Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4ZS8M)

• Drug Name: Nefazodone Drug Info
• Synonyms: Nefazodona; Nefazodonum; Nefazodona [Spanish]; Nefazodone Hcl; Nefazodonum [Latin]; Nefadar (TN); Nefazodone (INN); Nefazodone [INN:BAN]; Serzone (TN); 1-(3-(4-(3-Chlorpheyl-1-piperazinylpropyl)-3-ethyl-4,5-dihydro-4-(2-phenoxyethyl)-1,2,4-triazol-5-on; 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one; 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one; 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one; 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one; 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-[2-(phenyloxy)ethyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Indication

Disease Entry	ICD 11	Status	REF
Major depressive disorder	6A70.3	Approved	[1]
Depression	6A70-6A7Z	Withdrawn from market	[2]

• Therapeutic Class: Antidepressants
• Cross-matching ID:
  PubChem CID: 4449
  ChEBI ID: CHEMBL623
  CAS Number: CAS 83366-66-9
  TTD Drug ID: DM4ZS8M
  VARIDT Drug ID: DR00468
  INTEDE Drug ID: DR1135
  ACDINA Drug ID: D00460

Molecule-Related Drug Atlas

Drug(s) Targeting 5-HT 2C receptor (HTR2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[10]
Lorcaserin	DMG6OYJ	Obesity	5B81	Approved	[11]
Tramadol	DMRQD04	Osteoarthritis	FA00-FA05	Approved	[12]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[6]
Methysergide	DM1EF73	Migraine	8A80	Approved	[13]
Eltoprazine	DMW6C81	Attention deficit hyperactivity disorder	6A05.Z	Phase 3	[14]
M100907	DM7ZFBA	Sleep-wake disorder	7A00-7B2Z	Phase 3	[15]
SR46349B	DM1ODMR	Primary insomnia	7A00	Phase 3	[16]
Vabicaserin	DM9GZW6	Psychotic disorder	6A20-6A25	Phase 2	[17]
Nuplazid	DMOJA5G	Alzheimer disease	8A20	Phase 2	[18]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[19]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[20]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[23]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[25]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[26]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[20]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[27]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[29]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[23]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[31]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[32]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[33]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[34]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[35]

Drug(s) Affected By 5-hydroxytryptamine receptor 2C (HTR2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[6]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[6]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Clomipramine	DMINRKW	Depression	6A70-6A7Z	Approved	[6]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[48]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[50]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]

Drug(s) Affected By Ectoderm-neural cortex protein 1 (ENC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[58]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[60]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[8]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[65]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[66]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[67]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[68]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[71]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[72]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[74]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[76]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[56]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[83]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[89]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]

Drug(s) Affected By Transcription factor MafK (MAFK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[95]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[96]

Drug(s) Affected By Auxilin (DNAJC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[98]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[100]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[95]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[101]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[101]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[102]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[103]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[104]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[101]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[101]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[101]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[105]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[106]

Drug(s) Affected By Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma (PIK3C2G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[7]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[108]

Drug(s) Affected By Aflatoxin B1 aldehyde reductase member 3 (AKR7A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[110]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[41]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[112]
7-hydroxycoumarin	DMTMNO7	Discovery agent	N.A.	Investigative	[113]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[114]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[115]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[115]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[116]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[114]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[115]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[117]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[114]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[118]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[114]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[7]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Cytochrome c oxidase subunit 1 (COX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[126]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[127]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[128]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[130]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[131]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[132]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[134]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[135]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[134]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]

Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 5 (ND5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[140]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
INX-189	DMSTJ6Q	Hepatitis C virus infection	1E51.1	Phase 2	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[144]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[145]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[147]

Drug(s) Affected By ATP synthase protein 8 (ATP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[148]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[145]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[147]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[149]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[8]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[8]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[8]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[8]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[152]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[153]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[155]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[156]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[161]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[128]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[166]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[167]
Fructose	DM43AN2	Vomiting	MD90	Approved	[168]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[170]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[175]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[176]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[177]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[152]

Drug(s) Affected By 5-hydroxytryptamine receptor 1A (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[5]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[178]
Methamphetamine	DMPM4SK	Anxiety		Approved	[179]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[180]
Perospirone	DMVHJLX	Psychotic disorder	6A20-6A25	Approved	[180]
Etoperidone	DMR7U8F	N. A.	N. A.	Phase 4	[5]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[181]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[108]
DU 125530	DM63UA9	Mood disorder	6A60-6E23	Discontinued in Phase 2	[182]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[181]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[183]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[184]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[185]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[186]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[170]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[187]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[188]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[189]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]

Drug(s) Affected By Ras-related protein Ral-A (RALA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[193]
Bortezomib	DMNO38U	Leukemia		Approved	[194]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[170]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]

Drug(s) Affected By Glutathione peroxidase 2 (GPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[203]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[204]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[135]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Selenium	DM25CGV	N. A.	N. A.	Approved	[206]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[195]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[207]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[208]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[209]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[211]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[213]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[207]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[214]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[216]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[217]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[218]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[219]
Methysergide	DM1EF73	Migraine	8A80	Approved	[117]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[220]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[221]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[222]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[226]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[90]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[227]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[228]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[56]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[230]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[232]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[235]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[236]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[135]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[205]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[237]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]

Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[240]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[241]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Minodronate	DM50PMY	Osteoporosis	FB83.0	Approved	[243]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[244]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[246]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]

Drug(s) Affected By Flavin-containing monooxygenase 1 (FMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[248]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Dihydroxyacetone	DMM1LG2	Sunburn	EJ40	Approved	[250]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[7]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[252]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[253]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[254]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[255]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[256]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[258]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[259]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[262]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[264]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[265]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[90]

Drug(s) Affected By Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[266]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[220]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[267]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[268]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[269]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[270]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[271]

Drug(s) Affected By Sodium channel protein type 5 subunit alpha (SCN5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[168]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[272]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[273]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[267]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[276]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[268]
Luvox	DMJKROX	Anxiety disorder	6B00-6B0Z	Approved	[277]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[278]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[221]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[281]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[282]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[283]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[282]

Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[135]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[228]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[285]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[286]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[287]

Drug(s) Affected By DnaJ homolog subfamily C member 21 (DNAJC21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[288]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[98]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[289]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[290]

Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[8]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[8]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[8]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[8]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[8]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[8]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[8]

Drug(s) Affected By DnaJ homolog subfamily C member 10 (DNAJC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[292]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[98]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[7]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[98]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[293]

Drug(s) Affected By Mixed lineage kinase domain-like protein (MLKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[295]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[201]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[296]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[297]

Drug(s) Affected By Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[220]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[204]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[298]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[299]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[300]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[300]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit TIM14 (DNAJC19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[301]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[302]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[303]

Drug(s) Affected By DnaJ homolog subfamily C member 1 (DNAJC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[305]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[306]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[95]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[307]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[261]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[195]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[262]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[308]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[309]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[249]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[311]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[312]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[313]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[315]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[313]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[314]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[316]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[317]

Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[254]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[319]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[320]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[322]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[323]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[324]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[216]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[325]

Drug(s) Affected By Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[306]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[327]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[228]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[224]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[83]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[285]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[328]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[83]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[58]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[190]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[329]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]

Drug(s) Affected By Endophilin-B1 (SH3GLB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[98]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[7]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[331]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[332]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[116]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[333]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[334]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[335]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[336]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[336]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[337]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[338]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2C receptor (HTR2C)	TTWJBZ5	5HT2C_HUMAN	Antagonist	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5-hydroxytryptamine receptor 1A (HTR1A)	OT38K9MK	5HT1A_HUMAN	Protein Interaction/Cellular Processes	[5]
5-hydroxytryptamine receptor 2C (HTR2C)	OT6H8DE0	5HT2C_HUMAN	Protein Interaction/Cellular Processes	[6]
Aflatoxin B1 aldehyde reductase member 3 (AKR7A3)	OTW3GO4Y	ARK73_HUMAN	Gene/Protein Processing	[7]
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Gene/Protein Processing	[8]
ATP synthase protein 8 (ATP8)	OTYQQR53	ATP8_HUMAN	Gene/Protein Processing	[9]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Gene/Protein Processing	[7]
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Gene/Protein Processing	[7]
Auxilin (DNAJC6)	OT1P6ZIE	AUXI_HUMAN	Gene/Protein Processing	[7]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[9]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Gene/Protein Processing	[7]

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