Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNBA0G)

• Drug Name: BENZOQUINONE Drug Info
• Synonyms: p-benzoquinone; Benzoquinone; 1,4-BENZOQUINONE; Quinone; 106-51-4; p-Quinone; Chinone; 2,5-Cyclohexadiene-1,4-dione; para-Benzoquinone; cyclohexa-2,5-diene-1,4-dione; Cyclohexadienedione; para-Quinone; 1,4-Benzoquine; Steara pbq; 1,4-Dioxybenzene; p-Chinon; 1,4-Cyclohexadienedione; Benzo-chinon; Benzo-1,4-quinone; 1,4-Diossibenzene; Chinon; 1,4-Dioxy-benzol; 1,4-Cyclohexadiene dioxide; Semiquinone anion; semiquinone radicals; RCRA waste number U197; p-Chinon [German]; NCI-C55845; Caswell No. 719C; Benzo-chinon [German]; USAF P-220

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 4650
  ChEBI ID: CHEMBL8320
  CAS Number: CAS 106-51-4
  TTD Drug ID: DMNBA0G
  INTEDE Drug ID: DR2205

Molecule-Related Drug Atlas

Drug(s) Targeting Acetylcholinesterase (AChE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[11]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[12]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[13]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[14]
Huperzine A	DMMAWLU	Alzheimer disease	8A20	Approved	[15]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[16]
YM443	DMNZCI1	Functional dyspepsia	DD90.3	Approved	[17]
Ambenonium	DMOP0BL	Myasthenia gravis	8C6Y	Approved	[18]
Demecarium bromide	DMAYEU1	Open-angle glaucoma	9C61	Approved	[19]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[20]

Drug(s) Targeting Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hexafluronium bromide	DMFY307	Spasm	MB47.3	Approved	[21]
MEPTAZINOL	DMPSB8F	Pain	MG30-MG3Z	Approved	[22]
Eptastigmine	DMTV7ZM	Cognitive impairment	6D71	Phase 3	[23]
(-)-Phenserine	DMNCY1I	Alzheimer disease	8A20	Phase 3	[24]
Plasma derived human butyrylcholinesterase	DMF3IBC	Neurotoxicity	NE61	Phase 1	[25]
Protexia	DME1Y9W	Alzheimer disease	8A20	Phase 1	[26]
JES-9501	DMYR3IE	Alzheimer disease	8A20	Phase 1	[27]
Tetra-hydro-isoquinoline derivative 3	DMCZA45	N. A.	N. A.	Patented	[28]
Tetra-hydro-isoquinoline derivative 1	DML86IO	N. A.	N. A.	Patented	[28]
Tetra-hydro-isoquinoline derivative 2	DM5CKVF	N. A.	N. A.	Patented	[28]

Drug(s) Metabolized By Nitroreductase (NTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metronidazole	DMTIVEN	Abscess		Approved	[3]
Tindamax	DM3OWT4	Bacterial infection	1A00-1C4Z	Approved	[3]
Secnidazole	DMJ18YL	Amoebiasis	1A36	Approved	[3]
AI3-23606	DMHMT49	N. A.	N. A.	Phase 1	[3]

Drug(s) Metabolized By Retro-nitroreductase (rNR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AI3-23606	DMHMT49	N. A.	N. A.	Phase 1	[4]
Nitroimidazole	DMMY2S5	Trypanosomiasis	1D51-1F53	Investigative	[4]

Drug(s) Metabolized By Sulfide-quinone reductase (SQR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1,4-Naphthoquinone	DMTCMH7	Discovery agent	N.A.	Investigative	[5]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[9]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[35]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[35]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[29]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[9]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[37]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[35]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[41]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[44]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[45]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[46]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[54]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[9]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[55]

Drug(s) Affected By Eotaxin (CCL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[9]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[58]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[59]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[62]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[64]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[8]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[64]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[71]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[76]

Drug(s) Affected By E3 ubiquitin-protein ligase parkin (PRKN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Emtricitabine	DMBMUWZ	Hepatitis virus infection	1E50-1E51	Approved	[77]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[79]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[80]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[81]
Methamphetamine	DMPM4SK	Anxiety		Approved	[82]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[62]

Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[93]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[94]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[97]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[98]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[102]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[100]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[103]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[103]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[108]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[110]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[114]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[118]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]

Drug(s) Affected By ATP-dependent 6-phosphofructokinase, liver type (PFKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[123]
Penfluridol	DMG1DTE	Schizophrenia	6A20	Approved	[124]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[125]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[62]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[113]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[126]

Drug(s) Affected By Kit ligand (KITLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[133]

Drug(s) Affected By Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[137]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[123]

Drug(s) Affected By Interleukin-12 subunit beta (IL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[139]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[142]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[143]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[144]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[145]

Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[149]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[150]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[151]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[150]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[152]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[153]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[154]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[156]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[158]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[159]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[160]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[134]

Drug(s) Affected By Trifunctional enzyme subunit alpha, mitochondrial (HADHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[123]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[161]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[162]
Bortezomib	DMNO38U	Leukemia		Approved	[163]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[113]

Drug(s) Affected By Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Haloperidol	DM96SE0	Delirium		Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[123]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[168]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[169]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[171]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[172]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[173]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[176]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[177]

Drug(s) Affected By Histone-lysine N-methyltransferase MECOM (MECOM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[178]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[88]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[180]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[123]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[181]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[88]

Drug(s) Affected By Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[182]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[93]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[79]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[184]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[185]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[187]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 7 (DHRS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[123]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[125]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[189]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[190]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[62]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[192]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[193]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[194]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[195]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[196]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[197]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[198]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[2]
Cholinesterase (BCHE)	TTEB0GD	CHLE_HUMAN	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Nitroreductase (NTR)	DEAN5EW	NFSB_ENTCL	Substrate	[3]
Retro-nitroreductase (rNR)	DEKVGPX	A0A0H3CM55_ENTCC	Substrate	[4]
Sulfide-quinone reductase (SQR)	DEGLTNR	SQRD_ACIF2	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)	OT25JBA3	F263_HUMAN	Gene/Protein Processing	[6]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Drug Response	[7]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[8]
ATP-dependent 6-phosphofructokinase, liver type (PFKL)	OTVHGAT7	PFKAL_HUMAN	Gene/Protein Processing	[6]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[9]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Gene/Protein Processing	[9]
C-C motif chemokine 4 (CCL4)	OT6B8P25	CCL4_HUMAN	Gene/Protein Processing	[9]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Gene/Protein Processing	[9]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Gene/Protein Processing	[10]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)	OTIN6G20	CPT2_HUMAN	Gene/Protein Processing	[10]

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