Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDI269)

• Drug Name: Docetaxel Drug Info
• Synonyms: EmDOC; TXL; Taxotere; Docetaxel anhydrous; ANX-514; Docetaxel (INN); Docetaxel, Trihydrate; RP-56976; SDP-014; Taxotere (TN); Taxotere(R); XRP-6976L; Docetaxel 114977-28-5; N-debenzoyl-N-Boc-10-deacetyl taxol; N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel; N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol; (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; 4-(acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate

Indication

Disease Entry	ICD 11	Status	REF
Advanced cancer	2A00-2F9Z	Approved	[1]
Breast carcinoma		Approved	[1]
Head and neck cancer	2D42	Approved	[1]
Leiomyosarcoma	2B58	Approved	[1]
Lung cancer	2C25.0	Approved	[1]
Non-small-cell lung cancer	2C25.Y	Approved	[1]
Prostate adenocarcinoma		Approved	[1]
Prostate cancer	2C82.0	Approved	[1]
Solid tumour/cancer	2A00-2F9Z	Approved	[2]
Urinary system neoplasm		Approved	[1]
Gastric cancer	2B72	Investigative	[1]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 148124
  ChEBI ID: CHEBI:4672
  CAS Number: CAS 114977-28-5
  TTD Drug ID: DMDI269
  VARIDT Drug ID: DR00251
  INTEDE Drug ID: DR0520
  ACDINA Drug ID: D01011

Molecule-Related Drug Atlas

Drug(s) Targeting Tubulin (TUB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vinorelbine	DMVXFYE	Advanced cancer	2A00-2F9Z	Approved	[23]
Cabazitaxel	DMPAZHC	Breast cancer	2C60-2C65	Approved	[24]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[25]
Ixabepilone	DM2OZ3G	Breast cancer	2C60-2C65	Approved	[24]
Eribulin	DM1DX4Q	Breast cancer	2C60-2C65	Approved	[24]
Epothilon	DMITJRU	Ovarian cancer	2C73	Phase 3	[26]
DOLASTATIN-10	DMDUV1S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[27]
BMS-188797	DML1CK2	Solid tumour/cancer	2A00-2F9Z	Phase 2	[28]
Indibulin	DM6OFJ8	Advanced sarcoma	2A60-2C35	Phase 2	[29]
Soblidotin	DMO4EYX	Solid tumour/cancer	2A00-2F9Z	Phase 2	[30]

Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[35]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[7]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[36]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[37]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[38]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[119]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[121]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[123]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[123]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[124]

Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[42]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[43]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[47]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[48]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[49]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[7]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[52]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[51]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[53]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[55]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[58]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[60]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[61]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[62]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[61]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[63]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[64]

Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[66]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[68]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[67]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[69]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[70]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[71]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[9]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[69]

Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[72]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[73]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[74]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[67]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[75]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[70]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[9]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[76]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[9]

Drug(s) Transported By TAP-like protein (ABCB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[77]

Drug(s) Transported By Multidrug resistance-associated protein 7 (ABCC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[5]
Tenofovir	DM1IS6U	Chronic hepatitis B virus infection		Approved	[78]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[5]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[79]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[80]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[81]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[85]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[86]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[80]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[87]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[100]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[103]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[105]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[106]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[107]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[108]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[88]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[89]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[13]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[92]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[94]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[95]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[13]

Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[96]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[13]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[13]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[13]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[97]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[98]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[13]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[13]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[13]
Metronidazole	DMTIVEN	Abscess		Approved	[99]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[109]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[110]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[114]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[115]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[116]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[118]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[125]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[126]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[127]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[128]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[129]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[130]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[131]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[132]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[133]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[131]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[136]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[139]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[140]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[142]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[143]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[146]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[147]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[148]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[151]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[152]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[154]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[155]
Fructose	DM43AN2	Vomiting	MD90	Approved	[137]
Ketoprofen	DMRKXPT	Bursitis		Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[157]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[158]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[161]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[162]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[163]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[164]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[166]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[161]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[168]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[171]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[172]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[173]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[174]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[175]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[178]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[180]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[180]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[183]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[185]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[180]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[186]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[187]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[188]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[190]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[191]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[192]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]

Drug(s) Affected By Dihydropyrimidine dehydrogenase (DPYD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[195]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[196]
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[197]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[206]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[209]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[212]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[214]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[215]
Selenium	DM25CGV	N. A.	N. A.	Approved	[216]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[211]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[217]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[219]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[220]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[221]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[223]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[224]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[225]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[227]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[228]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[229]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[229]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[230]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[232]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[229]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[229]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[229]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[233]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[234]

Drug(s) Affected By PC4 and SFRS1-interacting protein (PSIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[235]
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[239]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[240]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[246]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[247]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[248]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[250]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[251]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[253]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[254]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[255]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[256]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[257]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[228]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[258]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[259]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[260]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[147]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[264]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[265]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[266]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[267]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[268]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[269]
Fructose	DM43AN2	Vomiting	MD90	Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[271]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[272]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[273]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[275]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[276]

Drug(s) Affected By Protein kinase C beta type (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[225]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[281]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[277]

Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[283]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[235]
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[284]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[285]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[225]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[286]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[287]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[289]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[290]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[291]
Selenium	DM25CGV	N. A.	N. A.	Approved	[292]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[293]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[294]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[295]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[296]

Drug(s) Affected By Prostate-specific antigen (KLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[297]
Selenium	DM25CGV	N. A.	N. A.	Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[299]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[300]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[301]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[286]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[302]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[303]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[304]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[305]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[307]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[308]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[309]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[308]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[310]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[311]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[312]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[313]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[313]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[313]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[314]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[315]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[168]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[316]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[317]
Selenium	DM25CGV	N. A.	N. A.	Approved	[298]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[318]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[319]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[320]
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[321]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[322]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[323]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[324]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[325]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[326]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]

Drug(s) Affected By Natriuretic peptides B (NPPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[328]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[329]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[330]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[331]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[333]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[334]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[337]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[295]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[340]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[341]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[335]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[272]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[342]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[343]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[337]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[345]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[347]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[348]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[289]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[349]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[350]
Selenium	DM25CGV	N. A.	N. A.	Approved	[292]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[309]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[351]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[352]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[353]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[296]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[283]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[307]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[354]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[356]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[357]
Fructose	DM43AN2	Vomiting	MD90	Approved	[358]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[359]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[360]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[361]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[363]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[364]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[365]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[366]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[367]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[368]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[369]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[361]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[370]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[371]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[372]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[360]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[363]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[373]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[374]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[142]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[375]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[376]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[377]
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[378]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[379]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[380]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[381]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[273]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[382]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[383]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[293]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[384]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[309]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[211]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[385]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[386]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[387]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[388]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]

Drug(s) Affected By Caspase-2 (CASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[391]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[392]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[393]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[394]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[395]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[282]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[396]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[384]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[398]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[399]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[400]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[402]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[403]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[404]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[405]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[406]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[407]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[223]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[408]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[410]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[395]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[412]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[413]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[414]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[414]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[415]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[416]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[326]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[396]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[417]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[140]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[418]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[419]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[307]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[420]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[421]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[422]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[143]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[424]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[262]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[341]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[425]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[364]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[295]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[427]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[428]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[429]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[430]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[431]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[134]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[152]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[139]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[283]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[418]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[383]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[433]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[309]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[283]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[434]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[352]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[435]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[356]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[436]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[437]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[438]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[439]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[440]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[441]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[442]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[443]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[307]
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[421]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[444]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[445]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[446]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[448]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[449]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[450]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[451]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[452]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[152]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[453]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[454]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[455]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[456]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[247]

Drug(s) Affected By ELL-associated factor 2 (EAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[338]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[303]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[457]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[458]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[240]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[303]

Drug(s) Affected By Small integral membrane protein 14 (SMIM14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[338]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[304]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[304]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[199]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[338]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[458]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[459]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[338]

Drug(s) Affected By Protein FAM117A (FAM117A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[291]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[228]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[338]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[460]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[338]

Drug(s) Affected By Delta-like protein 4 (DLL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[461]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[462]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[282]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[463]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[464]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[465]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[466]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[467]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[338]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[287]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[468]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[469]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[470]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[471]

Drug(s) Affected By Tropomodulin-2 (TMOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[471]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[472]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[473]
Oxamflatin	DM1TG3C	Solid tumour/cancer	2A00-2F9Z	Terminated	[338]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[474]
Apicidin	DM83WVF	Solid tumour/cancer	2A00-2F9Z	Investigative	[338]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[475]

Drug(s) Affected By Flavin-containing monooxygenase 3 (FMO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[459]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[476]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[477]
Almogran	DM7I64Z	Migraine	8A80	Approved	[478]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[479]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[480]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[481]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[482]

Drug(s) Affected By Kinesin heavy chain isoform 5A (KIF5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[483]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[484]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[485]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[463]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[472]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[235]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[486]

Drug(s) Affected By Proteinase-activated receptor 1 (F2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[273]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[487]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[488]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[489]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[490]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[490]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[491]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[492]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[395]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[493]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[493]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[493]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[359]

Drug(s) Affected By Regulator of G-protein signaling 17 (RGS17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[489]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[304]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[304]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[459]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[494]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[495]
Methamphetamine	DMPM4SK	Anxiety		Approved	[496]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[290]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[405]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[497]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[304]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[304]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[282]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[498]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[499]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[500]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[501]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[502]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[503]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Selenium	DM25CGV	N. A.	N. A.	Approved	[504]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[505]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[290]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[382]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[506]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[307]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[293]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[337]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[507]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[508]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[509]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[510]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[511]
Selenium	DM25CGV	N. A.	N. A.	Approved	[512]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[161]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[513]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[514]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[515]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[516]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[200]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[517]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[407]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[518]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[518]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[518]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[519]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[520]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[521]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[522]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[523]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[524]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[137]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[525]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[471]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[526]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[526]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[527]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[528]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[529]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[530]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[531]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[532]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[533]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]

Drug(s) Affected By Kinesin-like protein KIFC3 (KIFC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[534]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[471]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[495]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[535]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[536]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[472]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[473]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[406]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[537]

Drug(s) Affected By Regulator of G-protein signaling 10 (RGS10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[239]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[458]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[538]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[460]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[539]

Drug(s) Affected By E3 ubiquitin-protein ligase CHFR (CHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[534]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[459]
Bortezomib	DMNO38U	Leukemia		Approved	[540]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[460]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[541]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[495]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[542]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[543]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[472]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[544]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[307]
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[545]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[143]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[546]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[399]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[254]

Drug(s) Affected By Cell surface glycoprotein MUC18 (MCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[547]
Haloperidol	DM96SE0	Delirium		Approved	[548]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[332]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[549]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[239]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[550]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[459]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[240]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[460]

Drug(s) Affected By Kinesin-like protein KIF12 (KIF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[463]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[464]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[472]

Drug(s) Affected By Nucleophosmin (NPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[551]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[529]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[285]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[552]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[553]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[246]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[304]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[304]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[554]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]

Drug(s) Affected By Flavin-containing monooxygenase 2 (FMO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[555]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[555]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[287]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[556]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[483]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[557]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[472]
PMID28454500-Compound-96	DM2A75P	N. A.	N. A.	Patented	[555]

Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[483]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[558]
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[559]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[560]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]

Drug(s) Affected By Kinesin-like protein KIF14 (KIF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[304]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[304]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[561]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[562]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[290]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[295]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[563]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[304]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[304]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]

Drug(s) Affected By Cellular retinoic acid-binding protein 2 (CRABP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[565]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[345]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[566]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[225]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[395]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[567]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[459]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[568]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[569]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[570]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[571]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[572]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[573]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[574]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[575]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[163]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[576]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[577]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[578]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[579]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[580]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[581]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[519]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[104]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[582]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[583]

Drug(s) Affected By ATP-binding cassette sub-family C member 6 (ABCC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzbromarone	DMC3YUA	Gout	FA25	Approved	[584]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[584]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[340]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[585]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[586]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[587]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[588]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tubulin (TUB)	TTML2WA	NOUNIPROTAC	Inhibitor	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
TAP-like protein (ABCB9)	DT68UV2	ABCB9_HUMAN	Substrate	[4]
Multidrug resistance-associated protein 7 (ABCC10)	DTPS120	MRP7_HUMAN	Substrate	[5]
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[6]
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[7]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[8]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[9]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[10]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[11]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[12]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[13]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[13]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Gene/Protein Processing	[14]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[15]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[16]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[17]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Drug Response	[18]
ATP-binding cassette sub-family C member 6 (ABCC6)	OTZT0LKT	MRP6_HUMAN	Drug Response	[19]
ATP-binding cassette sub-family G member 1 (ABCG1)	OT5BG6MK	ABCG1_HUMAN	Drug Response	[19]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Drug Response	[20]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Drug Response	[21]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Gene/Protein Processing	[22]

References

• [1] Docetaxel FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6809).
• [3] Docetaxel: a review of its use in metastatic breast cancer. Drugs. 2005;65(17):2513-31.
• [4] RNA-sequencing dissects the transcriptome of polyploid cancer cells that are resistant to combined treatments of cisplatin with paclitaxel and docetaxel. Mol Biosyst. 2017 Sep 26;13(10):2125-2134.
• [5] Modulation of the ATPase and transport activities of broad-acting multidrug resistance factor ABCC10 (MRP7). Cancer Res. 2012 Dec 15;72(24):6457-67.
• [6] Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone. Drug Metab Dispos. 2009 Jan;37(1):129-36.
• [7] Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
• [8] Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2011 May;337(2):423-32.
• [9] FDA Drug Development and Drug Interactions
• [10] Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes. Cancer Lett. 2008 Feb 18;260(1-2):163-9.
• [11] Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to menopausal status in breast cancer patients. Br J Cancer. 2010 Aug 10;103(4):560-6.
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