Details of Disease

Disease Name

Skin neoplasm

skin benign neoplasm; skin; zone of skin tumour; zone of skin tumor; zone of skin neoplasm (disease); zone of skin neoplasm; tumour of zone of skin; tumour of the skin; tumour of skin; tumor of zone of skin; tumor of the skin; tumor of skin; skin tumour; skin tumor; skin neoplasms; skin neoplasm; neoplasm of zone of skin; neoplasm of the skin; neoplasm of skin by site; neoplasm of skin

Definition

A benign or malignant tumor involving the skin. Representative examples of benign skin neoplasms include the benign melanocytic skin nevus, acanthoma, sebaceous adenoma, sweat gland adenoma, lipoma, hemangioma, fibroma, and benign fibrous histiocytoma. Representative examples of malignant skin neoplasms include basal cell carcinoma, squamous cell carcinoma, melanoma, and Kaposi sarcoma.

Disease Hierarchy

DISTBY9Z: Tumour

DIS9YPUQ: Dermatological disease

DIS16DDV: Skin neoplasm

Disease Identifiers

MONDO ID

MONDO_0002531

MESH ID

D012878

UMLS CUI

C0037286

MedGen ID

19993

HPO ID

HP:0008069

SNOMED CT ID

126488004

General Information of Disease (ID: DIS16DDV)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 54 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
MGMT	TTJ8DV7	Limited	Biomarker	[1]
CASP10	TTX5HEK	moderate	Biomarker	[2]
CASP8	TT6SZNG	moderate	Biomarker	[2]
CEBPA	TT5LWG1	moderate	Biomarker	[3]
CSF3	TT5TQ2W	moderate	Therapeutic	[4]
CSNK2A1	TTER6YH	moderate	Biomarker	[5]
CSNK2A2	TT7GR5W	moderate	Biomarker	[5]
ERBB4	TTWALCO	moderate	Biomarker	[6]
FLT1	TT1VAUK	moderate	Biomarker	[6]
GJA1	TT4F7SL	moderate	Altered Expression	[7]
GJB2	TTRGZX3	moderate	Biomarker	[8]
GJB5	TTL9MHP	moderate	Biomarker	[8]
HCAR2	TTWNV8U	moderate	Biomarker	[9]
HCAR3	TT8WFXV	moderate	Biomarker	[9]
HIF1A	TTSN6QU	moderate	Biomarker	[10]
IGF1R	TTQFBMY	moderate	Biomarker	[11]
IL1A	TTPM6HI	moderate	Biomarker	[12]
KIT	TTX41N9	moderate	Genetic Variation	[13]
NOTCH2	TT82FVD	moderate	Biomarker	[14]
NOTCH4	TTXDIK2	moderate	Biomarker	[14]
PPARD	TT2JWF6	moderate	Therapeutic	[15]
SMO	TT8J1S3	moderate	Biomarker	[16]
SP1	TTZEP6S	moderate	Biomarker	[17]
TYR	TTULVH8	moderate	Biomarker	[18]
AKT1	TTWTSCV	Strong	Genetic Variation	[19]
ALOX12	TT12ABZ	Strong	Altered Expression	[20]
AQP3	TTLDNMQ	Strong	Altered Expression	[21]
CD248	TTYJWT7	Strong	Biomarker	[22]
CDC25B	TTR0SWN	Strong	Biomarker	[23]
CHUK	TT1F8OQ	Strong	Biomarker	[24]
CMKLR1	TT4UGZL	Strong	Biomarker	[25]
EPHA1	TTLFZVU	Strong	Biomarker	[26]
ERBB3	TTSINU2	Strong	Biomarker	[27]
F2RL2	TTVSEBF	Strong	Biomarker	[28]
GLI2	TT045OH	Strong	Altered Expression	[29]
GPR55	TTNET8J	Strong	Altered Expression	[30]
HRAS	TT28ZON	Strong	Biomarker	[31]
IGF1	TTT6LOU	Strong	Biomarker	[32]
KLK6	TTLPF4X	Strong	Biomarker	[33]
KRT17	TTKV0EC	Strong	Biomarker	[34]
MC1R	TT0MV2T	Strong	Genetic Variation	[35]
MMP11	TTZW4MV	Strong	Biomarker	[36]
NFE2L2	TTA6ZN2	Strong	Biomarker	[37]
NOTCH1	TTB1STW	Strong	Biomarker	[14]
NOTCH3	TTVX7IA	Strong	Biomarker	[14]
ODC1	TTUMGNO	Strong	Altered Expression	[38]
PCSK6	TT75LN9	Strong	Biomarker	[39]
PDGFB	TTQA6SX	Strong	Genetic Variation	[40]
PTK2B	TTTEFBV	Strong	Biomarker	[6]
PTPN2	TTY8PUS	Strong	Biomarker	[41]
TGFBR1	TTP4520	Strong	Biomarker	[42]
USP1	TTG9MT5	Strong	Altered Expression	[43]
XPA	TTGT87E	Strong	Biomarker	[44]
MRC1	TTKV8W5	Definitive	Genetic Variation	[45]
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⏷ Show the Full List of 54 DTT(s)

This Disease Is Related to 3 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
EPHX1	DELB4KP	moderate	Biomarker	[46]
GSTT1	DE3PKUG	moderate	Biomarker	[46]
GSTA4	DEH7XYP	Strong	Biomarker	[47]
------------------------------------------------------------------------------------

This Disease Is Related to 50 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CYLD	OT37FKH0	Limited	Genetic Variation	[48]
CSNK2B	OT2WW7R1	moderate	Biomarker	[5]
IVL	OT4VPNGY	moderate	Biomarker	[5]
KRT10	OTSVRD3Q	moderate	Biomarker	[5]
LORICRIN	OTFRPVEO	moderate	Biomarker	[5]
NPPA	OTMQNTNX	moderate	Therapeutic	[49]
POT1	OTNBXJCQ	moderate	Biomarker	[50]
RELA	OTUJP9CN	moderate	Biomarker	[51]
ADAMTSL3	OTMC2WFG	Strong	Altered Expression	[52]
AFAP1L2	OTJBI0VN	Strong	Biomarker	[53]
AIRE	OTA7G1Y1	Strong	Altered Expression	[54]
ATF2	OTNIZPEA	Strong	Biomarker	[55]
BCAM	OTHZOPSD	Strong	Biomarker	[56]
CASP14	OTKY93H9	Strong	Altered Expression	[57]
CASP8AP2	OTTWT68S	Strong	Genetic Variation	[58]
CEBPD	OTNBIPMY	Strong	Altered Expression	[59]
CLIC4	OT6KTPKD	Strong	Biomarker	[60]
COL1A1	OTI31178	Strong	Genetic Variation	[40]
DDB2	OTO8HVVB	Strong	Altered Expression	[61]
DESI2	OTHUOKOC	Strong	Biomarker	[62]
DSC2	OTODVH8K	Strong	Biomarker	[63]
DSC3	OTYG47F8	Strong	Altered Expression	[63]
ERCC2	OT1C8HQ4	Strong	Biomarker	[64]
ERRFI1	OT7VZ2IZ	Strong	Biomarker	[65]
FETUB	OT7V07NI	Strong	Genetic Variation	[66]
GYPA	OTABU4YV	Strong	Genetic Variation	[67]
HOXC4	OT52VJ6V	Strong	Altered Expression	[68]
HRG	OTPLUFOG	Strong	Genetic Variation	[66]
KRT1	OTIOJWA4	Strong	Biomarker	[69]
KRT15	OTS6WLF7	Strong	Biomarker	[69]
KRT5	OTVGI9HT	Strong	Biomarker	[70]
LRIG1	OTY5HZN5	Strong	Altered Expression	[71]
MMP19	OTLSTT2B	Strong	Biomarker	[72]
MMRN2	OT4IRL0U	Strong	Altered Expression	[22]
OVOL2	OTFM1GKF	Strong	Biomarker	[73]
PADI2	OTT40K94	Strong	Altered Expression	[74]
PARD3	OTH5BPLO	Strong	Biomarker	[28]
POLH	OTN07WXU	Strong	Biomarker	[75]
POLQ	OTBHK0E6	Strong	Biomarker	[75]
RAB23	OTBAKFBR	Strong	Altered Expression	[76]
RALGDS	OTG36NI7	Strong	Biomarker	[77]
RNASE4	OTA5SZLC	Strong	Altered Expression	[78]
RPA1	OT76POLP	Strong	Altered Expression	[61]
SERPINB4	OT88LHZ8	Strong	Genetic Variation	[79]
SMNDC1	OTGUZYMJ	Strong	Biomarker	[80]
SOS2	OTV3XRE5	Strong	Biomarker	[81]
SPANXA1	OTMK3QIS	Strong	Biomarker	[82]
TCHH	OT4J7EFT	Strong	Biomarker	[83]
TFAP2E	OTA4B1SG	Strong	Altered Expression	[84]
TSGA10	OTIF1O1T	Strong	Altered Expression	[85]
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⏷ Show the Full List of 50 DOT(s)

References

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52	ADAMTSL3/punctin-2, a gene frequently mutated in colorectal tumors, is widely expressed in normal and malignant epithelial cells, vascular endothelial cells and other cell types, and its mRNA is reduced in colon cancer.Int J Cancer. 2007 Oct 15;121(8):1710-6. doi: 10.1002/ijc.22882.
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