Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYXI2V)

• Drug Name: (E)-4-(3,5-dimethoxystyryl)phenol Drug Info
• Synonyms: Pterostilbene; 537-42-8; 4-(3,5-Dimethoxystyryl)phenol; 3',5'-Dimethoxy-4-stilbenol; trans-pterostilbene; 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol; pterostilben; 4-[(E)-2-(3,5-dimethoxyphenyl)vinyl]phenol; UNII-26R60S6A5I; 3,5-Dimethoxy-4'-hydroxy-trans-stilbene; 3,5-Dimethoxy-4'-hydroxystilbene; 18259-15-9; trans-3,5-dimethoxy-4'-hydroxystilbene; CHEMBL83527; CHEBI:8630; VLEUZFDZJKSGMX-ONEGZZNKSA-N; 4-((E)-2-(3,5-dimethoxyphenyl)ethenyl)phenol; 26R60S6A5I; Pterostilbene, Pterocarpus; pterostilbene

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5281727
  ChEBI ID: CHEMBL83527
  CAS Number: CAS 537-42-8
  TTD Drug ID: DMYXI2V

Molecule-Related Drug Atlas

Drug(s) Targeting Fusion protein Bcr-Abl (Bcr-Abl)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[10]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[10]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[11]
Asciminib	DM7EVUF	Chronic myeloid leukaemia	2A20	Approved	[12]
Radotinib	DMWA74Y	leukaemia	2A60-2B33	Phase 3	[13]
ABL 001	DMMF5K4	Chronic myeloid leukaemia	2A20	Phase 3	[14]
ICLUSIG	DM1SQSE	Acute lymphoblastic leukaemia	2A85	Phase 3	[15]
Bafetinib	DM7586F	Bone disease	FC0Z	Phase 2	[16]
AN-019	DMJ7QP8	Chronic myelogenous leukaemia	2A20.0	Phase 2	[17]
HQP1351	DMQ30X2	Chronic myeloid leukaemia	2A20	Phase 2	[18]

Drug(s) Targeting Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lobeglitazone	DMHY3IP	Type-2 diabetes	5A11	Approved	[19]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[20]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[21]
Ciprofibrate	DMGC5DB	Hyperlipoproteinemia	5C80	Approved	[20]
Pemafibrate	DMD1VZL	Hyperlipidemia	5C80.Z	Approved	[22]
MURAGLITAZAR	DMG3NFZ	N. A.	N. A.	Phase 3	[23]
Ragaglitazar	DMFSHEM	Type-1 diabetes	5A10	Phase 3	[24]
CS-038	DM67P0F	Type-2 diabetes	5A11	Phase 3	[25]
TESAGLITAZAR	DMGRBN5	Type-1 diabetes	5A10	Phase 3	[26]
GFT-505	DM7ZOAE	Non-alcoholic steatohepatitis	DB92.1	Phase 3	[27]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[28]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[34]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[35]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[41]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[42]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[43]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[42]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[44]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[45]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[46]

Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[29]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[61]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[62]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[63]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[64]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[64]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[65]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[67]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[64]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[64]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[64]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[68]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[69]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[71]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[72]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[73]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[74]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[75]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[76]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[75]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[71]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[77]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[78]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[83]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[85]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[94]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[95]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[99]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[102]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]

Drug(s) Affected By Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[107]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[112]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[114]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[115]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[119]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[120]

Drug(s) Affected By Phosphoglycerate mutase 1 (PGAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[112]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[124]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[125]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[126]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[127]

Drug(s) Affected By Galactoside alpha-(1,2)-fucosyltransferase 1 (FUT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[128]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[129]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[112]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[59]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[131]

Drug(s) Affected By C-X-C motif chemokine 3 (CXCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[98]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[135]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[138]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[140]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[141]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[142]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[143]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[144]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[147]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[138]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[148]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[149]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[150]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[77]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[140]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[141]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[152]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[153]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[29]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[47]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[155]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]

Drug(s) Affected By Stress-70 protein, mitochondrial (HSPA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[161]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[162]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[112]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[163]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[164]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[165]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[166]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[167]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[169]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[170]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[43]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[171]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[172]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[173]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[175]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]

Drug(s) Affected By Serine--tRNA ligase, cytoplasmic (SARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Haloperidol	DM96SE0	Delirium		Approved	[162]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[181]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[162]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[162]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein M (HNRNPM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[158]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[184]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[186]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[158]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[126]

Drug(s) Affected By Proteasome activator complex subunit 3 (PSME3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[190]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[191]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[192]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[193]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]

Drug(s) Affected By 10 kDa heat shock protein, mitochondrial (HSPE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[196]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[197]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[198]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[199]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[39]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[202]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[204]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[41]
Selenium	DM25CGV	N. A.	N. A.	Approved	[158]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[207]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[209]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[212]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[214]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[215]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[217]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[218]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[112]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[219]

Drug(s) Affected By Mitogen-activated protein kinase 7 (MAPK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[221]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[184]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[223]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[224]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[224]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[225]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[228]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[229]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[231]

Drug(s) Affected By Serine/threonine-protein kinase STK11 (STK11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Selenium	DM25CGV	N. A.	N. A.	Approved	[158]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[234]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[235]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[184]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[236]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[237]
GDC-0980/RG7422	DMF3MV1	Non-hodgkin lymphoma	2B33.5	Phase 2	[238]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[241]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[245]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[246]

Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[247]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[250]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[181]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[181]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[251]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]

Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[252]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[256]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[221]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Fructose	DM43AN2	Vomiting	MD90	Approved	[257]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[258]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[259]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[260]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[261]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[262]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[262]

Drug(s) Affected By Krueppel-like factor 2 (KLF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[263]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[264]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[266]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[112]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[267]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[268]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fusion protein Bcr-Abl (Bcr-Abl)	TTS7G69	BCR_HUMAN-ABL1_HUMAN	Inhibitor	[2]
Peroxisome proliferator-activated receptor alpha (PPARA)	TTJ584C	PPARA_HUMAN	Agonist	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
10 kDa heat shock protein, mitochondrial (HSPE1)	OT7JSZLB	CH10_HUMAN	Gene/Protein Processing	[4]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)	OT7TNF0L	AAPK1_HUMAN	Post-Translational Modifications	[5]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Gene/Protein Processing	[6]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[6]
C-X-C motif chemokine 3 (CXCL3)	OTSL94KH	CXCL3_HUMAN	Gene/Protein Processing	[7]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[6]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Gene/Protein Processing	[6]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Gene/Protein Processing	[5]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Gene/Protein Processing	[9]

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