Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMW4X37)

• Drug Name: Diphenylpyraline Drug Info
• Synonyms: Allergen; Belfene; Dafen; Dayfen; Diafen; Difenilpiralina; Diphenylpyralamine; Diphenylpyralinum; Diphenylpyrilene; Hispril; Histryl; Histyn; Hystryl; Lergobine; Lyssipoll; Mepiben; Neargal; AN 1041; Difenilpiralina [INN-Spanish]; Diphenylpyraline (INN); Diphenylpyraline [INN:BAN]; Diphenylpyralinum [INN-Latin];Diphenylpyraline maleate (2:1); N-Methylpiperidyl-(4)-benzhydrylaether salzsauren salze; N-Methylpiperidyl-(4)-benzhydrylaether salzsauren salze [German]; 1-Methyl-4-piperidyl benzhydryl ether; 1-methyl-4-hydroxypiperidine benzhydryl ether; 4-(Benzhydryloxy)-1-methylpiperidine; 4-(Diphenylmethoxy)-1-methylpiperidine; 4-(benzhydryloxy)-N-methylpiperidine; 4-DIPHENYLMETHOXY-1-METHYLPIPERIDINE; 4-[(diphenylmethyl)oxy]-1-methylpiperidine; 4-benzhydryloxy-1-methylpiperidine

Indication

Disease Entry	ICD 11	Status	REF
Allergic rhinitis	CA08.0	Approved	[1]
Urticaria	EB00-EB05	Approved	[2]
Vasomotor/allergic rhinitis	CA08	Approved	[2]
Pruritus	EC90	Investigative	[2]

• Therapeutic Class: Antihistamines
• Cross-matching ID:
  PubChem CID: 3103
  ChEBI ID: CHEBI:59788
  CAS Number: CAS 147-20-6
  TTD Drug ID: DMW4X37
  INTEDE Drug ID: DR2281

Molecule-Related Drug Atlas

Drug(s) Targeting Histamine H1 receptor (H1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[6]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[7]
Azelastine	DMXTMBJ	Allergic conjunctivitis	9A60.02	Approved	[8]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[9]
Cinnarizine	DM7U5QJ	Meniere disease	AB31.0	Approved	[10]
Diphenhydramine	DMKQTBA	Hyperemesis gravidarum		Approved	[8]
Doxepin	DMPI98T	Anxiety		Approved	[11]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[8]
Epinastine	DMX0K3Q	Allergic conjunctivitis	9A60.02	Approved	[12]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[13]

Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[4]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[19]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[21]
fMet-Leu-Phe	DMQ391A	N. A.	N. A.	Investigative	[22]

Drug(s) Affected By CD63 antigen (CD63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[27]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]

Drug(s) Affected By Aminopeptidase N (ANPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]

Drug(s) Affected By Atypical chemokine receptor 2 (ACKR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[36]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[40]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[41]

Drug(s) Affected By Suppressor of cytokine signaling 3 (SOCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[45]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Fedratinib	DM4ZBK6	Myelofibrosis	2A20.2	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[48]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[46]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[50]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[57]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[58]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 12 (TNFSF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[59]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[61]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[28]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]

Drug(s) Affected By PR domain zinc finger protein 1 (PRDM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[70]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[70]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[71]

Drug(s) Affected By Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Hydroxychloroquine	DMSIVND	Chronic renal failure	GB61.Z	Approved	[75]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]

Drug(s) Affected By Complement factor D (CFD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[28]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[86]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[87]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[91]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[92]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[93]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[94]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]

Drug(s) Affected By Polymeric immunoglobulin receptor (PIGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[104]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[106]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[59]

Drug(s) Affected By Lactotransferrin (LTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[82]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[107]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[108]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[109]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[110]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[113]

Drug(s) Affected By HLA class II histocompatibility antigen gamma chain (CD74)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]

Drug(s) Affected By HLA class I histocompatibility antigen, A alpha chain (HLA-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[120]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[121]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[123]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[124]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[125]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[115]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[115]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[126]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[129]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[130]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[131]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[133]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]

Drug(s) Affected By Complement factor I (CFI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[28]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Fructose	DM43AN2	Vomiting	MD90	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]

Drug(s) Affected By Complement C2 (C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[143]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[144]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[145]

Drug(s) Affected By Complement factor H (CFH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[146]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[148]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[149]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Selenium	DM25CGV	N. A.	N. A.	Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[155]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[156]

Drug(s) Affected By Macrophage colony-stimulating factor 1 (CSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[158]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[159]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[162]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[164]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[165]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[166]

Drug(s) Affected By Complement C4-A (C4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[167]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[168]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[169]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[171]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[172]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[176]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[174]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[178]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[182]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[183]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[183]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[177]

Drug(s) Affected By HLA class I histocompatibility antigen, C alpha chain (HLA-C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[121]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[125]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[187]

Drug(s) Affected By Mast/stem cell growth factor receptor Kit (KIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[188]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[148]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[191]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[192]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[193]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[194]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[157]

Drug(s) Affected By Eosinophil cationic protein (RNASE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[195]
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[196]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[195]
Arformoterol	DMYM974	Chronic obstructive pulmonary disease	CA22	Approved	[197]
Beclomethasone dipropionate	DM5NW1E	Allergic rhinitis	CA08.0	Phase 4	[198]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[199]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[203]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[204]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[205]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]

Drug(s) Affected By CD99 antigen (CD99)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[207]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[208]

Drug(s) Affected By Interleukin-1 receptor type 1 (IL1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[209]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[209]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]

Drug(s) Affected By Interferon gamma receptor 1 (IFNGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[211]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[213]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[27]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[214]

Drug(s) Affected By Membrane cofactor protein (CD46)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[215]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[215]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]

Drug(s) Affected By Transcription factor 4 (TCF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[40]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[217]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[216]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]

Drug(s) Affected By Mucin-1 (MUC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[104]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[221]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[222]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[223]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[224]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 2 (PTPN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[228]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[229]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[225]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[230]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[84]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[231]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[234]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[235]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[236]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[239]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[240]

Drug(s) Affected By HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[115]
Cinoxacin	DM4EWNS	Urinary tract infection	GC08	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[115]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[115]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[241]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[241]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[245]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[241]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[87]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[246]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[248]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[249]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]

Drug(s) Affected By CD82 antigen (CD82)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[211]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[28]
Bortezomib	DMNO38U	Leukemia		Approved	[251]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[253]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[254]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[255]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[256]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[257]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[258]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[87]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[259]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[260]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[262]
Bortezomib	DMNO38U	Leukemia		Approved	[263]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]

Drug(s) Affected By Cytokine receptor common subunit gamma (IL2RG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[265]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]

Drug(s) Affected By MHC class II transactivator (CIITA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[267]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[266]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[268]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[269]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[273]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[274]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[275]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[276]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[277]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[278]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[279]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[280]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[281]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[283]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[284]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[285]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]

Drug(s) Affected By Prostaglandin E2 receptor EP4 subtype (PTGER4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[164]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[287]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[288]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[289]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[291]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[292]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[294]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[295]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[296]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[297]

Drug(s) Affected By TGF-beta receptor type-1 (TGFBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[299]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[300]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[301]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[209]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[209]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 3 (LTBR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[210]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[61]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[302]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[303]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[304]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[305]

Drug(s) Affected By TGF-beta receptor type-2 (TGFBR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[298]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[307]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[308]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[311]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[312]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[313]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[314]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[315]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[316]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[317]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[318]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[319]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[65]

Drug(s) Affected By Proteasome subunit beta type-10 (PSMB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[320]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[28]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[321]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[87]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[322]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[323]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[324]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[325]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[326]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[202]

Drug(s) Affected By Signal transducer and activator of transcription 6 (STAT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[327]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[328]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[329]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[28]

Drug(s) Affected By Signal transducer and activator of transcription 5A (STAT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[329]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[331]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[332]

Drug(s) Affected By Tyrosine-protein kinase SYK (SYK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[334]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[49]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[335]

Drug(s) Affected By Interferon alpha/beta receptor 2 (IFNAR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[37]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[166]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[336]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[337]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[338]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[229]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[207]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[339]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[135]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[340]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[341]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[342]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[343]

Drug(s) Affected By Nuclear receptor ROR-gamma (RORC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[45]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[344]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[345]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[346]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[165]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[15]

Drug(s) Affected By B-cell receptor-associated protein 31 (BCAP31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[347]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[87]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[36]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[30]

Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[348]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[117]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[331]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[349]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[350]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[351]

Drug(s) Affected By Rho GDP-dissociation inhibitor 2 (ARHGDIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[352]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[352]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[288]

Drug(s) Affected By Signal transducer and activator of transcription 2 (STAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[187]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[28]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[353]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[77]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[165]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[354]

Drug(s) Affected By Dipeptidyl peptidase 1 (CTSC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[70]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[70]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[355]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]

Drug(s) Affected By Toll/interleukin-1 receptor domain-containing adapter protein (TIRAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[356]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[229]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[357]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[358]

Drug(s) Affected By CD81 antigen (CD81)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[359]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[18]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[295]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[360]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[361]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[362]

Drug(s) Affected By HLA class II histocompatibility antigen, DR beta 3 chain (HLA-DRB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[115]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[30]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[41]

Drug(s) Affected By Interferon-induced 35 kDa protein (IFI35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[155]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[104]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]

Drug(s) Affected By Sialomucin core protein 24 (CD164)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[356]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[28]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[364]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[365]

Drug(s) Affected By Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[367]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[28]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[368]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[369]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[370]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[371]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[372]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[373]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[373]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[374]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[375]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[376]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[377]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[373]

Drug(s) Affected By Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[378]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[379]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[380]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[379]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[19]

Drug(s) Affected By Interferon regulatory factor 5 (IRF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[381]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[43]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[382]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[381]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[228]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[383]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[384]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[385]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[211]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[385]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[268]

Drug(s) Affected By Interferon regulatory factor 3 (IRF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[386]
Hydroxychloroquine	DMSIVND	Chronic renal failure	GB61.Z	Approved	[384]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[387]

Drug(s) Affected By Signal transducer and activator of transcription 4 (STAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[155]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[240]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[388]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[155]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[155]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[155]

Drug(s) Affected By Leukotriene B4 receptor 1 (LTB4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[82]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[185]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
BRN-3548355	DM4KXT0	N. A.	N. A.	Investigative	[389]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[164]

Drug(s) Affected By Programmed cell death protein 2 (PDCD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[390]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[61]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[391]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[392]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[229]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[393]

Drug(s) Affected By Nuclear factor interleukin-3-regulated protein (NFIL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[394]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[395]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[396]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]

Drug(s) Affected By Gamma-interferon-inducible protein 16 (IFI16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[397]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[164]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[28]

Drug(s) Affected By Single Ig IL-1-related receptor (SIGIRR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[300]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[398]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[305]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[337]

Drug(s) Affected By T-cell activation Rho GTPase-activating protein (TAGAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[385]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[385]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[399]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[400]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]

Drug(s) Affected By Intelectin-1 (ITLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[401]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]

Drug(s) Affected By Interferon regulatory factor 7 (IRF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[402]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[403]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[149]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[155]

Drug(s) Affected By Proteasome subunit beta type-7 (PSMB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[240]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[405]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[405]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[165]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[406]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[387]

Drug(s) Affected By Mothers against decapentaplegic homolog 5 (SMAD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[240]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[407]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]

Drug(s) Affected By NF-kappa-B inhibitor zeta (NFKBIZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[408]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[409]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]

Drug(s) Affected By Serine/threonine-protein kinase TBK1 (TBK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[384]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[410]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[411]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Flavonoid derivative 1	DMCQP0B	N. A.	N. A.	Patented	[411]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[207]

Drug(s) Affected By Zinc finger protein Helios (IKZF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[288]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[268]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[399]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[354]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[305]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[49]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[412]

Drug(s) Affected By Interleukin-1 receptor-associated kinase 3 (IRAK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[355]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[18]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[413]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[414]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[164]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[355]

Drug(s) Affected By NF-kappa-B essential modulator (IKBKG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[415]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[416]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[417]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[61]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[418]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[418]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[419]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[15]

Drug(s) Affected By Lymphocyte antigen 96 (LY96)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Antagonist	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aminopeptidase N (ANPEP)	OTP3WYFD	AMPN_HUMAN	Gene/Protein Processing	[4]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Gene/Protein Processing	[5]
Atypical chemokine receptor 2 (ACKR2)	OTWYY14H	ACKR2_HUMAN	Gene/Protein Processing	[5]
B-cell receptor-associated protein 31 (BCAP31)	OTKSACR4	BAP31_HUMAN	Gene/Protein Processing	[5]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Gene/Protein Processing	[5]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Gene/Protein Processing	[5]
C-X-C motif chemokine 2 (CXCL2)	OTEJCYMY	CXCL2_HUMAN	Gene/Protein Processing	[5]
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)	OTQOUHVK	CEAM6_HUMAN	Gene/Protein Processing	[5]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Gene/Protein Processing	[5]
CD63 antigen (CD63)	OT2UGZA9	CD63_HUMAN	Gene/Protein Processing	[4]

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