Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC5Q8X)

• Drug Name: Berberine Drug Info
• Synonyms: berberine; 2086-83-1; Berberin; Umbellatine; UNII-0I8Y3P32UF; 0I8Y3P32UF; CHEBI:16118; EINECS 218-229-1; Berberal; BRN 3570374; ST055798; 9,10-Dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetrahydroberbinium; Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-; 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium; Berbamine sulphate acid; CHEMBL12089; 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium; BERBINIUM, 7,8,13,13a-TETRAHYDRO-9,10-DIMETHOXY-2,3-(METHYLE
• Cross-matching ID:
  PubChem CID: 2353
  ChEBI ID: CHEMBL16118
  CAS Number: CAS 2086-83-1
  TTD Drug ID: DMC5Q8X
  VARIDT Drug ID: DR00307

Molecule-Related Drug Atlas

Drug(s) Targeting Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GV1001	DMHULRK	Pancreatic cancer	2C10	Phase 3	[10]
Imetelstat	DMONWJ4	Myelodysplastic syndrome	2A37	Phase 2/3	[11]
VM1500A	DM9YSSY	Human immunodeficiency virus-1 infection	1C62	Phase 2/3	[12]
Dendritic cell vaccine	DML4PMG	Ovarian cancer	2C73	Phase 2	[13]
GRNVAC1	DMAHOEP	Acute myeloid leukaemia	2A60	Phase 2	[14]
Vx-001	DMDKWA3	Breast cancer	2C60-2C65	Phase 2	[15]
CB-10-01	DM2IFYZ	Melanoma	2C30	Phase 2	[16]
Epithalon	DMWSGZU	Ocular inflammation	9C61.24	Phase 1/2	[17]
OBP-301	DM9MF08	Breast cancer	2C60-2C65	Phase 1/2	[18]
KML-001	DM1D2O0	Solid tumour/cancer	2A00-2F9Z	Phase 1	[19]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[23]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[24]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[26]

Drug(s) Transported By Organic cation transporter 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[28]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[20]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[31]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[32]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[33]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[34]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[35]

Drug(s) Affected By Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[45]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[50]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[54]

Drug(s) Affected By Histone acetyltransferase type B catalytic subunit (HAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[65]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[66]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[68]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]

Drug(s) Affected By Lysine-specific demethylase 6A (KDM6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[79]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[82]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[90]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]

Drug(s) Affected By Histone H2B type 1-K (H2BC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[99]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[100]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[101]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[101]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[102]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[103]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[104]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[101]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[101]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[101]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[105]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[106]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[107]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[109]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[112]

Drug(s) Affected By Histone-lysine N-methyltransferase NSD2 (NSD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[117]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[119]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[121]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[125]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[126]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]

Drug(s) Affected By Collagen alpha-1(II) chain (COL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[130]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[132]
Indomethacin	DMSC4A7	Bursitis		Approved	[133]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[134]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[137]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[138]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[139]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]

Drug(s) Affected By Histone H2A type 1-B/E (H2AC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[99]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]

Drug(s) Affected By Histone H2B type 1-J (H2BC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[145]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[100]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[146]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[147]

Drug(s) Affected By SPARC (SPARC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[149]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[150]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[151]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[152]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[153]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[65]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[156]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[157]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[156]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[158]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]

Drug(s) Affected By Histone H2A type 1 (H2AC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[161]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[99]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[163]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]

Drug(s) Affected By Histone H2B type F-M (H2BW2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[164]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[166]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[167]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[168]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[169]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[173]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[176]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[177]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[179]

Drug(s) Affected By Aggrecan core protein (ACAN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[129]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[116]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[181]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[132]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[182]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[183]
Diacerein	DMN2Q5I	N. A.	N. A.	Phase 4	[184]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[180]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[190]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[191]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[192]

Drug(s) Affected By Histone H2B type 1-O (H2BC17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[193]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[194]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[195]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[196]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[65]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[200]
Fructose	DM43AN2	Vomiting	MD90	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[202]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[208]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[215]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[191]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[216]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[208]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[218]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[63]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[219]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[66]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[220]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[157]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[221]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[222]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[223]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[224]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[226]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[223]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[229]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[230]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[231]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[232]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[233]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[234]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[235]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[237]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[238]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[240]
Fructose	DM43AN2	Vomiting	MD90	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[241]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[242]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[243]

Drug(s) Affected By Transcription factor SOX-9 (SOX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[246]

Drug(s) Affected By CCAAT/enhancer-binding protein alpha (CEBPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[250]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[251]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[251]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[252]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[253]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[254]

Drug(s) Affected By Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[257]
Bortezomib	DMNO38U	Leukemia		Approved	[258]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[258]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[259]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[117]

Drug(s) Affected By Protein arginine N-methyltransferase 2 (PRMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[193]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[261]

Drug(s) Affected By Histone H2B type 1-D (H2BC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[262]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[263]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[265]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[267]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[268]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[109]

Drug(s) Affected By Histone H2B type 1-C/E/F/G/I (H2BC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[100]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[131]

Drug(s) Affected By Histone H3.1 (H3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[161]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]

Drug(s) Affected By Histone H3.3 (H3-3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[273]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[117]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[274]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[275]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[276]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[154]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[277]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[279]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[280]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[281]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[282]

Drug(s) Affected By Collagen alpha-1(X) chain (COL10A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[261]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[283]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[284]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[65]
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[287]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[288]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[240]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[91]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[291]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[292]

Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[294]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[295]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[99]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[296]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[297]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[298]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[248]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[300]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[301]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[302]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[303]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[304]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]

Drug(s) Affected By Histone-lysine N-methyltransferase SETDB1 (SETDB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[305]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[306]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[307]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[113]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[113]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[308]

Drug(s) Affected By Histone H3.1t (H3-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[309]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[310]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[271]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[311]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[312]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[313]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[261]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[314]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[315]

Drug(s) Affected By Histone H2A type 2-A (H2AC18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[316]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[317]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[117]

Drug(s) Affected By Histone H2A type 3 (H2AC25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[261]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[319]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[307]

Drug(s) Affected By Actin-histidine N-methyltransferase (SETD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[307]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[320]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[321]

Drug(s) Affected By E3 ubiquitin-protein ligase DZIP3 (DZIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[322]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[274]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[323]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[324]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[307]

Drug(s) Affected By FUN14 domain-containing protein 1 (FUNDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[146]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[325]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[284]

Drug(s) Affected By Thiosulfate:glutathione sulfurtransferase (TSTD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[326]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By N-lysine methyltransferase SETD6 (SETD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[280]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[320]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[172]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[307]

Drug(s) Affected By Transcription factor Sp7 (SP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[328]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[329]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[330]
alpha-ketoglutaric acid	DM5LFYN	Discovery agent	N.A.	Investigative	[331]
PD98059	DMZC90M	Cardiac arrest	MC82	Investigative	[329]

Drug(s) Affected By Histone H2A type 1-C (H2AC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[333]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[316]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[334]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[335]

Drug(s) Affected By Histone H2B type 1-H (H2BC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[272]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[146]

Drug(s) Affected By Histone H2A type 1-H (H2AC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[336]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[337]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[338]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[339]

Drug(s) Affected By Protein arginine N-methyltransferase 6 (PRMT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[340]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[117]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[261]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[324]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[341]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[65]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[342]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[224]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[343]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[344]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[345]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[86]

Drug(s) Affected By Histone-lysine N-methyltransferase SETDB2 (SETDB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[346]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[347]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[348]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[349]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[349]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]

Drug(s) Affected By Histone H2B type 1-N (H2BC15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[350]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[274]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[351]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[307]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[352]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[353]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[354]

Drug(s) Affected By Histone H2A type 1-J (H2AC14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[161]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[355]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[339]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[356]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[307]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[357]

Drug(s) Affected By Histone H2B type 1-M (H2BC14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[358]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[100]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[350]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[261]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[339]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[359]

Drug(s) Affected By Histone H2B type 1-L (H2BC13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[194]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[324]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[360]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[352]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[361]

Drug(s) Affected By Osteomodulin (OMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[362]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[363]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]

Drug(s) Affected By Histone-lysine N-methyltransferase SETD2 (SETD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[320]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[172]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[366]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[306]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[367]

Drug(s) Affected By Histone-lysine N-methyltransferase SETD5 (SETD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[99]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[368]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[369]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[370]

Drug(s) Affected By N-lysine methyltransferase KMT5A (KMT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[347]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[371]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[372]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[373]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[367]

Drug(s) Affected By Protein arginine N-methyltransferase 8 (PRMT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[260]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[117]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[374]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[375]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[376]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[377]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[376]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[378]

Drug(s) Affected By DNA (DNMT3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[379]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[380]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[381]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[347]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[368]

Drug(s) Affected By Long-chain fatty acid transport protein 5 (SLC27A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[382]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[77]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[383]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[193]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Telomerase reverse transcriptase (TERT)	TTUJFD0	TERT_HUMAN	Inhibitor	[1]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[2]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Actin-histidine N-methyltransferase (SETD3)	OTO5RAU2	SETD3_HUMAN	Gene/Protein Processing	[4]
Aggrecan core protein (ACAN)	OTUOCW8K	PGCA_HUMAN	Gene/Protein Processing	[5]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Protein Interaction/Cellular Processes	[6]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[7]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[8]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Gene/Protein Processing	[7]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Gene/Protein Processing	[9]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)	OTJKOMXE	BNI3L_HUMAN	Gene/Protein Processing	[9]
Cadherin-2 (CDH2)	OTH0Y56P	CADH2_HUMAN	Gene/Protein Processing	[5]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Gene/Protein Processing	[5]

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