAN	Decreases Expression	[109]
Ran-binding protein 3 (RANBP3)	OTI8ESC3	RANB3_HUMAN	Decreases Expression	[40]
Homeobox protein NANOG (NANOG)	OTUEY1FM	NANOG_HUMAN	Decreases Expression	[36]
Ceramide synthase 4 (CERS4)	OTV5ENAX	CERS4_HUMAN	Increases Expression	[44]
p53-induced death domain-containing protein 1 (PIDD1)	OTWFM930	PIDD1_HUMAN	Increases Expression	[284]
Tensin-1 (TNS1)	OTZ8S1PL	TENS1_HUMAN	Increases Expression	[311]
CD209 antigen (CD209)	OTCAX8NI	CD209_HUMAN	Decreases Expression	[312]
Transcription factor 7-like 2 (TCF7L2)	OTVWPZ8B	TF7L2_HUMAN	Decreases Expression	[120]
Anillin (ANLN)	OTXJY54C	ANLN_HUMAN	Decreases Expression	[24]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Affects Localization	[313]
Lymphoid-specific helicase (HELLS)	OTVVV668	HELLS_HUMAN	Decreases Expression	[24]
Fibroblast growth factor 21 (FGF21)	OT3RXVRD	FGF21_HUMAN	Increases Expression	[314]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)	OTMEF544	SIR3_HUMAN	Decreases Expression	[303]
Structural maintenance of chromosomes protein 4 (SMC4)	OTEJE6AG	SMC4_HUMAN	Decreases Expression	[24]
Protein AATF (AATF)	OT1QOKLD	AATF_HUMAN	Increases Phosphorylation	[45]
Sphingosine kinase 1 (SPHK1)	OTWYPBVD	SPHK1_HUMAN	Decreases Expression	[44]
Cyclin-dependent kinase 12 (CDK12)	OTZUDGNU	CDK12_HUMAN	Affects Phosphorylation	[45]
G2 and S phase-expressed protein 1 (GTSE1)	OTPP742Z	GTSE1_HUMAN	Decreases Expression	[109]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Increases Phosphorylation	[119]
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13)	OT0UOKIT	NDUAD_HUMAN	Increases Expression	[315]
Interleukin-17C (IL17C)	OTKXIVNQ	IL17C_HUMAN	Decreases Expression	[48]
DNA (DNMT3B)	OTZ0JCNP	DNM3B_HUMAN	Decreases Expression	[256]
Cardiotrophin-like cytokine factor 1 (CLCF1)	OTHQUDDI	CLCF1_HUMAN	Decreases Expression	[48]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)	OTHCDQ22	PRGC1_HUMAN	Increases Expression	[316]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)	OTOSRDJT	TR10D_HUMAN	Increases Expression	[46]
NK1 transcription factor-related protein 2 (NKX1-2)	OTVKHT23	NKX12_HUMAN	Increases Phosphorylation	[45]
Serine/threonine-protein kinase 17A (STK17A)	OTS87MOT	ST17A_HUMAN	Increases Expression	[24]
AF4/FMR2 family member 4 (AFF4)	OTTL5Y8R	AFF4_HUMAN	Increases Phosphorylation	[45]
Mitochondrial peptide methionine sulfoxide reductase (MSRA)	OTBS15SD	MSRA_HUMAN	Increases Expression	[317]
Lymphoid enhancer-binding factor 1 (LEF1)	OTWS5I5H	LEF1_HUMAN	Decreases Expression	[156]
Histone deacetylase 9 (HDAC9)	OTO8O0LF	HDAC9_HUMAN	Increases Expression	[318]
Bcl-2-related ovarian killer protein (BOK)	OTDQPDIX	BOK_HUMAN	Increases Expression	[24]
Membrane-associated transporter protein (SLC45A2)	OTNZ268J	S45A2_HUMAN	Decreases Expression	[29]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Increases Expression	[114]
Histone deacetylase 5 (HDAC5)	OTWG387P	HDAC5_HUMAN	Increases Phosphorylation	[180]
RAC-gamma serine/threonine-protein kinase (AKT3)	OT5M2LFI	AKT3_HUMAN	Decreases Expression	[49]
Axin-2 (AXIN2)	OTRMGQNU	AXIN2_HUMAN	Decreases Expression	[156]
Mitochondrial fission 1 protein (FIS1)	OT2HL10J	FIS1_HUMAN	Increases Expression	[302]
Plakophilin-3 (PKP3)	OTPL1HRB	PKP3_HUMAN	Decreases Expression	[40]
Insulin receptor substrate 2 (IRS2)	OT46MJBE	IRS2_HUMAN	Decreases Expression	[49]
Krueppel-like factor 2 (KLF2)	OTIP1UFX	KLF2_HUMAN	Increases Expression	[158]
DNA (DNMT3A)	OTEJP0GH	DNM3A_HUMAN	Decreases Expression	[256]
NF-kappa-B essential modulator (IKBKG)	OTNWJWSD	NEMO_HUMAN	Decreases Expression	[156]
Sestrin-1 (SESN1)	OTSFDZWL	SESN1_HUMAN	Increases Expression	[24]
Nuclear receptor coactivator 3 (NCOA3)	OTBX300Z	NCOA3_HUMAN	Decreases Expression	[40]
Dual specificity protein phosphatase 10 (DUSP10)	OTNG467B	DUS10_HUMAN	Increases Expression	[319]
E3 SUMO-protein ligase PIAS3 (PIAS3)	OT3TWH9R	PIAS3_HUMAN	Increases Expression	[27]
Sodium/glucose cotransporter 1 (SLC5A1)	OT0T78JI	SC5A1_HUMAN	Affects Uptake	[320]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Response To Substance	[321]
ATP-binding cassette sub-family C member 5 (ABCC5)	OT34G4US	MRP5_HUMAN	Decreases Response To Substance	[61]
Sulfotransferase 1A2 (SULT1A2)	OT7EJ6LQ	ST1A2_HUMAN	Increases Sulfation	[322]
Forkhead box protein O4 (FOXO4)	OT90X9LN	FOXO4_HUMAN	Decreases Response To Substance	[323]
Beta-arrestin-2 (ARRB2)	OTAEJZCI	ARRB2_HUMAN	Affects Response To Substance	[324]
Caveolin-1 (CAV1)	OTEZUR1L	CAV1_HUMAN	Increases Response To Substance	[325]
Sulfotransferase 1A3 (SULT1A4)	OTHJ8WWV	ST1A3_HUMAN	Increases Sulfation	[322]
Histone-lysine N-methyltransferase EZH2 (EZH2)	OTIEHTKW	EZH2_HUMAN	Increases Response To Substance	[23]
Pyruvate kinase PKM (PKM)	OTLHHMC2	KPYM_HUMAN	Decreases Response To Substance	[326]
DNA excision repair protein ERCC-1 (ERCC1)	OTNPYQHI	ERCC1_HUMAN	Affects Response To Substance	[327]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Increases Response To Substance	[123]
Forkhead box protein O1 (FOXO1)	OTPJRB6D	FOXO1_HUMAN	Decreases Response To Substance	[323]
Carbonyl reductase 1 (CBR1)	OTQ3A541	CBR1_HUMAN	Affects Binding	[328]
Oxidized low-density lipoprotein receptor 1 (OLR1)	OTS44RIC	OLR1_HUMAN	Decreases Response To Substance	[329]
FAS-associated death domain protein (FADD)	OTV7GFHH	FADD_HUMAN	Increases Response To Substance	[330]
Insulin (INS)	OTZ85PDU	INS_HUMAN	Decreases Response To Substance	[331]

Indication(s) of Losartan

Disease Entry	ICD 11	Status	REF
Diabetic kidney disease	GB61.Z	Approved	[5]
Hypertension	BA00-BA04	Approved	[6]
Prediabetes syndrome	N.A.	Approved	[5]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3	[7]

Losartan Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Angiotensin II receptor type-1 (AGTR1)	TT8DBY3	AGTR1_HUMAN	Antagonist	[332]
HUMAN type-1 angiotensin II receptor (AGTR1)	TTPKMXQ	AGTR1_HUMAN	Blocker	[333]

Losartan Interacts with 2 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[334]
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[335]

Losartan Interacts with 8 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[336]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[337]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[336]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[338]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[339]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DEB3CV1	UD2B7_HUMAN	Metabolism	[339]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DEF2WXN	UD13_HUMAN	Metabolism	[339]
UDP-glucuronosyltransferase 1A10 (UGT1A10)	DEL5N6Y	UD110_HUMAN	Metabolism	[339]

Losartan Interacts with 2 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Increases ADR	[340]
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Increases ADR	[340]

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