Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNBA0G)

Drug Name
BENZOQUINONE Drug Info
Synonyms
p-benzoquinone; Benzoquinone; 1,4-BENZOQUINONE; Quinone; 106-51-4; p-Quinone; Chinone; 2,5-Cyclohexadiene-1,4-dione; para-Benzoquinone; cyclohexa-2,5-diene-1,4-dione; Cyclohexadienedione; para-Quinone; 1,4-Benzoquine; Steara pbq; 1,4-Dioxybenzene; p-Chinon; 1,4-Cyclohexadienedione; Benzo-chinon; Benzo-1,4-quinone; 1,4-Diossibenzene; Chinon; 1,4-Dioxy-benzol; 1,4-Cyclohexadiene dioxide; Semiquinone anion; semiquinone radicals; RCRA waste number U197; p-Chinon [German]; NCI-C55845; Caswell No. 719C; Benzo-chinon [German]; USAF P-220
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4650
ChEBI ID
CHEBI:16509
CAS Number
CAS 106-51-4
TTD Drug ID
DMNBA0G
INTEDE Drug ID
DR2205

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Acetylcholinesterase (AChE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [14]
Donepezil DMIYG7Z Advanced cancer 2A00-2F9Z Approved [15]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [16]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [17]
Huperzine A DMMAWLU Alzheimer disease 8A20 Approved [18]
Neostigmine DM6T2J3 Myasthenia gravis 8C6Y Approved [19]
YM443 DMNZCI1 Functional dyspepsia DD90.3 Approved [20]
Ambenonium DMOP0BL Myasthenia gravis 8C6Y Approved [21]
Demecarium bromide DMAYEU1 Open-angle glaucoma 9C61 Approved [22]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [23]
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Drug(s) Targeting Cholinesterase (BCHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hexafluronium bromide DMFY307 Spasm MB47.3 Approved [24]
MEPTAZINOL DMPSB8F Pain MG30-MG3Z Approved [25]
Eptastigmine DMTV7ZM Cognitive impairment 6D71 Phase 3 [26]
(-)-Phenserine DMNCY1I Alzheimer disease 8A20 Phase 3 [27]
Plasma derived human butyrylcholinesterase DMF3IBC Neurotoxicity NE61 Phase 1 [28]
Protexia DME1Y9W Alzheimer disease 8A20 Phase 1 [29]
JES-9501 DMYR3IE Alzheimer disease 8A20 Phase 1 [30]
Tetra-hydro-isoquinoline derivative 3 DMCZA45 N. A. N. A. Patented [31]
Tetra-hydro-isoquinoline derivative 1 DML86IO N. A. N. A. Patented [31]
Tetra-hydro-isoquinoline derivative 2 DM5CKVF N. A. N. A. Patented [31]
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Drug(s) Metabolized By Nitroreductase (NTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metronidazole DMTIVEN Abscess Approved [3]
Tindamax DM3OWT4 Bacterial infection 1A00-1C4Z Approved [3]
Secnidazole DMJ18YL Amoebiasis 1A36 Approved [3]
AI3-23606 DMHMT49 N. A. N. A. Phase 1 [3]
Drug(s) Metabolized By Retro-nitroreductase (rNR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AI3-23606 DMHMT49 N. A. N. A. Phase 1 [4]
Nitroimidazole DMMY2S5 Trypanosomiasis 1D51-1F53 Investigative [4]
Drug(s) Metabolized By Sulfide-quinone reductase (SQR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
1,4-Naphthoquinone DMTCMH7 Discovery agent N.A. Investigative [5]
Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [32]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [33]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [34]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [35]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [36]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [39]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
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Drug(s) Affected By C-C motif chemokine 3 (CCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [36]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [42]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [45]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [13]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [46]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [46]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [36]
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Drug(s) Affected By C-C motif chemokine 4 (CCL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [42]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [13]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [48]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [46]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [36]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Gefitinib DM15F0X Colon adenocarcinoma Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [54]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [55]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [56]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
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Drug(s) Affected By C-C motif chemokine 5 (CCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [62]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [64]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [13]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [65]
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Drug(s) Affected By Eotaxin (CCL11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prednisone DM2HG4X Acute asthma CA23 Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [67]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [13]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [68]
Ethanol DMDRQZU Chronic pain MG30 Approved [69]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [70]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [71]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [72]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [73]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [74]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [75]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [76]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [77]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [42]
Ethacrynic acid DM60QMR Edema MG29 Approved [79]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [80]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [81]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [82]
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Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [83]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [84]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [87]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [88]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [89]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [92]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [93]
Diazepam DM08E9O Alcohol withdrawal Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [9]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [97]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [93]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [98]
Testosterone DM7HUNW Hot flushes GA30 Approved [99]
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Drug(s) Affected By Transcription factor MafF (MAFF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [9]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [103]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [104]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [105]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [106]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [35]
Verapamil DMA7PEW Angina pectoris BA40 Approved [107]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Selenium DM25CGV N. A. N. A. Approved [109]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [56]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [110]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
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Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [112]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [103]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [116]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [117]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [118]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [119]
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Drug(s) Affected By Glutathione synthetase (GSS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [121]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [123]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [125]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [126]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [127]
Arsenic DMTL2Y1 N. A. N. A. Approved [128]
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Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [129]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [130]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [131]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [136]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [137]
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Drug(s) Affected By Transcription regulator protein BACH1 (BACH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [139]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [140]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [141]
Leflunomide DMR8ONJ Arthritis FA20 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
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Drug(s) Affected By E3 ubiquitin-protein ligase parkin (PRKN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Emtricitabine DMBMUWZ Hepatitis virus infection 1E50-1E51 Approved [144]
Tubocurarine DMBZIVP Anaesthesia 9A78.6 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ethanol DMDRQZU Chronic pain MG30 Approved [146]
Trifluoperazine DMKBYWI Anxiety Approved [147]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [148]
Methamphetamine DMPM4SK Anxiety Approved [149]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [150]
Arsenic DMTL2Y1 N. A. N. A. Approved [151]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [72]
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Drug(s) Affected By Dickkopf-related protein 1 (DKK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [152]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [154]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [68]
Leflunomide DMR8ONJ Arthritis FA20 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [155]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
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Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [156]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [157]
Etretinate DM2CZFA Keratosis ED56 Approved [158]
Quercetin DM3NC4M Obesity 5B81 Approved [159]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [160]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [161]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [163]
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Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Etretinate DM2CZFA Keratosis ED56 Approved [158]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [165]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [166]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [163]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [155]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [167]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [168]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [169]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [170]
Paclitaxel DMLB81S Breast carcinoma Approved [171]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [172]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [173]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [174]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [175]
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Drug(s) Affected By Protein kinase C beta type (PRKCB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [176]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [178]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Panobinostat DM58WKG Chronic graft versus host disease Approved [179]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [118]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [180]
Leflunomide DMR8ONJ Arthritis FA20 Approved [142]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [155]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [177]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [181]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [182]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [183]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [35]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [184]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [185]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [186]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [185]
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Drug(s) Affected By Transcriptional activator Myb (MYB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [187]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [188]
Quercetin DM3NC4M Obesity 5B81 Approved [189]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [190]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Estrone DM5T6US Acne vulgaris ED80 Approved [187]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [192]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [193]
Testosterone DM7HUNW Hot flushes GA30 Approved [194]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [195]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [196]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [197]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [198]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [157]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [34]
Verapamil DMA7PEW Angina pectoris BA40 Approved [199]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [200]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [201]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [202]
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Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [203]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [204]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [205]
Methotrexate DM2TEOL Anterior urethra cancer Approved [206]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [208]
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Drug(s) Affected By Pyruvate kinase PKM (PKM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [209]
Selenium DM25CGV N. A. N. A. Approved [176]
Epinephrine DM3KJBC Acute asthma CA23 Approved [210]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [211]
Panobinostat DM58WKG Chronic graft versus host disease Approved [179]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [212]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [166]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [163]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [213]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [214]
Selenium DM25CGV N. A. N. A. Approved [176]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [215]
Etretinate DM2CZFA Keratosis ED56 Approved [216]
Methotrexate DM2TEOL Anterior urethra cancer Approved [217]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [218]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [219]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [220]
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Drug(s) Affected By ATP-dependent 6-phosphofructokinase, liver type (PFKL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [176]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [143]
Testosterone enanthate DMB6871 N. A. N. A. Approved [221]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
Penfluridol DMG1DTE Schizophrenia 6A20 Approved [222]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [126]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [72]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [176]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [223]
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Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 1 (PTPN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [165]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [155]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [225]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [226]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [227]
Seocalcitol DMKL9QO Rickets 5B57 Phase 3 [228]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [229]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [223]
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Drug(s) Affected By Kit ligand (KITLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [230]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [231]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Panobinostat DM58WKG Chronic graft versus host disease Approved [179]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [232]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [154]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [233]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [234]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [61]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [235]
Methotrexate DM2TEOL Anterior urethra cancer Approved [236]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [237]
Quercetin DM3NC4M Obesity 5B81 Approved [238]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [239]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [240]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [241]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [242]
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Drug(s) Affected By Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [243]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [244]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [103]
Leflunomide DMR8ONJ Arthritis FA20 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [245]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [246]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [247]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [202]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [248]
Gefitinib DM15F0X Colon adenocarcinoma Approved [249]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [250]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [251]
Selenium DM25CGV N. A. N. A. Approved [176]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [252]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [253]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-12 subunit beta (IL12B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [240]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [242]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [254]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [255]
Capsaicin DMGMF6V Back pain ME84.Z Approved [256]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [257]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [258]
Bryostatin-1 DM1JOXY Alzheimer disease 8A20 Phase 2 [259]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [260]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [261]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [262]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [263]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [264]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [265]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [264]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [266]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [267]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [268]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [269]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Gefitinib DM15F0X Colon adenocarcinoma Approved [270]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [250]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Etretinate DM2CZFA Keratosis ED56 Approved [271]
Prednisone DM2HG4X Acute asthma CA23 Approved [272]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [273]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [243]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trifunctional enzyme subunit alpha, mitochondrial (HADHA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [176]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [143]
Testosterone enanthate DMB6871 N. A. N. A. Approved [221]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [274]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [275]
Bortezomib DMNO38U Leukemia Approved [276]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [176]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [277]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [61]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [278]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [279]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [278]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [232]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [278]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [280]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [281]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [282]
Gefitinib DM15F0X Colon adenocarcinoma Approved [283]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [284]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [252]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [285]
Quercetin DM3NC4M Obesity 5B81 Approved [286]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [287]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [288]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [289]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [290]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [291]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [170]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [292]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [293]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [294]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [295]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [296]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [297]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [176]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [232]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [298]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carnitine O-acetyltransferase (CRAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [176]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [103]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [126]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [299]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [157]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [300]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [301]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [302]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [187]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [303]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [103]
Panobinostat DM58WKG Chronic graft versus host disease Approved [179]
Estrone DM5T6US Acne vulgaris ED80 Approved [187]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [154]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [304]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [305]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [306]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [103]
Haloperidol DM96SE0 Delirium Approved [305]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [307]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [308]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [309]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [101]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [310]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [165]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [311]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [312]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [313]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [315]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [316]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [317]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [318]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [318]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [319]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [320]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [321]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [322]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [34]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [200]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [323]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [324]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [325]
Meloxicam DM2AR7L Arthritis FA20 Approved [326]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [327]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein jagged-1 (JAG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [329]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [211]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [154]
Leflunomide DMR8ONJ Arthritis FA20 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [330]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [331]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA topoisomerase 2-beta (TOP2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [204]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [332]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
Menthol DMG2KW7 Back pain ME84.Z Approved [333]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [334]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [100]
Arsenic DMTL2Y1 N. A. N. A. Approved [335]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-lysine N-methyltransferase MECOM (MECOM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Panobinostat DM58WKG Chronic graft versus host disease Approved [179]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [160]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [99]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [336]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [195]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [297]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [34]
Verapamil DMA7PEW Angina pectoris BA40 Approved [199]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [302]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [323]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [250]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [337]
Meloxicam DM2AR7L Arthritis FA20 Approved [338]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [281]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [282]
Gefitinib DM15F0X Colon adenocarcinoma Approved [339]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [209]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [340]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [341]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [211]
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Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [342]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [343]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [344]
Quercetin DM3NC4M Obesity 5B81 Approved [345]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [346]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [160]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [154]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [83]
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Drug(s) Affected By Beclin-1 (BECN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [347]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [284]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [348]
Fluoxetine DM3PD2C Bipolar depression Approved [349]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [350]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [351]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [352]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [353]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [354]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [355]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [356]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [357]
Gefitinib DM15F0X Colon adenocarcinoma Approved [358]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [359]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [325]
Selenium DM25CGV N. A. N. A. Approved [176]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [327]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [360]
Verapamil DMA7PEW Angina pectoris BA40 Approved [107]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [315]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Selenium DM25CGV N. A. N. A. Approved [176]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [139]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [89]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [361]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [362]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [363]
Prednisone DM2HG4X Acute asthma CA23 Approved [364]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [364]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [365]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [366]
Epinephrine DM3KJBC Acute asthma CA23 Approved [210]
Quercetin DM3NC4M Obesity 5B81 Approved [367]
Fluoxetine DM3PD2C Bipolar depression Approved [368]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [369]
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Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [211]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [116]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [341]
Leflunomide DMR8ONJ Arthritis FA20 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
Ethanol DMDRQZU Chronic pain MG30 Approved [370]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [116]
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Drug(s) Affected By Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [371]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [372]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [372]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [155]
Ethanol DMDRQZU Chronic pain MG30 Approved [146]
Capsaicin DMGMF6V Back pain ME84.Z Approved [373]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [374]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [375]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [376]
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Drug(s) Affected By NADPH oxidase 4 (NOX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [377]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [378]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [379]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Capsaicin DMGMF6V Back pain ME84.Z Approved [380]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [274]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [381]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [382]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [383]
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Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [384]
Haloperidol DM96SE0 Delirium Approved [157]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [385]
Selenium DM25CGV N. A. N. A. Approved [386]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [387]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [388]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [389]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
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Drug(s) Affected By Dehydrogenase/reductase SDR family member 7 (DHRS7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [390]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [307]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [375]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [126]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [127]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [391]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [72]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [392]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [157]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [393]
Diazepam DM08E9O Alcohol withdrawal Approved [394]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [395]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [396]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [397]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [398]
Methotrexate DM2TEOL Anterior urethra cancer Approved [399]
Quercetin DM3NC4M Obesity 5B81 Approved [400]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetylcholinesterase (AChE) TT1RS9F ACES_HUMAN Inhibitor [2]
Cholinesterase (BCHE) TTEB0GD CHLE_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Nitroreductase (NTR) DEAN5EW NFSB_ENTCL Substrate [3]
Retro-nitroreductase (rNR) DEKVGPX A0A0H3CM55_ENTCC Substrate [4]
Sulfide-quinone reductase (SQR) DEGLTNR SQRD_ACIF2 Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) OTGLVWOP THIM_HUMAN Gene/Protein Processing [6]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) OT25JBA3 F263_HUMAN Gene/Protein Processing [7]
Albumin (ALB) OTVMM513 ALBU_HUMAN Drug Response [8]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Gene/Protein Processing [9]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [10]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [10]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Protein Interaction/Cellular Processes [11]
ATP-dependent 6-phosphofructokinase, liver type (PFKL) OTVHGAT7 PFKAL_HUMAN Gene/Protein Processing [7]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Gene/Protein Processing [12]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [13]

References

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